357 research outputs found
e-Social Science and Evidence-Based Policy Assessment : Challenges and Solutions
Peer reviewedPreprin
Challenging Methods and Results Obtained from User-Generated Content in Barcelona’s Public Open Spaces
User-generated content (UGC) provides useful resources for academics, technicians and policymakers to obtain and analyse results in order to improve lives of individuals in urban settings. User-generated content comes from people who voluntarily contribute data, information, or media that then appears in a way which can be viewed by others; usually on the Web. However, to date little is known about how complex methodologies for getting results are subject to methodology-formation errors, personal data protection, and reliability of outcomes. Different researches have been approaching to inquire big data methods for a better understanding of social groups for planners and economic needs. In this chapter, through UGC from Tweets of users located in Barcelona, we present different research experiments. Data collection is based on the use of REST API; while analysis and representation of UGC follow different ways of processing and providing a plurality of information. The first objective is to study the results at a different geographical scale, Barcelona’s Metropolitan Area and at two Public Open Spaces (POS) in Barcelona, Enric Granados Street and the area around the Fòrum de les Cultures; during similar days in two periods of time - in January of 2015 and 2017. The second objective is intended to better understand how different types of POS’ Twitter-users draw urban patterns. The Origin-Destination patterns generated illustrate new social behaviours, addressed to multifunctional uses. This chapter aims to be influential in the use of UGC analysis for planning purposes and to increase quality of life
NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. Further analysis of miRNAs concomitantly regulated by knockdown of the NRF2 inhibitor KEAP1 revealed the major candidate NRF2-mediated miRNAs in AML. We identified miR-125B to be upregulated and miR-29B to be downregulated by NRF2 in AML. Subsequent bioinformatic analysis identified putative NRF2 binding sites upstream of the miR-125B1 coding region and downstream of the mir-29B1 coding region. Chromatin immunoprecipitation analyses showed that NRF2 binds to these antioxidant response elements (AREs) located in the 5′ untranslated regions of miR-125B and miR-29B. Finally, primary AML samples transfected with anti-miR-125B antagomiR or miR-29B mimic showed increased cell death responsiveness either alone or co-treated with standard AML chemotherapy. In summary, we find that NRF2 regulation of miR-125B and miR-29B acts to promote leukaemic cell survival, and their manipulation enhances AML responsiveness towards cytotoxic chemotherapeutics
Infiltration efficiency and subsurface water processes of a sustainable drainage system and consequences to flood management
With increased intensity rainfall events globally and urban expansion decreasing permeable surfaces, there is an increasing problem of urban flooding. This study aims to better understand rainfall infiltration into a Sustainable Drainage System (SuDS) permeable pavement, compared with an adjacent Green Area of made ground, in relationship to groundwater levels below both areas. Both areas were instrumented with soil water content and matric potential sensors and four shallow boreholes were instrumented with groundwater level sensors. Surface infiltration rates were measured using a double‐ring infiltrometer. Results showed that average infiltration rates of the SuDS (1,925 mm/hr) were significantly higher than the Green Area (56 mm/hr). The SuDS was well designed to transfer rainfall rapidly to the aquifer below, where groundwater levels rapidly rose within 1 hr of a 1 in 30 year event (32.8 mm/hr). In comparison, soil compaction of the made ground Green Area decreased infiltration rates, but still enabled the majority of rainfall events to infiltrate. The aquifer below the Green Area responded more slowly, as lower matrix potentials facilitated water retention in the soil profile, slowing water draining to the aquifer. This work reiterates the importance of ensuring a 1 m separation depth between the base of the SuDS infiltration zone and aquifer depth
Valley-spin blockade and spin resonance in carbon nanotubes
Manipulation and readout of spin qubits in quantum dots made in III-V
materials successfully rely on Pauli blockade that forbids transitions between
spin-triplet and spin-singlet states. Quantum dots in group IV materials have
the advantage of avoiding decoherence from the hyperfine interaction by
purifying them with only zero-spin nuclei. Complications of group IV materials
arise from the valley degeneracies in the electronic bandstructure. These lead
to complicated multiplet states even for two-electron quantum dots thereby
significantly weakening the selection rules for Pauli blockade. Only recently
have spin qubits been realized in silicon devices where the valley degeneracy
is lifted by strain and spatial confinement. In carbon nanotubes Pauli blockade
can be observed by lifting valley degeneracy through disorder. In clean
nanotubes, quantum dots have to be made ultra-small to obtain a large energy
difference between the relevant multiplet states. Here we report on
low-disorder nanotubes and demonstrate Pauli blockade based on both valley and
spin selection rules. We exploit the bandgap of the nanotube to obtain a large
level spacing and thereby a robust blockade. Single-electron spin resonance is
detected using the blockade.Comment: 31 pages including supplementary informatio
Dispersively detected Pauli Spin-Blockade in a Silicon Nanowire Field-Effect Transistor
We report the dispersive readout of the spin state of a double quantum dot
formed at the corner states of a silicon nanowire field-effect transistor. Two
face-to-face top-gate electrodes allow us to independently tune the charge
occupation of the quantum dot system down to the few-electron limit. We measure
the charge stability of the double quantum dot in DC transport as well as
dispersively via in-situ gate-based radio frequency reflectometry, where one
top-gate electrode is connected to a resonator. The latter removes the need for
external charge sensors in quantum computing architectures and provides a
compact way to readout the dispersive shift caused by changes in the quantum
capacitance during interdot charge transitions. Here, we observe Pauli
spin-blockade in the high-frequency response of the circuit at finite magnetic
fields between singlet and triplet states. The blockade is lifted at higher
magnetic fields when intra-dot triplet states become the ground state
configuration. A lineshape analysis of the dispersive phase shift reveals
furthermore an intradot valley-orbit splitting of 145 eV.
Our results open up the possibility to operate compact CMOS technology as a
singlet-triplet qubit and make split-gate silicon nanowire architectures an
ideal candidate for the study of spin dynamics
Nanoscale spin rectifiers controlled by the Stark effect
The control of orbital and spin state of single electrons is a key ingredient
for quantum information processing, novel detection schemes, and, more
generally, is of much relevance for spintronics. Coulomb and spin blockade (SB)
in double quantum dots (DQDs) enable advanced single-spin operations that would
be available even for room-temperature applications for sufficiently small
devices. To date, however, spin operations in DQDs were observed at sub-Kelvin
temperatures, a key reason being that scaling a DQD system while retaining an
independent field-effect control on the individual dots is very challenging.
Here we show that quantum-confined Stark effect allows an independent
addressing of two dots only 5 nm apart with no need for aligned nanometer-size
local gating. We thus demonstrate a scalable method to fully control a DQD
device, regardless of its physical size. In the present implementation we show
InAs/InP nanowire (NW) DQDs that display an experimentally detectable SB up to
10 K. We also report and discuss an unexpected re-entrant SB lifting as a
function magnetic-field intensity
Giga-Hertz quantized charge pumping in bottom gate defined InAs nanowire quantum dots
Semiconducting nanowires (NWs) are a versatile, highly tunable material
platform at the heart of many new developments in nanoscale and quantum
physics. Here, we demonstrate charge pumping, i.e., the controlled transport of
individual electrons through an InAs NW quantum dot (QD) device at frequencies
up to GHz. The QD is induced electrostatically in the NW by a series of
local bottom gates in a state of the art device geometry. A periodic modulation
of a single gate is enough to obtain a dc current proportional to the frequency
of the modulation. The dc bias, the modulation amplitude and the gate voltages
on the local gates can be used to control the number of charges conveyed per
cycle. Charge pumping in InAs NWs is relevant not only in metrology as a
current standard, but also opens up the opportunity to investigate a variety of
exotic states of matter, e.g. Majorana modes, by single electron spectroscopy
and correlation experiments.Comment: 21 page
Academic freedom in Europe: a preliminary comparative analysis
Using comparative data from 23 states within the European Union, this paper is a preliminary assessment of the protection for, and (by extension) the health of, academic freedom in the universities of the nations of the European Union. The paper examines constitutional and legislative protection for academic freedom, along with legal regulations concerning institutional governance, the appointment of the Rector and the existence of academic tenure, in order to create a composite picture of the health of academic freedom in the universities within the European Union nations. Additionally the paper considers how this preliminary analysis could be extended through possible further research to aid refinement of the results, and what policy steps could usefully be adopted at European level to protect and strengthen academic freedom
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