Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Correction: Volume53, Issue5 Page 762-762 DOI: 10.1038/s41588-021-00832-z Published MAY 2021Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequencyPeer reviewe

Scintillation readout with MAPD array for gamma spectrometer

In this study, we present the gamma-ray detection performance of LYSO, YSO(Ce) and BGO scintillators read out by a 9 ch. micropixel avalanche photodiode (MAPD) array with a high pixel density (PD) and photon detection efficiency (PDE). The array with an active area of 11,5x11,5mm2 was assembled using single MAPDs with an active area of 3,7x3,7mm2. It had a single output signal and was developed for gamma spectroscopy. Breakdown voltage measurements were carried out for each channel, as a result of which the optimal operating voltage for the array was found. The linearity range and energy resolution for each crystal were determined in the energy range from 30 to 1770 keV. The high pixel density of the array allowed to achieve good linearity in the studied energy range

A program for data analysis of rare fission mode processes from neutron-induced and spontaneous fissions

Rare fission mode processes (ternary or quaternary fission) of low-energy and spontaneous fission of heavy nuclei, in which light charged particles are emitted, are the subject of intense experimental and theoretical studies, since these studies can be attributed to one of the main sources of information on the mechanism of nuclear fission. To study these processes, a detection system has been assembled, consisting of three semiconductor ΔE-E telescopes and a silicon detector. In addition, the program has been developed for proceeding experimental data. This paper has been dedicated to the program written on the basis of ROOT software consisting of many scripts to analyze and/or filtrate ternary and quaternary fission particles among different fission events. The program can proceed long collected files in ASCII and binary formats, correlate results from all detectors, give results on particle interaction time, coordinates, particle energy and its types. The performance of the program has been tested to proceed ternary fission data from 252Cf spontaneous fission source

A synchronization and data acquisition system for silicon detectors

A dedicated synchronization bus has been developed and integrated into the FITPix COMBO device. It can be used as Timepix read-out (involving back-side-pulse acquisition) or as a simple spectrometer device—Spectrig (when an external single pad sensor is connected, e.g. Δ E detector). The synchronization bus permits the implementation of a system of up to 32 distinct devices running in clock locked mode while the absolute value of the timestamp is distributed to all devices in the system. Any combination of Timepix or spectrometer devices (up to 32) can be connected-up to create a final measurement set-up. The synchronization bus has also been designed to control a trigger signal and busy signal to allow an effective filtration of unpaired events when coincidence measurement is performed. The system has been tested with a Δ E− E telescope consisting of a thin detector and Timepix. The thin detector has been used for Δ E and the Timepix detector for E measurements. The Δ E detector has an area of 10×10 mm2 and a thickness of 12 μm with non-uniformity of 8%. The area and thickness of Timepix are 14×14 mm2 and 300 μm, respectively. The detection system can provide simultaneous information about position, energy, time and type of registered particles with high synchronization accuracy. Test measurements have been carried out with an alpha particle source (Ra-226) in a vacuum and the results of these measurements are presented in this paper

Gamma-ray spectroscopy with MAPD array in the readout of LaBr3:Ce scintillator

This paper presented a new detector module consisting of a micropixel avalanche photodiode (MAPD-3NM), LaBr3:Ce scintillator, and a compact read-out interface system for detecting gamma-rays in a wide energy range. The MAPD array (4 × 4 channels) was assembled using a singleMAPD-3NMcharacterized by its high photon detection efficiency (∼25%),pixel density (10 000 pixels/mm2), lowoperation voltage (74.5 V), and lowdark current. An active area of a singleMAPD-3NMwas 3.7 × 3.7 mm2, while this value was 17 × 17 mm2 for the assembled array with pixel density of 2190 000. The size of the tested LaBr3:Ce scintillator was 15 × 15 × 15 mm3. According to the characteristics of the detector module, a compact read-out interface device (SPECTRIG MAPD) was developed. SPECTRIG MAPD was designed as a miniature device with low power consumption, which continues to provide a wide spectrum of functions needed for measurement and test silicon photomultipliers (SiPM) and scintillation detectors on their basis. The various experiments were implemented to test the detection performance of a detector module to gamma radiation in the range from 30 keV to 4400 keV