Hydrogeologic Investigation of a Landfill Site in Washington County, Arkansas

A proposed landfill site near Wheeler, Washington Co., Arkansas, was investigated for its hydrogeologic suitability. The site is located on the highly fractured, cavernous, and cherty Boone Ls. The site is a small upland valley 4500 ft. north of Clear Creek. The valley containing the proposed site is a karst dry valley in which precipitation rapidly infiltrates, recharging the water table and local springs. The water table around the site was mapped to determine the hydraulic gradient and direction of ground-water movement. The water table slopes in a SE direction from the landfill towards Clear Creek with a steep hydraulic gradient of an average 200 ft/mile. Water levels in wells near the site are 17-80 ft. below the surface of the valley. Specific capacity values of 0.54 and 0.94 gpm/ft. and transmissibility values of 257 and 301 gpd/ft were determined from two pumping tests in the unconfined and semi-confined Boone-St. Joe aquifer. These values indicate a relatively high permeability of the aquifer. The cherty soil to be used as a liner is inadequate due to its highly variable permeability. Therefore, the site as designed, is judged unsuitable. One large spring and five wells in the area were monitored for Cl⁻,NO₃⁻¹ and SO⁻² and found uncontaminated according to health standards. Since the Arkansas DPCE has granted permission for the landfill, these same sites will be monitored through time to detect any leachate contamination

Mitochondria-induced immune response as a trigger for neurodegeneration : A pathogen from within

Funding: This work was supported by a Juan de la Cierva grant (IJC2018-036938-I). A.Q. received funds from the European Research Council (Starting grant NEUROMITO, ERC-2014-StG-638106), MINECO Proyectos I + D de Excelencia (SAF2014-57981P; SAF2017-88108-R), AGAUR (2017SGR- 323), and "la Caixa" Foundation (ID 100010434), under the agreement LCF/PR/HR20/52400018.This work was supported by a Juan de la Cierva grant (IJC2018?036938?I). A.Q. received funds from the European Research Council (Starting grant NEUROMITO, ERC?2014?StG?638106), MINECO Proyectos I + D de Excelencia (SAF2014?57981P; SAF2017?88108?R), AGAUR (2017SGR? 323), and ?la Caixa? Foundation (ID 100010434), under the agreement LCF/PR/HR20/52400018.Altres ajuts: NEUROMITOAltres ajuts: "la Caixa" FoundationSymbiosis between the mitochondrion and the ancestor of the eukaryotic cell allowed cellular complexity and supported life. Mitochondria have specialized in many key functions ensuring cell homeostasis and survival. Thus, proper communication between mitochondria and cell nucleus is paramount for cellular health. However, due to their archaebacterial origin, mitochondria possess a high immunogenic potential. Indeed, mitochondria have been identified as an intracellular source of molecules that can elicit cellular responses to pathogens. Compromised mitochondrial integrity leads to release of mitochondrial content into the cytosol, which triggers an unwanted cellular immune response. Mitochondrial nucleic acids (mtDNA and mtRNA) can interact with the same cytoplasmic sensors that are specialized in recognizing genetic material from pathogens. High-energy demanding cells, such as neurons, are highly affected by deficits in mitochondrial function. Notably, mitochondrial dysfunction, neurodegeneration, and chronic inflammation are concurrent events in many severe debilitating disorders. Interestingly in this context of pathology, increasing number of studies have detected immune-activating mtDNA and mtRNA that induce an aberrant production of pro-inflammatory cytokines and interferon effectors. Thus, this review provides new insights on mitochondria-driven inflammation as a potential therapeutic target for neurodegenerative and primary mitochondrial diseases

Hay lugar para las famílias en la educación secundaria? Percepciones y propuestas para una transformación del programa institucional de los centros educativos

Las respuestas a un cuestionario realizado al inicio de una investigación-acción en diferentes institutos de secundaria, nos muestran las opiniones que el profesorado de estos centros tiene acerca de la relación con las familias. Se trataba no sólo de conocer los puntos de vista de los y las docentes sino de utilizarlos en el claustro de los centros implicados para abrir un proceso de reflexión y de implementación de propuestas pedagógicas dirigidas a modificar aspectos de la cultura escolar. Todo ello en beneficio de una relación más fluida y, a la vez, más profunda, con las familias. Precisamente, el papel y el lugar de las familias en los institutos supone una de las claves para avanzar hacia un nuevo programa institucional en los centros de secundaria, una reinstitucionalización que tendría que situar en el centro de las preocupaciones docentes, la vinculación con las familias y la comunidad, aspecto indispensable para la mejora de los aprendizajes de todo el alumnado

Llacunes de nova creació

Oasis d'optimisme enmig de la degradaci&oacute

Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome

Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. Basal ganglia nuclei, including the striatum, are affected in LS patients. However, neither the identity of the affected cell types in the striatum nor their contribution to the disease has been established. Here, we used a mouse model of LS lacking Ndufs4, a mitochondrial complex I subunit, to confirm that loss of complex I, but not complex II, alters respiration in the striatum. To assess the role of striatal dysfunction in the pathology, we selectively inactivated Ndufs4 in the striatal medium spiny neurons (MSNs), which account for over 95% of striatal neurons. Our results show that lack of Ndufs4 in MSNs causes a non-fatal progressive motor impairment without affecting the cognitive function of mice. Furthermore, no inflammatory responses or neuronal loss were observed up to 6 months of age. Hence, complex I deficiency in MSNs contributes to the motor deficits observed in LS, but not to the neural degeneration, suggesting that other neuronal populations drive the plethora of clinical signs in LS

Las Webquests : Una metodología de aprendizaje cooperativo, basada en el acceso, el manejo y el uso de información de la red

Podeu consultar la versió catalana a recurs relacionat.Las WQ son propuestas de trabajo para los y las estudiantes en las que, a partir de la presentación de una situación relativa a un tema o más, y de su contexto, se propone al alumnado la realización de un trabajo o de un proyecto en grupo, a partir del uso de información ubicada bási-camente en Internet, la cual ha sido preseleccionada para garantizar la calidad, y que a menudo concluye con una presentación pública.Los procesos mencionados son facilitadores de la transformación de la información recibida o localizada y recuperada, en conocimiento cons-truido, a partir de su contextualización, de la atribución de significa-dos, del contraste y colaboración con compañeros y compañeras, y de su aplicación y utilización práctica.de hecho, podemos considerar el trabajo con WQ como una metodo-logía de aprendizaje que se lleva a cabo en un marco constructivista y de trabajo cooperativo (Adell y Bernabé, en línea), lo cual se basa en la gestión y el manejo de la información, a partir de la localización y bús-queda guiada por la red, y en su uso y comunicación