"Los Bienaventurados”: un encuentro con Fernando Soto Aparicio. Un tributo en su cumpleaños 82

Al final de nuestra travesía literaria por este texto, en compañía del Club de Lectura de la Universidad Militar Nueva Granada, reconoceremos cómo, desde la literatura, específicamente desde la obra del escritor colombiano Fernando Soto Aparicio y su novela “Los Bienaventurados”, surge la realidad misma, y cómo aquellos mundos “ficcionales” se deslizan por nuestro pasado, presente y futuro para despertarnos en la realidad colombiana actual para, finalmente, dejar en lectores de diferentes disciplinas cuestionamientos alrededor del tema de la paz y el post-conflicto

“Los Bienaventurados”: un encuentro con Fernando Soto Aparicio. Un tributo en su cumpleaños 82

Al final de nuestra travesía literaria por este texto, en compañía del Club de Lectura de la Universidad Militar Nueva Granada, reconoceremos cómo, desde la literatura, específicamente desde la obra del escritor colombiano Fernando Soto Aparicio y su novela “Los Bienaventurados”, surge la realidad misma, y cómo aquellos mundos “ficcionales” se deslizan por nuestro pasado, presente y futuro para despertarnos en la realidad colombiana actual para, finalmente, dejar en lectores de diferentes disciplinas cuestionamientos alrededor del tema de la paz y el post-conflicto

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Investigaciones en construcción

El Instituto Unidad de Investigaciones Jurídico-Sociales Gerardo Molina, UNIJUS promueve y apoya el desarrollo e implementación de programas y proyectos de investigación que aporten al conocimiento de la realidad nacional e internacional, de las instituciones jurídicas, políticas y sociales, así como de las teorías jurídicas y políticas que contribuyan a la construcción de nuevas propuestas para la solución de las problemáticas que aquejan la sociedad. Por tal motivo, es fundamental el apoyo constante a la formación de semilleros de investigación en la Facultad de Derecho, Ciencias Políticas y Sociales de la Sede Bogotá, así como la consolidación de los semilleros ya existentes. En el año 2012, se desarrollaron las Convocatorias No. 12 y No. 13 para la selección de semilleros de Investigación en modalidad I y modalidad II. Como resultado de dicho proceso fueron seleccionadas doce propuestas de investigación integradas por un total de 32 estudiantes, quienes a su vez se encontraban vinculados a nueve grupos de investigación