Analytical Characterization and Sensory Analysis of Distillates of Di erent Varieties of Grapes Aged by an Accelerated Method

The wine spirits used for the elaboration of Brandy de Jerez are mainly obtained from wines produced from the Airen type of grape, which comes from the vineyards located in the region of La Mancha (Central Spain). This entails a limitation when achieving a product classified as "protected geographic designation". For that purpose, it is necessary that the grape used for the wine spirit comes from the area and not from Castile la Mancha, as has happened until now. Due to this fact, it is necessary to search for a possible alternative grape variety which allows the produced brandy to be eligible for a "protected geographic designation". For that purpose, an accelerated ageing process has been implemented with a method previously optimized to distillates obtained from wines from different varieties of grapes (Airen, Colombard, Corredera, Doradilla, Garrido Fino, Jaen blanco, Moscatel de Alejandria, Palomino Fino, Ugni Blanc, and Zalema) grown in the Jerez Area. They were evaluated, both from the analytical and sensory points of view. The distillates made from Jaen Blanco and Zalema have properties that make them interesting for future development and incorporation into oenological practice

Impact of preharvest and postharvest treatment combinations on increase of stilbene content in grape

Aims : Stilbene-enriched grape is an interesting new food product with numerous health-promoting properties, mainly due to its high added-value compound content, notably resveratrol. The aim of this study was to evaluate the effects of different elicitors, alone or in combination with ultraviolet C light (UVC) postharvest treatment, on stilbene concentration in grapes. Methods and results : Three preharvest treatments were tested, namely benzothiadiazole, (BTH), methyl jasmonate (MEJA) and chitosan (CHIT). After harvesting, these treatments were combined with UVC postharvest treatment. The stilbene extraction method was validated method. Moreover, and grape quality was evaluated. Of the preharvest treatments, only BTH significantly increased trans-resveratrol concentration in grape, but this appears to be linked to a ripening delay. When pre- and postharvest treatments were combined, only the MEJA-UVC combination was successful in reducing by three days the day of maximum induction of stilbenes (trans resveratrol and piceatannol). Conclusion: The MEJA-UVC combination reached similar grape trans-resveratrol contents than UVC alone, but additionally the time to reach maximum trans-resveratrol after the UVC treatment was reduced by three days and therefore grape quality was preserved. Significance and impact of the study: The achieved results provide a potential treatment combination that allows functional grapes to be obtained in a shorter period than with UVC light alone, making it more applicable

Transdiagnostic model of psychological factors and sex differences in depression in a large sample of Ecuador

Background/Objective: depression represents a leading cause of disability and a major contributor to the overall global burden of disease with women systematically reporting a higher prevalence than men. This study aimed to examine the predictive value and relation of three transdiagnostic psychological factors (perceived stress, psychological inflexibility and loneliness) on depression and its sex differences for the general population in a large sample of Ecuador. Method: a non-probabilistic and non-clinical sample of 16.074 people from across Ecuador were online surveyed using a cross-sectional design. The structural equation model was based on scores from standardized questionnaires as measures of depression, psychological perceived stress, psychological inflexibility, and loneliness. Results: women reported significantly higher levels of depression, mediated by differences in perceived stress, psychological inflexibility and loneliness. Perceived stress was the most important predictor of depression and mediated the effect of loneliness on depression. Complementarily, psychological inflexibility partially mediated the effect of perceived stress and loneliness on depression. The overall model accounted for the 78% of the total variance in depression. Conclusions: results of this study provide a novel and robust transdiagnostic model of sex differences on depression and insights on how to design effective programs for preventing depression targeting modifiable transdiagnostic risk factors.The study was funded by the Particular Technical University of Loja (Ecuador) (PROY-INV-PSI2020-2781). Additional funding to P.R. was provided by the European Union— 'NextGenerationEU' through the Grant for the Requalification of the Spanish University System for 2021-2023 at the Public University of Navarra (Resolution 1402/2021)

Mercado de trabajo en León presente y futuro

p. 16La provincia de León cuenta en la actualidad con 499.517 habitantes. En la década de los 60 comienza un proceso de emigración interna de los pueblos de la provincia. Es necesario crear en esta provincia en torno a 6.000 puesto de trabajo al año si no queremos tener una provincia empobrecida de aquí a 10 añosS

Explorando el potencial bioestimulante del alga invasora Rugulopterix okamurae en vid

Trabajo presentado en las IV Jornadas del Grupo de Viticultura de la Sociedad Española de Ciencias Hortícolas, celebradas en Pamplona (España), del 26 al 28 de octubre de 202

MERLIN: A new tool for flood hazard forecasting at the Galicia-Costa Hydrographic Demarcation

[EN] This article presents MERLIN, a tool for flood hazard evaluation, which forecasts discharges and water depths in flood prone areas of the Galicia Costa district. The warning system operates in two stages. During the hindcast stage, hydrological models of the basins included in the system assimilate hydro-meteorological data in order to characterize soil infiltration capacity. During the forecast stage, hydrological models are fed with meteorological predictions and discharge forecasts along the basins. Forecasted discharges define boundary conditions of hydraulic models, which compute the flood extent and the water depths over the upcoming days. The performance of MERLIN was evaluated in 4 areas using discharge data from the winter months of 2019-2020. Results proved MERLIN’s ability of predicting the discharges observed afterwards.[ES] Este artículo presenta MERLIN, una nueva herramienta para estimar el riesgo de inundaciones a partir de predicciones de caudales y calados en Áreas de Riesgo Potencial Significativo de Inundaciones (ARPSIS) de la demarcación hidrográfica Galicia-Costa. El sistema MERLIN opera en dos fases. Durante una primera fase de inicialización, modelos hidrológicos de las cuencas incluidas en el sistema asimilan datos hidro-meteorológicos para caracterizar la capacidad de infiltración del terreno. Durante la fase de predicción, los modelos hidrológicos previamente inicializados se alimentan con predicciones meteorológicas para determinar los caudales esperados durante los próximos días. Las predicciones de caudal alimentan a modelos hidráulicos de las ARPSIS que determinan los calados y la extensión de zonas inundadas. El funcionamiento de MERLIN se evaluó en 4 cuencas piloto a partir de los caudales registrados durante los temporales del invierno del 2019-2020, mostrando una buena capacidad de predecir los valores posteriormente observados.El desarrollo del sistema MERLIN y el resto de trabajos presentados en este artículo fue posible gracias a la financiación aportada por Augas de Galicia dentro del Convenio de colaboración entre Augas de Galicia e a Fundación de Enxeñería Civil de Galicia para a mellora do sistema de alerta temperá de risco de inundación na demarcación hidrográfica Galicia-costa.Fraga, I.; Cea, L.; Puertas, J.; Mosqueira, G.; Quinteiro, B.; Botana, S.; Fernández, L.... (2021). MERLIN: Una nueva herramienta para la predicción del riesgo de inundaciones en la demarcación hidrográfica Galicia-Costa. Ingeniería del agua. 25(3):215-227. https://doi.org/10.4995/ia.2021.15565OJS215227253Alvarez-Garreton, C., Ryu, D., Western, A.W., Su, C.H., Crow, W.T., Robertson, E., Leahy, C. 2015. Improving operational flood ensemble prediction by the assimilation of satellite soil moisture: Comparison between lumped and semi-distributed schemes. Hydrology and Earth System Sciences, 19(4), 1659-1676. https://doi.org/10.5194/hess-19-1659-2015Arnell, N.W., Gosling, S.N. 2016. The impacts of climate change on river flood risk at the global scale. Climatic Change, 134(3), 387-401. https://doi.org/10.1007/s10584-014-1084-5Bennett, T.H., Peters, J.C. 2000. Continuous soil moisture accounting in the hydrologic Engineering Center Hydrologic Modeling System (HEC-HMS). Building partnerships, 1-10.Berghuijs, W.R., Aalbers, E.E., Larsen, J.R., Trancoso, R., Woods, R.A. 2017. Recent changes in extreme floods across multiple continents. Environmental Research Letters, 12(11), 114035. https://doi.org/10.1088/1748-9326/aa8847Bladé, E., Cea, L., Corestein, G., Escolano, E., Puertas, J., Vázquez-Cendón, E., Dolz, J., Coll, A. 2014. Iber: herramienta de simulación numérica del flujo en ríos. Revista Internacional de Metodos Numericos en Ingeniería, 30(1), 1-10. https://doi.org/10.1016/j.rimni.2012.07.004Carracedo, P. 2003. Acoplamiento de un modelo hidrodinámico de escala global con uno de escala regional para Galicia. Revista Real Academia Galega de Ciencias, 22, 85.Cea, L., Fraga, I. 2018. Incorporating antecedent moisture conditions and intraevent variability of rainfall on flood frequency analysis in poorly gauged basins. Water Resources Research, 54, 8774-8791. https://doi.org/10.1029/2018WR023194Cronshey, R. 1986. Urban hydrology for small watersheds. US Department of Agriculture Soil Conservation Service Engineering Division.García-Feal, O., González-Cao, J., Gómez-Gesteira, M., Cea, L., Domínguez, J., Formella, A. 2018. An accelerated tool for flood modelling based on Iber. Water, 10(10) 1459. https://doi.org/10.3390/w10101459Hossain, F., Siddique-E-Akbor, A.H.M., Yigzaw, W., Shah-Newaz, S., Hossain, M., Mazumder, L.C., Turk, F.J. 2014. Crossing the "valley of death": lessons learned from implementing an operational satellite-based flood forecasting system. Bulletin of the American Meteorological Society, 95(8), 1201-1207. https://doi.org/10.1175/BAMS-D-13-00176.1IPCC (2018). Global warming of 1.5°C. An IPCC Special Report on the impacts of global warming of 1.5°C above pre-industrial levels and related global greenhouse gas emission pathways in the context of strengthening the global response to the threat of climate change sustainable development and efforts to eradicate poverty. In Press.Jewell, S.A., Gaussiat, N. 2015. An assessment of kriging-based rain-gauge-radar merging techniques. Quarterly Journal of the Royal Meteorological Society, 141(691), 2300-2313. https://doi.org/10.1002/qj.2522Kasiviswanathan, K.S., He, J., Sudheer, K.P., Tay, J.H. 2016. Potential application of wavelet neural network ensemble to forecast streamflow for flood management. Journal of hydrology, 536, 161-173. https://doi.org/10.1016/j.jhydrol.2016.02.044Kellens, W., Vanneuville, W., Verfaillie, E., Meire, E., Deckers, P., De Maeyer, P. 2013. Flood risk management in Flanders: past developments and future challenges. Water Resources Management, 27(10), 3585-3606. https://doi.org/10.1007/s11269-013-0366-4Krajewski, W.F., Ceynar, D., Demir, I., Goska, R., Kruger, A., Langel, C., Small, S.J. 2017. Real-time flood forecasting and information system for the state of Iowa. Bulletin of the American Meteorological Society, 98(3), 539-554. https://doi.org/10.1175/BAMS-D-15-00243.1Kumar, M., Sahay, R.R. 2018. Wavelet-genetic programming conjunction model for flood forecasting in rivers. Hydrology Research, 49(6), 1880-1889. https://doi.org/10.2166/nh.2018.183Massari, C., Brocca, L., Tarpanelli, A., Moramarco, T. 2015. Data assimilation of satellite soil moisture into rainfall-runoff modelling: A complex recipe?. Remote Sensing, 7(9), 11403-11433. https://doi.org/10.3390/rs70911403McKay, M.D., Beckman, R.J., Conover, W.J. 1979 A Comparison of three methods for selecting values of input variables in the analysis of output from a computer code. Technometrics, 21(2), 239-245.Mure-Ravaud, M., Binet, G., Bracq, M., Perarnaud, J.J., Fradin, A., Litrico, X. 2016. A web based tool for operational realtime flood forecasting using data assimilation to update hydraulic states. Environmental Modelling and Software, 84, 35-49. https://doi.org/10.1016/j.envsoft.2016.06.002Naranjo, L., Taboada, J.J., Lage, A., Salsón, S., Montero, P., Souto, J.A., Pérez-Muñuzuri, V. 2001. Estudio de las anómalas condiciones meteorológicas sobre Galicia durante el otoño de los años 2000 y 2001. Revista Real Academia Galega de Ciencias, 20, 113-133Nguyen, P., Thorstensen, A., Sorooshian, S., Hsu, K., AghaKouchak, A., Sanders, B., Koren, V., Cui, Z., Smith, M. 2016. A high resolution coupled hydrologic-hydraulic model (HiResFlood-UCI) for flash flood modeling. Journal of Hydrology, 541, 401-420. https://doi.org/10.1016/j.jhydrol.2015.10.047Razmkhah, H. 2016. Comparing performance of different loss methods in rainfall-runoff modeling. Water resources, 43(1), 207-224. https://doi.org/10.1134/S0097807816120058Rosburg, T.T., Nelson, P.A., Bledsoe, B.P. 2017. Effects of urbanization on flow duration and stream flashiness: a case study of Puget Sound streams, western Washington, USA. Journal of the American Water Resources Association, 53(2), 493-507. https://doi.org/10.1111/1752-1688.12511Sanz-Ramos, M., Amengual, A., Bladé i Castellet, E., Romero, R., Roux, H. 2018. Flood forecasting using a coupled hydrological and hydraulic model (based on FVM) and highresolution meteorological model. Proceedings of River Flow 2018-Ninth International Conference on Fluvial Hydraulics (pp. 1-8) Lyon France. https://doi.org/10.1051/e3sconf/20184006028Scharffenberg, W.A, Fleming, M.J. 2006. Hydrologic modeling system HEC-HMS: User's manual. US Army Corps of Engineers Hydrologic Engineering Center.Shchepetkin, A.F., McWilliams, J.C. 2005. The regional oceanic modeling system (ROMS): a split-explicit free-surface topographyfollowing-coordinate oceanic model. Ocean Modelling, 9(4), 347-404. https://doi.org/10.1016/j.ocemod.2004.08.002Skamarock, W.C., Klemp, J.B., Dudhia, J., Gill, D.O., Barker, D.M., Wang, W., Powers, J.G. 2008. A description of the Advanced Research WRF version 3. NCAR Technical note-475+ STR.Sopelana, J., Cea, L., Ruano, S. 2018. A continuous simulation approach for the estimation of extreme flood inundation in coastal river reaches affected by meso and macro tides. Natural Hazards, 93(3) 1337-1358. https://doi.org/10.1007/s11069-018-3360-6Thielen, J., Bartholmes, J., Ramos, M. H., & Roo, A. D. 2009. The European flood alert system-part 1: concept and development. Hydrology and Earth System Sciences, 13(2), 125-140. https://doi.org/10.5194/hess-13-125-2009Thiemig, V., Bisselink, B., Pappenberger, F., Thielen, J. 2015. A pan-African medium-range ensemble flood forecast system. Hydrology and Earth System Sciences, 19(8), 3365-3385. https://doi.org/10.5194/hess-19-3365-2015U.S. Department of Agriculture, Natural Resources Conservation Service. 2010. National Engineering Handbook, Washington, DCVenâncio, A., Montero, P., Costa, P., Regueiro, S., Brands, S., Taboada, J. 2019. An Integrated Perspective of the Operational Forecasting System in Rías Baixas (Galicia, Spain) with Observational Data and End-Users. In International Conference on Computational Science (pp. 229-239). Springer, Cham. https://doi.org/10.1007/978-3-030-22747-0_18Wallemarq, P., Below, R., McLean, D. 2018. UNISDR and CRED report: Economic Losses, Poverty & Disasters (1998-2017).Wanders, N., Karssenberg, D., Roo, A.D., De Jong, S.M., Bierkens, M.F.P. 2014. The suitability of remotely sensed soil moisture for improving operational flood forecasting. Hydrology and Earth System Sciences, 18(6), 2343-2357. https://doi.org/10.5194/hess-18-2343-2014Weerts, A.H., Winsemius, H.C., Verkade, J.S. 2011. Estimation of predictive hydrological uncertainty using quantile regression: examples from the National Flood Forecasting System (England and Wales). Hydrology and Earth System Sciences, 15(1), 255-265. https://doi.org/10.5194/hess-15-255-2011Xia, X., Liang, Q., Ming, X. 2019. A full-scale fluvial flood modelling framework based on a high-performance integrated hydrodynamic modelling system (HiPIMS). Advances in Water Resources, 132, 103392. https://doi.org/10.1016/j.advwatres.2019.10339

Estilbenos como una alternativa sostenible al anhídrido sulfuroso en vinos

Resumen El anhídrido sulfuroso (SO2) es el conservante más empleado en la industria agroalimentaria y enológica por sus propiedades antioxidantes y antimicrobianas. Sin embargo, también es un alérgeno que puede provocar problemas de salud en personas sensibles a él. Por otra parte, la madera de poda procedente de los viñedos es uno de los principales subproductos de la industria vitivinícola, con un volumen estimado entre 2 y 4 toneladas por hectárea y año. Este subproducto vitícola contiene polifenoles, entre otros estilbenos bioactivos con propiedades saludables. En el presente trabajo se ha elaborado y caracterizado un extracto puro de estilbenos obtenido a partir de madera de poda de la vid, para utilizarlo como alternativa sostenible al SO2 en la elaboración de vinos blancos y rosados. Se evaluó el impacto del extracto sobre la calidad de los vinos (parámetros enológicos, color, compuestos fenólicos y perfil sensorial) tanto en el embotellado y a los doce meses del embotellado. En paralelo se evaluó la posible toxicidad del extracto. Los resultados obtenidos concluyen que el extracto puro de estilbenos, obtenido a partir de madera de poda de la vid, puede proponerse como alternativa natural y sostenible al empleo de SO2 en la vinificación de vinos blancos y rosados. Además, el extracto no mostró toxicidad ni in vitro ni in vivo

Variation in Susceptibility to Downy Mildew Infection in Spanish Minority Vine Varieties

Downy mildew is one of the most destructive diseases affecting grapevines (Vitis vinifera L.). Caused by the oomycete Plasmopara viticola (Berk. and Curt.) Berl. and de Toni, it can appear anywhere where vines are cultivated. It is habitually controlled by the application of phytosanitary agents (copper-based or systemic) at different stages of the vine growth cycle. This, however, is costly, can lead to reduced yields, has a considerable environmental impact, and its overuse close to harvest can cause fermentation problems. All grapevines are susceptible to this disease, although the degree of susceptibility differs between varieties. Market demands and European legislation on viticulture and the use of phytosanitary agents (art. 14 of Directive 128/2009/EC) now make it important to know the sensitivity of all available varieties, including minority varieties. Such knowledge allows for a more appropriate use of phytosanitary agents, fosters the commercial use of these varieties and thus increases the offer of wines associated with different terroirs, and helps identify material for use in crop improvement programmes via crossing or genetic transformation, etc. Over 2020–2021, the susceptibility to P. viticola of 63 minority vine varieties from different regions of Spain was examined in the laboratory using the leaf disc technique. Some 87% of these varieties were highly susceptible and 11% moderately susceptible; just 2% showed low susceptibility. The least susceptible of all was the variety Morate (Madrid, IMIDRA). Those showing intermediate susceptibility included the varieties Sanguina (Castilla la Mancha, IVICAM), Planta Mula (Comunidad Valenciana, ITVE), Rayada Melonera (Madrid, IMIDRA), Zamarrica (Galicia, EVEGA), Cariñena Roja (Cataluña, INCAVI), Mandrègue (Aragón, DGA) and Bastardo Blanco (Extremadura, CICYTEX). The highly susceptible varieties could be differentiated into three subgroups depending on sporulation severity and density

Variation in Susceptibility to Downy Mildew Infection in Spanish Minority Vine Varieties

Downy mildew is one of the most destructive diseases affecting grapevines (Vitis vinifera L.). Caused by the oomycete Plasmopara viticola (Berk. and Curt.) Berl. and de Toni, it can appear anywhere where vines are cultivated. It is habitually controlled by the application of phytosanitary agents (copper-based or systemic) at different stages of the vine growth cycle. This, however, is costly, can lead to reduced yields, has a considerable environmental impact, and its overuse close to harvest can cause fermentation problems. All grapevines are susceptible to this disease, although the degree of susceptibility differs between varieties. Market demands and European legislation on viticulture and the use of phytosanitary agents (art. 14 of Directive 128/2009/EC) now make it important to know the sensitivity of all available varieties, including minority varieties. Such knowledge allows for a more appropriate use of phytosanitary agents, fosters the commercial use of these varieties and thus increases the offer of wines associated with different terroirs, and helps identify material for use in crop improvement programmes via crossing or genetic transformation, etc. Over 2020–2021, the susceptibility to P. viticola of 63 minority vine varieties from different regions of Spain was examined in the laboratory using the leaf disc technique. Some 87% of these varieties were highly susceptible and 11% moderately susceptible; just 2% showed low susceptibility. The least susceptible of all was the variety Morate (Madrid, IMIDRA). Those showing intermediate susceptibility included the varieties Sanguina (Castilla la Mancha, IVICAM), Planta Mula (Comunidad Valenciana, ITVE), Rayada Melonera (Madrid, IMIDRA), Zamarrica (Galicia, EVEGA), Cariñena Roja (Cataluña, INCAVI), Mandrègue (Aragón, DGA) and Bastardo Blanco (Extremadura, CICYTEX). The highly susceptible varieties could be differentiated into three subgroups depending on sporulation severity and density.This work, performed by the VIOR (Viticultura, Olivo y Rosa) group of the Misión Biológica de Galicia (CSIC), forms part of the project “Valorización de variedades minoritarias de vid por su potencial para la diversificación vitivinícola. Resiliencia a enfermedades fúngicas influenciadas por el cambio climático” (MINORVIN) (RTI 2018-101085-RC32), funded by MCIN/AEI/, 10.13039/501100011033 and the European Regional Development Fund.info:eu-repo/semantics/publishedVersio

Nature-based strategies to regenerate the functioning and biodiversity of vineyards

16 páginas.- 2 figuras.- 1 Box.- 138 referenciasGrapevine is one of the most important perennial fruit crops worldwide. Historically, vineyards were compatible with soil conservation practices and multitrophic biodiversity, but vineyards are now generally eroded and biologically impoverished, making them more susceptible to pests and diseases. However, the idiosyncrasy of the wine sector places wine growers in a unique position to lead the adoption of a range of sustainable management strategies and, thus, to pioneer a wider transformation of the agricultural sector. In this article, we provide an overview of nature-based management strategies that may be used for the regeneration of the functioning and biodiversity of vineyards and that may also lead to improved plant nutrition, grape berry quality and the suppression of pathogens and pests. These strategies include the use of microbial and nonmicrobial biostimulants, fertilization with organic amendments as well as foliar fertilization with nature-based products, the use of cover crops and the reintegration of livestock in vineyards, especially sheep. We will also pay special attention to the implementation of circular economy in the vineyard in relation to the previously mentioned management strategies and will also discuss the importance of considering all these aspects from a holistic and integrative perspective, rather than taking them into account as single factors. Assuming the integral role of soils in the functioning of agroecosystems, soils will be considered transversally across all sections. Finally, we will argue that the time is now ripe for innovation from the public and private sectors to contribute to the sustainable management of vineyards while maintaining, or even improving, the profit margin for farmers and winemakers.This review article is, in part, the result of a workshop (I Jornadas ‘Suelos Vivos’ para la regeneración de la vida en suelos de viñedos gaditanos; https://suelosvivos.es/i-jornadas-suelos-vivos/) carried out within the context of the ‘Suelos Vivos’ Regional Operational Group of the EIP-Agri, which was celebrated between 23 and 24 March 2023 in Puerto Real, Cádiz. Raúl Ochoa-Hueso was supported by the Ramón y Cajal programme from the MICINN (RYC-2017 22032), by the Spanish Ministry of Science and Innovation for the I + D + i project PID2019-106004RA-I00 funded by MCIN/AEI/10.13039/501100011033, by the Fondo Europeo de Desarrollo Regional (FEDER) y la Consejería de Transformación Económica, Industria, Conocimiento y Universidades of the Junta de Andalucía (FEDER Andalucía 2014-2020 Objetivo temático ‘01 - Refuerzo de la investigación, el desarrollo tecnológico y la innovación’): P20_00323 (FUTUREVINES), and by the Fondo Europeo Agrícola de Desarrollo Rural (FEADER) through the ‘Ayudas a Grupos operativos de la Asociación Europea de Innovación (AEI) en materia de productividad y sostenibilidad agrícolas’, Referencia: GOPC-CA-20-0001. Manuel Delgado-Baquerizo acknowledges support from TED2021-130908B-C41/AEI/10.13039/501100011033/Unión Europea NextGenerationEU/PRTR and from the Spanish Ministry of Science and Innovation for the I + D + i project PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033. Cristina Lazcano acknowledges support from the California Department of Food and Agriculture (21-0433-021-SF) and the Foundation for Food and Agriculture Research (FFAR, CA21-SS-0000000193). Lilia Serrano-Grijalva thanks the European Union's Horizon 2020 research and innovation programme who funded her work under the Marie Skłodowska-Curie Grant Agreement No. 890874Peer reviewe