8 research outputs found
Development of an antimicrobial urinary catheter to inhibit urinary catheter encrustation.
- Publication venue
- 'Herbert Publications PVT LTD'
- Publication date
- 01/01/2015
- Field of study
Background: Encrustation of urinary catheters is a frequent problem in patients with long-term indwelling catheters colonised with urease-positive bacteria such as Proteus mirabilis. Catheter blockage may follow catheter encrustation, potentially leading to systemic infection. Prevention of encrustation is difficult and avoidance of recurrence often unsuccessful. One possible preventative strategy is to use a catheter with an antimicrobial surface and development and assessment of such a surface was the aim of this research.
Methods: Initial experiments assessed the antimicrobial activity of silicone impregnated with plant-derived antimicrobials and triclosan using agar diffusion. The longevity of activity of each antimicrobial silicone was examined over a period of 11 weeks following soaking individual pieces of antimicrobial silicone in an artificial urine solution before using agar diffusion to test remaining antimicrobial activity. Live/Dead staining of bacteria colonising the surface of each antimicrobial silicone was employed to determine the bactericidal properties of each antimicrobial silicone. Selected antimicrobial silicones were subsequently evaluated for their ability to prevent catheter encrustation in an in vitro bladder model.
Results: Results showed that antimicrobial activity was obtained using 1% triclosan-impregnated silicone and that this antimicrobial activity was long-lasting (up to 11 weeks). Use of a dip coat silicone formulation, containing 0.2% triclosan, proved effective at delaying catheter encrustation with P. mirabilis metabolites in vitro. In 8 out of 13 independent experiments using dip-coated catheters, no catheter blockage occurred over 7 days, whilst all control catheters blocked during this period. Only on one occasion was delayed encrustation not evident with the treated catheters.
Conclusions: In summary, a dip-coat silicone containing triclosan proved effective in preventing in vitro catheter encrustation caused by P. mirabilis infection. Further studies with triclosan silicone dip coat formulation are warranted, including those that investigate potential host cell toxicity and long-term benefits following its application to indwelling urinary catheters in clinical settings
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
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- Airaksinen JK
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- Akhter F
- Ako J
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- Al-Windy NYY
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- Alcocer Gamba MA
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- Yakushin S
- Yan AT-K
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- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zeiher AM
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu H
- Zirlik A
- Zizka J
- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Wood chips as soil conservation in field conditions
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- A Bento-Gonçalvesa
- A Cerda
- A Cerda
- A Cerda
- A Cerda
- A Cerda
- A Cerda
- A Cerda
- A Ghahramani
- A Jordan
- A Novara
- A Novara
- Abdulvahed Khaledi Darvishan
- AR Lattanzi
- Ataollah Kavian
- AV Khaledi Darvishan
- AV Khaledi Darvishan
- B Gessesse
- C Decock
- EC Brevik
- EI Ekwue
- F Berendse
- F Pérez-Cabello
- H Moreno-Ramon
- J León
- J León
- J Rodrigo Comino
- JF Martinez-Murillo
- JR Buchanan
- JV Mannering
- JWA Poesen
- K Nanko
- KA Yanosek
- KC McGregor
- KG Rohith
- KO Adekalu
- L Gholami
- L Gholami
- Leila Gholami
- LM Edwards
- M Fox
- M Mekonnen
- M Prosdocimi
- M Prosdocimi
- MB Defersha
- MN Jimenez
- NS Copeland
- P Borrelli
- P Morgan
- P Smith
- PK Wang
- PR Robichaud
- PR Robichaud
- R Lal
- RB Foltz
- RB Foltz
- RB Foltz
- RPC Morgan
- S Assouline
- S Keesstra
- S Miyata
- SB Mwango
- SD Keesstra
- SHR Sadeghi
- SHR Sadeghi
- SHR Sadeghi
- SS Kukal
- SS Kukal
- T Bisantino
- T Smets
- Y Liu
- ZH Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif
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- A Väkevä
- A Zomer
- AH Limper
- AH Limper
- AM Blom
- AR Aricescu
- AS Attia
- B Albiger
- B Singh
- B Singh
- B Singh
- B Singh
- Birendra Singh
- Brian Stevenson
- C Dehio
- C Heilmann
- C Sa E Cunha
- Christine Skerka
- CM Lopez
- DQ Li
- E Buommino
- E Spreghini
- ER Podack
- ETM Berends
- FC Greenwood
- GS Chhatwal
- I Leduc
- I Leduc
- I Schvartz
- I Styriak
- I Tyriak
- J Leroy-Dudal
- K Hubert
- K Triantafilou
- Kristian Riesbeck
- KS Kilgore
- KT Preissner
- KT Preissner
- LB Da Silva
- M Dehio
- M Kostrzynska
- M Reuter
- M Ringnér
- M Sheehan
- MA Hadders
- MJ Walport
- NJ Griffiths
- NS Merle
- OD Liang
- OD Liang
- OD Liang
- P Gerner-Smidt
- Peter F. Zipfel
- Peter Kraiczy
- PF Zipfel
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- R Virkola
- RJ Arko
- RPC Jordan
- S Bergmann
- S Hammerschmidt
- S Kohler
- S Luo
- S Voss
- SHM Rooijakkers
- SK Akiyama
- SP Riley
- Sven Hammerschmidt
- T Hallström
- T Hallström
- T Hallström
- T Hallström
- T Meri
- TD Duensing
- Teresia Hallström
- TP Kohler
- Y-C Su
- Y-C Su
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Geopolymerization of soil by sodium silicate as an approach to control wind erosion
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- A Behnood
- A Derkowski
- A Fernández-Jiménez
- A Grobelak
- A Lazaro
- A Mirzaii
- AG Vayghan
- AJ Puppala
- B Koohestani
- B Koohestani
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- B Marchand
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- CG Ruff
- CM Yonkofski
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- D Jordan
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- EA Gorrepati
- F Cihangir
- F Demoling
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- G Jovanovski
- G Négyesi
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- HA Nasr-El-Din
- I Alp
- J Tatarko
- J Xu
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- JF Kok
- JL Gurav
- K Wang
- KH Head
- L Yang
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- M Arnoult
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- MK Rakkar
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- R Dupuis
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- SMA Zomorodian
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- YP Kuo
- Z Feizi
- Z Meng
- Z Wang
- Z Zhang
- Ł Uzarowicz
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal
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- A Degterev
- A Nguyen
- A Patiño-García
- A Sakamoto
- AM Azarova
- AS Adhikari
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- C Yang
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- DM Townsend
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- DP Bartel
- E Desandes
- ED Fleuren
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- G Ottaviani
- GA Brown
- H Fujii
- H Fung
- H He
- H Minderman
- H Ozger
- H Tsuchiya
- H Uozaki
- H Zhang
- H-L Fu
- Hongsheng Wang
- I Ifergan
- J Li
- J Mei
- J Rousseau
- J Yang
- JD Wessler
- JL Nitiss
- JP Gillet
- JS Wunder
- JZ Li
- KA Tiwari
- KD Tew
- KM Goudarzi
- L Han
- L Wei
- L-M Yang
- LH Matherly
- M Lourda
- M Pasello
- M Pasello
- M Serra
- M Serra
- M Susa
- ML Fishel
- N Baldini
- P Biason
- P Limtrakul
- PA Meyers
- R Fiore Di
- R Gangemi
- RE Windsor
- RE Windsor
- RL Fine
- RPC Wong
- S Bruheim
- S He
- SD Vangipuram
- SH Hong
- SS Dhule
- Suoyuan Li
- T Hao
- T Murata
- T Nedelcu
- T Rajkumar
- UA Germann
- V Tirino
- Wei Sun
- X Wu
- Y Onishi
- Y Pignochino
- Y Pommier
- Y Zhou
- Yingqi Hua
- Z Duan
- Z Fu
- Z Wang
- Zhengdong Cai
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.
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- 6zkan Bb
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- \u160irok\ue1 M
- \u17debr\ue1k R
- Aarts E
- Abbas Z
- Abburu S
- Abd Ghaffar Mk
- Abdelgalil R
- Abdelhadi M
- Abdikadir Hr
- Abdulmajid A
- Abdulrahman N
- Abid A
- Abid H
- Abrisqueta Carrion J
- Abuhussein N
- Abul Mh
- Acar S
- Acherman Yiz
- Acquaah F
- Acres M
- Adams R
- Adams Rd
- Adebayo Aa
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- Adiyaman C
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- Adlan A
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- Agalar C
- Agarwal V
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- Alberti Delgado P
- Alcazar Montero Ja
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- Alizadeh M
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- Alonso Gon\ue7alves S
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- Alvarez Reyes I
- Amajuoyi A
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- de Vos Tot Nederveen Cappel Rj
- de Wilt H
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- Sena-Ruiz F
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- Shamsul Badrin Ak
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- Shaunak R
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- Shufflebotham H
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- Soldevila-Verdeguer C
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- Yildiz T
- Yilmaz I
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- Ziff O
- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
AIM:
Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.
METHODS:
This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.
RESULTS:
This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients.
CONCLUSIONS:
In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
- Author
- Aarts E
- Abbas Z
- Abburu S
- Abd Ghaffar Mk
- Abdelgalil R
- Abdelhadi M
- Abdikadir Hr
- Abdulmajid A
- Abdulrahman N
- Abid A
- Abid H
- Abrisqueta Carrion J
- Abuhussein N
- Abul Mh
- Acar S
- Acherman Yiz
- Acquaah F
- Acres M
- Adams R
- Adams Rd
- Adebayo Aa
- Adeleja I
- Adiyaman C
- Adjei H
- Adlan A
- Afzal Z
- Agalar C
- Agarwal V
- Agrawal M
- Ahern N
- Ahmad A
- Ahmad K
- Ahmad S
- Ahmed F
- Ahmed H
- Ahmed M
- Ahmed N
- Ahmed S
- Ahn Js
- Aidoo-Micah Ge
- Aildasani L
- Aithie Jm
- Akbulut F
- Akcaoglu T
- Akdogan A
- Akhtar S
- Akkaya E
- Akkucuk S
- Akpunarli B
- Aksoy K
- Aktas Mk
- Aktekin H
- Al-Mousawi A
- Al-Nasser A
- Al-Nasser Z
- Al-Obaedi O
- Al-Robeye A
- Albayrak D
- Alberdi San Roman I
- Alberti Delgado P
- Alcazar Montero Ja
- Alcocer Bp
- Alconchel-Gago F
- Aldrey I
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- Alim Ye
- Aliseda-Jover D
- Alizadeh M
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- Allot R
- Alonso Gonçalves S
- Alonso Hernandez N
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- Alvarez Reyes I
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- Amelung Fj
- Amin H
- Amin O
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- Hidalgo Pujol M
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- Hirani S
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- Hogendoorn W
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- Hughes Ba
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- Huseynova S
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- Hussain N
- Hussain O
- Hutchings I
- Huzmeli E
- Ibrahim A
- Ibrahim I
- Ilbak A
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- Ingham R
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- Innocenti P
- Iorga R
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- Khajuria A
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- Kloppenberg Fwh
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- Leafe O
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- Löwensteyn Yn
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- Pitts-Tucker T
- Pizzolato A
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- Player C
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- Prieto-Nieto Mi
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- Ruiz Montesinos I
- Ruiz Em
- Russell G
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- Sagmeister M
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- Sakman G
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- Sangal P
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- Saraceno F
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- Skalamera I
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- Soo Yh
- Soon Wc
- Sorah T
- Soria Aledo V
- Sotona O
- Soylemez Zobb
- Sozuer Em
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- Spijkerman R
- Springford Lr
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- Sreh A
- Srikantharajah M
- Sritharan P
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- Stanger Sa
- Stanley Gh
- Stanley S
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- Stechman M
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- Stein J
- Stellingwerf Me
- Steup Wh
- Stevens S
- Stewart Ge
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- Stijns Rch
- Stoddart Mt
- Stokes S
- Stone Ej
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- Subasi A
- Sukkari M
- Sukumar S
- Suleman Yn
- Sullivan Jal
- Sun E
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- Suppa A
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- Sykes Mc
- Szczap A
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- Tagariello F
- Tahir M
- Tahmina A
- Tai A
- Talukdar Ss
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- Tarantino M
- Targa S
- Taskin O
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- Tavuz Ai
- Tay Ay
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- Taylor F
- Taşçı Y
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- Teh Jw
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- Tejero Pintor Fj
- Telfer R
- Temiz C
- Teng V
- Teoh Pj
- Ter Bruggen Ffja
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- Thacoor A
- Thakker Ce
- Thakur H
- Tharakan Rg
- Tharmachandirar T
- Theodoreson Md
- Theodoropoulou K
- Thethi R
- Thevathasan Aa
- Thirumal V
- Thomas D
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- Tirnaksiz Mb
- Toale C
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- Toorenvliet Br
- Topal U
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- Tosun V
- Toto Of
- Trail M
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- Trecarten S
- Trimble A
- Trist Aj
- Troia A
- Trompetto M
- Truma A
- Truss A
- Tsui Ay
- Tulum H
- Tung L
- Turaga S
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- Turkmen M
- Turley H
- Turnbull Ja
- Turner Ejh
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- Uittenbogaart M
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- Ulusahin M
- Unal Ag
- Ungcharoen N
- Uppal E
- Urquhart A
- Uzun B
- Uzun O
- Uzun S
- Uzunoglu Ec
- Vable T
- Valderrama Pérez A
- Valli A
- Vallve-Bernal M
- Van Bruggen D
- van Dalen Ashm
- van de Ven Awh
- van der Harst E
- van der Hoeven Ac
- Van der Lubbe M
- van der Pool Aem
- van der Zee C
- Van Dijck Wpm
- van Elst Tr
- van Engelenburg T
- van Geloven A
- Van Grevenstein Wmu
- Van Heumen Tm
- van Leeuwen Bl
- van Rijckevorsel Vajim
- van Steensel L
- Van Tol Rr
- van Verschuer Vmt
- van Wijnbergen Jwm
- Vanmali P
- Varley R
- Varma D
- Varma N
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- Varo Muñoz A
- Vasko P
- Vasquez G
- Vaughan R
- Vazquez-Gonzalez I
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- Vendramin E
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- Verboeket B
- Verma K
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- Vernon Ok
- Villarejo Campos P
- Vinci A
- Vithanage Na
- Vivekanantham S
- Vives-Rodriguez E
- Viñas-Salas J
- Vries Jjm
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- Waldron Rm
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- Ward Ae
- Ward N
- Ward T
- Warren N
- Warwick Hl
- Watson N
- Watson Rp
- Weaver R
- Webb E
- Weinberg D
- Wells M
- Weston C
- Wetherall N
- Whacha C
- Whatling Ea
- Whewell H
- White A
- White Cj
- White U
- Whitehurst K
- Whitham Rdj
- Whittingham H
- Wiersema R
- Wiezer R
- Wijesekera M
- Wijffels N
- Wijnhoven Bpl
- Wild Jrl
- Wilkinson D
- Willems L
- Willems Yr
- Williams M
- Williams Mr
- Williams P
- Williams Rp
- Wills J
- Wilson H
- Wilson Hcp
- Wilson R
- Wilson T
- Wiltshire Jj
- Winarski A
- Wing Vc
- Wingfield Lr
- Winslow F
- Woin E
- Wong C
- Wong E
- Wong V
- Wood Ad
- Woodcock N
- Woodward H
- Woon E
- Wright A
- Wright Ev
- Wye J
- Wylam D
- Wylie J
- Wynell-Mayow Wm
- Xiao C
- Xu Gx
- Xylas D
- Yalcin Y
- Yaman S
- Yan A
- Yang T
- Yasar C
- Yates Ja
- Yauw S
- Yavuz G
- Yazkan Z
- Yekenkurul E
- Yener A
- Yeoh Tsl
- Yetiskin E
- Yıgman S
- Yildirim N
- Yildirim R
- Yildiz S
- Yildiz Ss
- Yildiz T
- Yilmaz I
- Yilmaz M
- Yilmaz S
- Yilmaz T
- Yim N
- Yoganathan S
- Yong Cs
- Yong N
- Yoruk I
- Yousif A
- Yow L
- Yuen R
- Yuksek B
- Yuksek Ma
- Yuksel A
- Yurdaor Ss
- Yurekli Am
- Zaidi R
- Zegeye Mi
- Zengin T
- Zhang Aa
- Zhao J
- Ziff O
- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Örhalmi J
- Özkan Bb
- Šimáčková B
- Široká M
- Žebrák R
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien\u2013Dindo Grades III\u2013V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49\u20132.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46\u20130.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease