MAPI: towards the integrated exploitation of bioinformatics Web Services

<p>Abstract</p> <p>Background</p> <p>Bioinformatics is commonly featured as a well assorted list of available web resources. Although diversity of services is positive in general, the proliferation of tools, their dispersion and heterogeneity complicate the integrated exploitation of such data processing capacity.</p> <p>Results</p> <p>To facilitate the construction of software clients and make integrated use of this variety of tools, we present a modular programmatic application interface (<it>MAPI</it>) that provides the necessary functionality for uniform representation of Web Services metadata descriptors including their management and invocation protocols of the services which they represent. This document describes the main functionality of the framework and how it can be used to facilitate the deployment of new software under a unified structure of bioinformatics Web Services. A notable feature of <it>MAPI </it>is the modular organization of the functionality into different modules associated with specific tasks. This means that only the modules needed for the client have to be installed, and that the module functionality can be extended without the need for re-writing the software client.</p> <p>Conclusions</p> <p>The potential utility and versatility of the software library has been demonstrated by the implementation of several currently available clients that cover different aspects of integrated data processing, ranging from service discovery to service invocation with advanced features such as workflows composition and asynchronous services calls to multiple types of Web Services including those registered in repositories (e.g. <it>GRID</it>-based, SOAP, <it>BioMOBY</it>, <it>R-bioconductor</it>, and others).</p

Diseño de un sistema de tratamiento de aguas residuales y su reutilización en la empresa agroindustrial Tumán S. A. A. para disminuir los costos de producción

El presente trabajo de investigación, se centra en un diseño de sistema de tratamiento de aguas residuales con la intención de disminuir los costos, por el uso excesivo del recurso hídrico en el proceso de producción de azúcar, llegando a consumir bajo una licencia de abastecimiento de agua la cantidad de 6 307 200 m³ anuales, generando gran cantidad de efluentes, determinándose que el agua residual va directamente al canal de regadío y el exceso, al cauce del rio chancay sin previo tratamiento, es por ese motivo que se procedió a caracterizar el agua residual, indicando que los parámetros DBO, DQO, coliformes totales, grasas y aceites se ubican fuera del límite máximo permisible, así mismo analizando su composición se procedió a evaluar los diferentes sistemas de tratamiento, llegando a seleccionar mediante factores ponderados, el mejor sistema de tratamiento siendo por lodos activados el tratamiento elegido, cabe indicar que para el diseño del sistema de tratamiento se desarrolló un tratamiento de desbaste, desengrasado, sedimentación primaria y sedimentador secundario, empleando el método Guerchet, para calcular las medidas exactas de las maquinas a emplear en cada uno de las etapas del tratamiento y se consideró usar el agua tratada para la etapa del lavado por lo que se proyectó la cantidad de agua empleada en el dicho proceso de lavado siendo esta de 1 576 800 m³ anuales, Asimismo se desarrolló el análisis costo beneficio, la inversión será S/ 489 434,55 teniendo un periodo de recuperación de 3 años, con un VAN de S/ 74 765,81 y un TIR de 19% que indica que es fiable y rentable la inversión por el sistema de tratamiento de aguas residuales

La informalidad en las construcciones como factor determinante de la vulnerabilidad física de las viviendas

La presente investigación respondió al siguiente problema general: ¿ Cuál es el impacto de las construcciones informales en la vulnerabilidad física de las viviendas en el distrito de San Juan de Lurigancho-Lima?,el objetivo general fue: Determinar el impacto de las construcciones informales en la vulnerabilidad física de las construcciones de las viviendas en el distrito de San Juan de Lurigancho-Lima y la hipótesis general que se verifico fue: “La informalidad en las construcciones constituyen un factor determinante de la vulnerabilidad física de las viviendas del distrito de San Juan de Lurigancho – Lima.” El método general de investigación fue el científico, y como método especifico se utilizó el analítico – sintético, con un enfoque cuantitativo, el tipo de investigación fue aplicado, el nivel descriptivo, explicativo, y de diseño No Experimental. La población estuvo conformada por las viviendas de la ampliación del AA.HH. Arriba Perú, Distrito de San Juan de Lurigancho - Lima, que son aproximadamente 200 viviendas; el tipo de muestreo fue no aleatorio o dirigido y estando conformado por 30 viviendas. La conclusión fundamental al que se arribó es que la informalidad en las construcciones constituye un factor determinante en la vulnerabilidad física de las viviendas en el distrito de San Juan de Lurigancho - Lima, que requiere el apoyo técnico y económico de profesionales especializados, así como el asesoramiento en las construcciones.Tesi

Gestión del talento humano basado en las necesidades de las empresas en Colombia

El Talento Humano según Chiavenato (2007, pág. 45) es la capacidad de las empresas para atraer, motivar, idelizar y desarrollar a los profesionales más competentes, más capaces, más comprometidos y sobre todo de su capacidad para convertir el talento individual, a través de un proyecto ilusionante, en Talento Organizativo y lo deine en el caso del profesional, como “una persona comprometido,práctica y capaz de dar resultados de manera eiciente”. Además considerado como materia prima de las corporaciones; tiene entre sus funciones, el reclutamiento, selección, inducción y capacitación, contratación, bienestar, evaluación de desempeño, y también la remuneración, de acuerdo a la empresa que labore, por tal razón se desprenden roles hacia el talento: comercial, directivo, liderazgo,técnico, administrativo; y de acuerdo a sus funciones, objetivos y aporte de valor a la organización, resalta el autor también al talento del innovador y emprendedor, estos últimos generadores de valor en las corporaciones. Ante la escasez de trabajo y laborar porque no existe otra alternativa, ya sea en entorno no deseado, está en el Gerente o Administrado del Talento Humano, las habilidades paramotivar o cambiar de roles en las organizaciones y está en eso el liderazgo de las corporaciones

Effect of size and composition on the second harmonic generation from lithium niobate powders at different excitation wavelengths

INVESTIGACIÓN DESARROLLADA EN COLABORACIÓN DE RED TEMATICA PRODEP /SEP/MEXICOLiNbO3 microcrystalline systems, possessing almost stoichiometric composition, were produced by varying the temperature and time parameters in the annealing processes following a mechanochemical reaction of raw powders. SHG from these samples, detected for every fundamental wavelength in the range 800-1300 nm, and being maximal at a certain wavelength, λmax, for each sample, has been addressed to a random scattering of the induced nonlinear polarizations. Possible tuning of λmax could be ascribed to control of composition and grain size of the sample. Random orientation of the produced nanocrystallites was verified since no dependence for SHG intensity on incident polarization was observed.PAPIIT-UNAM through grant IN117116 Y “RED PRODEP-SEP Compuestos poliméricos propiedades y aplicaciones 2015-2016

Additional information delivery to image content via improved unseen–visible watermarking

In a practical watermark scenario, watermarks are used to provide auxiliary information; in this way, an analogous digital approach called unseen–visible watermark has been introduced to deliver auxiliary information. In this algorithm, the embedding stage takes advantage of the visible and invisible watermarking to embed an owner logotype or barcodes as watermarks; in the exhibition stage, the equipped functions of the display devices are used to reveal the watermark to the naked eyes, eliminating any watermark exhibition algorithm. In this paper, a watermark complement strategy for unseen–visible watermarking is proposed to improve the embedding stage, reducing the histogram distortion and the visual degradation of the watermarked image. The presented algorithm exhibits the following contributions: first, the algorithm can be applied to any class of images with large smooth regions of low or high intensity; second, a watermark complement strategy is introduced to reduce the visual degradation and histogram distortion of the watermarked image; and third, an embedding error measurement is proposed. Evaluation results show that the proposed strategy has high performance in comparison with other algorithms, providing a high visual quality of the exhibited watermark and preserving its robustness in terms of readability and imperceptibility against geometric and processing attacks

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Background: Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascular effects of (S)- isometheptene and (R)-isometheptene, and the pharmacological profile of the more potent enantiomer. Methods: The effects of i.v. bolus injections (0.03, 0.1, 0.3, 1 and 3 mg/kg) of isometheptene racemate, (S)-isometheptene or (R)-isometheptene on heart rate and blood pressure were analyzed in control experiments. The enantiomer producing more pronounced tachycardic and/or vasopressor responses was further analyzed in rats receiving i.v. injections of prazosin (0.1 mg/kg), rauwolscine (0.3 mg/kg), propranolol (1 mg/kg) or intraperitoneal reserpine (5 mg/kg, -24 h). Results: Compared to (R)-isometheptene, (S)-isometheptene produced greater vasopressor responses, whilst both compounds equipotently increased heart rate. The tachycardic responses to (S)-isometheptene were abolished after propranolol, but remained unaffected by the other antagonists. In contrast, the vasopressor responses to (S)-isometheptene were practically abolished after prazosin. Interestingly, after reserpine, the tachycardic responses to (S)-isometheptene were abolished, whereas its vasopressor responses were attenuated and subsequently abolished by prazosin. Conclusions: The different cardiovascular effects of the isometheptene enantiomers are probably due to differences in their mechanism of action, namely: (i) a mixed sympathomimetic action for (S)-isometheptene (a tyramine-like action and a direct stimulation of α1-adrenoceptors); and (ii) exclusively a tyramine like action for (R)-isometheptene. Thus, (R)-isometheptene may represent a superior therapeutic benefit as an antimigraine agent

Population history, phylogeography, and conservation genetics of the last Neotropical mega-herbivore, the lowland tapir (Tapirus terrestris)

<p>Abstract</p> <p>Background</p> <p>Understanding the forces that shaped Neotropical diversity is central issue to explain tropical biodiversity and inform conservation action; yet few studies have examined large, widespread species. Lowland tapir (<it>Tapirus terrrestris</it>, Perissodactyla, Tapiridae) is the largest Neotropical herbivore whose ancestors arrived in South America during the Great American Biotic Interchange. A Pleistocene diversification is inferred for the genus <it>Tapirus </it>from the fossil record, but only two species survived the Pleistocene megafauna extinction. Here, we investigate the history of lowland tapir as revealed by variation at the mitochondrial gene Cytochrome <it>b</it>, compare it to the fossil data, and explore mechanisms that could have shaped the observed structure of current populations.</p> <p>Results</p> <p>Separate methodological approaches found mutually exclusive divergence times for lowland tapir, either in the late or in the early Pleistocene, although a late Pleistocene divergence is more in tune with the fossil record. Bayesian analysis favored mountain tapir (<it>T. pinchaque</it>) paraphyly in relation to lowland tapir over reciprocal monophyly, corroborating the inferences from the fossil data these species are sister taxa. A coalescent-based analysis rejected a null hypothesis of allopatric divergence, suggesting a complex history. Based on the geographic distribution of haplotypes we propose (<it>i</it>) a central role for western Amazonia in tapir diversification, with a key role of the ecological gradient along the transition between Andean subcloud forests and Amazon lowland forest, and (<it>ii</it>) that the Amazon river acted as an barrier to gene flow. Finally, the branching patterns and estimates based on nucleotide diversity indicate a population expansion after the Last Glacial Maximum.</p> <p>Conclusions</p> <p>This study is the first examining lowland tapir phylogeography. Climatic events at the end of the Pleistocene, parapatric speciation, divergence along the Andean foothill, and role of the Amazon river, have similarly shaped the history of other taxa. Nevertheless further work with additional samples and loci is needed to improve our initial assessment. From a conservation perspective, we did not find a correspondence between genetic structure in lowland tapir and ecogeographic regions proposed to define conservation priorities in the Neotropics. This discrepancy sheds doubt into this scheme's ability to generate effective conservation planning for vagile species.</p