The Medieval Climate Anomaly and Little Ice Age in Chesapeake Bay and the North Atlantic Ocean

This paper is not subject to U.S. copyright. The definitive version was published in Palaeogeography, Palaeoclimatology, Palaeoecology 297 (2010): 299-310, doi:10.1016/j.palaeo.2010.08.009.A new 2400-year paleoclimate reconstruction from Chesapeake Bay (CB) (eastern US) was compared to other paleoclimate records in the North Atlantic region to evaluate climate variability during the Medieval Climate Anomaly (MCA) and Little Ice Age (LIA). Using Mg/Ca ratios from ostracodes and oxygen isotopes from benthic foraminifera as proxies for temperature and precipitation-driven estuarine hydrography, results show that warmest temperatures in CB reached 16–17 °C between 600 and 950 CE (Common Era), centuries before the classic European Medieval Warm Period (950–1100 CE) and peak warming in the Nordic Seas (1000–1400 CE). A series of centennial warm/cool cycles began about 1000 CE with temperature minima of ~ 8 to 9 °C about 1150, 1350, and 1650–1800 CE, and intervening warm periods (14–15 °C) centered at 1200, 1400, 1500 and 1600 CE. Precipitation variability in the eastern US included multiple dry intervals from 600 to 1200 CE, which contrasts with wet medieval conditions in the Caribbean. The eastern US experienced a wet LIA between 1650 and 1800 CE when the Caribbean was relatively dry. Comparison of the CB record with other records shows that the MCA and LIA were characterized by regionally asynchronous warming and complex spatial patterns of precipitation, possibly related to ocean–atmosphere processes

Measurements of the Ratios B(Ds+→ηℓ+ν)/B(Ds+→ϕℓ+ν){\cal B}(D_s^+\to \eta\ell^+\nu)/{\cal B}(D_s^+\to \phi\ell^+\nu) and B(Ds+→η′ℓ+ν)/B(Ds+→ϕℓ+ν){\cal B}(D_s^+\to \eta'\ell^+\nu)/{\cal B}(D_s^+\to \phi\ell^+\nu)

Using the CLEO~II detector we measure ${\cal B}(D_s^+\to \eta e^+\nu)/{\cal B}(D_s^+\to \phi e^+\nu) =1.24\pm0.12\pm0.15$, ${\cal B}(D_s^+\to \eta' e^+\nu)/{\cal B}(D_s^+\to \phi e^+\nu) =0.43\pm0.11\pm0.07$ and ${\cal B}(D_s^+\to \eta' e^+\nu)/{\cal B}(D_s^+\to \eta e^+\nu) =0.35\pm0.09\pm0.07$. We find the vector to pseudoscalar ratio, ${\cal B}(D_s^+\to \phi e^+\nu)/{\cal B}(D_s^+\to (\eta+\eta') e^+\nu) =0.60\pm0.06\pm0.06$, which is similar to the ratio found in non strange $D$ decays.Comment: 11 page uuencoded postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN

EFFECT OF CHARCOAL -ENRICHED SUBSTRATE ON SEEDLINGS OF RHIZOBIUM-INOCULATED LEGUME TREES

ABSTRACT Native legume trees are planted in agroforestry systems for their hardiness and symbiosis with soil bacteria of the genus rhizobium, efficient in N2 fixation. The enrichment of the substrate composition with fine charcoal for seedling production of these trees is interesting for increasing soil porosity, water retention and the proliferation of beneficial microorganisms. Experiments were carried out to analyze the effect of substrate enrichment with charcoal on the quality of Clitoria fairchildiana, Enterolobium schomburgkii and Inga edulis seedlings. The treatments consisted of a 3:2:0.5 (v:v) mixture of clay soil, sand and bovine manure and a 3:2 (v:v) mixture of clay soil and sand combined with charcoal rates of 0, 10, 19 and 29%. After mixing the components, substrate samples were collected and chemically analyzed. The experiment was arranged in a completely randomized design with 5 treatments and 10 replications. The seedlings were inoculated with homologues rhizobia and growth controlled monthly. The plants were collected to determine the number of nodules and dry biomass of roots, shoots and nodules. Seedling growth was similar on substrates containing charcoal or manure, except for E. schomburkii, which increased by more than 100% on the charcoal-containing substrates. The number and dry biomass of nodules in the charcoal-containing substrates was up to 100% and 300% higher than in the manure-containing treatment, respectively. The results indicated that the substitution of manure by charcoal favors the seedling quality of the studied species

School-based prevention for adolescent Internet addiction: prevention is the key. A systematic literature review

Adolescents’ media use represents a normative need for information, communication, recreation and functionality, yet problematic Internet use has increased. Given the arguably alarming prevalence rates worldwide and the increasingly problematic use of gaming and social media, the need for an integration of prevention efforts appears to be timely. The aim of this systematic literature review is (i) to identify school-based prevention programmes or protocols for Internet Addiction targeting adolescents within the school context and to examine the programmes’ effectiveness, and (ii) to highlight strengths, limitations, and best practices to inform the design of new initiatives, by capitalizing on these studies’ recommendations. The findings of the reviewed studies to date presented mixed outcomes and are in need of further empirical evidence. The current review identified the following needs to be addressed in future designs to: (i) define the clinical status of Internet Addiction more precisely, (ii) use more current psychometrically robust assessment tools for the measurement of effectiveness (based on the most recent empirical developments), (iii) reconsider the main outcome of Internet time reduction as it appears to be problematic, (iv) build methodologically sound evidence-based prevention programmes, (v) focus on skill enhancement and the use of protective and harm-reducing factors, and (vi) include IA as one of the risk behaviours in multi-risk behaviour interventions. These appear to be crucial factors in addressing future research designs and the formulation of new prevention initiatives. Validated findings could then inform promising strategies for IA and gaming prevention in public policy and education

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers

The G4C2-repeat expansion in C9orf72 is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. The high phenotypic heterogeneity of C9orf72 patients includes a wide range in age of onset, modifiers of which are largely unknown. Age of onset could be influenced by environmental and genetic factors both of which may trigger DNA methylation changes at CpG sites. We tested the hypothesis that age of onset in C9orf72 patients is associated with some common single nucleotide polymorphisms causing a gain or loss of CpG sites and thus resulting in DNA methylation alterations. Combined analyses of epigenetic and genetic data have the advantage of detecting functional variants with reduced likelihood of false negative results due to excessive correction for multiple testing in genome-wide association studies. First, we estimated the association between age of onset in C9orf72 patients (n = 46) and the DNA methylation levels at all 7603 CpG sites available on the 450 k BeadChip that are mapped to common single nucleotide polymorphisms. This was followed by a genetic association study of the discovery (n = 144) and replication (n = 187) C9orf72 cohorts. We found that age of onset was reproducibly associated with polymorphisms within a 124.7 kb linkage disequilibrium

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy