7,466 research outputs found
Fluorine gas as a cleaning agent for Apollo bulk-sample containers
A technique has been developed for cleaning Apollo bulk sample containers using fluorine gas as the cleaning agent
Time maintenance of user clocks via the tracking and data relay satellite system
A system is described which uses the Tracking and Data Relay Satellite System (TDRSS) itself to compare the user satellite clock with a clock at the White Sands station that is referenced to Universal Time Coordinated (UTC). No command of the spacecraft by the system is required, and actual on-board clock corrections are made by the spacecraft control center at its discretion. Computer models were constructed using basic orbital parameters for user and TDRS satellites. With only first-order corrections and simple averaging techniques for constant clock rates, error measurement precision of better than one microsecond was obtained. More sophisticated computations should allow considerable improvement over this
The Interaction between the ISM and Star Formation in the Dwarf Starburst Galaxy NGC 4214
We present the first interferometric study of the molecular gas in the
metal-poor dwarf starburst galaxy NGC 4214. Our map of the 12CO(1-0) emission,
obtained at the OVRO millimeter array, reveals an unexpected structural wealth.
We detected three regions of molecular emission in the north-west (NW),
south-east (SE) and centre of NGC 4214 which are in very different and distinct
evolutionary stages (total molecular mass: 5.1 x 10^6 M_sun). These differences
are apparent most dramatically when the CO morphologies are compared to optical
ground based and HST imaging: massive star formation has not started yet in the
NW region; the well-known starburst in the centre is the most evolved and star
formation in the SE complex started more recently. We derive a star formation
efficiency of 8% for the SE complex. Using high--resolution VLA observations of
neutral hydrogen HI and our CO data we generated a total gas column density map
for NGC 4214 (HI + H_2). No clear correlation is seen between the peaks of HI,
CO and the sites of ongoing star formation. This emphasizes the irregular
nature of dwarf galaxies. The HI and CO velocities agree well, so do the
H-alpha velocities. In total, we cataloged 14 molecular clumps in NGC 4214. Our
results from a virial mass analysis are compatible with a Galactic CO-to-H_2
conversion factor for NGC 4214 (lower than what is usually found in metal-poor
dwarf galaxies).Comment: accepted for publication in the AJ (February 2001), full ps file at:
ftp://ftp.astro.caltech.edu/users/fw/ngc4214/walter_prep.p
Properties of a radiation-induced charge multiplication region in epitaxial silicon diodes
Charge multiplication (CM) in pn epitaxial silicon pad diodes of 75, 100
and 150 \upmum thickness at high voltages after proton irradiation with 1 MeV
neutron equivalent fluences in the order of cm was studied as
an option to overcome the strong trapping of charge carriers in the innermost
tracking region of future Super-LHC detectors. Charge collection efficiency
(CCE) measurements using the Transient Current Technique (TCT) with radiation
of different penetration (670, 830, 1060 nm laser light and -particles
with optional absorbers) were used to locate the CM region close to the
p-implantation. The dependence of CM on material, thickness of the
epitaxial layer, annealing and temperature was studied. The collected charge in
the CM regime was found to be proportional to the deposited charge, uniform
over the diode area and stable over a period of several days. Randomly
occurring micro discharges at high voltages turned out to be the largest
challenge for operation of the diodes in the CM regime. Although at high
voltages an increase of the TCT baseline noise was observed, the
signal-to-noise ratio was found to improve due to CM for laser light. Possible
effects on the charge spectra measured with laser light due to statistical
fluctuations in the CM process were not observed. In contrast, the relative
width of the spectra increased in the case of -particles, probably due
to varying charge deposited in the CM region.Comment: 11 pages, accepted by NIM
Timing of antenatal care and ART initiation in HIV-infected pregnant women before and after introduction of NIMART
In this review of routinely collected data from five community health centres in the Johannesburg Health District, we assess timing of antenatal care and antiretroviral therapy (ART) initiation in HIV-infected pregnant women before and after the introduction of nurse-initiated management of ART in antenatal clinics. There are important lessons to be learnt as we reflect on the South African prevention of mother-to-child transmission of HIV programme
Naturopathy as a model of prevention-oriented, patient-centered primary care: A disruptive innovation in health care
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background and Objective: The concept of a “disruptive innovation,” recently extended to health care, refers to an emerging technology that represents a new market force combined with a new value system, that eventually displaces some, or all, of the current leading “stakeholders, products and strategic alliances.” Naturopathy is a distinct system of traditional and complementary medicine recognized by theWorld Health Organization (WHO), emerging as a model of primary care. The objective here is to describe Naturopathy in the context of the criteria for a disruptive innovation. Methods: An evidence synthesis was conducted to evaluate Naturopathy as a potentially disruptive technology according to the defining criteria established by leading economists and health technology experts: (1) The innovation must cure disease; (2) must transform the way medicine is practiced; or (3) have an impact that could be disruptive or sustaining, depending on how it is integrated into the current healthcare marketplace. Results: The fact that Naturopathy de-emphasizes prescription drug and surgical interventions in favor of nonpharmacological health promotion and self-care could disrupt the present economic model that fuels health care costs. The patient-centered orientation of Naturopathy, combined with an emphasis on preventive behaviors and popular complementary and integrative health services like natural products, mind and body therapies, and other therapies not widely represented in current primary care models increase the likelihood for disruption. Conclusions: Because of its patient-centered approach and emphasis on prevention, naturopathy may disrupt or remain a durable presence in healthcare delivery depending on policymaker decisions
The Arecibo L-band Feed Array Zone of Avoidance Survey I: Precursor Observations through the Inner and Outer Galaxy
The Arecibo L-band Feed Array (ALFA) is being used to conduct a low-Galactic
latitude survey, to map the distribution of galaxies and large-scale structures
behind the Milky Way through detection of galaxies' neutral hydrogen (HI) 21-cm
emission. This Zone of Avoidance (ZOA) survey finds new HI galaxies which lie
hidden behind the Milky Way, and also provides redshifts for partially-obscured
galaxies known at other wavelengths. Before the commencement of the full
survey, two low-latitude precursor regions were observed, totalling 138 square
degrees, with 72 HI galaxies detected. Detections through the inner Galaxy
generally have no cataloged counterparts in any other waveband, due to the
heavy extinction and stellar confusion. Detections through the outer Galaxy are
more likely to have 2MASS counterparts. We present the results of these
precursor observations, including a catalog of the detected galaxies, with
their HI parameters. The survey sensitivity is well described by a flux- and
linewidth-dependent signal-to-noise ratio of 6.5. ALFA ZOA galaxies which also
have HI measurements in the literature show good agreement between our
measurements and previous work. The inner Galaxy precursor region was chosen to
overlap the HI Parkes Zone of Avoidance Survey so ALFA performance could be
quickly assessed. The outer Galaxy precursor region lies north of the Parkes
sky. Low-latitude large-scale structure in this region is revealed, including
an overdensity of galaxies near l = 183 deg and between 5000 - 6000 km/s in the
ZOA. The full ALFA ZOA survey will be conducted in two phases: a shallow survey
using the observing techniques of the precursor observations, and also a deep
phase with much longer integration time, with thousands of galaxies predicted
for the final catalog.Comment: 26 pages, 7 figures, 2 tables, Astronomical Journal accepte
Mechanisms underpinning adaptations in placental calcium transport in normal mice and those with fetal growth restriction
Fetal delivery of calcium, via the placenta, is crucial for appropriate skeletal mineralization. We have previously demonstrated that maternofetal calcium transport, per gram placenta, is increased in the placental specific insulin-like growth factor 2 knockout mouse (P0) model of fetal growth restriction (FGR) compared to wild type littermates (WTL). This effect was mirrored in wild-type (WT) mice comparing lightest vs. heaviest (LvH) placentas in a litter. In both models increased placental calcium transport was associated with normalization of fetal calcium content. Despite this adaptation being observed in small normal (WT), and small dysfunctional (P0) placentas, mechanisms underpinning these changes remain unknown. Parathyroid hormone-related protein (PTHrP), elevated in cord blood in FGR and known to stimulate plasma membrane calcium ATPase, might be important. We hypothesized that PTHrP expression would be increased in LvH WT placentas, and in P0 vs. WTL. We used calcium pathway-focused PCR arrays to assess whether mechanisms underpinning these adaptations in LvH WT placentas, and in P0 vs. WTL, were similar. PTHrP protein expression was not different between LvH WT placentas at E18.5 but trended toward increased expression (139%; P = 0.06) in P0 vs. WTL. PCR arrays demonstrated that four genes were differentially expressed in LvH WT placentas including increased expression of the calcium-binding protein calmodulin 1 (1.6-fold; P < 0.05). Twenty-four genes were differentially expressed in placentas of P0 vs. WTL; significant reductions were observed in expression of S100 calcium binding protein G (2-fold; P < 0.01), parathyroid hormone 1 receptor (1.7-fold; P < 0.01) and PTHrP (2-fold; P < 0.05), whilst serum/glucocorticoid-regulated kinase 1 (SGK1), a regulator of nutrient transporters, was increased (1.4 fold; P < 0.05). Tartrate resistant acid phosphatase 5 (TRAP5 encoded by Acp5) was reduced in placentas of both LvH WT and P0 vs. WTL (1.6- and 1.7-fold, respectively; P < 0.05). Signaling events underpinning adaptations in calcium transport are distinct between LvH placentas of WT mice and those in P0 vs. WTL. Calcium binding proteins appear important in functional adaptations in the former whilst PTHrP and SGK1 are also implicated in the latter. These data facilitate understanding of mechanisms underpinning placental calcium transport adaptation in normal and growth restricted fetuses
Noise spectroscopy of optical microcavity
The intensity noise spectrum of the light passed through an optical
microcavity is calculated with allowance for thermal fluctuations of its
thickness. The spectrum thus obtained reveals a peak at the frequency of
acoustic mode localized inside the microcavity and depends on the size of the
illuminated area. The estimates of the noise magnitude show that it can be
detected using the up-to-date noise spectroscopy technique.Comment: 10 pages, 1 figur
Detection of circulating prostate-specific antigen-positive cells in patients with prostate cancer by flow cytometry and reverse transcription polymerase chain reaction.
The presence of prostate-specific antigen (PSA)-positive cells has previously been demonstrated in the peripheral blood of prostate cancer patients by flow cytometry (FC), but the identity of these cells has not been established. In this study, the reverse transcriptase polymerase chain reaction (RT-PCR) was compared with analytical FC in an attempt to detect and characterise these cells. Peripheral blood was obtained from 12 patients with newly diagnosed and untreated prostate cancer and five controls. Nine of the 12 patients with prostate cancer (75%) had circulating PSA-positive cells as shown by FC. Only one of those patients (11.1%) was found to express PSA mRNA by RT-PCR. The absence of PSA mRNA in the majority of samples showing PSA-positive cells suggests that they do not represent haematogenous micrometastases. PSA-positive cells in the blood could represent monocytes that express PSA, either following binding/phagocytosis of free serum PSA or phagocytosis of tumour cells
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