Prediction of Vortex-Induced Vibration Response of Deep Sea Top-Tensioned Riser in Sheared Flow Considering Parametric Excitations

It is widely accepted that vortex-induced vibration (VIV) is a major concern in the design of deep sea top-tensioned risers, especially when the riser is subjected to axial parametric excitations. An improved time domain prediction model was proposed in this paper. The prediction model was based on classical van der Pol wake oscillator models, and the impacts of the riser in-line vibration and vessel heave motion were considered. The finite element, Newmark-β and Newton‒Raphson methods were adopted to solve the coupled nonlinear partial differential equations. The entire numerical solution process was realised by a self-developed program based on MATLAB. Comparisons between the numerical calculation and the published experimental test were conducted in this paper. The in-line and cross-flow VIV responses of a real size top-tensioned riser in linear sheared flow were analysed. The effects of the vessel heave amplitude and frequency on the riser VIV were also studied. The results show that the vibration displacements of the riser are larger than the case without vessel heave motion. The vibration modes and frequencies of the riser are also changed due to the vessel heave motio

Prediction of Vortex-Induced Vibration Response of Deep Sea Top-Tensioned Riser in Sheared Flow Considering Parametric Excitations

It is widely accepted that vortex-induced vibration (VIV) is a major concern in the design of deep sea top-tensioned risers, especially when the riser is subjected to axial parametric excitations. An improved time domain prediction model was proposed in this paper. The prediction model was based on classical van der Pol wake oscillator models, and the impacts of the riser in-line vibration and vessel heave motion were considered. The finite element, Newmark-β and Newton‒Raphson methods were adopted to solve the coupled nonlinear partial differential equations. The entire numerical solution process was realised by a self-developed program based on MATLAB. Comparisons between the numerical calculation and the published experimental test were conducted in this paper. The in-line and cross-flow VIV responses of a real size top-tensioned riser in linear sheared flow were analysed. The effects of the vessel heave amplitude and frequency on the riser VIV were also studied. The results show that the vibration displacements of the riser are larger than the case without vessel heave motion. The vibration modes and frequencies of the riser are also changed due to the vessel heave motio

Study on Vortex-Induced Vibration of Deep-Water Marine Drilling Risers in Linearly Sheared Flows in consideration of Changing Added Mass

In order to more accurately predict the coupled in-line and cross-flow vortex-induced vibration (VIV) response of deep-water marine drilling risers in linearly sheared flows, an improved three-dimensional time-domain coupled model based on van der Pol wake oscillator models was established in this paper. The impact of the in-line and cross-flow changing added mass coefficients was taken into account in the model. The finite element, Newmark-β, and Newton–Raphson methods were adopted to solve the coupled nonlinear partial differential equations. The entire numerical solution process was realized by a self-developed program based on MATLAB. Comparisons between the numerical calculations and the published experimental tests showed that the improved model can more accurately predict some main features of the coupled in-line and cross-flow VIV of long slender flexible risers in linearly sheared flows to some extent. The coupled in-line and cross-flow VIV of a real-size marine drilling riser, usually used in the deep-water oil/gas industry in the South China Sea, was analyzed. The influence of top tension force and seawater flow speed, as well as platform heave amplitude and frequency, on the riser in-line and cross-flow VIV was also discussed. The results show that the platform heave motion increases the VIV displacements and changes the magnitudes of peak frequencies as well as the components of frequencies. The platform heave motion also has a significant influence on the vibration modes of the middle and upper sections of the riser. The impact level of each factor on the in-line and cross-flow VIV response of the riser is different. The improved model and the results of this paper can be used as a reference for the engineering design of deep-water marine drilling risers

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract

We have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial cells (HBECs), and that IL-6/STAT3 signaling contributes to the cell survival. Since NF-κB is also involved in regulating apoptosis and cell survival, the current study was designed to investigate the role of NF-κB in mediating cell survival in response to cigarette smoke exposure in HBECs. Both the pharmacologic inhibitor of NF-κB, curcumin, and RNA interference targeting p65 were used to block NF-κB signaling in HBECs. Apoptosis and cell survival were then assessed by various methods including COMET assay, LIVE/DEAD Cytotoxicity/Viability assay and colony formation assay. Cigarette smoke extract (CSE) caused DNA damage and cell cycle arrest in S phase without leading to apoptosis in HBECs as evidenced by TUNEL assay, COMET assay and DNA content assay. CSE stimulated NF-κB -DNA binding activity and up-regulated Bcl-XL protein in HBECs. Inhibition of NF-κB by the pharmacologic inhibitor curcumin (20 μM) or suppression of p65 by siRNA resulted in a significant increase in cell death in response to cigarette smoke exposure. Furthermore, cells lacking p65 were incapable of forming cellular colonies when these cells were exposed to CSE, while they behaved normally in the regular culture medium. The current study demonstrates that CSE activates NF-κB and up-regulates Bcl-XL through NF-kB activation in HBECs, and that CSE induces cell death in cells lacking p65. These results suggest that activation of NF-κB regulates cell survival following DNA damage by cigarette smoke in human bronchial epithelial cells