First evidence of widespread, severe soil erosion underneath centre-pivot irrigation systems

Centre-pivot systems are widely used for irrigation in agriculture. However, excessive water application rates under low pressure centre-pivot systems can lead to soil erosion, which degrades soil structure and increases crop vulnerability to droughts. Although efforts have been deployed to measure soil erosion underneath individual centre pivots, a large-scale systematic assessment of extent and severity of soil erosion in centre-pivot irrigated fields is currently lacking. Here we used Google Earth™ satellite images to provide first evidence of widespread, severe soil erosion in centre-pivot irrigated agricultural land. We focused on the municipality of Cristalina (6154 km 2), in the Brazilian Central Highlands, where centre pivots irrigate approximately 60,000 ha of cropland. The study area is in the Cerrado biome, which is one of the most important grain-producing regions in the world and Brazil's main centre-pivot irrigation area. By mapping erosion features under centre pivots, we found that 29 % of centre-pivot fields displayed signs of rill erosion, with individual rills up to a length of 1200 m. Most erosion features were identified during the dry season of the Brazilian Cerrado, which coincided with the period of greater satellite-image availability. Moreover, we found that compacted centre-pivot-wheel tracks often triggered rill incision and that eroding centre-pivot fields displayed higher slope gradients and were better connected to surface waters than the non-eroding fields. Ultimately, the frequent identification of severe erosion features in the centre-pivot fields during the dry season indicates that irrigation causes and/or aggravates soil erosion in Cristalina and likely in other parts of the Brazilian Cerrado. This first systematic evidence of widespread soil erosion underneath centre-pivot systems highlights that irrigation erosion is an important but neglected driver of land degradation, and that urgent action is required to protect affected soils for future generations

Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

L'action du service de pathologies professionnelles du CHRU de Lille dans les avis concernant le contentieux des lésions professionnelles

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Utilisation et intérêt de la visite de pré-reprise : enquête réalisée auprès de médecins du travail

International audienc

Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies.

The β-amyloid peptide (Aβ) is found as amyloid fibrils in senile plaques, a typical hallmark of Alzheimer's disease (AD). However, intermediate soluble oligomers of Aβ are now recognized as initiators of the pathogenic cascade leading to AD. Studies using recombinant Aβ have shown that hexameric Aβ in particular acts as a critical nucleus for Aβ self-assembly. We recently isolated hexameric Aβ assemblies from a cellular model, and demonstrated their ability to enhance Aβ aggregation in vitro. Here, we report the presence of similar hexameric-like Aβ assemblies across several cellular models, including neuronal-like cell lines. In order to better understand how they are produced in a cellular context, we investigated the role of presenilin-1 (PS1) and presenilin-2 (PS2) in their formation. PS1 and PS2 are the catalytic subunits of the γ-secretase complex that generates Aβ. Using CRISPR-Cas9 to knockdown each of the two presenilins in neuronal-like cell lines, we observed a direct link between the PS2-dependent processing pathway and the release of hexameric-like Aβ assemblies in extracellular vesicles. Further, we assessed the contribution of hexameric Aβ to the development of amyloid pathology. We report the early presence of hexameric-like Aβ assemblies in both transgenic mice brains exhibiting human Aβ pathology and in the cerebrospinal fluid of AD patients, suggesting hexameric Aβ as a potential early AD biomarker. Finally, cell-derived hexameric Aβ was found to seed other human Aβ forms, resulting in the aggravation of amyloid deposition in vivo and neuronal toxicity in vitro

Uncertainties in assessing tillage erosion – how appropriate are our measuring techniques?

Trabajo presentado en la European Geosciences Union General Assembly (EGU 2017), celebrada en Viena del 23 al 28 de abril de 2017.In undulating arable landscapes tillage erosion is one of the dominant processes initiating lateral transfer of soil and soil constituents. Especially, in relatively dry regions, where tillage erosion can be much larger than water erosion, the associated changes in soil hydraulic properties might have substantial effects upon the sustainable use of soil resources. There have been some studies using different techniques to determine tillage erosion which build the basis for tillage erosion modelling approaches. However, tillage erosion is rather understudied compared to water erosion. The goal of this study was to bring together experts using different techniques to determine tillage erosion in an experimental set-up and to analyse the different results and assess the uncertainties associated with typical model inputs. Tillage erosion on a 50 x 10 m plot was determined after two phases of seven tillage passes performed within a week (simulating 10-14 yrs of tillage). As tracers, two different micro-tracers (magnetite mixed with soil and fluorescent sand) and one macro-tracer (passive Radio-Frequency Identification (RFID) transponders; dia. 3 mm, length 20 mm) were used. Moreover, tillage induced changes in topography were spatially determined for the entire plot with two different terrestrial laser scanners and an UAV-based structure by motion topography analysis. Topography changes were also evaluated at 12 points using buried concrete flagstones as reference. A preliminary analysis of tracer movement indicates substantial differences in tillage induced translocation depending on type of tracer. While the mean translocation of the RFIDs was 0.47 m per pass the mean movement of the micro-tracers was 0.70 m. Substantial differences were also found for the different techniques to determine changes in topography. Overall the experiment underlines the importance of tillage erosion for the lateral transfer of soil and soil constituents, but also shows the large discrepancies between measurements based on different techniques. The latter introduces substantial uncertainties in any existing tillage erosion modelling approach.N

Vers un conservatoire des gestes techniques et professionnels dans les IUT.

Projet financé par le service général SIAME de l'UBO. La présentation a eu lieu le 7/6/2012.National audienceAfin d'accroître l'efficacité de l'apprentissage des gestes techniques et professionnels nous avons expérimenté les techniques de films 3D en relief. Nous avons tourné de courtes séquences, dans différentes disciplines, biologie et mécanique, avec des caméras stéréoscopiques destinées à être exploitées en cours, travaux dirigés, au démarrage des travaux pratiques, et après les travaux pratiques