Unlike severe periodontitis, caries does not associate with intracranial aneurysms or aneurysmal subarachnoid hemorrhage.

Peer reviewe

Role of oral pathogens in the pathogenesis of intracranial aneurysm : review of existing evidence and potential mechanisms

Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.Peer reviewe

Increased tooth brushing frequency is associated with reduced gingival pocket bacterial diversity in patients with intracranial aneurysms

Objectives The objective of this study was to investigate the association of tooth brushing frequency and bacterial communities of gingival crevicular fluid in patients subjected to preoperative dental examination prior to operative treatment for unruptured intracranial aneurysms. Methods Gingival crevicular fluid samples were taken from their deepest gingival pocket from a series of hospitalized neurosurgical patients undergoing preoperative dental screening (n = 60). The patients were asked whether they brushed their teeth two times a day, once a day, or less than every day. Total bacterial DNA was isolated and the V3–V4 region of the 16S rRNA gene was amplificated. Sequencing was performed with Illumina’s 16S metagenomic sequencing library preparation protocol and data were analyzed with QIIME (1.9.1) and R statistical software (3.3.2). Results Bacterial diversity (Chao1 index) in the crevicular fluid reduced along with reported tooth brushing frequency (p = 0.0002; R2 = 34%; p (adjusted with age and sex) = 0.09; R2 = 11%) showing that patients who reported brushing their teeth twice a day had the lowest bacterial diversity. According to the differential abundant analysis between the tooth brushing groups, tooth brushing associated with two phyla of fusobacteria [p = 0.0001; p = 0.0007], and one bacteroidetes (p = 0.004) by reducing their amounts. Conclusions Tooth brushing may reduce the gingival bacterial diversity and the abundance of periodontal bacteria maintaining oral health and preventing periodontitis, and thus it is highly recommended for neurosurgical patients

FinGPT: Large Generative Models for a Small Language

Large language models (LLMs) excel in many tasks in NLP and beyond, but most open models have very limited coverage of smaller languages and LLM work tends to focus on languages where nearly unlimited data is available for pretraining. In this work, we study the challenges of creating LLMs for Finnish, a language spoken by less than 0.1% of the world population. We compile an extensive dataset of Finnish combining web crawls, news, social media and eBooks. We pursue two approaches to pretrain models: 1) we train seven monolingual models from scratch (186M to 13B parameters) dubbed FinGPT, 2) we continue the pretraining of the multilingual BLOOM model on a mix of its original training data and Finnish, resulting in a 176 billion parameter model we call BLUUMI. For model evaluation, we introduce FIN-bench, a version of BIG-bench with Finnish tasks. We also assess other model qualities such as toxicity and bias. Our models and tools are openly available at https://turkunlp.org/gpt3-finnish.Comment: 17 pages (10 main), 7 figures, 5 table

Absolute Radiometric Calibration of ALS Intensity Data: Effects on Accuracy and Target Classification

Radiometric calibration of airborne laser scanning (ALS) intensity data aims at retrieving a value related to the target scattering properties, which is independent on the instrument or flight parameters. The aim of a calibration procedure is also to be able to compare results from different flights and instruments, but practical applications are sparsely available, and the performance of calibration methods for this purpose needs to be further assessed. We have studied the radiometric calibration with data from three separate flights and two different instruments using external calibration targets. We find that the intensity data from different flights and instruments can be compared to each other only after a radiometric calibration process using separate calibration targets carefully selected for each flight. The calibration is also necessary for target classification purposes, such as separating vegetation from sand using intensity data from different flights. The classification results are meaningful only for calibrated intensity data

Relatório de estágio em farmácia comunitária

Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr

CoZone-asiakasportaalin käyttökokemus — Case Azets Insight Oy

Tämän opinnäytetyön tavoitteena oli kerätä tietoa CoZone-asiakasportaalin käytöstä asiakasyrityksiltä ja pääkäyttäjiltä sekä käytön mahdollisista ongelmakohdista. Työ toteutettiin laadullisena tutkimuksena ja menetelmänä käytettiin teemahaastattelua. Tutkimuksesta hyötyvät sekä toimeksiantaja Azets Insight Oy että kaikki järjestelmän käyttäjät järjestelmäkehityksen kautta. Tietoperustassa käsiteltiin järjestelmän käytettävyyttä, palvelun tuottamaa lisäarvoa ja asiakaskokemusta. Lähteinä käytettiin kirjallisuutta ja verkkolähteitä käytettävyydestä sekä digiajan asiakaskokemuksesta ja lisäarvon tuottamisesta. Haastattelujen tulokset analysoitiin hyödyntäen tietoperustaa. Tuloksista selvisi, että haastateltavat kokevat työaikaraportointisovelluksessa ongelmalliseksi työaikaraporteilta koostuvien saldojen seurannan. Järjestelmän tulisi myös paremmin estää käyttäjiä tekemästä virheellisiä kirjauksia. Lisäarvoa tuotettiin toiminnolla, jolla voi muistuttaa työntekijöitä ja esimiehiä hoitamaan tehtävänsä ajallaan

Maatalouslomittajille tarkoitettu sähköinen työnhallinta työkalu käyttäen NFC-tekniikkaa.

Opinnäytetyön tarkoituksena oli toteuttaa maatalouslomittajille sähköinen työnhallinta työkalu. Työssä suunniteltiin ja toteutettiin mobiilisovellus sekä palvelimella sijaitseva ohjelma ja ohjelmalle tietokanta. Työ oli kaksiosainen. Toinen oppilas toteutti työssä vaadittavan käyttöliittymän Nokia N9 puhelimelle ja minun osuuteni oli toteuttaa työlle sille vaadittavan palvelinpään ohjelman ja tietokannan. Työn idea oli luoda maatalousmittajille sähköinen työnhallinta työkalu, jolla voitaisiin demonstroida maatalouslomittajille ja maatilayrittäjille nykyaikaista työnhallinta menetelmää. Opinnäytetyössä käytettiin PHP-, MySQL- ja XML-ohjelmointikieliä.The purpose of this thesis was to create electric work control tool for stand-ins using NFC-technology. In this work we have planned and implemented mobile application, program what is located in server and database for program. This thesis was separated in two-pieces. Another student implemented work required interface for Nokia N9 phone and my half from thesis was to create server and database for program. The idea of the work is to create electric work control tool which can be demonstrate stand-ins and farmers what is modern work control method. In this thesis program have been used PHP-, MySQL- and XML-programming languages

Aivovaltimoaneurysmat ja suun terveys

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