190 research outputs found
Confocal Laser Scanning Microscopy, a New In Vivo Diagnostic Tool for Schistosomiasis
- Author
- Publication venue
- Public Library of Science
- Publication date
- Field of study
BACKGROUND: The gold standard for the diagnosis of schistosomiasis is the detection of the parasite's characteristic eggs in urine, stool, or rectal and bladder biopsy specimens. Direct detection of eggs is difficult and not always possible in patients with low egg-shedding rates. Confocal laser scanning microscopy (CLSM) permits non-invasive cell imaging in vivo and is an established way of obtaining high-resolution images and 3-dimensional reconstructions. Recently, CLSM was shown to be a suitable method to visualize Schistosoma mansoni eggs within the mucosa of dissected mouse gut. In this case, we evaluated the suitability of CLSM to detect eggs of Schistosoma haematobium in a patient with urinary schistosomiasis and low egg-shedding rates. METHODOLOGY/PRINCIPAL FINDINGS: The confocal laser scanning microscope used in this study was based on a scanning laser system for imaging the retina of a living eye, the Heidelberg Retina Tomograph II, in combination with a lens system (image modality). Standard light cystoscopy was performed using a rigid cystoscope under general anaesthesia. The CLSM endoscope was then passed through the working channel of the rigid cystoscope. The mucosal tissue of the bladder was scanned using CLSM. Schistoma haematobium eggs appeared as bright structures, with the characteristic egg shape and typical terminal spine. CONCLUSION/SIGNIFICANCE: We were able to detect schistosomal eggs in the urothelium of a patient with urinary schistosomiasis. Thus, CLSM may be a suitable tool for the diagnosis of schistosomiasis in humans, especially in cases where standard diagnostic tools are not suitable
Confocal Laser Scanning Microscopy for Detection of Schistosoma mansoni Eggs in the Gut of Mice
- Author
- A Gerger
- A Zhivov
- AD Jurberg
- AK Sarvel
- AW Cheever
- B Farahati
- B Tarp
- C Nohr-Westphal
- D Wichmann
- Emil Christian Reisinger
- HM Mudawi
- J Pellegrino
- J Pellegrino
- J Stave
- J Utzinger
- J Xu
- JR Cancado
- LM Oliveira
- M Giboda
- Maria Reichard
- Martha Charlotte Holtfreter
- MC Holtfreter
- ME Dailey
- Micha Loebermann
- MJ Doenhoff
- N Sandoval
- Oliver Stachs
- Patricia T. Bozza
- RF Guthoff
- RJ Ten Hove
- Rudolf Friedrich Guthoff
- T Van Gool
- WH Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Background: The gold standard for diagnosing Schistosoma mansoni infections is the detection of eggs from stool or biopsy specimens. The viability of collected eggs can be tested by the miracidium hatching procedure. Direct detection methods are often limited in patients with light or early infections, whereas serological tests and PCR methods fail to differentiate between an inactive and persistent infection and between schistosomal species. Recently, confocal laser scanning microscopy (CLSM) has been introduced as a diagnostic tool in several fields of medicine. In this study we evaluated CLSM for the detection of viable eggs of S. mansoni directly within the gut of infected mice. Methodology/Principal Findings: The confocal laser scanning microscope used in this study is based on the Heidelberg Retina Tomograph II scanning laser system in combination with the Rostock Cornea Module (image modality 1) or a rigid endoscope (image modality 2). Colon sections of five infected mice were examined with image modalities 1 and 2 for schistosomal eggs. Afterwards a biopsy specimen was taken from each colon section and examined by bright-field microscopy. Visualised eggs were counted and classified in terms of viability status. Conclusions/Significance: We were able to show that CLSM visualises eggs directly within the gut and permits discrimination of schistosomal species and determination of egg viability. Thus, CLSM may be a suitable non-invasive too
Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy.
- Author
- A Fujiwara
- A Jindal
- AM Almanjoumi
- CV Regatieri
- DC Hood
- EE Karaca
- Endophthalmitis Vitrectomy Study Group
- FJ Medina
- GĂĄbor MĂĄrk Somfai
- H Koizumi
- HS Al-Mezaine
- HY Park
- I Krebs
- I Maruko
- Irén Szalai
- J Cao
- J Noori
- J NĂ©meth
- J NĂ©meth
- J NĂ©meth
- JC Mwanza
- JĂĄnos NĂ©meth
- L El Matri
- M Gemenetzi
- M Inoue
- M Jambulingam
- M Nakayama
- M Stopa
- ME Correa-PĂ©rez
- MiklĂłs DĂ©nes Resch
- MT Leite
- NK Wang
- Otto Alexander Maneschg
- P Barry
- R Guthoff
- R Margolis
- RF Spaide
- RF Spaide
- SJ Ryan
- SW Kim
- T Yamashita
- U Schmidt-Erfurth
- Zsuzsanna GĂ©hl
- Ăva Volek
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND: Acute severe postoperative endophthalmitis may lead to severe vision loss. The aim of this study was the analysis of macular microstructure imaged by spectral domain optical coherence tomography in patients after pars plana vitrectomy due to postcataract endophthalmitis. METHODS: A cross sectional study was carried out in 17 patients who had cataract surgery in both eyes and underwent unilateral pars plana vitrectomy due to postcataract endophthalmitis. Postoperative best corrected visual acuity was determined in both eyes. Evaluation of macular thickness, macular volume, peripapillary retinal nerve fiber layer thickness and choroidal thickness using enhanced depth imaging technique was performed by spectral domain optical coherence tomography. The measurements obtained in the operated eye were compared to the fellow eye by Wilcoxon matched pair test. Correlation test was performed by Spearman rank order. RESULTS: A mean postoperative best corrected visual acuity of 63 +/- 30 ETDRS letters versus 75 +/- 21 letters was achieved in the study and fellow eyes, respectively, after a mean of 5.3 +/- 4.5 months (p = 0.1). The mean macular thickness was 320.6 +/- 28.8 mum SD in the study eyes compared to 318.4 +/- 18.8 mum in the fellow eyes (p = 0.767). No differences were noted in macular volume (p = 0.97) and in peripapillary retinal nerve fiber layer thickness (p = 0.31). Choroidal thickness was significantly lower in the study eyes compared to the fellow eyes (p = 0.018). Epiretinal membrane was found in 7 eyes after endophthalmitis, while in the fellow eyes only in 3 cases (p = 0.13, Fisher's exact test). CONCLUSION: Choroidal thickness decreased significantly after endophthalmitis, but there was no functional correlation with the changes in choroidal microstructure. The development of epiretinal membranes may be associated with either vitrectomy or endophthalmitis in the history. Absence of other significant structural and morphological findings shows that successful treatment may guarantee good clinical results even in long term after this severe postoperative complication
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Abu Zeid S
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Antchev G
- Anthony D
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
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- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
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- Banerjee S
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- Ăzçelik Ă
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of Ï Leptons in pp collisions at sqrt[s]=13ââTeV
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- Yao Y
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- Yi K
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- Yohay R
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- Yuan S
- Yuldashev BS
- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
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- Zhizhin I
- Zhokin A
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- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the Ï lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13ââTeV and corresponding to an integrated luminosity of 138ââfb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two Ï leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Recommended from our members
Search for Higgs boson decays to a Z boson and a photon in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abercrombie D
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- Zorbilmez C
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- Zuolo D
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 01/08/2022
- Field of study
A preprint version of the article is available at arXiv:2204.12945v2 [hep-ex], https://arxiv.org/abs/2204.12945v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-19-014 (CMS Public Pages). Report number: CMS-HIG-19-014, CERN-EP-2022-019.Results are presented from a search for the Higgs boson decay H â ZÎł, where Z â â+ââ with â = e or ÎŒ. The search is performed using a sample of proton-proton (pp) collision data at a center-of-mass energy of 13 TeV, recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 138 fb^{â1}. Events are assigned to mutually exclusive categories, which exploit differences in both event topology and kinematics of distinct Higgs production mechanisms to enhance signal sensitivity. The signal strength ÎŒ, defined as the product of the cross section and the branching fraction [Ï(pp â H)B(H â ZÎł)] relative to the standard model prediction, is extracted from a simultaneous fit to the â+ââÎł invariant mass distributions in all categories and is found to be ÎŒ = 2.4 ± 0.9 for a Higgs boson mass of 125.38 GeV. The statistical significance of the observed excess of events is 2.7 standard deviations. This measurement corresponds to Ï(pp â H)B(H â ZÎł) = 0.21 ± 0.08 pb. The observed (expected) upper limit at 95% confidence level on ÎŒ is 4.1 (1.8). The ratio of branching fractions B(H â ZÎł)/B(H â γγ) is measured to be 1.5 +0.7â0.6, which agrees with the standard model prediction of 0.69 ± 0.04 at the 1.5 standard deviation level.SCOAP3
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Measurements of the Higgs boson production cross section and couplings in the W boson pair decay channel in proton-proton collisions at sâ = 13 TeV
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 09/10/2022
- Field of study
A preprint version of the article is available at arXiv:2206.09466v2 [hep-ex], https://arxiv.org/abs/2206.09466v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at httpS://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-20-013 (CMS Public Pages). Report number: CMS-HIG-20-013, CERN-EP-2022-120.Production cross sections of the standard model Higgs boson decaying to a pair of W bosons are measured in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis targets Higgs bosons produced via gluon fusion, vector boson fusion, and in association with a W or Z boson. Candidate events are required to have at least two charged leptons and moderate missing transverse momentum, targeting events with at least one leptonically decaying W boson originating from the Higgs boson. Results are presented in the form of inclusive and differential cross sections in the simplified template cross section framework, as well as couplings of the Higgs boson to vector bosons and fermions. The data set collected by the CMS detector during 2016-2018 is used, corresponding to an integrated luminosity of 138 fb^â1. The signal strength modifier ÎŒ, defined as the ratio of the observed production rate in a given decay channel to the standard model expectation, is measured to be ÎŒ = 0.95 +0.10â0.09. All results are found to be compatible with the standard model within the uncertainties.SCOAP3
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Search for Higgs boson decays into Z and J/Ï and for Higgs and Z boson decays into J/Ï or ΄ pairs in pp collisions at sâ = 13 TeV
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Elsevier
- Publication date
- 21/10/2022
- Field of study
Data availability
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2).A preprint version of this article is archived at: arXiv:2206.03525v2 [hep-ex], https://arxiv.org/abs/2206.03525v2 . Comments: Replaced with the published version. Added the journal reference. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-20-008 (CMS Public Pages). Report number: CMS-HIG-20-008, CERN-EP-2022-074.Decays of the Higgs boson into a Z boson and a J/Ï or Ï(2S) meson are searched for in four-lepton final states with the CMS detector at the LHC. A data set of proton-proton collisions corresponding to an integrated luminosity of 138 fb^{-1} is used. Using the same data set, decays of the Higgs and Z boson into quarkonium pairs are also searched for. An observation of such decays with this sample would indicate the presence of physics beyond the standard model. No evidence for these decays has been observed and upper limits at the 95% confidence level are placed on the corresponding branching fractions (B). Assuming longitudinal polarization of the Higgs boson decay products, 95% confidence level observed upper limits for B(H â J/Ï) and B(H â ZÏ(2S)) are 1.9Ă10^{-3} and 6.6Ă10^{-3}, respectively.SCOAP3
Search for WÎł resonances in proton-proton collisions at s=13 TeV using hadronic decays of Lorentz-boosted W bosons
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Copyright © The Author(s). A search for resonances in the mass range between 0.7 and 6.0 TeV is presented. The W boson is reconstructed via its hadronic decays, with the final-state products forming a single large-radius jet, owing to a high Lorentz boost of the W boson. The search is based on proton-proton collision data at TeV, corresponding to an integrated luminosity of 137 fbâ1, collected with the CMS detector at the LHC in 2016â2018. The mass spectrum is parameterized with a smoothly falling background function and examined for the presence of resonance-like signals. No significant excess above the predicted background is observed. Model-specific upper limits at 95% confidence level on the product of the cross section and branching fraction to the channel are set. Limits for narrow resonances and for resonances with an intrinsic width equal to 5% of their mass, for spin-0 and spin-1 hypotheses, range between 0.17 fb at 6.0 TeV and 55 fb at 0.7 TeV. These are the most restrictive limits to date on the existence of such resonances over a large range of probed masses. In specific heavy scalar (vector) triplet benchmark models, narrow resonances with masses between 0.75 (1.15) and 1.40 (1.36) TeV are excluded for a range of model parameters. Model-independent limits on the product of the cross section, signal acceptance, and branching fraction to the channel are set for minimum mass thresholds between 1.5 and 8.0 TeV.SCOAP3
Recommended from our members
Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdullah Al-Mashad M
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
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- Aldaya Martin M
- AldĂĄ JĂșnior WL
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/11/2023
- Field of study
A preprint version of the article is available at arXiv:2309.16003v2 [hep-ex], https://arxiv.org/abs/2309.16003v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-005 (CMS Public Pages). Report number: CMS-EXO-21-005, CERN-EP-2023-165.A search for direct production of low-mass dimuon resonances is performed using sâ = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017-2018 operation of the CERN LHC with an integrated luminosity of 96.6 fbâ1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1-2.6 GeV and 4.2-7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world's best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient Δ2 in the dark photon model above 10â6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(ΞH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tanÎČ = 0.5.SCOAP3
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