Evaluation of HBV-Like circulation in wild and farm animals from Brazil and Uruguay

The origin of the hepatitis B virus is a subject of wide deliberation among researchers. As a result, increasing academic interest has focused on the spread of the virus in different animal species. However, the sources of viral infection for many of these animals are unknown since transmission may occur from animal to animal, human to human, animal to human, and human to animal. The aim of this study was to evaluate hepadnavirus circulation in wild and farm animals (including animals raised under wild or free conditions) from different sites in Brazil and Uruguay using serological and molecular tools. A total of 487 domestic wild and farm animals were screened for hepatitis B virus (HBV) serological markers and tested via quantitative and qualitative polymerase chain reaction (PCR) to detect viral DNA. We report evidence of HBsAg (surface antigen of HBV) and total anti-HBc (HBV core antigen) markers as well as low-copy hepadnavirus DNA among domestic and wild animals. According to our results, which were confirmed by partial genome sequencing, as the proximity between humans and animals increases, the potential for pathogen dispersal also increases. A wider knowledge and understanding of reverse zoonoses should be sought for an effective One Health response

Long-range Angular Correlations On The Near And Away Side In P-pb Collisions At √snn=5.02 Tev

7191/Mar294

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Observational study on the breeding performance of emus (Dromaius novaehollandiae) in Brazil

ABSTRACT The objective of this study was to describe emus’ breeding performance in Brazil at different ages, grouped in couples or colonies. The duration of the breeding season and the production of eggs per female housed were recorded, and the productivity and breeding variables were associated with the variation of the photoperiod. The total production of the flock was 180 eggs, and the breeding season lasted 167 days (April-September), a period with an average of 11 h and 11min of daylight. The breeding season lasted 113, 133 and 82 days, the numbers of eggs produced per female were 7.29, 25.67 and 17.3, and productivity values were 31.6, 38.6, and 45.4% in the groups of birds with ages of two, four and seven years, respectively. The breeding season in 2016 occurred between April and August in Brazil. Older birds tended to start breeding later. The production rate observations indicated that earlier peak production was associated with lower egg production potential. Finally, there was a tendency for better breeding performance of birds housed in couples than in groups with more birds.</jats:p

Physicochemical and morphometric characterization of eggs from emus (Dromaius novaehollandiae)

There is a dearth of scientific information about the physicochemical characteristics of eggs from ratite birds including emus. Thus, an experiment was carried out with 19 laying emu ((Dromaius novaehollandiae) hens, maintained in cages, and divided into two groups according to age, to record morphometric and physicochemical characteristics of the eggs. The width, length, average weight, form index, Haugh unit, yolk index, percentage of egg components, yolk pigmentation, pH of yolk and albumen, and eggshell weight and thickness were recorded. This morphometric characterization was influenced by the age of the hen. Neither the yolk nor albumen pH was influenced by the age of the bird. The eggs from emus that were raised in captivity presented physical and morphometric characteristics that varied with age, although they remained within the ranges of observations that were previously observed for ratite species, but were different from those of domestic chickens. The high fragility and easy rupture of the vitelline membrane in the emu eggs may limit the use of this product in industrial applications. Further studies of emu eggs are needed to improve their suitability for consumption and for the food industry.</jats:p