Development of platform-independent web-based telecardiology application for pilot case study

Telecardiology is one of the branches from telemedicine that transmits cardiac data such as electrocardiogram (ECG) and medical records from the patient site to cardiologist for the purpose of diagnosis by using telecommunication and information technologies. Most of the current commercialized telecardiology applications are cost expensive, vendor-specific, and dependent on computing platform and operating system (OS). There are plenty of research have been done on web-based telecardiology application either in real-time transmission or store - And-forward. In this paper, a platform-independent and OS-independent web-based telecardiology application, named VirtualDave System, is developed. The proposed system allow users to log on and access from any computer or mobile communication devices such as smart phone as long as they have internet access and web browser. The developed application allows users in categories of patient, administrator, medical officer and cardiologist, to communicate and get medical consultation without long distance traveling. With the improvement to the system dependency and functionality enhancement such as instant messaging, this web-based telecardiology could significantly help to improve the health care services especially in rural area

On the distance spectrum and distance energy of complement of subgroup graphs of dihedral group

Let G is a connected simple graph and V(G) = {v1, v2, ..., vp} is vertex set of G. The distance matrix of G is a matrix D(G) = [d ij ] of order p where [d ij ] = d(v i , v j ) is distance between v i and v j in G. The set of all eigenvalues of matrix D(G) together with their corresponding multiplicities is named the distance spectrum of G and denoted by spec D (G). The distance energy of G is ${E}_{D}(G)={\sum }_{i=1}^{p}|{\lambda }_{i}|$, where λi are eigenvalues of D(G). In the recent paper, the distance spectrum and distance energy of complement of subgroup graphs of dihedral group are determined

Detour spectrum and detour energy of conjugate graph complement of dihedral group

Study of graph from a group has become an interesting topic until now. One of the topics is spectra of a graph from finite group. Spectrum of a finite graph is defined as collection of all distinct eigenvalues and their algebraic multiplicity of its matrix. The most related topic in the study of spectrum of finite graph is energy. Energy of a finite graph is defined as sum of absolute value of all its eigenvalues. In this paper, we study the spectrum and energy of detour matrix of conjugate graph complement of dihedral group. The main result is presented as theorems with complete proof

Delineating the GRIN1 phenotypic spectrum: a distinct genetic NMDA receptor encephalopathy

Objective:To determine the phenotypic spectrum caused by mutations in GRIN1 encoding the NMDA receptor subunit GluN1 and to investigate their underlying functional pathophysiology.Methods:We collected molecular and clinical data from several diagnostic and research cohorts. Functional consequences of GRIN1 mutations were investigated in Xenopus laevis oocytes.Results:We identified heterozygous de novo GRIN1 mutations in 14 individuals and reviewed the phenotypes of all 9 previously reported patients. These 23 individuals presented with a distinct phenotype of profound developmental delay, severe intellectual disability with absent speech, muscular hypotonia, hyperkinetic movement disorder, oculogyric crises, cortical blindness, generalized cerebral atrophy, and epilepsy. Mutations cluster within transmembrane segments and result in loss of channel function of varying severity with a dominant-negative effect. In addition, we describe 2 homozygous GRIN1 mutations (1 missense, 1 truncation), each segregating with severe neurodevelopmental phenotypes in consanguineous families.Conclusions:De novo GRIN1 mutations are associated with severe intellectual disability with cortical visual impairment as well as oculomotor and movement disorders being discriminating phenotypic features. Loss of NMDA receptor function appears to be the underlying disease mechanism. The identification of both heterozygous and homozygous mutations blurs the borders of dominant and recessive inheritance of GRIN1-associated disorders.Johannes R. Lemke (32EP30_136042/1) and Peter De Jonghe (G.A.136.11.N and FWO/ESF-ECRP) received financial support within the EuroEPINOMICS-RES network (www.euroepinomics.org) within the Eurocores framework of the European Science Foundation (ESF). Saskia Biskup and Henrike Heyne received financial support from the German Federal Ministry for Education and Research (BMBF IonNeurONet: 01 GM1105A and FKZ: 01EO1501). Katia Hardies is a PhD fellow of the Institute for Science and Technology (IWT) Flanders. Ingo Helbig was supported by intramural funds of the University of Kiel, by a grant from the German Research Foundation (HE5415/3-1) within the EuroEPINOMICS framework of the European Science Foundation, and additional grants of the German Research Foundation (DFG, HE5415/5-1, HE 5415/6-1), German Ministry for Education and Research (01DH12033, MAR 10/012), and grant by the German chapter of the International League against Epilepsy (DGfE). The project also received infrastructural support through the Institute of Clinical Molecular Biology in Kiel, supported in part by DFG Cluster of Excellence "Inflammation at Interfaces" and "Future Ocean." The project was also supported by the popgen 2.0 network (P2N) through a grant from the German Ministry for Education and Research (01EY1103) and by the International Coordination Action (ICA) grant G0E8614N. Christel Depienne, Caroline Nava, and Delphine Heron received financial support for exome analyses by the Centre National de Genotypage (CNG, Evry, France)

Corrigendum to “On the conjecture of Sombor energy of a graph” [Examples and Counterexamples 3 (2023) 100115]

In this corrigendum, we correct some errors in the proof of Theorem 2.1 in “On the conjecture of Sombor energy of a graph” [Examples and Counterexamples 3 (2023) 100115]

General sum-connectivity index, general product-connectivity index, general Zagreb index and coindices of line graph of subdivision graphs

The general sum-connectivity index, general product-connectivity index, general Zagreb index and coindices of line graphs of subdivision graphs of tadpole graphs, wheels and ladders have been reported in the literature. In this paper, we obtain general expressions for these topological indices for the line graph of the subdivision graphs, thus generalizing the existing results