Limits to coseismic landslides triggered by Cascadia Subduction Zone earthquakes

Landslides are a significant hazard and dominant feature throughout the landscape of the Pacific Northwest. However, the hazard and risk posed by coseismic landslides triggered by great Cascadia Subduction Zone (CSZ) earthquakes is highly uncertain due to a lack of local and global data. Despite a wealth of other geologic evidence for past earthquakes on the Cascadia Subduction Zone, no landslides have been definitively linked to such earthquakes, even in areas otherwise highly susceptible to failure. While shallow landslides may not leave a lasting topographical signature in the landscape, there are thousands of deep-seated landslides in Cascadia, and these deposits often persist for hundreds of years and multiple earthquake cycles. Synthesizing newly developed inventories of dated large deep-seated landslides in the Oregon Coast Range, we use statistical methods to estimate the proportion of these types of landslides that could have been triggered during past great Cascadia Subduction Zone earthquakes. Statistical analysis of high-precision dendrochronology ages of landslide-dammed lakes and surface roughness-dated bedrock landslides reveal Cascadia Subduction Zone earthquakes may have triggered 0–15 % of large deep-seated landslides in the Oregon Coast Range over multiple earthquake cycles. Our results refine estimates from previous studies and further suggest that coseismic triggering accounts for a small fraction of the total deep-seated bedrock landslides mapped in coastal Cascadia. However, if the real rate of coseismic landslide triggering during CSZ earthquakes is near our estimated upper bound for the 1700 CSZ earthquake, we estimate up to 2400 coseismic large deep-seated landslides could occur in the Oregon Coast Range in a single earthquake. These findings suggest Cascadia is consistent with global observations from other subduction zones and that coseismic landslides may still represent a serious geohazard in the region

Acute Sensitivity of Landslide Rates to Initial Soil Porosity

Some landslides move imperceptibly downslope, whereas others accelerate catastrophically. Experimental landslides triggered by rising pore water pressure moved at sharply contrasting rates due to small differences in initial porosity. Wet sandy soil with porosity of about 0.5 contracted during slope failure, partially liquefied, and accelerated within 1 second to speeds over 1 meter per second. The same soil with porosity of about 0.4 dilated during failure and slipped episodically at rates averaging 0.002 meter per second. Repeated slip episodes were induced by gradually rising pore water pressure and were arrested by pore dilation and attendant pore pressure decline

Proteomic Analysis of Pathways Involved in Estrogen-Induced Growth and Apoptosis of Breast Cancer Cells

Estrogen is a known growth promoter for estrogen receptor (ER)-positive breast cancer cells. Paradoxically, in breast cancer cells that have been chronically deprived of estrogen stimulation, re-introduction of the hormone can induce apoptosis.Here, we sought to identify signaling networks that are triggered by estradiol (E2) in isogenic MCF-7 breast cancer cells that undergo apoptosis (MCF-7:5C) versus cells that proliferate upon exposure to E2 (MCF-7). The nuclear receptor co-activator AIB1 (Amplified in Breast Cancer-1) is known to be rate-limiting for E2-induced cell survival responses in MCF-7 cells and was found here to also be required for the induction of apoptosis by E2 in the MCF-7:5C cells. Proteins that interact with AIB1 as well as complexes that contain tyrosine phosphorylated proteins were isolated by immunoprecipitation and identified by mass spectrometry (MS) at baseline and after a brief exposure to E2 for two hours. Bioinformatic network analyses of the identified protein interactions were then used to analyze E2 signaling pathways that trigger apoptosis versus survival. Comparison of MS data with a computationally-predicted AIB1 interaction network showed that 26 proteins identified in this study are within this network, and are involved in signal transduction, transcription, cell cycle regulation and protein degradation.G-protein-coupled receptors, PI3 kinase, Wnt and Notch signaling pathways were most strongly associated with E2-induced proliferation or apoptosis and are integrated here into a global AIB1 signaling network that controls qualitatively distinct responses to estrogen

Changing Fields of Solidarity in France: A Cross-field Analysis of Migration, Unemployment and Disability

AbstractThis chapter evaluates the implications of recent crises for solidarity organisations in France. The main aim is to assess whether solidarity remains nationally bounded or otherwise follows some consistent pattern of transnationalisation. By focusing on the fields of migration, unemployment and disability, the chapter examines the main attributes of solidarity organisations; in particular, the analysis aims to evaluate how transnational features relate to endogenous characteristics, such as activities, roles and networks affecting their particular experiences within changing fields of solidarity. Crucially, findings show that the economic crisis and welfare retrenchment in France have well served the purpose of governments willing to pre-empt strong political challenge by potential solidarity movements

Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1/CYCLIN B

Although the AIB1 oncogene has an important role during the early phase of the cell cycle as a coactivator of E2F1, little is known about its function during mitosis.Mitotic cells isolated by nocodazole treatment as well as by shake-off revealed a post-translational modification occurring in AIB1 specifically during mitosis. This modification was sensitive to the treatment with phosphatase, suggesting its modification by phosphorylation. Using specific inhibitors and in vitro kinase assays we demonstrate that AIB1 is phosphorylated on Ser728 and Ser867 by Cdk1/cyclin B at the onset of mitosis and remains phosphorylated until exit from M phase. Differences in the sensitivity to phosphatase inhibitors suggest that PP1 mediates dephosphorylation of AIB1 at the end of mitosis. The phosphorylation of AIB1 during mitosis was not associated with ubiquitylation or degradation, as confirmed by western blotting and flow cytometry analysis. In addition, luciferase reporter assays showed that this phosphorylation did not alter the transcriptional properties of AIB1. Importantly, fluorescence microscopy and sub-cellular fractionation showed that AIB1 phosphorylation correlated with the exclusion from the condensed chromatin, thus preventing access to the promoters of AIB1-dependent genes. Phospho-specific antibodies developed against Ser728 further demonstrated the presence of phosphorylated AIB1 only in mitotic cells where it was localized preferentially in the periphery of the cell.Collectively, our results describe a new mechanism for the regulation of AIB1 during mitosis, whereby phosphorylation of AIB1 by Cdk1 correlates with the subcellular redistribution of AIB1 from a chromatin-associated state in interphase to a more peripheral localization during mitosis. At the exit of mitosis, AIB1 is dephosphorylated, presumably by PP1. This exclusion from chromatin during mitosis may represent a mechanism for governing the transcriptional activity of AIB1

Perceived economic self‑sufficiency: a countryand generation‑comparative approach

We thank Michael Camasso and Radha Jagannathan as well as Asimina Christoforou, Gerbert Kraaykamp, Fay Makantasi, Tiziana Nazio, Kyriakos Pierrakakis, Jacqueline O’Reilly and Jan van Deth for their contribution to the CUPESSE project (Seventh Framework Programme; Grant Agreement No. 61325). CUPESSE received additional funding from the Mannheim Centre for European Social Research (MZES) and the Field of Focus 4 “Self-Regulation and Regulation: Individuals and Organisations” at Heidelberg University. We further acknowledge helpful comments on this article by two anonymous reviewers. Julian Rossello provided valuable research assistance.Electronic supplementary material The online version of this article (https ://doi.org/10.1057/ s4130 4-018-0186-3) contains supplementary material, which is available to authorized users.Existing datasets provided by statistical agencies (e.g. Eurostat) show that the economic and financial crisis that unfolded in 2008 significantly impacted the lives and livelihoods of young people across Europe. Taking these official statistics as a starting point, the collaborative research project “Cultural Pathways to Economic Self-Sufficiency and Entrepreneurship in Europe” (CUPESSE) generated new survey data on the economic and social situation of young Europeans (18–35 years). The CUPESSE dataset allows for country-comparative assessments of young people’s perceptions about their socio-economic situation. Furthermore, the dataset includes a variety of indicators examining the socio-economic situation of both young adults and their parents. In this data article, we introduce the CUPESSE dataset to political and social scientists in an attempt to spark a debate on the measurements, patterns and mechanisms of intergenerational transmission of economic self-sufficiency as well as its political implications.CUPESSE project (Seventh Framework Programme; Grant Agreement No. 61325

Trajectories of Solidarities in France Across Fields of Vulnerability

This chapter approaches the study of solidarity in France by comparing three important vulnerable groups, namely, the disabled, the unemployed, and refugees. The way we approach solidarity hinges on an important distinction between two different meanings of solidarity: solidarity understood as an input and solidarity understood as an output. In particular, we distinguish between two main \u201ctrajectories of solidarity\u201d, which helps us to understand the way certain individual variables (such as self-identification and proximity) combine with political variables (like voting, an interest in politics, or the reading of newspapers) in very different ways. Our main finding is the political trajectory of solidarity can have a remarkable potential even when it comes to helping vulnerable people outside the national boundaries of the political community in France

The Perfect Debris Flow? Aggregated Results from 28 Large-scale Experiments

Aggregation of data collected in 28 controlled experiments reveals reproducible debris-flow behavior that provides a clear target for model tests. In each experiment ∼10 m3 of unsorted, water-saturated sediment composed mostly of sand and gravel discharged from behind a gate, descended a steep, 95-m flume, and formed a deposit on a nearly horizontal runout surface. Experiment subsets were distinguished by differing basal boundary conditions (1 versus 16 mm roughness heights) and sediment mud contents (1 versus 7 percent dry weight). Sensor measurements of evolving flow thicknesses, basal normal stresses, and basal pore fluid pressures demonstrate that debris flows in all subsets developed dilated, coarse-grained, high-friction snouts, followed by bodies of nearly liquefied, finer-grained debris. Mud enhanced flow mobility by maintaining high pore pressures in flow bodies, and bed roughness reduced flow speeds but not distances of flow runout. Roughness had these effects because it promoted debris agitation and grain-size segregation, and thereby aided growth of lateral levees that channelized flow. Grain-size segregation also contributed to development of ubiquitous roll waves, which had diverse amplitudes exhibiting fractal number-size distributions. Despite the influence of these waves and other sources of dispersion, the aggregated data have well-defined patterns that help constrain individual terms in a depth-averaged debris-flow model. The patterns imply that local flow resistance evolved together with global flow dynamics, contradicting the hypothesis that any consistent rheology applied. We infer that new evolution equations, not new rheologies, are needed to explain how characteristic debris-flow behavior emerges from the interactions of debris constituents

Limits to coseismic landslides triggered by Cascadia Subduction Zone earthquakes

Landslides are a significant hazard and dominant feature throughout the landscape of the Pacific Northwest. However, the hazard and risk posed by coseismic landslides triggered by great Cascadia Subduction Zone (CSZ) earthquakes is highly uncertain due to a lack of local and global data. Despite a wealth of other geologic evidence for past earthquakes on the Cascadia Subduction Zone, no landslides have been definitively linked to such earthquakes, even in areas otherwise highly susceptible to failure. While shallow landslides may not leave a lasting topographical signature in the landscape, there are thousands of deep-seated landslides in Cascadia, and these deposits often persist for hundreds of years and multiple earthquake cycles. Synthesizing newly developed inventories of dated large deep-seated landslides in the Oregon Coast Range, we use statistical methods to estimate the proportion of these types of landslides that could have been triggered during past great Cascadia Subduction Zone earthquakes. Statistical analysis of high-precision dendrochronology ages of landslide-dammed lakes and surface roughness-dated bedrock landslides reveal Cascadia Subduction Zone earthquakes may have triggered 0–15 % of large deep-seated landslides in the Oregon Coast Range over multiple earthquake cycles. Our results refine estimates from previous studies and further suggest that coseismic triggering accounts for a small fraction of the total deep-seated bedrock landslides mapped in coastal Cascadia. However, if the real rate of coseismic landslide triggering during CSZ earthquakes is near our estimated upper bound for the 1700 CSZ earthquake, we estimate up to 2400 coseismic large deep-seated landslides could occur in the Oregon Coast Range in a single earthquake. These findings suggest Cascadia is consistent with global observations from other subduction zones and that coseismic landslides may still represent a serious geohazard in the region.24 month embargo; available online: 03 October 2022This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]