A Study of Energy in Rock Blasting

Creation impacts have been observed in quarry so as to evaluate the quantifiable structures of energy in which the energy conveyed by the unstable is changed in rock impacting. The seismic field from Minimate readings, the introductory speed of the impacted rock face acquired utilizing Gurney condition, and the section size disseminations from picture investigation of the muckpile material are utilized to decide the seismic wave energy, the Kinetic energy and the Fragmentation energy, individually, moved in the impacting procedure. The impacting information and the techniques for figuring of the energy terms from those are depicted in subtle element. The most extreme aggregate energy measured records for not more than 26% of the accessible dangerous energy in the event that this is appraised as the warmth of blast, however lower figures are normally acquired. Sample of iron ore collected for laboratory experiment to find out the fragmentation energy with the help of “WipFarg Software (used for sieving of different rock sizes)”, drilling and blasting data, average size of fine and coarser particles, data for ppv to find out seismic energy, also Gurney equation for calculation of kinetic energy The energy discharged by the explosive, borne in the detonation endless supply of the chemical reaction, is changed over into heat and work to the surroundings as indicated by the first principle of thermodynamics. Some of these structures get to be obvious amid the impact, to be specific: • the fracture work, that eventually shows up as new surface in the rock fragments; • the work exchanged as shock wave into the rock, that proliferates as plastic and at last elastic waves, showing up as seismic wave or ground vibration; and • the work to uproot the rock and shape the muckpile, that shows up as kinetic energy conferred to the rock. Other energy exchange happens, in a less evident manner, as takes after: • expansion work of the fractures, that is consumed as elastic and plastic miss happening of the rock in the surface of the fractures as they are infiltrated by the gasses; • heat exchanged to the rock from the hot detonation items; and • heat and work passed on as enthalpy of the gasses venting to the air through open fractures and stemming. The energetic analysis provides a good insight of the explosive/rock interaction and a better understanding of the blasting process, encompassing a broad range of scientifically challenging subjects .For each energy component, first of all some experiments have been carried out in laboratory and some data collected from Iron Ore Mine to find out some results for different energy. Then with the help of some software and some equations from literature helped me to do my project work with efficiency. Energies ratios with respect to the total explosive energy are: Fragmentation energy is 31.45%, seismic energy is 1.69%, kinetic energy 13.599%. Total explosive energy measured is equal to 2.434 G

Efficacy, tolerability and safety of intravenous iron sucrose in postpartum anaemia

Background: Anemia is one of major contributing factor in maternal mortality and morbidity in third world countries and according to the WHO, contributes to 40% maternal deaths. Postpartum anemia is observed in up to 27% of women.It is a common problem throughout the world. Treatment of postpartum iron deficiency anemia includes oral and parenteral iron supplmentaion as well as blood transfusion in severe cases. Methods: This was a prospective longitudinal study carried out in Department of Obstetrics & Gynaecology of PRH, Loni. Total 80 women suffering from postpartum anemia of age above 18 years with haemoglobin (HB) level below 11gm/dl and above 6gm/dl were included for the study. After history taking, clinical examination and baseline Hb level, all of them were administered intravenous iron sucrose 200 mg per dose per day till the total calculated dose was administered. The post therapy evaluation was done with the estimation of Hb on day 1, day 7, day 14 and day 21. Results: 31.25% women belonged to the age group each of 19-21 years and 22-24 years. Maximum number of patients received 3 doses of IV Iron sucrose (i.e. total 600mg) followed by 2 doses (i.e. total 400mg), 4 doses (i.e. total 800mg) and 5 doses (i.e. total 1000mg) respectively. Hb level rises extremely significantly (p<0.001) after IV Iron Sucrose administration on day 1, 7, 14 & 21 as compared to corresponding values before delivery as analyzed by Friedman Test (Nonparametric Repeated Measures ANOVA) . 16 patients (20%) experienced thrombophlebitis to IV Iron Sucrose administration. About 12 (15%) patients experienced rigor followed by sweating in 10 patients (12.5%) and fever in 8 patients (10%). About 62 patients (77.5%) from total 80 reported well tolerability to IV Iron Sucrose while remaining 18 patients (22.5%) reported poor tolerability to IV Iron Sucrose Conclusion: Intravenous iron sucrose increases the haemoglobin more rapidly in first week as compared to second and third week in women with postpartum iron deficiency anemia. Hypersensitivity reaction, chest pain, dyspnoea reported with iron dextran and iron sorbitol citric acid were not observed with iron sucrose. Intravenous iron sucrose can be used safely to fill a rift between blood transfusion and oral iron in treatment of postpartum iron deficiency anemia

Efficacy, tolerability and safety of intravenous iron sucrose in postpartum anaemia

Background: Anemia is one of major contributing factor in maternal mortality and morbidity in third world countries and according to the WHO, contributes to 40% maternal deaths. Postpartum anemia is observed in up to 27% of women.It is a common problem throughout the world. Treatment of postpartum iron deficiency anemia includes oral and parenteral iron supplmentaion as well as blood transfusion in severe cases. Methods: This was a prospective longitudinal study carried out in Department of Obstetrics & Gynaecology of PRH, Loni. Total 80 women suffering from postpartum anemia of age above 18 years with haemoglobin (HB) level below 11gm/dl and above 6gm/dl were included for the study. After history taking, clinical examination and baseline Hb level, all of them were administered intravenous iron sucrose 200 mg per dose per day till the total calculated dose was administered. The post therapy evaluation was done with the estimation of Hb on day 1, day 7, day 14 and day 21. Results: 31.25% women belonged to the age group each of 19-21 years and 22-24 years. Maximum number of patients received 3 doses of IV Iron sucrose (i.e. total 600mg) followed by 2 doses (i.e. total 400mg), 4 doses (i.e. total 800mg) and 5 doses (i.e. total 1000mg) respectively. Hb level rises extremely significantly (p<0.001) after IV Iron Sucrose administration on day 1, 7, 14 & 21 as compared to corresponding values before delivery as analyzed by Friedman Test (Nonparametric Repeated Measures ANOVA) . 16 patients (20%) experienced thrombophlebitis to IV Iron Sucrose administration. About 12 (15%) patients experienced rigor followed by sweating in 10 patients (12.5%) and fever in 8 patients (10%). About 62 patients (77.5%) from total 80 reported well tolerability to IV Iron Sucrose while remaining 18 patients (22.5%) reported poor tolerability to IV Iron Sucrose Conclusion: Intravenous iron sucrose increases the haemoglobin more rapidly in first week as compared to second and third week in women with postpartum iron deficiency anemia. Hypersensitivity reaction, chest pain, dyspnoea reported with iron dextran and iron sorbitol citric acid were not observed with iron sucrose. Intravenous iron sucrose can be used safely to fill a rift between blood transfusion and oral iron in treatment of postpartum iron deficiency anemia

FORMULATION AND EVALUATION OF TASTE MASK ORALLY DISPERSIBLE PARACETAMOL TABLET

Mostly the drugs are administered by oral route. Orally dispersible tablets are achieving importance when compared to novel oral drug delivery system. Orodispersible tablets are suitable for all age patients by masking the taste of drug. The objective of the present study was to optimize, formulate and evaluate orally dispersible tablet (ODT) of Paracetamol which disintegrates within few seconds in presence of saliva fluid by the use of super disintegrants.  Paracetamol is widely used over-the counter analgesic (pain reliever) and antipyretic (fever reducer). It is a very bitter drug so the patients unable to take orally; hence their bitter taste were masked. ODTs Formulations were prepared by Direct Compression and wet granulation method by the use of superdisintegrants and taste masking (F7;F8) is done by Eudragit EPO. The developed formulations were evaluated in terms of weight variation, drug content, friability, thickness, hardness, disintegration and in vitro dissolution test. Stability study of optimized formulation was also carried out as per ICH guidelines. The effects of disintegrants as well as binders in different concentration on the release profile of paracetamol ODTs were studied. The studied parameters were found to be satisfactory for all formulations. Disintegration time for the formulations was found to be less than 40 seconds. Disintegration time for all ODTs decreased with increase in disintegrant concentration. ODTs prepared using Avicel possessed least disintegration time (11s), offered better dissolution profile than that of all the ODTs formulations. Accelerated studies proved that the optimized formulation was stable even after three months. Keywords: Orodispersible tablets, Paracetamol, Prosolv ODT; Eudragit EPO, physical characterization. in-vitro dissolution,Â

Design of Reconfigurable Crossbar Switch for BiNoC Router

this paper presents implementation of 10x10 reconfigurable crossbar switch (RCS) architecture for Dynamic Self-Reconfigurable BiNoC Architecture for Network On Chip. Its main purpose is to increase the performance, flexibility. This paper presents a VHDL based cycle accurate register transfer level model for evaluating the, Power and Area of reconfigurable cross bar switch in BiNoC architectures. We implemented a parameterized register transfer level design of reconfigurable crossbar switch (RCS) architecture. The design is parameterized on (i) size of packets, (ii) length and width of physical links, (iii) number, and depth of arbiters, and (iv) switching technique. The paper discusses in detail the architecture and characterization of the various reconfigurable crossbar switch (RCS) architecture components. The characterized values were integrated into the VHDL based RTL design to build the cycle accurate performance model. In this paper we show the result of simple 10x10 crossbar switch .The results include VHDL simulation of RCS on Xilinx ISE 13.1 software tool

Socio-economic upliftment of farmers through model irrigated village approach in East Champaran (Bihar), India: A case study

In India, the precious freshwater resources are becoming scarcer due to the climate change effect coupled with their inappropriate planning and management at the field level. Development of water resources and sensitization of farming community/irrigators towards effective utilization of these resources is need of the hour and it is one of the most important factors in conservation and preservation water resources for future requirements. This case study has highlighted the direct and indirect benefits derived by implementation of National Innovations on Climate Resilient Agriculture (NICRA) scheme in Nawada, a village of the district East Champaran in Bihar state initiated by Krishi Vigyan Kendra, Piprakothi, East Champaran under Dr. Rajendra Prasad Central Agricultural University, Pusa, Bihar. Two groups of farmers of the village was chosen to evaluate the benefits derived from this scheme. Under this scheme, tube-wells were developed to facilitate assured irrigation. This study revealed that the total savings of approximate Rs.10,000 ($140) per hectare to irrigate wheat crop three times in Rabi season was achieved over conventional irrigation system. This scheme has also resulted in other intangible benefits which included a reduction in pollution, an increase in the number of crops- rabi , kharif and zaid  seasons and adequate time to carryout out other farm operations

Systematic analysis of the gerontome reveals links between aging and age-related diseases

In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call the ‘gerontome’. Although some individual aging-related genes have been the subject of intense scrutiny, their analysis as a whole has been limited. In particular, the genetic interaction of aging and age-related pathologies remain a subject of debate. In this work, we perform a systematic analysis of the gerontome across species, including human aging-related genes. First, by classifying aging-related genes as pro- or anti-longevity, we define distinct pathways and genes that modulate aging in different ways. Our subsequent comparison of aging-related genes with age-related disease genes reveals species-specific effects with strong overlaps between aging and age-related diseases in mice, yet surprisingly few overlaps in lower model organisms. We discover that genetic links between aging and age-related diseases are due to a small fraction of aging-related genes which also tend to have a high network connectivity. Other insights from our systematic analysis include assessing how using datasets with genes more or less studied than average may result in biases, showing that age-related disease genes have faster molecular evolution rates and predicting new aging-related drugs based on drug-gene interaction data. Overall, this is the largest systems-level analysis of the genetics of aging to date and the first to discriminate anti- and pro-longevity genes, revealing new insights on aging-related genes as a whole and their interactions with age-related diseases

Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice

Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method in mice, translational responses of five neural subtypes to acquired prion disease (PrD) were measured. Pre-onset and disease onset timepoints were chosen based on longitudinal electroencephalography (EEG) that revealed a gradual increase in theta power between 10- and 18-weeks after prion injection, resembling a clinical feature of human PrD. At disease onset, marked by significantly increased theta power and histopathological lesions, mice had pronounced translatome changes in all five cell types despite appearing normal. Remarkably, at a pre-onset stage, prior to EEG and neuropathological changes, we found that 1) translatomes of astrocytes indicated reduced synthesis of ribosomal and mitochondrial components, 2) glutamatergic neurons showed increased expression of cytoskeletal genes, and 3) GABAergic neurons revealed reduced expression of circadian rhythm genes. These data demonstrate that early translatome responses to neurodegeneration emerge prior to conventional markers of disease and are cell type-specific. Therapeutic strategies may need to target multiple pathways in specific populations of cells, early in disease

ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control

The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in mammals is chiefly mediated by gamma motor neurons. The diversification of motor neurons into alpha and gamma types and their respective contributions to movement control have been firmly established in the past 7 decades, while recent studies identified gene expression signatures linked to both motor neuron types. However, the mechanisms that promote the specification of gamma motor neurons and/or their unique properties remained unaddressed. Here, we found that upon selective loss of the orphan nuclear receptors ERR2 and ERR3 (also known as ERR beta, ERR gamma or NR3B2, NR3B3, respectively) in motor neurons in mice, morphologically distinguishable gamma motor neurons are generated but do not acquire characteristic functional properties necessary for regulating muscle proprioception, thus disrupting gait and precision movements. Complementary gain-of-function experiments in chick suggest that ERR2 and ERR3 could operate via transcriptional activation of neural activity modulators to promote a gamma motor neuron biophysical signature of low firing thresholds and high firing rates. Our work identifies a mechanism specifying gamma motor neuron functional properties essential for the regulation of proprioceptive movement control