Harnessing the Power of Gravitational Lensing: Resolved Star Formation at Redshift 1 - 4

In the coming decade, new observational facilities will enable galaxies seen in the first half of the Universe's history (z > 1) to be mapped on ~100pc scales routinely for the first time. As a preview of the science capabilities of these facilities, we can use clusters of galaxies, the largest gravitationally-bound structures in the Universe, as natural telescopes. Using this technique, we examine star formation within galaxies at 1 < z < 5, during the peak epoch of cosmic star formation density. We begin in Chapter 3 by targeting Halpha emission with narrowband imaging from HST/WFC3 in eight lensed galaxies at z = 1 - 1.5. We identify star-forming clumps in these galaxies and compare their properties directly to those of local spirals. In Chapter 4 we consider the fuel for star formation, with a search for molecular gas in a z ~ 5 lensed galaxy. We obtain a tentative detection that implies a gas fraction Mgas/(Mgas + M*) ~0.6, suggesting slow evolution at z > 2. In Chapter 5, we present the largest survey to date of gravitationally-lensed galaxies observed with integral field spectroscopy. We present observations of 12 new galaxies, increasing the total sample to 17 lensed galaxies at 1 < z < 4 observed on 100pc scales, and investigate the global disc dynamics and map the star formation. With these combined observations, we present a simple theoretical model in which star formation in galaxy discs is driven by the same physical processes at all redshifts. We find that the scale of collapse depends on the galaxy's gas content and kinematics, and show that our observations are consistent with the necessary evolution in these properties

Keck/MOSFIRE Spectroscopy of z=7-8 Galaxies: Lyα\alpha Emission from a Galaxy at z=7.66

We report the results from some of the deepest Keck/Multi-Object Spectrometer For Infra-Red Exploration data yet obtained for candidate $z \gtrsim 7$ galaxies. Our data show one significant line detection with 6.5$\sigma$ significance in our combined 10 hr of integration which is independently detected on more than one night, thus ruling out the possibility that the detection is spurious. The asymmetric line profile and non-detection in the optical bands strongly imply that the detected line is Ly$\alpha$ emission from a galaxy at $z$(Ly$\alpha)=7.6637 \pm 0.0011$, making it the fourth spectroscopically confirmed galaxy via Ly$\alpha$ at $z>7.5$. This galaxy is bright in the rest-frame ultraviolet (UV; $M_{\rm UV} \sim -21.2$) with a moderately blue UV slope ($\beta=-2.2^{+0.3}_{-0.2}$), and exhibits a rest-frame Ly$\alpha$ equivalent width of EW(Ly$\alpha$) $\sim 15.6^{+5.9}_{-3.6}$ \AA. The non-detection of the 11 other $z \sim$ 7-8 galaxies in our long 10 hr integration, reaching a median 5$\sigma$ sensitivity of 28 \AA\ in the rest-frame EW(Ly$\alpha$), implies a 1.3$\sigma$ deviation from the null hypothesis of a non-evolving distribution in the rest-frame EW(Ly$\alpha$) between $3<z<6$ and $z=$ 7-8. Our results are consistent with previous studies finding a decline in Ly$\alpha$ emission at $z>6.5$, which may signal the evolving neutral fraction in the intergalactic medium at the end of the reionization epoch, although our weak evidence suggests the need for a larger statistical sample to allow for a more robust conclusion.Comment: 10 pages, 4 figures, ApJ, in pres

Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles

Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against ‘problem’ isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms. Ceftolozane/tazobactam had good activity against unselected ESBL producers in the BSAC series, but activity was reduced against ertapenem-resistant ESBL producers, which were numerous among reference submissions. AmpC-derepressed Enterobacter spp. were widely resistant, but Escherichia coli with raised chromosomal AmpC frequently remained susceptible, as did Klebsiella pneumoniae with acquired DHA-1-type AmpC. Carbapenemase-producing Enterobacteriaceae were mostly resistant, except for ceftazidime-susceptible isolates with OXA-48-like enzymes. Ceftolozane/tazobactam was active against 99.8% of the BSAC Pseudomonas aeruginosa isolates; against referred P. aeruginosa it was active against 99.7% with moderately raised efflux, 94.7% with strongly raised efflux and 96.6% with derepressed AmpC. Resistance in P. aeruginosa was largely confined to isolates with metallo-β-lactamases (MBLs) or ESBLs. MICs for referred Burkholderia spp. and Stenotrophomonas maltophilia were 2–4-fold lower than those of ceftazidime. Conclusions: Ceftolozane/tazobactam is active against ESBL-producing Enterobacteriaceae; gains against other problem Enterobacteriaceae groups were limited. Against P. aeruginosa it overcame the two most prevalent mechanisms (up-regulated efflux and derepressed AmpC) and was active against 51.9% of isolates non-susceptible to all other β-lactams, rising to 80.9% if ESBL and MBL producers were excluded

The Sizes of z ∼ 9-10 Galaxies Identified in the Brightest of Reionizing Galaxies (BoRG) Survey

Redshift z = 9-10 object selection is the effective limit of Hubble Space Telescope (HST) imaging capability, even when confirmed with Spitzer. If only a few photometry data points are available, it becomes attractive to add criteria based on their morphology in these J- and H-band images. One could do so through visual inspection, a size criterion, or alternate morphometrics. We explore a vetted sample of Brightest of Reionizing Galaxies (BoRG) z ∼ 9 and z ∼ 10 candidate galaxies and the object rejected by Morishita+ to explore the utility of a size criterion in z = 9-10 candidate selection. A stringent, point-spread function (PSF)-corrected effective radius criterion (re \u3c 0″.3) would result in the rejection of 65%-70% of the interlopers visually rejected by Morishita et al. It may also remove up to ∼20% of bona fide brightest (L ≫ L∗) z = 9 or 10 candidates from a BoRG selected sample based on the Mason et al. luminosity functions, assuming the Holwerda et al. z ∼ 9 size-luminosity relation. We argue that including a size constraint in lieu of a visual inspection may serve in wide-field searches for these objects in, e.g., Euclid or HST archival imaging with the understanding that some brightest (L ≫ L∗) candidates may be missed. The sizes of the candidates found by Morishita et al. follow the expected size distribution of z ∼ 9 for bright galaxies, consistent with the log normal in Shibuya et al. and single objects. Two candidates show high star formation surface density (ΣSFR \u3e 25M⊙ kpc-2) and all merit further investigation and follow-up observations

The Sizes of z∼9−10z\sim9-10 Galaxies Identified in the BoRG Survey

Redshift $z=9--10$ object selection is the effective limit of Hubble Space Telescope imaging capability, even when confirmed with Spitzer. If only a few photometry data points are available, it becomes attractive to add criteria based on their morphology in these J- and H-band images. One could do so through visual inspection, a size criterion, or alternate morphometrics. We explore a vetted sample of BoRG $z\sim9$ and $z\sim10$ candidate galaxies and the object rejected by Morishita+ (2018) to explore the utility of a size criterion in z=9-10 candidate selection. A stringent, PSF-corrected effective radius criterion (r_e<0\farcs3) would result in the rejection of 65-70\% of the interlopers visually rejected by Morishita+. It may also remove up to $\sim20$\% of bona-fide brightest ($L>>L^*$) z=9 or 10 candidates from a BoRG selected sample based on the Mason+ (2015) luminosity functions, assuming the Holwerda+ (2015) $z\sim9$ size-luminosity relation. We argue that including a size constraint in lieu of a visual inspection may serve in wide-field searches for these objects in e.g. EUCLID or HST archival imaging with the understanding that some brightest ($L>>L^*$) candidates may be missed. The sizes of the candidates found by Morishita+ (2018) follow the expected size distribution of $z\sim9$ for bright galaxies, consistent with the lognormal in Shibuya+ (2015) and single objects. Two candidates show high star-formation surface density ($\Sigma_{SFR} > 25 M_\odot/kpc^2$) and all merit further investigation and follow-up observations.Comment: 9 Figures, 1 table, 13 pages, accepted for publication in The Astronomical Journa

Genomic sequences of Streptococcus agalactiae with high-level gentamicin resistance, collected in the BSAC bacteraemia surveillance

Background: Like other streptococci, Streptococcus agalactiae typically has intrinsic low-level aminoglycoside resistance. High-level gentamicin resistance was seen in 2 of 1125 isolates collected in the BSAC Bacteraemia Surveillance Programme between 2001 and 2014. These organisms, both isolated in 2014, were characterized. Methods: Identifications were by latex agglutination, MICs by BSAC agar dilution and sequencing by Illumina methodology. Results: Gentamicin MICs were >1024 mg/L versus a species mode of 8 mg/L; both isolates also were unusually ciprofloxacin resistant with MICs of 64 mg/L versus a species mode of 1 mg/L. They were distinct by sequence, but both belonged to the ST19 clone, which occurs globally. Both had aac(6′)-aph(2″), carried by different transposons, explaining their gentamicin resistance, and had gyrA[81:S-L];parC[79:S-Y], accounting for ciprofloxacin resistance. Conclusions: These are the first multiresistant S. agalactiae with the bifunctional AAC(6′)-APH(2″) enzyme to be reported in the UK for >10 years. Despite belonging to the same clonal complex, the two isolates and their resistance transposons were distinct. Both retained full susceptibility to penicillin, but any penicillin/gentamicin synergy is likely to be lost

Keck/MOSFIRE Spectroscopy of z = 7–8 Galaxies: Lyα Emission from a Galaxy at z = 7.66

We report the results from some of the deepest Keck/Multi-Object Spectrometer For Infra-Red Exploration data yet obtained for candidate z gsim 7 galaxies. Our data show one significant line detection with 6.5σ significance in our combined 10 hr of integration which is independently detected on more than one night, thus ruling out the possibility that the detection is spurious. The asymmetric line profile and non-detection in the optical bands strongly imply that the detected line is Lyα emission from a galaxy at z(Lyα) = 7.6637 ± 0.0011, making it the fourth spectroscopically confirmed galaxy via Lyα at z > 7.5. This galaxy is bright in the rest-frame ultraviolet (UV; M_(UV) ~ −21.2) with a moderately blue UV slope β=-2.2_(-0.2)^(+0.3), and exhibits a rest-frame Lyα equivalent width of EW(Lyα) ~ 15.6_(-3.6)^(+5.9) Å. The non-detection of the 11 other z ~ 7–8 galaxies in our long 10 hr integration, reaching a median 5σ sensitivity of 28 Å in the rest-frame EW(Lyα), implies a 1.3σ deviation from the null hypothesis of a non-evolving distribution in the rest-frame EW(Lyα) between 3 6.5, which may signal the evolving neutral fraction in the intergalactic medium at the end of the reionization epoch, although our weak evidence suggests the need for a larger statistical sample to allow for a more robust conclusion