13 research outputs found
Information Needs and Disclosure Preferences among Jordanian Women Diagnosed with Breast Cancer
Bioprospecting of Thermotolerant Bacteria from Hot Water Springs of Himachal Pradesh for the Production of Taq DNA Polymerase
Assessment of land use/land cover change and its environmental impacts using remote sensing and GIS techniques, Yarmouk River Basin, north Jordan
To Share or Not to Share: Malaysian Healthcare Professionals' Views on Localized Prostate Cancer Treatment Decision Making Roles
Arabidopsis response to the spider mite Tetranychus urticae depends on the regulation of reactive oxygen species homeostasis
Organizational- and system-level characteristics that influence implementation of shared decision-making and strategies to address them — a scoping review
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer