CP-odd static electromagnetic properties of the W gauge boson and the t quark via the anomalous tbW coupling

In the framework of the electroweak chiral Lagrangian, the one-loop induced effects of the anomalous $tbW$ coupling, which includes both left- and right-handed complex components, on the static electromagnetic properties of the $W$ boson and the $t$ quark are studied. The attention is focused mainly on the CP-violating electromagnetic properties. It is found that the $tbW$ anomalous coupling can induce both CP-violating moments of the $W$ boson, namely, its electric dipole ($\tilde{\mu}_W$) and magnetic quadrupole ($\tilde{Q}_W$) moments. As far as the $t$ quark is concerned, a potentially large electric dipole moment $(d_t)$ can arise due to the anomalous $tbW$ coupling. The most recent bounds on the left- and right-handed parameters from $B$ meson physics lead to the following estimates $\tilde{\mu}_W ~ 10^{-23}-10^{-22}$ e-cm and $\tilde{Q}_W~ 10^{-38}-10^{-37}$ e-cm$^2$, which are 7 and 14 orders of magnitude larger than the standard model (SM) predictions, whereas $d_t$ may be as large as $10^{-22}$ e-cm, which is about 8 orders of magnitude larger than its SM counterpart.Comment: This paper has been merged with hep-ph/0612171 for publication in Physical Review

Two-dimensional Quantum Black Holes, Branes in BTZ and Holography

We solve semiclassical Einstein equations in two dimensions with a massive source and we find a static, thermodynamically stable, quantum black hole solution in the Hartle-Hawking vacuum state. We then study the black hole geometry generated by a boundary mass sitting on a non-zero tension 1-brane embedded in a three-dimensional BTZ black hole. We show that the two geometries coincide and we extract, using holographic relations, information about the CFT living on the 1-brane. Finally, we show that the quantum black hole has the same temperature of the bulk BTZ, as expected from the holographic principle.Comment: 10 pages, 2 figures, RevTex, ``point particle of mass \mu '' changed with ``massive boundary source'' for better clarity. Action in (50) written in Z_2 symmetric form. Appendix clarified. Minor corrections and references added. Version accepted for pubblication in PRD15 (2006

A 20 GHz bright sample for {\delta} > +72{\deg}: I. Catalogue

During 2010-2011, the Medicina 32-m dish hosted the 7-feed 18-26.5 GHz receiver built for the Sardinia Radio Telescope, with the goal to perform its commissioning. This opportunity was exploited to carry out a pilot survey at 20 GHz over the area for {\delta} > + 72.3{\deg}. This paper describes all the phases of the observations, as they were performed using new hardware and software facilities. The map-making and source extraction procedures are illustrated. A customised data reduction tool was used during the follow-up phase, which produced a list of 73 confirmed sources down to a flux density of 115 mJy. The resulting catalogue, here presented, is complete above 200 mJy. Source counts are in agreement with those provided by the AT20G survey. This pilot activity paves the way to a larger project, the K-band Northern Wide Survey (KNoWS), whose final aim is to survey the whole Northern Hemisphere down to a flux limit of 50 mJy (5{\sigma}).Comment: 10 pages, 10 figures. Accepted by MNRA

Casimir-like tunneling-induced electronic forces

We study the quantum forces that act between two nearby conductors due to electronic tunneling. We derive an expression for these forces by calculating the flux of momentum arising from the overlap of evanescent electronic fields. Our result is written in terms of the electronic reflection amplitudes of the conductors and it has the same structure as Lifshitz's formula for the electromagnetically mediated Casimir forces. We evaluate the tunneling force between two semiinfinite conductors and between two thin films separated by an insulating gap. We discuss some applications of our results.Comment: 8 pages, 3 figs, submitted to Proc. of QFEXT'05, to be published in J. Phys.

Combined use of x-ray fluorescence microscopy, phase contrast imaging for high resolution quantitative iron mapping in inflamed cells

X-ray fluorescence microscopy (XRFM) is a powerful technique to detect and localize elements in cells. To derive information useful for biology and medicine, it is essential not only to localize, but also to map quantitatively the element concentration. Here we applied quantitative XRFM to iron in phagocytic cells. Iron, a primary component of living cells, can become toxic when present in excess. In human fluids, free iron is maintained at 10-18 M concentration thanks to iron binding proteins as lactoferrin (Lf). The iron homeostasis, involving the physiological ratio of iron between tissues/secretions and blood, is strictly regulated by ferroportin, the sole protein able to export iron from cells to blood. Inflammatory processes induced by lipopolysaccharide (LPS) or bacterial pathoge inhibit ferroportin synthesis in epithelial and phagocytic cells thus hindering iron export, increasing intracellular iron and bacterial multiplication. In this respect, Lf is emerging as an important regulator of both iron and inflammatory homeostasis. Here we studied phagocytic cells inflamed by bacterial LPS and untreated or treated with milk derived bovine Lf. Quantitative mapping of iron concentration and mass fraction at high spatial resolution is obtained combining X-ray fluorescence microscopy, atomic force microscopy and synchrotron phase contrast imaging

Efeito da palhada de trigo na emergência de digitaria insularis (capim-amargoso).

Herbicidas são importantes alternativas de controle, mas devem ser utilizados como parte integrante de um programa de manejo de plantas daninhas. Resultados de pesquisas mostram que o controle químico das plantas daninhas na Soja RR é facilitado ao ser integrado com outras práticas, especialmente como o cultivo de espécies que possibilitem a formação de palhada. Foram conduzidos dois experimentos em casa de vegetação , com o objetivo de avaliar os efeitos da palhada de trigo sobre a emergência de capim-amargoso, uma espécie que está se disseminado nas áreas de produção e apresenta biótipos resistentes ao glifosato. Cinquenta sementes viáveis de capim-amargoso foram semeadas em vasos plásticos com capacidade de 3,5 L, preparado com três partes de terra e uma parte de composto orgânico associado a adubo formulado. No primeiro experimento o solo foi superficialmente coberto com palha de trigo picada, tendo sido estabelecidas oito diferentes quantidades, cada uma representando um tratamento: 1. Sem cobertura ou 0 tonelada/ha; 2. Equivalente a 1 tonelada/ha; 3. Equivalente a 2 toneladas/ha; 4. Equivalente a 3 toneladas/ha; 5. Equivalente a 4 toneladas/ha; 6. O segundo experimento foi instalado com os mesmos tratamentos, adicionando-se mais um com o equivalente a 8 toneladas/há. Foi possível concluir que a palhada de trigo pode ser uma alternativa para compor o manejo integrado em áreas infestadas com capim-amargoso, desde que seja em quantidade igual ou superior a 4 toneladas por hectare

Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program

Background: The Italian Renal Cell Cancer Early Access Program was an expanded access program that allowed access to nivolumab, for patients (pts) with metastatic renal cell carcinoma (mRCC) prior to regulatory approval. Methods: Pts with previously treated advanced or mRCC were eligible to receive nivolumab 3 mg/kg every 2 weeks. Pts included in the analysis had received ≥1 dose of nivolumab and were monitored for drug-related adverse events (drAEs) using CTCAE v.4.0. Immune-related (ir) AEs were defined as AEs displaying a certain, likely or possible correlation with immunotherapy (cutaneous, endocrine, hepatic, gastro-intestinal and pulmonary). The association between overall survival (OS) and irAEs was assessed, and associations between variables were evaluated with a logistic regression model. Results: A total of 389 pts were enrolled between July 2015 and April 2016. Overall, the objective response rate was 23.1%. At a median follow-up of 12 months, the median progression-free survival was 4.5 months (95% CI 3.7-6.2) and the 12-month overall survival rate was 63%. Any grade and grade 3-4 drAEs were reported in 124 (32%) and 27 (7%) of pts, respectively, and there were no treatment-related deaths. Any grade irAEs occurred in 76 (20%) of patients, 8% cutaneous, 4% endocrine, 2% hepatic, 5% gastro-intestinal and 1% pulmonary. Of the 22 drAEs inducing treatment discontinuation, 10 (45%) were irAEs. Pts with drAEs had a significantly longer survival than those without drAEs (median OS 22.5 versus 16.4 months, p = 0.01). Pts with irAEs versus without irAEs had a more significant survival benefit (median OS not reached versus 16.8 months, p = 0.002), confirmed at the landmark analysis at 6 weeks. The occurrence of irAEs displayed a strong association with OS in univariable (HR 0.48, p = 0.003) and multivariable (HR 0.57, p = 0.02) analysis. Conclusions: The appearance of irAEs strongly correlates with survival benefit in a real-life population of mRCC pts treated with nivolumab

Calibration and Stokes Imaging with Full Embedded Element Primary Beam Model for the Murchison Widefield Array

15 pages, 11 figures. Accepted for publication in PASA. © Astronomical Society of Australia 2017The Murchison Widefield Array (MWA), located in Western Australia, is one of the low-frequency precursors of the international Square Kilometre Array (SKA) project. In addition to pursuing its own ambitious science program, it is also a testbed for wide range of future SKA activities ranging from hardware, software to data analysis. The key science programs for the MWA and SKA require very high dynamic ranges, which challenges calibration and imaging systems. Correct calibration of the instrument and accurate measurements of source flux densities and polarisations require precise characterisation of the telescope's primary beam. Recent results from the MWA GaLactic Extragalactic All-sky MWA (GLEAM) survey show that the previously implemented Average Embedded Element (AEE) model still leaves residual polarisations errors of up to 10-20 % in Stokes Q. We present a new simulation-based Full Embedded Element (FEE) model which is the most rigorous realisation yet of the MWA's primary beam model. It enables efficient calculation of the MWA beam response in arbitrary directions without necessity of spatial interpolation. In the new model, every dipole in the MWA tile (4 x 4 bow-tie dipoles) is simulated separately, taking into account all mutual coupling, ground screen and soil effects, and therefore accounts for the different properties of the individual dipoles within a tile. We have applied the FEE beam model to GLEAM observations at 200 - 231 MHz and used false Stokes parameter leakage as a metric to compare the models. We have determined that the FEE model reduced the magnitude and declination-dependent behaviour of false polarisation in Stokes Q and V while retaining low levels of false polarisation in Stokes U.Peer reviewedFinal Accepted Versio