1,491 research outputs found
2D kinematics of the edge-on spiral galaxy ESO 379-G006
We present a kinematical study of the nearly edge-on galaxy ESO 379-G006 that
shows the existence of extraplanar ionized gas. With Fabry-Perot spectroscopy
at H-alpha, we study the kinematics of ESO 379-G006 using velocity maps and
position-velocity diagrams parallel to the major and to the minor axis of the
galaxy. We build the rotation curve of the disk and discuss the role of
projection effects due to the fact of viewing this galaxy nearly edge-on. The
twisting of the isovelocities in the radial velocity field of the disk of ESO
379-G006 as well as the kinematic asymmetries found in some position-velocity
diagrams parallel to the minor axis of the galaxy suggest the existence of
deviations to circular motions in the disk that can be modeled and explained
with the inclusion of a radial inflow probably generated by a bar or by spiral
arms. We succeeded in detecting extraplanar Diffuse Ionized Gas in this galaxy.
At the same time, from the analysis of position-velocity diagrams, we found
some evidence that the extraplanar gas could lag in rotation velocity with
respect to the midplane rotation.Comment: 61 pages, 15 figures. Accepted for publication in A
The global ALPL gene variant classification project: dedicated to deciphering variants
Artículo escrito por un elevado número de autores, sólo se referencian el que aparece en primer lugar y los autores pertenecientes a la UAMHypophosphatasia (HPP) is an inherited multisystem disorder predominantly affecting the mineralization of bones and teeth. HPP is caused by pathogenic variants in ALPL, which encodes tissue non-specific alkaline phosphatase (TNSALP). Variants of uncertain significance (VUS) cause diagnostic delay and uncertainty amongst patients and health care providers. The ALPL gene variant database (https://alplmutationdatabase.jku.at/) is an open-access archive for interpretation of the clinical significance of variants reported in ALPL. The database contains coding and non-coding variants, including single nucleotide variants, insertions/deletions and structural variants affecting coding or non-coding sequences of ALPL. Each variant in the database is displayed with details explaining the corresponding pathogenicity, and all reported genotypes and phenotypes, including references. In 2021, the ALPL gene variant classification project was established to reclassify VUS and continuously assess and update genetic, phenotypic, and functional variant information in the database. For this purpose, the database provides a unique submission system for clinicians, geneticists, genetic counselors, and researchers to submit VUS within ALPL for classification. An international, multidisciplinary consortium of HPP experts has been established to reclassify the submitted VUS using a multi-step process adhering to the stringent ACMG/AMP variant classification guidelines. These steps include a clinical phenotype assessment, deep literature research including artificial intelligence technology, molecular genetic assessment, and in-vitro functional testing of variants in a co-transfection model to measure ALP residual activity. This classification project and the ALPL gene variant database will serve the global medical community, widen the genotypic and phenotypic HPP spectrum by reporting and characterizing new ALPL variants based on ACMG/AMP criteria and thus facilitate improved genetic counseling and medical decision-making for affected patients and families. The project may also serve as a gold standard framework for multidisciplinary collaboration for variant interpretation in other rare diseasesThis investigator-initiated project is funded through an externally sponsored research agreement with Alexion, AstraZeneca Rare Disease. This agreement funds the research team at JKU and the consortium
molecular genetics teams (Ordensklinikum Linz and Duke University).
CRG, KD, GAMM, AL, KO, LS, PSK, WH are steering committee members of the HPP global registry sponsored by Alexion, AstraZeneca Rare Disease, have worked as consultants, and received research funding and honoraria from Alexion, AstraZeneca Rare Disease. PK is a member of the Scientific Advisory Board for Alexion Pharmaceuticals, Inc. ETR has worked as a speaker, consultant, and has received research funding from Alexion AstraZeneca Rare Disease. GdA is a current employee of Alexion, AstraZeneca Rare Disease and may own stock and/or options therei
Red de aprendizaje en la universidad
El objetivo de esta investigación es la creación de una red social, en la asignatura
Didáctica General del Grado de Pedagogía, adaptada a este ámbito del conocimiento y al
contexto universitario, para permitir herramientas de comunicación e intercambio de
información en tiempo real entre los estudiantes, las profesoras y compañeros/as de otras
Facultades de Ciencias de la Educación españolas.
Las redes sociales están adquiriendo una importancia extraordinaria, convirtiéndose en un
nuevo fenómeno sociológico a escala global. Por este motivo, hemos querido incluirlas
como metodología activa para el conocimiento de esta asignatura, además de ser un
elemento motivador por la utilización que los estudiantes hacen de ellas en su vida
cotidiana.This research is aimed to creating a social network for students of the course
"General Didactics" in 1st year of Pedagogy; a network adapted to this field and to
a university context, to provide a tool for real-time communication and information
exchange between students, teachers and colleagues at other Spanish Education
Schools.
Social networks are taking an extraordinary importance, becoming a new
sociological phenomenon at a global scale. That’s why we chose to include them as
an active methodology for the study of this subject, besides being a motivating
element given the use that students make of them in their daily life
Metabolic and Stress Responses in Senegalese Soles (Solea senegalensis Kaup) Fed Tryptophan Supplements: E ects of Concentration and Feeding Period
The objective of this study was to assess the impact of di erent dietary Trp concentrations on
the stress and metabolism response of juvenile Senegalese soles (Solea senegalensis). Fish (38.1 1.9 g)
were fed di erent Trp-enriched feeds (0%, 1% and 2% Trp added) for two and eight days, and later
exposed to air stress for three min. Samples were taken pre- and 1 h post-stress (condition). Plasma
cortisol, lactate, glucose and proteins were significantly a ected by the sampling time, showing higher
values at 1 h post-stress. Trp concentration in food also had significant e ects on lactate and glucose
levels. However, the feeding period did not a ect these parameters. Post-stress values were higher
than in the pre-stress condition for every plasma parameter, except for lactate in two days and 1% Trp
treatment. Nevertheless, cortisol, glucose and lactate did not vary significantly between pre- and
post-stress samplings in fish fed the 1% Trp-enriched diet for two days. The lack of variability in
cortisol response was also due to the high pre-stress value, significantly superior to pre-stress control.
The exposure time to Trp feeding did not significantly a ect any enzyme activity; however, Trp added
and condition influenced protein-related enzyme activities. In spite of decreasing stress markers,
Trp-enriched diets altered the protein metabolism
Health conditions in adults with HIV compared with the general population:A population-based cross-sectional analysis
BACKGROUND: Life expectancy in adults with human immunodeficiency virus (HIV) has increased and managing other health conditions is increasingly important for patients and healthcare planning. The aim of this study was to examine the prevalence and association between different health conditions and HIV status. METHODS: We performed a cross-sectional analysis of adult UK Clinical Practice Research Datalink primary care electronic medical records linked to hospital admissions as of Nov 30, 2015. We examined 47 health condition groups and 304 physical and mental health conditions by HIV status, after adjustment for age, sex, social deprivation status using logistic regression. FINDINGS: There were 964 patients with HIV (61.7% male; 92.8% aged <65 years) and 941,113 non-HIV patients (49.4% male; 75.2% aged <65 years). Condition groups with the greatest prevalence in HIV that were also highly prevalent in adults without HIV included: lipid disorder (41.4% vs 40.2%), and hypertension (19.1% vs 24.6%). Following adjustment, 18 (37.5%) condition groups were more likely in adults with HIV and ten (20.8%) were less likely. Individual conditions that were less likely in adults with HIV included: atrial fibrillation (odds ratio [OR] 0.37 [95% CI 0.20–0.64]) and hypertension (OR_0.78 [0.65–0.94]); rheumatoid arthritis (OR 0.27 [0.05–0.84]); asthma (OR_0.65 (0.53–0.80]); and certain eye diseases such as macular degeneration (OR_0.30 [0.09–0.70]). Meanwhile individual conditions that were more likely included: liver fibrosis, sclerosis, and cirrhosis (OR_3.23 [1.85–5.20]); pulmonary embolism (OR_2.06 [1.15–3.36]); male infertility (OR_2.23 [1.50–3.16]) and female infertility (OR_2.01 [1.34–2.88]); bipolar disorder (OR_2.93 [1.52–5.05]) and depression (OR_1.49 [1.28–1.71]); cervical malignancy (OR_4.64 [1.15–12.15]); and infections. INTERPRETATION: Comorbidity is common in adults with HIV, with physical and mental health conditions spanning a wide spectrum. HIV management should consider multidisciplinary care models to provide optimal patient care. FUNDING: The project was funded by the Bart’s Charity; DRM was funded by a Wellcome Trust Clinical Research Career Development Fellowship; DRM and DMM received funding from the HDR-UK Precision therapeutics programme
La evaluación a partir de un perfil de competencias
El estudio que nos planteamos pretendía realizar un análisis del perfil de
competencias para poder evaluar de forma cualitativa y cuantitativa cada una de las
capacidades genéricas que se pretenden desarrollar en la asignatura de Didáctica
General, en el curso primero del Grado de Pedagogía, de la Facultad de Ciencias de la
Educación en la Universidad de Sevilla.
Nos plantemos la necesidad de diseñar instrumentos que nos ayuden a evaluar
capacidades de forma objetiva y precisa. Hasta ahora la evaluación se ha centrado en los
conocimientos que se han valorado como cualidad o cantidad con diferentes
instrumentos, pero nos encontramos con la dificultad de evaluar el desarrollo de esas
capacidades que nos planteamos en cada uno de nuestros proyectos docentes y de la que
no tenemos tradición ni experiencia.This study intended to make an analysis about the profile of competences to assess
qualitatively and quantitatively each of generic abilities that are to be developed in the
course of General Didactics in the first year of Pedagogy Degree, Faculty Science
Education at the University of Seville.
We considered the need to design instruments that help us assess abilities objectively
and accurately. So far the assessment has focused on knowledge that has been valued as
a quality or quantity with different instruments, but we find difficulties to assessment
the development of those abilities which we set in each of our educational projects and
we don’t have tradition and experience
The Use of Digital Portfolio in Higher Education before and during the COVID-19 Pandemic
This study is focused on the advantages and disadvantages of using a digital portfolio to
improve the learning and evaluation processes in the initial teacher training of 4th-year students in
the University of Seville (Spain). One of the interests of this research was to compare the learning
capacities perceived by the students to improve their learning process before and during the COVID 19 pandemic. A qualitative, descriptive methodology was applied, identifying the most relevant
dimensions, categories and codes for the analysis, management and interpretation of the opinions of
the students, with a research triangulation (Cohen’s kappa coefficient) and a coding performed using
the ATLAS.ti 8.4 software. The results show that the advantages with greater percentage correspond
to the following categories: learning, usefulness of OneDrive, autonomy and evaluation. The greatest
disadvantages detected were: time, uncertainty, usefulness of OneDrive and autonomy. There are
differences in the perceptions of the students, between before and during the COVID-19 pandemic,
about the learning capacities developed with the use of digital portfolio, since they consider that
they have acquired more significant learning, greater self-regulation of their learning and greater
reflection capacity
Production of Pectinolytic Enzymes by the Yeast Wickerhanomyces anomalus Isolated from Citrus Fruits Peels
Wickerhamomyces anomalus is pectinolytic yeast isolated from citrus fruits peels in the province of Misiones, Argentine. In the present work, enzymes produced by this yeast strain were characterized, and polygalacturonase physicochemical properties were determined in order to evaluate the application of the supernatant in the maceration of potato tissues. W. anomalus was able to produce PGin liquid mediumcontaining glucose and citrus pectin,whosemode of actionwas mainly of endo type.The supernatant did not exhibit esterase or lyase activity. No others enzymes, capable of hydrolyzing cell wall polymers, such as cellulases and xylanases,were detected. PGshowedmaximal activity atpH4.5 and at temperature range between 40∘Cand50∘C. It was stable in the pH range from3.0 to 6.0 and up to 50∘Cat optimumpH.The enzymatic extractmacerated potato tissues efficiently.Volume of single cells increased with the agitation speed.The results observed make the enzymatic extract produced by W. anomalus appropriate for future application in food industry, mainly for the production of fruit nectars or mashed of vegetables such as potato or cassava, of regional interest in the province of Misiones, Argentine.Fil: Martos, María Alicia. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Zubreski, Emilce R.. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Garro, Oscar Alfredo. Universidad Nacional del Chaco Austral. Departamento de Ciencias Basicas y Aplicadas. Laboratorio de Microbiologia de Alimentos; ArgentinaFil: Hours, Roque Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales (i); Argentin
ACQUISITION AND REPRODUCTION OF SURFACE APPEARANCE IN ARCHITECTURAL ORTHOIMAGES
Software tools for photogrametric and multi-view stereo reconstruction are nowadays of generalized use in the digitization of architectural
cultural heritage. Together with laser scanners, these are well established methods to digitize the three-dimensional geometric
properties of real objects. However, the acquired photographic colour mapping of the resulting point clouds or the textured mesh cannot
differentiate the proper surface appearance from the influence of the particular illumination present at the moment of the digitization.
Acquisition of the actual surface appearance, separated from the existing illumination, is still a challenge for any kind of cultural
heritage item, but very specially for architectural elements. Methods based on systematic sampling with commuting light patterns
in a laboratory set-up are not suitable. Immovable and outdoor items are normally limited to the existing and uncontrolled natural
illumination.
This paper demonstrates a practical methodology for appearance acquisition, previously introduced in (Martos and Ruiz, 2013), applied
here specifically for the production of re-illuminable architectural orthoimages. It is suitable for outdoor environments, where the
illumination is variable and uncontrolled. In fact, naturally occurring changes in light among different images along the day are actually
desired and exploited, producing an enhanced multi-layer dynamic texture that is not limited to a frozen RGB colour map. These layers
contain valuable complementary information about the depth of the geometry, surface normal fine details and other illuminationdependent
parameters, such as direct and indirect light and projected self-shadows, allowing an enhanced and re-illuminable ortoimage
representation
A Paraneoplastic Syndrome to Remember: A Case of Disseminated Intravascular Coagulation in Lung Cancer
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by the widespread activation of coagulation. It can
present as an acute life-threatening emergency or as a chronic process. Mortality is highly dependent on the reversibility of the aetiology
and degree of coagulation impairment, so treatment of the underlying cause is vital. The authors present the case of a 57-year-old man
whose inaugural presentation of lung cancer was chronic DIC, characterized by three thrombotic events, followed by acute DIC, culminating
in death. Metastatic lung cancer was diagnosed only after death
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