Digital Platform of the second industrial market

Treball Final de Grau en Administració d'Empreses. Codi: AE1049. Curs 2018-2019The online platform of the second industrial market is an idea of a business project for the creation and implementation of a new business model without a presence in the network today. A project with global cavity with the use of new technologies. The idea is born from one of the most important needs and duties of the world and society today: caring for the planet. Focused on the ideas and creation of sustainable products in contribution to the environment, which make use of the 3 rd rule: reduce, reuse and recycle. The objective of the project is to take care and protect the world where we live, reusing and taking advantage of all those materials that do not need companies, and that can be used by others. Giving them a new value in the form of a product and at an economic level, putting them back into circulation in the market with innovative concepts and different utilities. Throughout this project the possible viability of the project is studied, analyzed and concluded, and what objectives and incentives it has for companies that participate in the digital platform. The viability of the project goes through a necessary online presence, where reuse and recycle have the digital transformation they deserve, making it possible for companies from different locations to get in touch in order to exchange useful materials between them. What may be no longer necessary materials in the value chain of one company, in that of another, may be the input of its product manufacturing

Diseño de un Plan de Respuesta para la conservación y mejoramiento en caminos de acceso en la Línea de Transmisión Moín-Cahuita- Sixaola del ICE

Proyecto de Graduación (Licenciatura en Ingeniería en Construcción) Instituto Tecnológico de Costa Rica. Escuela de Ingeniería en Construcción, 2014.This Graduation Project (GP) was developed as a Professional Guided Practice modality, it was carried out in the Ways Construction Area from the UEN PySA, specifically in the Instituto Costarricense de Electricidad (ICE). This work contributes to the improvement of several procedures that involve conservation and penetration way´s enhancement in the transmission line from Moín-Cahuita-Sixaola. The project is based on a reply plan for conservation and penetration way´s enhancement through administrative aspects and technical emphasis evaluation; all this according to national laws and field needs. The administrative approach takes into consideration the internal planning procedures and the Project Management Institute´s good administration practices by means of the PMBOK ® guide. The technical emphasis considers the control tools. For construction procedures, many tools were made, as: flowcharts, evaluation sheets and verification lists. The material mentioned was supplemented by field viewings and it was validated in new projects from the area. Finally, a good practices for penetration way´s construction guide was obtained, it is a compilation of recommendations for evaluating constructive procedures in aspects like environment, work organization, machinery and cement stabilized bases.Instituto Tecnológico de Costa Rica. Escuela de Ingeniería en Construcción. Instituto Costarricense de Electricidad

Metal-Doping of La5.4MoO11.1 Proton Conductors: Impact on the Structure and Electrical Properties.

La5.4MoO11.1 proton conductors with different metal doping (Ca2+, Sr2+, Ba2+, Ti4+, Zr4+, and Nb5+) have been prepared and structurally and electrically characterized. Different polymorphs are stabilized depending on the doping and cooling rate used during the synthesis process. The most interesting results are obtained for Nb-doping, La5.4Mo1−xNbxO11.1−x/2, where single compounds are obtained in the compositional range 0 ≤ x ≤ 0.2. These materials are fully characterized by structural techniques such as X-ray and neutron powder diffraction and transmission electron microscopy, which independently confirm the changes of polymorphism. Scanning electron microscopy and impedance spectroscopy measurements in dry/wet gases (N2, O2, and 5% H2−Ar) showed an enhancement of the sinterability and electrical properties of the materials after Nb-doping. Conductivity measurements under very reducing conditions revealed that these materials are mixed ionic-electronic conductors, making them potential candidates for hydrogen separation membranes

Biología del virus del papiloma humano y técnicas de diagnóstico

El virus del papiloma humano (VPH) pertenece al grupo de virus con tropismo por los epitelios; infectan predominantemente la piel y las membranas mucosas y producen proliferaciones benignas o papilomas, que bajo ciertas circunstancias pueden experimentar transformación maligna. El VPH es considerado el agente causal más importante del carcinoma del cérvix uterino y el conocimiento de su biología es fundamental para el entendimiento de la carcinogénesis cervical. Existe evidencia epidemiológica y molecular sobre la estrecha relación del VPH en el desarrollo del carcinoma cervical y sus precursores. La infección por el virus del papiloma humano es un importante problema de salud pública en nuestro país, para lo cual se ha identificado a la población con claros factores de riesgo, tales como: inicio temprano de vida sexual activa y múltiples parejas sexuales, hacia quienes se dirigen todos los esfuerzos de prevención y diagnóstico temprano, donde ya se incluyen estudios avanzados y cada vez más sensibles y específicos, con el fin de detectar más oportunamente esta mortal enfermedad

Synergic Effect of Metal and Fluorine Doping on the Structural and Electrical Properties of La5.4MoO11.1-Based Materials.

Cationic and anionic frameworks of La5.4MoO11.1 proton conductors have been modified by means of metal (Ti4+, Zr4+, and Nb5+) and fluorine (F−) doping. This synergic effect leads to the stabilization of highsymmetry and single-phase polymorphs. The materials have been fully characterized by structural techniques, such as X-ray and neutron powder diffraction and transmission electron microscopy. The fluorine content was determined by ion chromatography. Impedance spectroscopy analysis under different atmospheres (dry and wet N2 and O2 and wet 5% H2−Ar) showed an improvement in the electronic conductivity under reducing conditions, making these materials potential candidates for hydrogen separation membranes

Hipovitaminose D em pacientes com diabetes tipo 2 : fatores de risco e associação com controle glicêmico e complicações microvasculares estabelecidas

Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25OHD, glycemic control and chronic complications of T2DM. Methods. A cross-sectional study was carried out, in which 25OHD levels were evaluated in adult patients (over 18 years) with T2DM. Correlation analyses were performed to evaluate the interdependence of the 25OHD with other continuous variables. A receiver operating characteristic analysis was also performed to identify cutoff values for diagnosing vitamin D deficiency. Logistic regression was performed to identify the independent association between vitamin D deficiency and the variables associated with lower 25OHD. Results. 208 patients were analyzed. The mean age of the patients was 62 years.  The 25OHD level was 19 ng/ml (IQR 13.28-24.43), 59.78% had vitamin D deficiency, and 10.33% had severe deficiency. Glycemia, HbA1c, and BMI were negatively correlated with 25OHD. Cutoff point for vitamin D deficiency was 33.39 kg/m2 for body mass index (BMI), 123 mg/dl for glycemia, and 6.65% for HbA1c. In multivariate logistic regression, BMI>33.39 kg/m2, glycemia >123.5 mg/dl, and albuminuria presented higher odds of vitamin D deficiency. Major conclusion. Vitamin D deficiency was highly prevalent among patients with T2DM. Low levels were related to higher fasting plasma glucose, higher BMI, and diabetic nephropathy.Introducción. Varios estudios reportaron que la deficiencia de vitamina D aumenta el riesgo de enfermedad macrovascular y microvascular en pacientes con diabetes tipo 2 (DM2). Investigamos los niveles de 25OHD en adultos con DM2, factores de riesgo de deficiencia de 25OHD y relación entre 25OHD, control glucémico y complicaciones crónicas de la DM2. Métodos. Se realizó un estudio transversal en el que se evaluaron los niveles de 25OHD en adultos (mayores de 18 años) con DM2. Se realizaron análisis de correlación para evaluar la interdependencia de la 25OHD con otras variables continuas. Se realizó un análisis de las características operativas del receptor para identificar valores de corte para diagnóstico de deficiencia de vitamina D. Se realizó una regresión logística para identificar asociación independiente entre deficiencia de 25OHD y variables asociadas con una menor 25OHD. Resultados. Se analizaron 208 pacientes. La edad media fue 62 años. El nivel de 25OHD fue 19 ng/ml (IQR 13.28-24.43), 59.78% tenía deficiencia de vitamina D y 10.33% tenía deficiencia severa. Glucemia, HbA1c y IMC correlacionaron negativamente con 25OHD. El punto de corte para deficiencia de vitamina D fue 33,39 kg/m2 para índice de masa corporal (IMC), 123 mg/dl para glucemia y 6,65% para HbA1c. En la regresión logística multivariada, IMC >33,39 kg/m2, glucemia >123,5 mg/dl y albuminuria presentaron mayores probabilidades de deficiencia de vitamina D. Conclusión principal. La deficiencia de vitamina D fue altamente prevalente en los pacientes con DM2. Niveles bajos de 25OHD se relacionaron con mayor glucemia, mayor IMC y nefropatía diabética.Introdução. Vários estudos relataram que a deficiência de vitamina D aumenta o risco de doença macrovascular e microvascular em pacientes com diabetes tipo 2 (DM2). Nós investigamos os níveis de 25OHD em adultos com DM2, fatores de risco para deficiência de 25OHD e a relação entre 25OHD, controle glicêmico e complicações crônicas do DM2. Métodos. Foi realizado um estudo transversal em que os níveis de 25OHD foram avaliados em adultos (maiores de 18 anos) com DM2. Análises de correlação foram realizadas para avaliar a interdependência de 25OHD com outras variáveis ​​contínuas. Uma análise das características operatórias do receptor foi realizada para identificar valores de corte para o diagnóstico de deficiência de vitamina D. Uma regressão logística foi realizada para identificar uma associação independente entre a deficiência de 25OHD e variáveis ​​associadas a uma menor 25OHD. Resultados. 208 pacientes foram analisados. A média de idade foi de 62 anos. O nível de 25OHD foi de 19 ng/ml (IQR 13,28-24,43), 59,78% eram deficientes em vitamina D e 10,33% eram severamente deficientes. Glicemia, HbA1c e IMC correlacionaram-se negativamente com 25OHD. O ponto de corte para deficiência de vitamina D foi de 33,39 kg/m2 para índice de massa corporal (IMC), 123 mg/dl para glicose no sangue e 6,65% para HbA1c. Na regressão logística multivariada, IMC> 33,39 kg/m2, glicemia >123,5 mg/dl e albuminúria apresentaram maiores probabilidades de deficiência de vitamina D. Conclusão principal. A deficiência de vitamina D foi altamente prevalente em pacientes com DM2. Níveis baixos de 25OHD foram associados a maior glicose no sangue, maior IMC e nefropatia diabética

Instituciones locales y procesos organizativos: el caso de la Reserva de la Biósfera Sian Ka’an

Se analiza desde una perspectiva histórica, los procesos organizativos y el papel de las instituciones locales en el aprovechamiento de sus recursos naturales, en el marco de la dinámica regional relacionada con las políticas ambientales que destacan la importancia de las áreas naturales protegidas. Nos referimos a la relación entre la biósfera Sian Ka'an y las localidades con actividades pesqueras y forestales. Los resultados muestran que en la reserva Sian Ka’an se dan procesos organizativos previos al establecimiento de la reserva; procesos que mantienen instituciones locales consolidadas que han servido para el buen manejo de sus recursos naturales, por lo tanto, para que la política de conservación instrumentada en áreas naturales protegidas sea viable debe ir vinculada a los procesos históricos y culturales de los actores locales

Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women

Background: A number of studies have demonstrated that receptor and co-receptor expression levels which may affect viral entry, promoting cervical HIV infection. The aim was to evaluate the expression levels of CCR5, CXCR4 and DC-SIGN mRNA in a sample of heterosexually HIV infected Mexican women. Methods: We enrolled twenty-six HIV heterosexual infected women attending a local infectious diseases medical unit. RNA was isolated from the cervix and gene expression analysis was performed using real-time PCR. Results: Expression rates for mRNA of CCR5 (median 1.82; range 0.003–2934) were higher than those observed for CXCR4 (0.79; 0.0061–3312) and DC-SIGN (0.33; 0.006–532) receptors (p < 0.05). A high correlation was found between the mRNA expression levels of these three receptors (rs = 0.52 to 0.85, p < 0.01). Conclusion: Levels of expression of the tested chemokine receptors in the cervix are different from each other and also vary from woman to woman, and seem to support the suggestion that chemokine receptor expression in genital tissues may be playing a role in the HIV transmission

Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic

Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, suchas type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lyso-phospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer)

Violence of women againt men, myth or reality?

Artículo revisado por: Marzia Fiorini. Grupo de Investigación: Aprendizaje y Desarrollo en Contextos Educativos. Universidad de Granada; Jory Bolton. Trent UniversityEl sexismo ambivalente afectan de manera inmediata y permanente interfiriendo en la necesidad de cierre cognitivo, generando confusión, ambigüedad e incertidumbre en las personas victimas de la violencia de género. Este estudio explora la visión de que las mujeres puedan ejercer la violencia hacia los hombres. Método: Estudio exploratorio realizado en la Facultad de Ciencias de la Educación de la Universidad de Granada. Cuarenta y nueve mujeres, cumplimentaron el Inventario de Sexismo Ambivalente y la escala de Necesidad de Cierre Cognitivo. Resultados: El análisis estadístico muestra que no existen correlaciones significativas entre los resultados obtenidos. Conclusiones: La violencia de las mujeres hacia los hombres no es reconocida.Sexism affects victims in an immediate and permanent way, interfering with the need for cognitive closure and generating confusion, ambiguity and uncertainty in people victimized by gender-based violence. This study explores the idea that women can exercise violence against men. Method: Exploratory study carried out at the Faculty of Education of the University of Granada. Forty-nine women completed the Ambivalent Sexism Inventory and the Need for Cognitive Closure scale. Results: The statistical analysis shows that there is no significant correlation between the results obtained. Conclusions: Violence by women against men is not recognized.Universidad de Granada. Departamento de Psicología Social. Proyecto de Innovación Docente ReiDoCre