46 research outputs found
Patterns and processes in shorebird survival rates: a global review
Changes in demographic rates underpin changes in population size, and understanding demographic rates can greatly aid the design and development of strategies to maintain populations in the face of environmental changes. However, acquiring estimates of demographic parameters at relevant spatial scales is difficult. Measures of annual survival rates can be particularly challenging to obtain because large-scale, long-term tracking of individuals is difficult and the resulting data contain many inherent biases. In recent years, advances in both tracking and analytical techniques have meant that, for some taxonomic groups, sufficient numbers of survival estimates are available to allow variation within and among species to be explored. Here we review published estimates of annual adult survival rates in shorebird species across the globe, and construct models to explore the phylogenetic, geographical, seasonal and sex-based variation in survival rates. Models of 295 survival estimates from 56 species show that survival rates calculated from recoveries of dead individuals or from return rates of marked individuals are significantly lower than estimates from mark–recapture models. Survival rates also vary across flyways, largely as a consequence of differences in the genera that have been studied and the analytical methods used, with published estimates from the Americas and from smaller shorebirds (Actitis, Calidris and Charadrius spp.) tending to be underestimated. By incorporating the analytical method used to generate each estimate within a mixed model framework, we provide method-corrected species-specific and genus-specific adult annual survival estimates for 52 species of 15 genera
177Lu-immunotherapy of experimental peritoneal carcinomatosis shows comparable effectiveness to 213Bi-immunotherapy, but causes toxicity not observed with 213Bi
Abstract
Purpose 213Bi-d9MAb-immunoconjugates targeting gastric
cancer cells have effectively cured peritoneal carcinomatosis
in a nude mouse model following intraperitoneal
injection. Because the β-emitter 177Lu has proven to be
beneficial in targeted therapy, 177Lu-d9MAb was investigated
in this study in order to compare its therapeutic
efficacy and toxicity with those of 213Bi-d9MAb.
Methods Nude mice were inoculated intraperitoneally with
HSC45-M2 gastric cancer cells expressing d9-E-cadherin
and were treated intraperitoneally 1 or 8 days later with
different activities of specific 177Lu-d9MAb immunoconjugates
targeting d9-E-cadherin or with nonspecific 177Lud8MAb.
Therapeutic efficacy was evaluated by monitoring
survival for up to 250 days. For evaluation of toxicity, both
biodistribution of 177Lu-d9MAb and blood cell counts were
determined at different time points and organs were
examined histopathologically.
Results Treatment with 177Lu-immunoconjugates (1.85,
7.4, 14.8 MBq) significantly prolonged survival. As
expected, treatment on day 1 after tumour cell inoculation
was more effective than treatment on day 8, and specific
177Lu-d9MAb conjugates were superior to nonspecific
177Lu-d8MAb. Treatment with 7.4 MBq of 177Lu-d9MAb
was most successful, with 90% of the animals surviving
longer than 250 days. However, treatment with therapeutically
effective activities of 177Lu-d9MAb was not free of
toxic side effects. In some animals lymphoblastic lymphoma,
proliferative glomerulonephritis and hepatocarcinoma
were seen but were not observed after treatment with 213Bid9MAb
at comparable therapeutic efficacy.
Conclusion The therapeutic efficacy of 177Lu-d9MAb
conjugates in peritoneal carcinomatosis is impaired by
toxic side effects. Because previous therapy with 213Bid9MAb
revealed comparable therapeutic efficacy without
toxicity it should be preferred for the treatment of
peritoneal carcinomatosis.JRC.DG.E.5-Nuclear chemistr