Christians and war. a survey of Christian thought in the United Kingdom 1914 - 1948

Christians during the years between 1914 and 1948 were living continually in the shadow of war, either a war departing or a war gathering on the horizon.War was near them daily, and Christlans wrote and spoke much about it. Far too many of their thoughts were recorded to include them all in a survey such as this.An attempt has been made in this work to give a view of the thoughts of both individuals and official Church organizations which appear not only to be representative but also to be in such a position as would give them influence over the minds of a considerable number of other Christians. The men and the organizations have been permitted to speak their n words with a minimum of commentary or bias.Enough history has been sketched in to show the background against which the thought was expressed, but a constant effort has been made to exclude details of generally known historical events, the Inclusion of which would only detract from the central purpose of the survey.There has been am effort to maintain a balance between the two extremes of giving so little of a quotation that the thought would not be grasped, and of giving so much that the reading would become burdensome long after the thought had been made clear

Premotor cortex in observing erroneous action: An fMRI study

The lateral premotor cortex (PMC) is involved during action observation in monkeys and humans, reflecting a matching process between observed actions and their corresponding motor schemata. In the present study, functional magnetic resonance imaging (fMRI) was used to investigate if paying attention to the two observable action components, objects and movements, modulates premotor activation during the observation of actions. Participants were asked to classify presented movies as showing correct actions, erroneous actions, or senseless movements. Erroneous actions were incorrect either with regard to employed objects, or to performed movements. The experiment yielded two major results: (1) The ventrolateral premotor cortex (vPMC) and the anterior part of the intraparietal sulcus (aIPS) are strongly activated during the observation of actions in humans. Premotor activation was dominantly located within Brodmann Area (BA) 6, and sometimes extended into BA 44. (2) The presentation of object errors and movements errors allowed to disentangle brain activations corresponding to the analysis of movements and objects in observed actions. Left premotor areas were more involved in the analysis of objects, whereas right premotor areas were dominant in the analysis of movements. It is suggested that the analysis of categorical information, like objects, and that of coordinate information, like movements, are pronounced in different hemispheres

Complete metamorphosis and microbiota turnover in insects

The insects constitute the majority of animal diversity. Most insects are holometabolous: during complete metamorphosis their bodies are radically reorganized. This reorganization poses a significant challenge to the gut microbiota, as the gut is replaced during pupation, a process that does not occur in hemimetabolous insects. In holometabolous hosts, it offers the opportunity to decouple the gut microbiota between the larval and adult life stages resulting in high beta diversity whilst limiting alpha diversity. Here, we studied 18 different herbivorous insect species from five orders of holometabolous and three orders of hemimetabolous insects. Comparing larval and adult specimens, we find a much higher beta-diversity and hence microbiota turnover in holometabolous insects compared to hemimetabolous insects. Alpha diversity did not differ between holo- and hemimetabolous insects nor between developmental stages within these groups. Our results support the idea that pupation offers the opportunity to change the gut microbiota and hence might facilitate ecological niche shifts. This possible effect of niche shift facilitation could explain a selective advantage of the evolution of complete metamorphosis, which is a defining trait of the most speciose insect taxon, the holometabola

Complete metamorphosis and microbiota turnover in insects

This study was funded by the DFG (Deutsche Forschungsgemeinschaft, RO 2284/2-1).The insects constitute the majority of animal diversity. Most insects are holometabolous: during complete metamorphosis their bodies are radically reorganized. This reorganization poses a significant challenge to the gut microbiota, as the gut is replaced during pupation, a process that does not occur in hemimetabolous insects. In holometabolous hosts, it offers the opportunity to decouple the gut microbiota between the larval and adult life stages resulting in high beta diversity whilst limiting alpha diversity. Here, we studied 18 different herbivorous insect species from five orders of holometabolous and three orders of hemimetabolous insects. Comparing larval and adult specimens, we find a much higher beta-diversity and hence microbiota turnover in holometabolous insects compared to hemimetabolous insects. Alpha diversity did not differ between holo- and hemimetabolous insects nor between developmental stages within these groups. Our results support the idea that pupation offers the opportunity to change the gut microbiota and hence might facilitate ecological niche shifts. This possible effect of niche shift facilitation could explain a selective advantage of the evolution of complete metamorphosis, which is a defining trait of the most speciose insect taxon, the holometabola.Peer reviewe

Goals of Fecal Incontinence Management Identified by Community-Living Incontinent Adults

The purpose of this study was to identify goals of fecal incontinence (FI) management and their importance to community-living adults if complete continence would not be possible. Participants expressed their goals of FI management in a semi structured interview, selected others from 12 investigator-identified goals, and rated their importance. Five thematic categories emerged from the 114 participant-identified goal statements: Fecal Incontinence/Bowel Pattern, Lifestyle, Emotional Responses, Adverse Effects of Fecal Incontinence, and Self-Care Practices. Participants selected a median of seven investigator-identified goals (range = 2 to 12). Goals selected by the most participants were decreased number of leaks of stool and greater confidence in controlling fecal incontinence. These goals also had the highest importance along with decreased leakage of loose or liquid stool. The type and number of management goals identified by participants offer a toolbox of options from which to focus therapy when cure is not possible and promote patient satisfaction

The Paediatric Glaucoma Diagnostic Ability of Optical Coherence Tomography: A Comparison of Macular Segmentation and Peripapillary Retinal Nerve Fibre Layer Thickness

Paediatric glaucoma leads to a decreased thickness of the peripapillary retinal nerve fibre layer (pRNFL) and of the macula. These changes can be precisely quantified using spectral domain-optical coherence tomography (SD-OCT). Despite abundant reports in adults, studies on the diagnostic capacity of macular SD-OCT in paediatric glaucoma are rare. The aim of this study was to compare the glaucoma discriminative ability of pRNFL and macular segment thickness in paediatric glaucoma patients and healthy children. Data of 72 children aged 5–17 years (glaucoma: 19 (26.4%), healthy: 53 (73.6%)) examined with SD-OCT (SPECTRALIS®, Heidelberg Engineering) were analysed retrospectively. The thickness of pRNFL sectors and of macular segment subfields were compared between diseased and healthy participants. Areas under the receiver-operating characteristic curves (AUC), sensitivity, and specificity from logistic regression were used to evaluate the glaucoma discriminative capacity of single and combined pRNFL and macular segments’ thickness. The results revealed a reduced thickness of the pRNFL and of the three inner macular layers in glaucoma patients, which correlates highly with the presence of glaucoma. The highest glaucoma discriminative ability was observed for the combination of pRNFL sectors or inner macular segments (AUC: 0.83 and 0.85, respectively), although sensitivity remained moderate (both 63% at 95% specificity). In conclusion, while confirmation from investigations in larger cohorts is required, SD-OCT-derived pRNFL and macular thickness measurements seem highly valuable for the diagnosis of paediatric glaucoma

MaxPre : An Extended MaxSAT Preprocessor

We describe MaxPre, an open-source preprocessor for (weighted partial) maximum satisfiability (MaxSAT). MaxPre implements both SAT-based and MaxSAT-specific preprocessing techniques, and offers solution reconstruction, cardinality constraint encoding, and an API for tight integration into SAT-based MaxSAT solvers.Peer reviewe

Generalized Totalizer Encoding for Pseudo-Boolean Constraints

Pseudo-Boolean constraints, also known as 0-1 Integer Linear Constraints, are used to model many real-world problems. A common approach to solve these constraints is to encode them into a SAT formula. The runtime of the SAT solver on such formula is sensitive to the manner in which the given pseudo-Boolean constraints are encoded. In this paper, we propose generalized Totalizer encoding (GTE), which is an arc-consistency preserving extension of the Totalizer encoding to pseudo-Boolean constraints. Unlike some other encodings, the number of auxiliary variables required for GTE does not depend on the magnitudes of the coefficients. Instead, it depends on the number of distinct combinations of these coefficients. We show the superiority of GTE with respect to other encodings when large pseudo-Boolean constraints have low number of distinct coefficients. Our experimental results also show that GTE remains competitive even when the pseudo-Boolean constraints do not have this characteristic.Comment: 10 pages, 2 figures, 2 tables. To be published in 21st International Conference on Principles and Practice of Constraint Programming 201

Random Shortest Paths: {Non-Euclidean} Instances for Metric Optimization Problems

Probabilistic analysis for metric optimization problems has mostly been conducted on random Euclidean instances, but little is known about metric instances drawn from distributions other than the Euclidean. This motivates our study of random metric instances for optimization problems obtained as follows: Every edge of a complete graph gets a weight drawn independently at random. The distance between two nodes is then the length of a shortest path (with respect to the weights drawn) that connects these nodes. We prove structural properties of the random shortest path metrics generated in this way. Our main structural contribution is the construction of a good clustering. Then we apply these findings to analyze the approximation ratios of heuristics for matching, the traveling salesman problem (TSP), and the k-median problem, as well as the running-time of the 2-opt heuristic for the TSP. The bounds that we obtain are considerably better than the respective worst-case bounds. This suggests that random shortest path metrics are easy instances, similar to random Euclidean instances, albeit for completely different structural reasons

Improving alcohol health literacy and reducing alcohol consumption: recommendations for Germany

Background: Although the detrimental health effects of alcohol are well established, consumption levels are high in many high-income countries such as Germany. Improving alcohol health literacy presents an integrated approach to alcohol prevention and an important complement to alcohol policy. Our aim was to identify and prioritize measures to enhance alcohol health literacy and hence to reduce alcohol consumption, using Germany as an example.Methods: A series of recommendations for improving alcohol health literacy were derived from a review of the literature and subsequently rated by five experts. Recommendations were rated according to their likely impact on enhancing (a) alcohol health literacy and (b) reducing alcohol consumption. Inter-rater agreement was assessed using a two-way intra-class correlation coefficient (ICC).Results: Eleven recommendations were established for three areas of action: (1) education and information, (2) health care system, and (3) alcohol control policy. Education and information measures were rated high to increase alcohol health literacy but low to their impact on alcohol consumption, while this pattern was reversed for alcohol control policies. The ratings showed good agreement (ICC: 0.85-0.88).Conclusions: Improving alcohol health literacy and reducing alcohol consumption should be considered complementary and become part of a comprehensive alcohol strategy to curb the health, social, and economic burden of alcohol