367 research outputs found
Motion of rotatory molecular motor and chemical reaction rate
We examine the dependence of the physical quantities of the rotatory
molecular motor, such as the rotation velocity and the proton translocation
rate, on the chemical reaction rate using the model based only on diffusion
process. A peculiar behavior of proton translocation is found and the energy
transduction efficiency of the motor protein is enhanced by this behavior. We
give a natural explanation that this behavior is universal when certain
inequalities between chemical reaction rates hold. That may give a clue to
examine whether the motion of the molecular motor is dominated by diffusion
process or not.Comment: 12 pages, 8 figure
Studies of Phase Turbulence in the One Dimensional Complex Ginzburg-Landau Equation
The phase-turbulent (PT) regime for the one dimensional complex
Ginzburg-Landau equation (CGLE) is carefully studied, in the limit of large
systems and long integration times, using an efficient new integration scheme.
Particular attention is paid to solutions with a non-zero phase gradient. For
fixed control parameters, solutions with conserved average phase gradient
exist only for less than some upper limit. The transition from phase to
defect-turbulence happens when this limit becomes zero. A Lyapunov analysis
shows that the system becomes less and less chaotic for increasing values of
the phase gradient. For high values of the phase gradient a family of
non-chaotic solutions of the CGLE is found. These solutions consist of
spatially periodic or aperiodic waves travelling with constant velocity. They
typically have incommensurate velocities for phase and amplitude propagation,
showing thereby a novel type of quasiperiodic behavior. The main features of
these travelling wave solutions can be explained through a modified
Kuramoto-Sivashinsky equation that rules the phase dynamics of the CGLE in the
PT phase. The latter explains also the behavior of the maximal Lyapunov
exponents of chaotic solutions.Comment: 16 pages, LaTeX (Version 2.09), 10 Postscript-figures included,
submitted to Phys. Rev.
Mode-Locking in Driven Disordered Systems as a Boundary-Value Problem
We study mode-locking in disordered media as a boundary-value problem.
Focusing on the simplest class of mode-locking models which consists of a
single driven overdamped degree-of-freedom, we develop an analytical method to
obtain the shape of the Arnol'd tongues in the regime of low ac-driving
amplitude or high ac-driving frequency. The method is exact for a scalloped
pinning potential and easily adapted to other pinning potentials. It is
complementary to the analysis based on the well-known Shapiro's argument that
holds in the perturbative regime of large driving amplitudes or low driving
frequency, where the effect of pinning is weak.Comment: 6 pages, 7 figures, RevTeX, Submitte
Artificial Intelligence and Human Error Prevention: A Computer Aided Decision Making Approach: Technical Report No. 4: Survey and Analysis of Research on Learning Systems from Artificial Intelligence
Coordinated Science Laboratory was formerly known as Control Systems LaboratoryU.S. Department of Transportation / DOT FA79WA-4360 ABFederal Aviation Administratio
Counter-propagating radiative shock experiments on the Orion laser and the formation of radiative precursors
We present results from new experiments to study the dynamics of radiative
shocks, reverse shocks and radiative precursors. Laser ablation of a solid
piston by the Orion high-power laser at AWE Aldermaston UK was used to drive
radiative shocks into a gas cell initially pressurised between and $1.0 \
bar with different noble gases. Shocks propagated at {80 \pm 10 \ km/s} and
experienced strong radiative cooling resulting in post-shock compressions of {
\times 25 \pm 2}. A combination of X-ray backlighting, optical self-emission
streak imaging and interferometry (multi-frame and streak imaging) were used to
simultaneously study both the shock front and the radiative precursor. These
experiments present a new configuration to produce counter-propagating
radiative shocks, allowing for the study of reverse shocks and providing a
unique platform for numerical validation. In addition, the radiative shocks
were able to expand freely into a large gas volume without being confined by
the walls of the gas cell. This allows for 3-D effects of the shocks to be
studied which, in principle, could lead to a more direct comparison to
astrophysical phenomena. By maintaining a constant mass density between
different gas fills the shocks evolved with similar hydrodynamics but the
radiative precursor was found to extend significantly further in higher atomic
number gases (\sim4$ times further in xenon than neon). Finally, 1-D and 2-D
radiative-hydrodynamic simulations are presented showing good agreement with
the experimental data.Comment: HEDLA 2016 conference proceeding
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement in models to detect toxicity may reduce the incidence of unexpected post-marketing toxicity and reduce or eliminate the need for animal testing. The safety of novel products of the pharmaceutical, chemical, or cosmetics industry must be assured; therefore, toxicological properties need to be assessed. Accepted methods for gathering the information required by law for approval of substances are often animal methods. To reduce, refine, and replace animal testing, innovative organotypic in vitro models have emerged. Such models appear at different levels of complexity ranging from simpler, self-organized three-dimensional (3D) cell cultures up to more advanced scaffold-based co-cultures consisting of multiple cell types. This review provides an overview of recent developments in the field of toxicity testing with in vitro models for three major organ types: heart, skin, and liver. This review also examines regulatory aspects of such models in Europe and the UK, and summarizes best practices to facilitate the acceptance and appropriate use of advanced in vitro models
Colossal dielectric constants in transition-metal oxides
Many transition-metal oxides show very large ("colossal") magnitudes of the
dielectric constant and thus have immense potential for applications in modern
microelectronics and for the development of new capacitance-based
energy-storage devices. In the present work, we thoroughly discuss the
mechanisms that can lead to colossal values of the dielectric constant,
especially emphasising effects generated by external and internal interfaces,
including electronic phase separation. In addition, we provide a detailed
overview and discussion of the dielectric properties of CaCu3Ti4O12 and related
systems, which is today's most investigated material with colossal dielectric
constant. Also a variety of further transition-metal oxides with large
dielectric constants are treated in detail, among them the system La2-xSrxNiO4
where electronic phase separation may play a role in the generation of a
colossal dielectric constant.Comment: 31 pages, 18 figures, submitted to Eur. Phys. J. for publication in
the Special Topics volume "Cooperative Phenomena in Solids: Metal-Insulator
Transitions and Ordering of Microscopic Degrees of Freedom
Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
Background: Luminal A breast cancer defined as hormone receptor positive and human epidermal growth factor receptor 2 (HER2) negative is known to be heterogeneous. Previous study showed that luminal A tumours with the expression of basal markers ((cytokeratin (CK) 5 or CK5/6) or epidermal growth factor receptor (EGFR)) were associated with poorer prognosis compared with those that stained negative for basal markers. Prompted by this study, we assessed whether tumour characteristics and risk factors differed by basal marker status within luminal A tumours.
Methods: We pooled 5040 luminal A cases defined by immunohistochemistry (4490 basal-negative ((CK5 (or CK5/6))− and EGFR−) and 550 basal-positive ((CK5 (or CK5/6+)) or EGFR+)) from eight studies participating in the Breast Cancer Association Consortium. Case–case comparison was performed using unconditional logistic regression.
Results: Tumour characteristics and risk factors did not vary significantly by the expression of basal markers, although results suggested that basal-positive luminal tumours tended to be smaller and node negative, and were more common in women with a positive family history and lower body mass index.
Conclusions: Most established breast cancer risk factors were similar in basal-positive and basal-negative luminal A tumours. The non-significant but suggestive differences in tumour features and family history warrant further investigations
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
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