The German Press about Russian Foreign Policy Activities: The Crisis in Ukraine (2013–2014) and its Consequences

The article is devoted to identifying the current image of Russia in the mirror of the German media after the Ukrainian crisis. The role of the media is noted, the crisis situation in Ukraine is characterized. Analyzed publications in the leading print media of Germany on the topic of Russian foreign policy in Ukraine and the role of the Russian Federation in the political crisis in Ukraine (2013–2014). The authors have identified and identified key approaches in the formation of German society a certain idea of Russia and its foreign policy. As conclusions, it is noted that both for objective reasons, and not least thanks to the German media, which use a lot of negative characteristics when constructing the image of Russia, relations between the Russian Federation and the Federal Republic of Germany go through a zone of mutual exclusion. However, relations between the Russian Federation and the Federal Republic of Germany can go to a new level, taking into account the possible pragmatic cooperation of the two states, and provided, among other things, a reduction in the degree of anti-Russian rhetoric in the German media

Условия питания и изменчивость ледников архипелага Северная Земля по результатам наблюдений 2014–2015 гг.

Glaciological investigations on the Severnaya Zemlya archipelago were resumed in 2013 when a new research station «Ice base Cape Baranova» had been organized by Arctic and Antarctic Research Institute in the North-West of the Island Bolshevik. In 2014–2015, the glaciological polygon named after Leonid Govorukha was established on glaciers Mushketov and Semenov-Tyan-Shanskiy. Two years of observations on the glaciers allowed us to estimate the mass balance of the Mushketov Glacier, which was positive in the 2013–2015. By the end of the melting periods, a superimposed ice was formed on the glacier with thickness of 4 cm in 2014 and 17 cm in 2015, on the average. A snow-firn mass with its vertical thickness exceeding 3 m had been found on the upper part of the Semenov-Tyan-Shansky Glacier. Based on analyses of summer air temperatures and precipitation at the meteorological station «The Golomyanny Island», we assumed that in 2013–2015 the mass balance was also positive on the other glaciers of the archipelago, located to the North of the studied glaciers on the Island of Bolshevik. Data of remote sensing of the catastrophic advancing of the outlet glacier from the Vavilov Ice Cap, obtained in 2013–2016, testify that for much longer period, i.e. during 25 years, conditions for the ice mass accumulation were favorable on the southern and eastern slopes of the Vavilov Ice Cap.Гляциологические исследования ААНИИ продолжены работами 2014–2015  гг. на ледниках о.  Большевик (архипелаг Северная Земля): Мушкетова высотой 560 м и Семенова-Тян-Шанского высотой 725 м. Работы на полигоне показали положительный баланс массы ледника Мушкетова, питающегося наложенным льдом, и наличие мощной (более 3 м) снежно-фирновой толщи в вершинной части ледника Семенова-Тян-Шанского. Данные метеостанции «Ледовая база «Мыс Баранова» и автоматической метеостанции на леднике Мушкетова позволили определить условия накопления льда. Катастрофическая подвижка на запад выводного ледника из ледникового купола Вавилова обусловлена более чем 25-летним периодом преобладания накопления льда, подлёдным рельефом и всплыванием ледника на глубине моря около 40 м

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)

Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF.

AIMS: The relationship between outcomes and time after diagnosis for patients with non-valvular atrial fibrillation (NVAF) is poorly defined, especially beyond the first year. METHODS AND RESULTS: GARFIELD-AF is an ongoing, global observational study of adults with newly diagnosed NVAF. Two-year outcomes of 17 162 patients prospectively enrolled in GARFIELD-AF were analysed in light of baseline characteristics, risk profiles for stroke/systemic embolism (SE), and antithrombotic therapy. The mean (standard deviation) age was 69.8 (11.4) years, 43.8% were women, and the mean CHA2DS2-VASc score was 3.3 (1.6); 60.8% of patients were prescribed anticoagulant therapy with/without antiplatelet (AP) therapy, 27.4% AP monotherapy, and 11.8% no antithrombotic therapy. At 2-year follow-up, all-cause mortality, stroke/SE, and major bleeding had occurred at a rate (95% confidence interval) of 3.83 (3.62; 4.05), 1.25 (1.13; 1.38), and 0.70 (0.62; 0.81) per 100 person-years, respectively. Rates for all three major events were highest during the first 4 months. Congestive heart failure, acute coronary syndromes, sudden/unwitnessed death, malignancy, respiratory failure, and infection/sepsis accounted for 65% of all known causes of death and strokes for <10%. Anticoagulant treatment was associated with a 35% lower risk of death. CONCLUSION: The most frequent of the three major outcome measures was death, whose most common causes are not known to be significantly influenced by anticoagulation. This suggests that a more comprehensive approach to the management of NVAF may be needed to improve outcome. This could include, in addition to anticoagulation, interventions targeting modifiable, cause-specific risk factors for death. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Conditions of the alimentation and the variability of glaciers of the Severnaya Zemlya Archipelago from observations of 2014–2015

Glaciological investigations on the Severnaya Zemlya archipelago were resumed in 2013 when a new research station «Ice base Cape Baranova» had been organized by Arctic and Antarctic Research Institute in the North-West of the Island Bolshevik. In 2014–2015, the glaciological polygon named after Leonid Govorukha was established on glaciers Mushketov and Semenov-Tyan-Shanskiy. Two years of observations on the glaciers allowed us to estimate the mass balance of the Mushketov Glacier, which was positive in the 2013–2015. By the end of the melting periods, a superimposed ice was formed on the glacier with thickness of 4 cm in 2014 and 17 cm in 2015, on the average. A snow-firn mass with its vertical thickness exceeding 3 m had been found on the upper part of the Semenov-Tyan-Shansky Glacier. Based on analyses of summer air temperatures and precipitation at the meteorological station «The Golomyanny Island», we assumed that in 2013–2015 the mass balance was also positive on the other glaciers of the archipelago, located to the North of the studied glaciers on the Island of Bolshevik. Data of remote sensing of the catastrophic advancing of the outlet glacier from the Vavilov Ice Cap, obtained in 2013–2016, testify that for much longer period, i.e. during 25 years, conditions for the ice mass accumulation were favorable on the southern and eastern slopes of the Vavilov Ice Cap