642 research outputs found
Soft systems methodology: a context within a 50-year retrospective of OR/MS
Soft systems methodology (SSM) has been used in the practice of operations research and management science OR/MS) since the early 1970s. In the 1990s, it emerged as a viable academic discipline. Unfortunately, its proponents consider SSM and traditional systems thinking to be mutually exclusive. Despite the differences claimed by SSM proponents between the two, they have been complementary. An extensive sampling of the OR/MS literature over its entire lifetime demonstrates the richness with which the non-SSM literature has been addressing the very same issues as does SSM
Oscillatory cAMP signaling rapidly alters H3K4 methylation
receptors (GPCRs) alter H3K4 methylation via oscillatory intracellular cAMP. Activation of Gs-coupled receptors caused a rapid decrease of H3K4me3 by elevating cAMP, whereas stimulation of Gi-coupled receptors increased H3K4me3 by diminishing cAMP. H3K4me3 gradually recovered towards baseline levels after the removal of GPCR ligands, indicating that H3K4me3 oscillates in tandem with GPCR activation. cAMP increased intracellular labile Fe(II), the cofactor for histone demethylases, through a non-canonical cAMP target—Rap guanine nucleotide exchange factor-2 (RapGEF2), which subsequently enhanced endosome acidification and Fe(II) release from the endosome via vacuolar H+-ATPase assembly. Removing Fe(III) from the media blocked intracellular Fe(II) elevation after stimulation of Gs-coupled receptors. Iron chelators and inhibition of KDM5 demethylases abolished cAMP-mediated H3K4me3 demethylation. Taken together, these results suggest a novel function of cAMP signaling in modulating histone demethylation through labile Fe(II)
Relativistic MHD with Adaptive Mesh Refinement
This paper presents a new computer code to solve the general relativistic
magnetohydrodynamics (GRMHD) equations using distributed parallel adaptive mesh
refinement (AMR). The fluid equations are solved using a finite difference
Convex ENO method (CENO) in 3+1 dimensions, and the AMR is Berger-Oliger.
Hyperbolic divergence cleaning is used to control the
constraint. We present results from three flat space tests, and examine the
accretion of a fluid onto a Schwarzschild black hole, reproducing the Michel
solution. The AMR simulations substantially improve performance while
reproducing the resolution equivalent unigrid simulation results. Finally, we
discuss strong scaling results for parallel unigrid and AMR runs.Comment: 24 pages, 14 figures, 3 table
Entanglement of distant flux qubits mediated by non-classical electromagnetic field
The mechanism for entanglement of two flux qubits each interacting with a
single mode electromagnetic field is discussed. By performing a Bell state
measurements (BSM) on photons we find the two qubits in an entangled state
depending on the system parameters. We discuss the results for two initial
states and take into consideration the influence of decoherence.Comment: 20 pages, 8 figure
The relativistic Sagnac Effect: two derivations
The phase shift due to the Sagnac Effect, for relativistic matter and
electromagnetic beams, counter-propagating in a rotating interferometer, is
deduced using two different approaches. From one hand, we show that the
relativistic law of velocity addition leads to the well known Sagnac time
difference, which is the same independently of the physical nature of the
interfering beams, evidencing in this way the universality of the effect.
Another derivation is based on a formal analogy with the phase shift induced by
the magnetic potential for charged particles travelling in a region where a
constant vector potential is present: this is the so called Aharonov-Bohm
effect. Both derivations are carried out in a fully relativistic context, using
a suitable 1+3 splitting that allows us to recognize and define the space where
electromagnetic and matter waves propagate: this is an extended 3-space, which
we call "relative space". It is recognized as the only space having an actual
physical meaning from an operational point of view, and it is identified as the
'physical space of the rotating platform': the geometry of this space turns out
to be non Euclidean, according to Einstein's early intuition.Comment: 49 pages, LaTeX, 3 EPS figures. Revised (final) version, minor
corrections; to appear in "Relativity in Rotating Frames", ed. G. Rizzi and
M.L. Ruggiero, Kluwer Academic Publishers, Dordrecht, (2003). See also
http://digilander.libero.it/solciclo
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard.
The PHENIX AutoBuild wizard is a highly automated tool for iterative model building, structure refinement and density modification using RESOLVE model building, RESOLVE statistical density modification and phenix.refine structure refinement. Recent advances in the AutoBuild wizard and phenix.refine include automated detection and application of NCS from models as they are built, extensive model-completion algorithms and automated solvent-molecule picking. Model-completion algorithms in the AutoBuild wizard include loop building, crossovers between chains in different models of a structure and side-chain optimization. The AutoBuild wizard has been applied to a set of 48 structures at resolutions ranging from 1.1 to 3.2 A, resulting in a mean R factor of 0.24 and a mean free R factor of 0.29. The R factor of the final model is dependent on the quality of the starting electron density and is relatively independent of resolution
Classification of non-Riemannian doubled-yet-gauged spacetime
Assuming covariant fields as the `fundamental' variables,
Double Field Theory can accommodate novel geometries where a Riemannian metric
cannot be defined, even locally. Here we present a complete classification of
such non-Riemannian spacetimes in terms of two non-negative integers,
, . Upon these backgrounds, strings become
chiral and anti-chiral over and directions respectively, while
particles and strings are frozen over the directions. In
particular, we identify as Riemannian manifolds, as
non-relativistic spacetime, as Gomis-Ooguri non-relativistic string,
as ultra-relativistic Carroll geometry, and as Siegel's
chiral string. Combined with a covariant Kaluza-Klein ansatz which we further
spell, leads to Newton-Cartan gravity. Alternative to the conventional
string compactifications on small manifolds, non-Riemannian spacetime such as
, may open a new scheme of the dimensional reduction from ten to
four.Comment: 1+41 pages; v2) Refs added; v3) Published version; v4) Sign error in
(2.51) correcte
The digital divide and ICT learning in rural communities:examples of good practice service delivery
This article aims to gain a greater understanding of relevant and successful methods of stimulating an ICT culture and skills development in rural areas. The paper distils good practice activities, utilizing criteria derived from a review of the rural dimensions of ICT learning, from a range of relevant initiatives and programmes. These good practice activities cover: community resource centres providing opportunities for ‘tasting’ ICTs; video games and Internet Cafe´s as tools removing ‘entry barriers’; emphasis on ‘user management’ as a means of creating ownership; service delivery beyond fixed locations; use of ICT capacities in the delivery of general services; and selected use of financial support
High-temperature ferromagnetism of electrons in narrow impurity bands: Application to CaB
Ferromagnetism with high Curie temperature , well above room
temperature, and very small saturation moment has been reported in various
carbon and boron systems. It is argued that the magnetization must be very
inhomogeneous with only a small fraction of the sample ferromagnetically
ordered. It is shown that a possible source of high within the
ferromagnetic regions is itinerant electrons occupying a narrow impurity band.
Correlation effects do not reduce the effective interaction which enters the
Stoner criterion in the same way as in a bulk band. It is also shown how, in
the impurity band case, spin wave excitations may not be effective in lowering
below its value given by Stoner theory. These ideas are applied to
CaB and a thorough review of the experimental situation in this material is
given. It is suggested that the intrinsic magnetism of the B and O
dimers might be exploited in suitable structures containing these elements.Comment: 26 pages, 2 figure
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