Revision sistematica de “canis” ensenadensis ameghino 1888 (carnivora, canidae) y la des- cripcion de un nuevo especimen del Pleistoceno de Argentina.

The fossil record of foxes in South America is very rich, with almost all extant South American species recorded. Currently, three fossil species are known in the Plio-Pleistocene of South America: "Dusicyon" cultridens, Dusicyon avus and "Canis" ensenadensis. In the present work we reviewed the systematics of "Canis" ensenadensis from the Pleistocene of Buenos Aires province using both qualitative and quantitative approaches. We also described a new fossil specimen (MCA 2082) from Buenos Aires Province (Argentina) that shares some similarities with "Canis" ensenadensis. We compared the fossil specimens with a large sample of specimens that includes the living species Lycalopex gymnocercus, L. culpaeus, Cerdocyon thous, L. fulvipes, L. vetulus, L. sechurae and Atelocynus microtis. We performed a Principal Component Analysis using mandibular and dental measurements, and then a geometric morphometric analysis using photographs of the lateral view of the mandible. Our results indicate that "Canis" ensenadensis is a valid species and it should be included in the genus Lycalopex. We also conclude that MCA 2082 is a member of the genus Lycalopex, probably belonging to the species L. ensenadensis. These results suggest that the biochron of L. ensenadensis reaches the Lujanian Age. Even if our assignation of MCA 2082 is incorrect, this specimen represents a different taxon from those already described for the Lujanian, thus the diversity of foxes during the Lujanian is greater than previously known.El registro fósil de zorros en América del Sur es muy rico con prácticamente todas las especies sur americanas actuales representadas en él. En la actualidad se conocen tres especies extintas para el Plio-Pleistoceno de América del Sur. “Dusicyon” cultridens, Dusicyon avus y “Canis” ensenadensis. En el presente trabajo hemos reestu- diado la sistemática de “Canis” ensenadensis del Pleistoceno de la provincia de Buenos Aires abordando enfoques cualitativos y cuantitativos. Además describimos un nuevo espécimen proveniente de la Provincia de Buenos Aires (Argentina) que comparte ciertas características con “Canis” ensenadensis. Los especímenes fósiles fueron comparados con una gran muestra de especímenes actuales correspondientes a las espe- cies L. gymnocercus, L. culpaeus, Cerdocyon thous, L. fulvipes, L. vetulus, L. sechurae y Atelocynus microtis. Se realizó un Análisis de Componentes Principales, utilizando medidas mandibulares y dentarias, y un análisis de morfometría geométrica, utilizando fotografías de vistas laterales de la mandíbula. Nuestros resultados sugieren que “Canis” ensenadensis es una especie válida y que debe ser incluida en el género Lycalopex. Además concluímos que MCA 2082 es un miembro del género Lycalopex, perteneciendo tentativamente a la especie Lycalopex ensenadensis. Esto sugiere que el biocrón de Lycalopex ensenadensis alcanzaría la Edad Lujanense. Incluso si nuestra asignación fuese incorrecta, el espéci- men representaría una especie distinta a las descriptas para el Lujanense, por lo que la diversidad de zorros del Lujanense es mayor a la pre- viamente conocida.Fil: Ramirez, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "bernardino Rivadavia"; ArgentinaFil: Prevosti, Francisco Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "bernardino Rivadavia"; Argentina. Universidad Nacional de Luján; Argentin

Manufacture and use of ornaments made on carnivore teeth from archaeological sites of Low Paraná Wetland

En este trabajo se analizan una serie de piezas dentarias de carnívoros discutiendo su utilización como objetos ornamentales por las poblaciones humanas que ocuparon el sector meridional del humedal del Paraná inferior durante el Holoceno tardío. La identificación taxonómica de los distintos elementos dentarios se efectuó mediante estudios morfométricos, siendo de particular interés señalar el reconocimiento de especies que son poco frecuentes o que hasta ahora no estaban presentes en el registro arqueológico regional como Canis familiaris y Nasua nasua. A través del análisis microscópico, logramos identificar distintos rastros o huellas de transformación y utilización de los dientes, incluso en aquellos ejemplares que a ojo desnudo no presentaban modificaciones antrópicas. En función de los resultados obtenidos se discute la obtención y uso de estos objetos como objetos ornamentales y se realizan distintas consideraciones en cuanto a su potencial valor simbólico, señalando ciertas limitaciones interpretativas que existen sobre este tópico, así como las vías analíticas y conceptos desarrollados por otros autores para abordar problemáticas similares a las aquí estudiadas.This paper analyses Carnivore dental items, discussing their use as ornaments by human societies that inhabited the southern sector of Low Paraná wetland during the Late Holocene. Taxonomic identification of dental items was made trough morphometric analysis. It is very interesting to show the presence of taxa not available in the area as Canis familiaris and Nasua nasua. Through microscopic analysis, we identified use and manufacture process, also in those items which do not show anthropic modification at the naked eye. On the basis of these results, we discuss the bone raw material acquisition and their use as ornaments, arguing their symbolic value but pointing the analytical restrictions on this subject, as well as the methodological and theoretical lines developed by other authors to deal with similar topics.Fil: Acosta, Alejandro Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; ArgentinaFil: Buc, Natacha. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; ArgentinaFil: Ramirez, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Prevosti, Francisco Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: Loponte, Daniel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; Argentin

Experience with tocilizumab in severe COVID-19 pneumonia after 80 days of follow-up: A retrospective cohort study

Objectives: To describe the clinical characteristics and predictors of major outcomes in patients treated with tocilizumab (TCZ) for severe COVID-19 pneumonia.Patients and methods: Case series of all sequential patients with severe COVID-19 pneumonia treated with TCZ at an Academic Spanish hospital (March 12 - May 2, 2020). Clinical outcomes: death, length of hospital stay. An early clinical response to TCZ (48-72 h after the administration) was assessed by variations in respiratory function markers, Brescia COVID Respiratory Severity Scale (BCRSS), inflammatory parameters, and patients' and physicians' opinion. Associations were tested by multiple logistic regression.Results: From a cohort of 236 patients, 77 patients treated with TCZ were included (median age 62 years (IQR 53.0-72.0), 64.9% were males), 42.9% had Charlson index ≥3; hypertension (41.6%), obesity (34.7%), and diabetes (20.8%). Median follow-up was 83.0 days (78.0-86.5), no patient was readmitted. ICU admission was required for 42 (54.5%), invasive mechanical ventilation in 38 (49.4%) and 10 patients died (12.9% global, 23.8% at ICU admitted). After multivariate adjustment, TCZ response by BCRSS (OR 0.03 (0.01-0.68), p = 0.028), and Charlson index (OR 3.54 (1.20-10.44), p = 0.022) has been identified as independent factors associated with mortality. Median of hospital stay was 16.0 days (11.0-23.0); BCRSS, physician subjective and D-dimer response were associated with shorter hospitalization stay.Conclusions: In a Mediterranean cohort, use of tocilizumab for severe COVID-19 show 12.9% of mortality. Early TCZ-response by BCRSS and low comorbidity were associated with increased survival. Early TCZ-response was related to shorter median hospital stay

Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study

Objectives: This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, and to evaluate the acute infection phase associated risk factors.Methods: A prospective cohort study of adult patients who had recovered from COVID-19 (27th February to 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10-14 weeks after disease onset. PCS was defined as the persistence of at least one clinically relevant symptom, or abnormalities in spirometry or chest radiology. Outcome predictors were analyzed by multiple logistic regression (OR; 95%CI).Results: Two hundred seventy seven patients recovered from mild (34.3%) or severe (65.7%) forms of SARS-CoV-2 infection were evaluated 77 days (IQR 72-85) after disease onset. PCS was detected in 141 patients (50.9%; 95%CI 45.0-56.7%). Symptoms were mostly mild. Alterations in spirometry were noted in 25/269 (9.3%), while in radiographs in 51/277 (18.9%). No baseline clinical features behaved as independent predictors of PCS development.Conclusions: A Post-acute COVID-19 syndrome was detected in a half of COVID19 survivors. Radiological and spirometric changes were mild and observed in less than 25% of patients. No baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Variation on cranidial shape of Parabolinella argentinensis Kobayashi (Trilobita, Olenidae) from the Tremadocian of northwestern Argentina: Taxonomic implications

The late Cambrian-Early Ordovician sequences of the Cordillera Oriental in northwestern Argentina are extensive and highly fossiliferous. The olenid trilobite Parabolinella argentinensis Kobayashi sensu Harrington and Leanza, 1957 was reported from a great number of Tremadocian localities and includes a wide range of morphologies. Based on specimens collected from the type locality (Purmamarca, Jujuy) and the quebrada Moya (Huacalera, Jujuy), as well as on material of the Harrington and Leanza collections in the University of Buenos Aires, classic morphometry and geometric morphometry methods were used to evaluate the variability in the cranidium of P. Argentinensis. The results obtained from the two methodologies are similar. Both analyses allowed the review of the diagnosis of P. Argentinensis, and the distinction of two new morphologies: Parabolinella clarisae n. Sp. And Parabolinella pompadouris n. Sp. The results show how morphogeometrics distinguishes more clearly the three morphotypes and provides graphical representations of the differences between those groups and how from the representations plus the correlation between classical variables and principal components, new diagnostic characters that distinguish the three morphospecies, can be identified.Fil: Monti, Daniela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Benítez, María del Huerto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Ramirez, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; Argentin