750 research outputs found
Central Acceptance Testing for Camera Technologies for CTA
The Cherenkov Telescope Array (CTA) is an international initiative to build
the next generation ground based very-high energy gamma-ray observatory. It
will consist of telescopes of three different sizes, employing several
different technologies for the cameras that detect the Cherenkov light from the
observed air showers. In order to ensure the compliance of each camera
technology with CTA requirements, CTA will perform central acceptance testing
of each camera technology. To assist with this, the Camera Test Facilities
(CTF) work package is developing a detailed test program covering the most
important performance, stability, and durability requirements, including
setting up the necessary equipment. Performance testing will include a wide
range of tests like signal amplitude, time resolution, dead-time determination,
trigger efficiency, performance testing under temperature and humidity
variations and several others. These tests can be performed on fully-integrated
cameras using a portable setup at the camera construction sites. In addition,
two different setups for performance tests on camera sub-units are being built,
which can provide early feedback for camera development. Stability and
durability tests will include the long-term functionality of movable parts,
water tightness of the camera housing, temperature and humidity cycling,
resistance to vibrations during transport or due to possible earthquakes,
UV-resistance of materials and several others. Some durability tests will need
to be contracted out because they will need dedicated equipment not currently
available within CTA. The planned test procedures and the current status of the
test facilities will be presented.Comment: 8 pages, 3 figures. In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Political market and regulatory uncertainty: Insights and implications for integrated strategy
Managers can craft effective integrated strategy by properly assessing regulatory uncertainty. Leveraging the existing political markets literature, we predict regulatory uncertainty from the novel interaction of demand and supply side rivalries across a range of political markets. We argue for two primary drivers of regulatory uncertainty: ideology-motivated interests opposed to the firm and a lack of competition for power among political actors supplying public policy. We align three, previously disparate dimensions of nonmarket strategy - profile level, coalition breadth, and pivotal target - to levels of regulatory uncertainty. Through this framework, we demonstrate how and when firms employ different nonmarket strategies. To illustrate variation in nonmarket strategy across levels of regulatory uncertainty, we analyze several market entry decisions of foreign firms operating in the global telecommunications sector
Electron transport in carbon wires in contact with Ag electrodes : a detailed first principles investigation
The structure and electronic properties of carbon atom chains Cn in contact with Ag electrodes are investigated in detail with first principles means. The ideal Ag(100) surface is used as a model for binding, and electron transport through the chains is studied as a function of their length, applied bias voltage, presence of capping atoms (Si, S) and adsorption site. It is found that the metal\u2013molecule bond largely influences electronic coupling to the leads. Without capping atoms the quality of the electric contact improves when increasing the carbon atom coordination number to the metal (1, 2 and 4 for adsorption on a top, bridge and hollow position, respectively) and this finding translates almost unchanged in more realistic tip-like contacts which present one, two or four metal atoms at the contact. Current\u2013voltage characteristics show Ohmic behaviour over a wide range of bias voltages and the resulting conductances change only weakly when increasing the wire length. The effect of a capping species is typically drastic, and either largely reduces (S) or largely increases (Si) the coupling of the wire to the electrodes. Comparison of our findings with recent experimental results highlights the limits of the adopted approach, which can be traced back to the known gap problem of density-functional-theory
In silico identification of new putative pathogenic variants in the NEU1 sialidase gene affecting enzyme function and subcellular localization
The NEU1 gene is the first identified member of the human sialidases, glycohydrolitic enzymes that remove the terminal sialic acid from oligosaccharide chains. Mutations in NEU1 gene are causative of sialidosis (MIM 256550), a severe lysosomal storage disorder showing autosomal recessive mode of inheritance. Sialidosis has been classified into two subtypes: sialidosis type I, a normomorphic, late-onset form, and sialidosis type II, a more severe neonatal or early-onset form. A total of 50 causative mutations are reported in HGMD database, most of which are missense variants. To further characterize the NEU1 gene and identify new functionally relevant protein isoforms, we decided to study its genetic variability in the human population using the data generated by two large sequencing projects: the 1000 Genomes Project (1000G) and the NHLBI GO Exome Sequencing Project (ESP). Together these two datasets comprise a cohort of 7595 sequenced individuals, making it possible to identify rare variants and dissect population specific ones. By integrating this approach with biochemical and cellular studies, we were able to identify new rare missense and frameshift alleles in NEU1 gene. Among the 9 candidate variants tested, only two resulted in significantly lower levels of sialidase activity (pC and c.700G>A. These two mutations give rise to the amino acid substitutions p.V217A and p.D234N, respectively. NEU1 variants including either of these two amino acid changes have 44% and 25% residual sialidase activity when compared to the wild-type enzyme, reduced protein levels and altered subcellular localization. Thus they may represent new, putative pathological mutations resulting in sialidosis type I. The in silico approach used in this study has enabled the identification of previously unknown NEU1 functional alleles that are widespread in the population and could be tested in future functional studies
Photosystem II core phosphorylation and photosynthetic acclimation require two different protein kinases
Illumination changes elicit modifications of thylakoid proteins
and reorganization of the photosynthetic machinery. This involves, in the short term, phosphorylation of photosystem II
(PSII) and light-harvesting (LHCII) proteins. PSII phosphorylation
is thought to be relevant for PSII turnover1,2, whereas LHCII
phosphorylation is associated with the relocation of LHCII and
the redistribution of excitation energy (state transitions) between
photosystems3,4. In the long term, imbalances in energy distribution
between photosystems are counteracted by adjusting
photosystem stoichiometry5,6. In the green alga Chlamydomonas
and the plant Arabidopsis, state transitions require the orthologous
protein kinases STT7 and STN7, respectively7,8. Here we
show that in Arabidopsis a second protein kinase, STN8, is
required for the quantitative phosphorylation of PSII core proteins.
However, PSII activity under high-intensity light is affected
only slightly in stn8 mutants, and D1 turnover is indistinguishable
from the wild type, implying that reversible protein phosphorylation
is not essential for PSII repair. Acclimation to changes in
light quality is defective in stn7 but not in stn8 mutants, indicating
that short-term and long-term photosynthetic adaptations are
coupled. Therefore the phosphorylation of LHCII, or of an
unknown substrate of STN7, is also crucial for the control of
photosynthetic gene expressio
Migration routes of the Common Shoveler
This is where the abstract of this record would appear. This is only demonstration data
Realtime processing of LOFAR data for the detection of nano-second pulses from the Moon
The low flux of the ultra-high energy cosmic rays (UHECR) at the highest
energies provides a challenge to answer the long standing question about their
origin and nature. Even lower fluxes of neutrinos with energies above
eV are predicted in certain Grand-Unifying-Theories (GUTs) and e.g.\ models for
super-heavy dark matter (SHDM). The significant increase in detector volume
required to detect these particles can be achieved by searching for the
nano-second radio pulses that are emitted when a particle interacts in Earth's
moon with current and future radio telescopes.
In this contribution we present the design of an online analysis and trigger
pipeline for the detection of nano-second pulses with the LOFAR radio
telescope. The most important steps of the processing pipeline are digital
focusing of the antennas towards the Moon, correction of the signal for
ionospheric dispersion, and synthesis of the time-domain signal from the
polyphased-filtered signal in frequency domain. The implementation of the
pipeline on a GPU/CPU cluster will be discussed together with the computing
performance of the prototype.Comment: Proceedings of the 22nd International Conference on Computing in High
Energy and Nuclear Physics (CHEP2016), US
Cosmic Ray Physics with the LOFAR Radio Telescope
The LOFAR radio telescope is able to measure the radio emission from cosmic
ray induced air showers with hundreds of individual antennas. This allows for
precision testing of the emission mechanisms for the radio signal as well as
determination of the depth of shower maximum , the shower observable
most sensitive to the mass of the primary cosmic ray, to better than 20
g/cm. With a densely instrumented circular area of roughly 320 m, LOFAR
is targeting for cosmic ray astrophysics in the energy range -
eV. In this contribution we give an overview of the status, recent
results, and future plans of cosmic ray detection with the LOFAR radio
telescope.Comment: Proceedings of the 26th Extended European Cosmic Ray Symposium
(ECRS), Barnaul/Belokurikha, 201
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