Homeless population

The aim was to derive and analyze a model for numbers of homeless and non-homeless people in a borough, in particular to see how these figures might be affected by different policies regarding housing various categories of people. Most attention was focused on steady populations although the stability of these and possible timescales of dynamic problems were also discussed. The main outcome of this brief study is the identification of the key role played by the constant k_1 - the constant which fixes the speed at which the homeless are rehoused in permanent council property. Reducing this constant, i.e. making the system "fairer" with less priority to accommodating homeless families, appears to have little effect on the sizes of other categories on the waiting list but there is a marked increase in the number of households in temporary accommodation. The model, indicated by the size of its longest time-scale, should be modified to allow for births etc. It could be varied by allowing people to remove themselves from the register or by allowing the rates at which registered and unregistered people become homeless to differ, but these modifications are unlikely to substantially change the main result. The inclusion of movement from the homeless to the general population would have the effect of limiting the numbers in temporary accommodation. However, it is thought this effect is very small so a great reduction in k_1 would be needed for this flow to become significant

Tourism and the smartphone app: capabilities, emerging practice and scope in the travel domain.

Based on its advanced computing capabilities and ubiquity, the smartphone has rapidly been adopted as a tourism travel tool.With a growing number of users and a wide varietyof applications emerging, the smartphone is fundamentally altering our current use and understanding of the transport network and tourism travel. Based on a review of smartphone apps, this article evaluates the current functionalities used in the domestic tourism travel domain and highlights where the next major developments lie. Then, at a more conceptual level, the article analyses how the smartphone mediates tourism travel and the role it might play in more collaborative and dynamic travel decisions to facilitate sustainable travel. Some emerging research challenges are discussed

On the heat waves over India and their future projections under different SSP scenarios from CMIP6 models

Thirteen Coupled Model Intercomparison Project phase 6 (CMIP6) models were employed to simulate mean, maximum, and minimum temperature across 7 homogenous temperature regions of India for both annual and summer season (June, July, and August (JJA)). The model fidelity was assessed by comparing them with observed Climate Research Unit temperature dataset. The JJA multi‐model ensemble for the present (1981–2014) suggests large warm biases in the temperature. Although the models could simulate the spatial variability of the mean and maximum temperature over most of the homogeneous regions, they do not compare well for representing the temporal variability. We also found, that although different individual models have strengths and weaknesses in representing spatial and temporal temperature characteristics over India, a few of the models perform better than the others. For example, CNRM‐CM6 could better represent the spatial temperature patterns however they struggle in capturing the temporal variability. HadGEM3‐GC31‐LL, KACE‐1‐0G, and UKESM1‐0‐LL are comparably the best‐performing models for temporal temperature features over India. The annual maximum temperature during far future period is projected to increase by 1.5°C, 2.3°C, and 4.1°C for Socioeconomic Pathways (SSPs) SSP1‐2.6, SSP2‐4.5, and SSP5‐8.5 respectively. At regional scales, JJA mean temperature for SSP5‐8.5 revealed significant increases in Interior Peninsula (3.8°C), Western Himalaya (5.6°C), Northwest (3.9°C), West Coast (3.6°C), East Coast (3.6°C), Northeast (3.6°C), and North Central (3.8°C), highlighting the Western Himalaya's heightened sensitivity. Further, heat wave frequency is projected to rise, with the northern territories (NW, NC, NE, and part of IP) most affected, anticipating week‐long heat waves affecting around 50% of India's population under stronger SSPs. Such unprecedented impacts seem to be less profound in case of abatement scenarios such as the SSP1‐2.6. Our findings support the urgent need for more ambitious mitigation and adaptation strategies to alleviate the public health impacts of climate change

Projected changes in heatwaves and its impact on human discomfort over India due to global warming under the CORDEX-CORE framework

Due to climate change, rapid warming and its further intensification over different parts of the globe have been recently reported. This has a direct impact on human health, agriculture, water availability, power generation, various ecosystems, and socioeconomic conditions of the exposed population. The current study thus investigates the frequency and duration of heatwaves, human discomfort, and exposure of the human population to these extremes using the high-resolution regional climate model experiments under two Representative Concentration Pathways (RCP2.6, RCP8.5) over India. We find that more than 90% of India will be exposed to uncomfortable warm nights by the end of the 21st century with the highest rise over western India, Madhya Pradesh (MP), Uttar Pradesh (UP), Punjab, and the Haryana region. States like Odisha, Chhattisgarh, eastern parts of MP and UP, and some parts of J&K will be the worst hit by the intense and frequent heatwaves and human discomfort followed by the densely populated Indo-Gangetic plains under RCP8.5. Strict enforcement of the stringent policies on stabilization of population growth, improvement of local adaptive capacities, and economic status of the vulnerable population along with enforcing effective measures to curb greenhouse gas emissions are important to reduce human exposure to future heat stress. We demonstrate that a proper mitigation-based development (RCP2.6) instead of a business-as-usual scenario (RCP8.5) may help to reduce 50–200 heatwave days, 3–10 heatwave spells, and 10–35% warm nights over the Indian region. Consequently, this can avoid the exposure of 135–143 million population to severe discomfort due to extreme heat conditions by the end of the 21st century

Detection of Genetically Altered Copper Levels in Drosophila Tissues by Synchrotron X-Ray Fluorescence Microscopy

Tissue-specific manipulation of known copper transport genes in Drosophila tissues results in phenotypes that are presumably due to an alteration in copper levels in the targeted cells. However direct confirmation of this has to date been technically challenging. Measures of cellular copper content such as expression levels of copper-responsive genes or cuproenzyme activity levels, while useful, are indirect. First-generation copper-sensitive fluorophores show promise but currently lack the sensitivity required to detect subtle changes in copper levels. Moreover such techniques do not provide information regarding other relevant biometals such as zinc or iron. Traditional techniques for measuring elemental composition such as inductively coupled plasma mass spectroscopy are not sensitive enough for use with the small tissue amounts available in Drosophila research. Here we present synchrotron x-ray fluorescence microscopy analysis of two different Drosophila tissues, the larval wing imaginal disc, and sectioned adult fly heads and show that this technique can be used to detect changes in tissue copper levels caused by targeted manipulation of known copper homeostasis genes

Tourism communities and social ties: the role of online and offline tourist social networks in building social capital and sustainable practice.

Mobile connectivity enables the adoption of new ways to connect with social networks which are changing how we might, and could, seek support. In the tourism domain we increasingly blend online and offline presence to engage with social networks in the spatial location, at a distance and across time. This paper explores the forms of community that exist in physical tourism contexts, contexts not previously analysed through a community lens, and explores how mobile technology is creating connections within and beyond existing social networks. It examines how sustainable tourism can be enhanced by mobile connectivity through new space-time practices and using ephemeral interpersonal relationships to harness niche groups to create bottom-up social systems interested in sharing experiences, ideas and resources. Special attention is given to the concept of gelling socialities which proposes a less ridged network structure, and to the need to understand the increasingly liquid social dynamics of mobile social interactions. The paper adds to the theories surrounding community, social ties and tourism’s value to society. It draws on data from in-depth interviews undertaken while designing and testing a collaborative travel app. It contributes to growing research into the new technologies increasingly available for sustainable tourism marketing and implementation

Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila

FK506 binding proteins (FKBPs), also called immunophilins, are prolyl-isomerases (PPIases) that participate in a wide variety of cellular functions including hormone signaling and protein folding. Recent studies indicate that proteins that contain PPIase activity can also alter the processing of Alzheimer's Amyloid Precursor Protein (APP). Originally identified in hematopoietic cells, FKBP52 is much more abundantly expressed in neurons, including the hippocampus, frontal cortex, and basal ganglia. Given the fact that the high molecular weight immunophilin FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, we investigated its role in Aβ toxicity. Towards this goal, we generated Aβ transgenic Drosophila that harbor gain of function or loss of function mutations of FKBP52. FKBP52 overexpression reduced the toxicity of Aβ and increased lifespan in Aβ flies, whereas loss of function of FKBP52 exacerbated these Aβ phenotypes. Interestingly, the Aβ pathology was enhanced by mutations in the copper transporters Atox1, which interacts with FKBP52, and Ctr1A and was suppressed in FKBP52 mutant flies raised on a copper chelator diet. Using mammalian cultures, we show that FKBP52 (−/−) cells have increased intracellular copper and higher levels of Aβ. This effect is reversed by reconstitution of FKBP52. Finally, we also found that FKBP52 formed stable complexes with APP through its FK506 interacting domain. Taken together, these studies identify a novel role for FKBP52 in modulating toxicity of Aβ peptides

Closed-Loop Recycling of Copper from Waste Printed Circuit Boards Using Bioleaching and Electrowinning Processes

International audienceIn the present study, a model of closed-loop recycling of copper from PCBs is demonstrated, which involves the sequential application of bioleaching and electrowinning to selectively extract copper. This approach is proposed as part of the solution to resolve the challenging ever-increasing accumulation of electronic waste, e-waste, in the environment. This work is targeting copper, the most abundant metal in e-waste that represents up to 20% by weight of printed circuit boards (PCBs). In the first stage, bioleaching was tested for different pulp densities (0.25–1.00% w/v) and successfully used to extract multiple metals from PCBs using the acidophilic bacterium, Acidithiobacillus ferrooxidans. In the second stage, the method focused on the recovery of copper from the bioleachate by electrowinning. Metallic copper foils were formed, and the results demonstrated that 75.8% of copper available in PCBs had been recovered as a high quality copper foil, with 99 + % purity, as determined by energy dispersive X-ray analysis and Inductively-Coupled Plasma Optical Emission Spectrometry. This model of copper extraction, combining bioleaching and electrowinning, demonstrates a closed-loop method of recycling that illustrates the application of bioleaching in the circular economy. The copper foils have the potential to be reused, to form new, high value copper clad laminate for the production of complex printed circuit boards for the electronics manufacturing industry. Graphic Abstract: [Figure not available: see fulltext.] © 2020, The Author(s)

Método para quantificação do consumo energético no ciclo de vida de equipamentos hidrossanitários

A escolha entre diferentes materiais, produtos ou sistemas empregados na construção civil pode levar em consideração diferentes critérios, sejam estes econômicos, sociais, culturais e ambientais. No caso de equipamentos hidrossanitários, a avaliação econômica e do consumo de recursos, tais como a água, são os critérios mais comumente empregados. O presente artigo objetiva a proposição de um método para quantificação do consumo energético de equipamentos hidrossanitários com base no conceito de Análise do Ciclo de Vida. Essa quantificação permite a comparação entre o desempenho de diferentes equipamentos hidrossanitários com base no dispêndio energético total. No presente artigo o método proposto é aplicado em um estudo de caso analisando dois modelos de torneira (convencional e com fechamento hidromecânico). O consumo energético total no ciclo de vida das torneiras convencional e economizadora de água utilizadas no estudo foi de respectivamente, 151,66 MJ e 127,58 MJ. A etapa de uso das torneiras apresentou peso preponderante nos resultados, com participação de 64,6% para a torneira convencional e 56,5% para a torneira com fechamento hidromecânico. O método proposto se mostrou adequado para quantificação do consumo energético no ciclo de vida e posterior escolha entre diferentes equipamentos hidrossanitários que exerçam a mesma função