Electroencephalography Findings in Healthy and Finnish Spitz Dogs with Epilepsy : Visual and Background Quantitative Analysis

Background: Qualitative and quantitative electroencephalography (EEG) parameters of healthy and Finnish Spitz dogs with epilepsy have not been determined. Objective: To determine if EEG can provide specific characteristics to distinguish between healthy dogs and dogs with epilepsy. Animals: Sixteen healthy and 15 Finnish Spitz dogs with epilepsy. Methods: A prospective clinical EEG study performed under medetomidine sedation. Blinded visual and quantitative EEG analyses were performed and results were compared between study groups. Results: Benign epileptiform transients of sleep and sleep spindles were a frequent finding in a majority of animals from both groups. The EEG analysis detected epileptiform activity in 3 Finnish Spitz dogs with epilepsy and in 1 healthy Finnish Spitz dog. Epileptiform activity was characterized by spikes, polyspikes, and spike slow wave complexes in posterior-occipital derivation in dogs with epilepsy and with midline spikes in control dog. The healthy dogs showed significantly less theta and beta activity than did the dogs with epilepsy (P < .01), but the only significant difference between healthy dogs and dogs with untreated epilepsy was in the alpha band (P < .001). Phenobarbital treatment increased alpha, beta (P < .001), and theta (P < .01), and decreased delta (P < .001) frequency bands compared with dogs with untreated epilepsy. Conclusions and Clinical Importance: Benign epileptiform transients of sleep could be easily misinterpreted as epileptiform activity. Epileptiform activity in Finnish Spitz dogs with epilepsy seems to originate from a posterior-occipital location. The EEG of dogs with epilepsy exhibited a significant difference in background frequency bands compared with the control dogs. Phenobarbital treatment markedly influenced all background activity bands. Quantitative EEG analysis, in addition to visual analysis, seems to be a useful tool in the examination of patients with epilepsy

Electric-field control of domain wall nucleation and pinning in a metallic ferromagnet

The electric (E) field control of magnetic properties opens the prospects of an alternative to magnetic field or electric current activation to control magnetization. Multilayers with perpendicular magnetic anisotropy (PMA) have proven to be particularly sensitive to the influence of an E-field due to the interfacial origin of their anisotropy. In these systems, E-field effects have been recently applied to assist magnetization switching and control domain wall (DW) velocity. Here we report on two new applications of the E-field in a similar material : controlling DW nucleation and stopping DW propagation at the edge of the electrode

Rancang Bangun Aplikasi Perkiraan Penjualan pada CV Mula Jaya Nofina Menggunakan Analisa Forecasting

CV Mula Jaya Nofina merupakan CV yang menyuplai barang kebutuhan Perusahaan-Perusahaan besar. Barang&nbsp; yang&nbsp; disediakan&nbsp; oleh&nbsp; CV&nbsp; Mula&nbsp; Jaya&nbsp; Nofina&nbsp; tidak&nbsp; terfokus&nbsp; pada&nbsp; satu&nbsp; jenis&nbsp; barang&nbsp; saja,&nbsp; melainkan meliputi seluruh jenis barang. Ada beberapa jenis barang yang pembeliannya terdeteksi dilakukan secara rutin setiap&nbsp; bulannya.&nbsp; Nilai&nbsp; penjualan&nbsp; barang&nbsp; tersebut&nbsp; tentunya&nbsp; mengalami&nbsp; kenaikan&nbsp; dan&nbsp; penurunan,&nbsp; baik&nbsp; yang signifikan&nbsp; maupun&nbsp; tidak.&nbsp; Dengan&nbsp; adanya&nbsp; data&nbsp; penjualan&nbsp; di&nbsp; tempo&nbsp; hari,&nbsp; maka&nbsp; pegawai&nbsp; dapat&nbsp; melakukan forecasting nominal penjualan berikutnya. Tujuan utama dibuatnya aplikasi ini adalah untuk membantu pegawai dalam melakukan forecasting, menggunakan Analisa Runtut Waktu (Time Series Analysis). Sedangkan metode yang digunakan adalah Metode Rata-rata Bergerak Sederhana (Simple Moving Average Method). Variabel yang dijadikan patokan hanya satu parameter untuk perhitungannya, sehingga dapat disebut Single Moving Average Method. Hasil dari aplikasi ini berupa informasi mengenai jumlah penjualan yang mungkin terjadi pada periode akan&nbsp; datang&nbsp; sehingga&nbsp; pegawai&nbsp; dapat&nbsp; mempersiapkan&nbsp; jumlah&nbsp; suatu&nbsp; barang&nbsp; sesuai&nbsp; dengan hasil&nbsp; forecasting tersebut. Namun hasil perhitungan pada aplikasi ini menghasilkan nilai kesalahan yang cukup besar, melebihi standar&nbsp; deviasinya.&nbsp; Sehingga&nbsp; dapat&nbsp; disimpulkan&nbsp; bahwa&nbsp; forecasting&nbsp; menggunakan&nbsp; Metode&nbsp; Single&nbsp; Moving Average ini kurang tepat apabila diterapkan pada pola data yang bersifat siklis

Investigation of nickel lattice sites in diamond: Density functional theory and x-ray absorption near-edge structure experiments

International audienc

Transport, optical and electronic properties of the half metal CrO2

The electronic structure of CrO_2 is critically discussed in terms of the relation of existing experimental data and well converged LSDA and GGA calculations of the electronic structure and transport properties of this half metal magnet, with a particular emphasis on optical properties. We find only moderate manifestations of many body effects. Renormalization of the density of states is not large and is in the typical for transition metals range. We find substantial deviations from Drude behavior in the far-infrared optical conductivity. These appear because of the unusually low energy of interband optical transitions. The calculated mass renormalization is found to be rather sensitive to the exchange-correlation functional used and varies from 10% (LSDA) to 90% (GGA), using the latest specific heat data. We also find that dressing of the electrons by spin fluctuations, because of their high energy, renormalizes the interband optical transition at as high as 4 eV by about 20%. Although we find no clear indications of strong correlations of the Hubbard type, strong electron-magnon scattering related to the half metallic band structure is present and this leads to a nontrivial temperature dependence of the resistivity and some renormalization of the electron spectra.Comment: 9 Revtex 2 column pages, including 8 postscript figures. Two more figures are included in the submission that are not embedded in the paper, representing DOS and bandstructure of the paramagnetic CrO

The skyrmion switch: turning magnetic skyrmion bubbles on and off with an electric field

Nanoscale magnetic skyrmions are considered as potential information carriers for future spintronics memory and logic devices. Such applications will require the control of their local creation and annihilation, which involves so far solutions that are either energy consuming or difficult to integrate. Here we demonstrate the control of skyrmion bubbles nucleation and annihilation using electric field gating, an easily integrable and potentially energetically efficient solution. We present a detailed stability diagram of the skyrmion bubbles in a Pt/Co/oxide trilayer and show that their stability can be controlled via an applied electric field. An analytical bubble model, with the Dzyaloshinskii-Moriya interaction imbedded in the domain wall energy, account for the observed electrical skyrmion switching effect. This allows us to unveil the origin of the electrical control of skyrmions stability and to show that both magnetic dipolar interaction and the Dzyaloshinskii-Moriya interaction play an important role in the skyrmion bubble stabilization

ADAM23 is a common risk gene for canine idiopathic epilepsy

Background: Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds. Results: GWA analysis did not reveal new epilepsy loci. ADAM23 association (p < 0.05) was identified in five breeds. Combined analysis of all eight breeds showed significant association (p = 4.6e(-6), OR 1.9). Conclusions: Our results further support the role of ADAM23 in multiple breeds as a common risk gene for epilepsy with low penetrance. The lack of findings in the GWA analyses points towards inefficient capture of genetic variation by the current SNP arrays, causal variant(s) with low penetrance and possible phenocopies. Future work will include studies on ADAM23 function and expression in canine neurons, as well as whole-genome sequencing in order to identify additional IE genes