Unidentified EGRET Sources and the Extragalactic Gamma-Ray Background

The large majority of EGRET point sources remain to this day without an identified low-energy counterpart. Whatever the nature of the EGRET unidentified sources, faint unresolved objects of the same class must have a contribution to the diffuse gamma-ray background: if most unidentified objects are extragalactic, faint unresolved sources of the same class contribute to the background, as a distinct extragalactic population; on the other hand, if most unidentified sources are Galactic, their counterparts in external galaxies will contribute to the unresolved emission from these systems. Understanding this component of the gamma-ray background, along with other guaranteed contributions from known sources, is essential in any attempt to use gamma-ray observations to constrain exotic high-energy physics. Here, we follow an empirical approach to estimate whether a potential contribution of unidentified sources to the extragalactic gamma-ray background is likely to be important, and we find that it is. Additionally, we comment on how the anticipated GLAST measurement of the diffuse gamma-ray background will change, depending on the nature of the majority of these sources.Comment: 6 pages, 3 figures, to appear in proceedings of "The Multi-Messenger Approach to High Energy Gamma-Ray Sources", Barcelona, 4-7 July 2006; comments welcom

Local Void vs Dark Energy: Confrontation with WMAP and Type Ia Supernovae

It is now a known fact that if we happen to be living in the middle of a large underdense region, then we will observe an "apparent acceleration", even when any form of dark energy is absent. In this paper, we present a "Minimal Void" scenario, i.e. a "void" with minimal underdensity contrast (of about -0.4) and radius (~ 200-250 Mpc/h) that can, not only explain the supernovae data, but also be consistent with the 3-yr WMAP data. We also discuss consistency of our model with various other measurements such as Big Bang Nucleosynthesis, Baryon Acoustic Oscillations and local measurements of the Hubble parameter, and also point out possible observable signatures.Comment: Minor numerical errors and typos corrected, references adde

Indications and outcomes of enucleation versus formal pancreatectomy for pancreatic neuroendocrine tumors

Background: Pancreatoduodenectomy (PD) or distal pancreatectomy (DP) are common procedures for patients with a pancreatic neuroendocrine tumor (pNET). Nevertheless, certain patients may benefit from a pancreas-preserving resection such as enucleation (EN). The aim of this study was to define the indications and differences in long-term outcomes among patients undergoing EN and PD/DP. Methods: Patients undergoing resection of a pNET between 1992 and 2016 were identified. Indications and outcomes were evaluated, and propensity score matching (PSM) analysis was performed to compare long-term outcomes between patients who underwent EN versus PD/DP. Results: Among 1034 patients, 143 (13.8%) underwent EN, 304 (29.4%) PD, and 587 (56.8%) DP. Indications for EN were small size (1.5 cm, IQR:1.0–1.9), functional tumors (58.0%) that were mainly insulinomas (51.7%). After PSM (n = 109 per group), incidence of postoperative pancreatic fistula (POPF) grade B/C was higher after EN (24.5%) compared with PD/DP (14.0%) (p = 0.049). Median recurrence-free survival (RFS) was comparable among patients who underwent EN (47 months, 95% CI:23–71) versus PD/DP (37 months, 95% CI: 33–47, p = 0.480). Conclusion: Comparable long-term outcomes were noted among patients who underwent EN versus PD/DP for pNET. The incidence of clinically significant POPF was higher after EN

The yields of r-process elements and chemical evolution of the Galaxy

The supernova yields of r-process elements are obtained as a function of the mass of their progenitor stars from the abundance patterns of extremely metal-poor stars on the left-side [Ba/Mg]-[Mg/H] boundary with a procedure proposed by Tsujimoto and Shigeyama. The ejected masses of r-process elements associated with stars of progenitor mass $M_{ms}\leq18M_{\odot}$ are infertile sources and the SNe II with 20$M_{\odot}\leq M_{ms}\leq 40M_{\odot}$are the dominant source of r-process nucleosynthesis in the Galaxy. The ratio of these stars 20$M_{\odot}\leq M_{ms}\leq40M_{\odot}$ with compared to the all massive stars is about $\sim$18%. In this paper, we present a simple model that describes a star's [r/Fe] in terms of the nucleosynthesis yields of r-process elements and the number of SN II explosions. Combined the r-process yields obtained by our procedure with the scatter model of the Galactic halo, the observed abundance patterns of the metal-poor stars can be well reproducedComment: 7 pages, 6 figures, Accepted for publication in Astrophysics and Space Scienc

Olber's Paradox for Superluminal Neutrinos: Constraining Extreme Neutrino Speeds at TeV-ZeV Energies with the Diffuse Neutrino Background

The only invariant speed in special relativity is c; therefore, if some neutrinos travel at even tiny speeds above c, normal special relativity is incomplete and any superluminal speed may be possible. I derive a limit on superluminal neutrino speeds v >> c at high energies by noting that such speeds would increase the size of the neutrino horizon. The increased volume of the Universe visible leads to a brighter astrophysical neutrino background. The nondetection of "guaranteed" neutrino backgrounds from star-forming galaxies and ultrahigh energy cosmic rays (UHECRs) constrains v/c at TeV--ZeV energies. I find that v/c <= 820 at 60 TeV from the nondetection of neutrinos from star-forming galaxies. The nondetection of neutrinos from UHECRs constrains v/c to be less than 2500 at 0.1 EeV in a pessimistic model and less than 4.6 at 4 EeV in an optimistic model. The UHECR neutrino background nondetection is strongly inconsistent with a naive quadratic extrapolation of the OPERA results to EeV energies. The limits apply subject to some caveats, particularly that the expected pionic neutrino backgrounds exist and that neutrinos travel faster than c when they pass the detector. They could be improved substantially as the expected neutrino backgrounds are better understood and with new experimental neutrino background limits. I also point out that extremely subluminal speeds would result in a much smaller neutrino background intensity than expected.Comment: 13 pages, 2 figures, fixed titl

The Standard Cosmological Model

The Standard Model of Particle Physics (SMPP) is an enormously successful description of high energy physics, driving ever more precise measurements to find "physics beyond the standard model", as well as providing motivation for developing more fundamental ideas that might explain the values of its parameters. Simultaneously, a description of the entire 3-dimensional structure of the present-day Universe is being built up painstakingly. Most of the structure is stochastic in nature, being merely the result of the particular realisation of the "initial conditions" within our observable Universe patch. However, governing this structure is the Standard Model of Cosmology (SMC), which appears to require only about a dozen parameters. Cosmologists are now determining the values of these quantities with increasing precision in order to search for "physics beyond the standard model", as well as trying to develop an understanding of the more fundamental ideas which might explain the values of its parameters. Although it is natural to see analogies between the two Standard Models, some intrinsic differences also exist, which are discussed here. Nevertheless, a truly fundamental theory will have to explain both the SMPP and SMC, and this must include an appreciation of which elements are deterministic and which are accidental. Considering different levels of stochasticity within cosmology may make it easier to accept that physical parameters in general might have a non-deterministic aspect.Comment: 16 pages, 2 figures, invited talk at "Theory Canada 1", June 2005, Vancouve

Using behavior-analytic implicit tests to assess sexual interests among normal and sex-offender populations

The development of implicit tests for measuring biases and behavioral predispositions is a recent development within psychology. While such tests are usually researched within a social-cognitive paradigm, behavioral researchers have also begun to view these tests as potential tests of conditioning histories, including in the sexual domain. The objective of this paper is to illustrate the utility of a behavioral approach to implicit testing and means by which implicit tests can be built to the standards of behavioral psychologists. Research findings illustrating the short history of implicit testing within the experimental analysis of behavior are reviewed. Relevant parallel and overlapping research findings from the field of social cognition and on the Implicit Association Test are also outlined. New preliminary data obtained with both normal and sex offender populations are described in order to illustrate how behavior-analytically conceived implicit tests may have potential as investigative tools for assessing histories of sexual arousal conditioning and derived stimulus associations. It is concluded that popular implicit tests are likely sensitive to conditioned and derived stimulus associations in the history of the test-taker rather than 'unconscious cognitions', per se

Controle associado de Alphitobius diaperinuse efeito de microrganismos eficazes no desenvolvimento de Beauveria bassiana

O objetivo deste trabalho foi avaliar a eficiência de Beauveria bassiana (Bb), terra diatomácea (TD) e microrganismos eficazes (EM-4), associados ou não, no controle de Alphitobius diaperinus, e o efeito de EM-4 no desenvolvimento de B. bassiana. Os agentes de controle (Bb, TD e EM-4), em diferentes concentrações e combinações, foram aplicados em uma mistura de cama-de-frango e ração, em que os insetos foram acondicionados por dez dias. Avaliaram-se, in vitro: a germinação, as unidades formadoras de colônia (UFC), o crescimento vegetativo e a produtividade de conídios de Bb em contato com suspensão aquosa de EM-4 (1%) não filtrada e filtrada. Os maiores índices de mortalidade foram observados nos tratamentos TD + Bb + EM-4 e TD + Bb, nas maiores concentrações. Verificou-se efeito não-aditivo sinérgico para TD + Bb nas três concentrações. Nos testes com EM-4 filtrado, não houve diferença em relação à testemunha quanto à germinação e às UFC, entretanto, o crescimento vegetativo e a produtividade de conídios foram negativamente afetados. O uso conjunto de B. bassiana e terra diatomácea, para o manejo de populações de A. diaperinus, pode reduzir o uso de produtos químicos

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy