351 research outputs found
Remarks of His Royal Highness the Prince Charles, Prince of Wales upon Dedication of the New Cleveland-Marshall College of Law Building
- Publication venue
- EngagedScholarship@CSU
- Publication date
- 01/01/1977
- Field of study
The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation
- Author
- Abbvie
- Albarouni
- All Wales Medicines Strategy Group
- All Wales Medicines Strategy Group
- All Wales Medicines Strategy Group
- All Wales Medicines Strategy Group
- Angeles-Han
- Arthritis Care
- Arthritis Care
- Arthritis Care
- Arthritis Care
- Arthritis Research UK
- Baildam
- Baildam
- Barton
- Baszis
- Bechtold
- Berard
- Bertilsson
- Briggs
- Briggs
- Bristol-Myers Squibb
- British Society for Paediatric and Adolescent Rheumatology
- British Society for Paediatric and Adolescent Rheumatology
- Brodszky
- Brunner
- Brunner
- Brunner
- Brunner
- Brunner
- Bruns
- Bucher
- Burgos-Vargas
- Burgos-Vargas
- Burgos-Vargas
- Burgos-Vargas
- Burgos-Vargas
- Burgos-Vargas
- Canadian Agency for Drugs and Technologies in Health
- Chang
- Chen
- Connock
- Consolaro
- Consolaro
- Consolaro
- Consolaro
- Cordero-Coma
- Costa
- Cummins
- Cummins
- Curtis
- Dakin
- De Benedetti
- De Benedetti
- Department of Health
- Dias
- Diaz-Llopis
- Donegan
- Drummond
- Duffy
- European Medicines Agency
- European Medicines Agency
- European Medicines Agency
- European Medicines Agency
- Feeny
- Foeldvari
- Gani
- Garcia-De-Vicuna
- Geikowski
- Giannini
- Glenny
- Haapasaari
- Heiligenhaus
- Hendry
- Higgins
- Higgins
- Horizon Scanning Centre
- Horneff
- Horneff
- Imagawa
- Joint Formulary Committee
- Kearsley-Fleet
- Kearsley-Fleet
- Kemper
- Khan
- Kingsbury
- Klein
- Kuhlthau
- Lloyd Jones
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Luca
- Luca
- Lundkvist
- Magli
- Malottki
- Martin
- McErlane
- McErlane
- Mills
- Minden
- Minden
- Monthly Index of Medical Specialties
- Moorthy
- National Institute for Health and Care Excellence
- National Institute for Health and Care Excellence
- National Institute for Health and Care Excellence
- National Institute for Health and Care Excellence
- National Rheumatoid Arthritis Society
- National Rheumatoid Arthritis Society (NRAS)
- NHS England Clinical Reference Group for Paediatric Medicine
- NHS England Specialised Services Clinical Reference Group for Specialised Ophthalmology
- Nikolakopoulou
- Office for National Statistics
- Otten
- Otten
- Packham
- Paediatric Formulary Committee
- Parsons
- Pennington
- Petty
- Pfizer Ltd
- Philips
- Prakken
- Prince
- Prince
- Prince
- Prince
- Ramanan
- Ravelli
- Ravelli
- Reeves
- Riemsma
- Rigante
- Roche
- Ruperto
- Ruperto
- Ruperto
- Ruperto
- Ruperto
- Ruperto
- Ruperto
- Simonini
- Simonini
- Simpson
- Simpson
- Simpson
- Smith
- Sonnenberg
- Stagi
- Stevenson
- Thierry
- Thomson
- Thornton
- Tong
- Tse
- Tynjala
- Ungar
- Ungar
- Vidqvist
- Wallace
- Wallace
- Wallace
- Yagudina
- Zannin
- Zeng
- Publication venue
- 'National Institute for Health Research'
- Publication date
- 01/04/2016
- Field of study
Background: Juvenile idiopathic arthritis (JIA) is characterised by joint pain, swelling and limitation of movement caused by inflammation. Subsequent joint damage can lead to disability and growth restriction. Treatment commonly includes disease modifying anti-rheumatic drugs (DMARD) such as methotrexate. Clinical practice now favours newer drugs termed biologic DMARDs where indicated.Objective: To assess the clinical and cost-effectiveness of four biologic DMARDs (etanercept, abatacept, adalimumab and tocilizumab - with or without methotrexate where indicated) for the treatment of JIA (systemic or oligoarticular JIA excluded).Data sources: Electronic bibliographic databases including MEDLINE, EMBASE, The Cochrane Library and DARE were searched for published studies from inception to May 2015 for English language articles. Bibliographies of related papers, systematic reviews and company submissions were screened and experts were contacted to identify additional evidence.Review methods: Systematic reviews of clinical-effectiveness, health-related quality of life and cost-effectiveness were undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. A cost-utility decision analytic model was developed to compare estimated cost-effectiveness of biologic DMARDs versus methotrexate. The base case time horizon was 30 years and the model took a National Health Service (NHS) perspective, with costs and benefits discounted at 3.5%.Results: Four placebo-controlled RCTs met the inclusion criteria for the clinical-effectiveness review (one RCT evaluating each biologic DMARD). Only one RCT included UK participants. Participants had to achieve an American College of Rheumatology Pediatric (ACR Pedi) 30 response to open-label lead-in treatment in order to be randomised. An exploratory adjusted indirect comparison suggests that the four biologic DMARDs are similar with fewer disease flares and greater proportions with ACR Pedi 50 and 70 responses among participants randomised to continued biologic DMARD. However, confidence intervals were wide, the number of trials was low and there was clinical heterogeneity between trials. Open-label extensions of the trials showed that generally ACR responses remained constant or even increased after the double-blind phase. The proportions of adverse events and serious adverse events were generally similar between treatment and placebo groups. Four economic evaluations of biologic DMARDs for patients with JIA were identified but all had limitations. Two quality of life studies were included, one of which informed the cost-utility model. The incremental cost-effectiveness ratio (ICER) for adalimumab, etanercept and tocilizumab versus methotrexate was ÂŁ38,127, ÂŁ32,526 and ÂŁ38,656 per QALY, respectively. The ICER for abatacept versus methotrexate as a second line biologic was ÂŁ39,536 per QALY.Limitations: The model does not incorporate the natural history of JIA in terms of long-term disease progression, as the current evidence is limited. There are no head-to-head trials of biologic DMARDs and clinical evidence for specific JIA subtypes is limited.Conclusions: Biologic DMARDs are superior to placebo (with methotrexate where permitted) in children with (predominantly) polyarticular course JIA, and an insufficient response to previous treatment. Randomised comparisons of biologic DMARDs with long-term efficacy and safety follow- are needed to establish comparative effectiveness. RCTs for JIA subtypes where evidence is lacking are also required.Funding: The National Institute for Health Research Health Technology Assessment programme. <br/
Nanotechnology, governance, and public deliberation: What role for the Social Sciences?
- Author
- Adam B.
- Bauman Z.
- Beck U.
- Bennett I.
- Bentley T.
- Better Regulation Task Force
- Brian Wynne
- Brown N.
- Brown N.
- Castells M.
- de Sousa Santos B.
- Department of Trade and Industry (DTI)
- Department of Trade and Industry (DTI)/Office of Science and Technology (OST)
- Drexler K. E.
- Erikson K.
- ETC Group
- European Commission
- European Environment Agency
- Fleck L.
- Grint K.
- Grove-White R.
- Grove-White R.
- HMGovernment
- HMTreasury/Department of Trade and Industry/Department of Education and Skills
- House of Lords
- HRHThe Prince of Wales
- Jessop B.
- Jonas H.
- Joy B.
- Kearnes M. B.
- Latour B.
- Latour B.
- Law J.
- Law J.
- Lux Research
- MacKenzie D.
- MacKenzie D.
- Macnaghten P.
- Marcus G.
- Marris C.
- Matthew B. Kearnes
- National Human Genome Research Institute
- National Science and Technology Council (NSTC) Interagency Working Group on Nanoscience Engineering and Technology (IWGN)
- Noble D.
- Noble D.
- Nordmann A.
- Nowotny H.
- Phil Macnaghten
- Power M.
- Prigogine I.
- Rip A.
- Rip A.
- Royal Commission on Environmental Pollution (RCEP)
- Royal Society
- Royal Society/Royal Academy of Engineering (RAE)
- Sarewitz D.
- Shapin S.
- Smith G.
- Squier S. M.
- Stirling A.
- Stirling A.
- Urry J.
- Wilsdon J.
- Wilsdon J.
- Winner L.
- Wood S.
- Wynne B.
- Wynne B.
- Publication venue
- SAGE Publications
- Publication date
- 01/12/2005
- Field of study
In this article we argue that nanotechnology represents an extraordinary opportunity to build in a robust role for the social sciences in a technology that remains at an early, and hence undetermined, stage of development. We examine policy dynamics in both the United States and United Kingdom aimed at both opening up, and closing down, the role of the social sciences in nanotechnologies. We then set out a prospective agenda for the social sciences and its potential in the future shaping of nanotechnology research and innovation processes. The emergent, undetermined nature of nanotechnologies calls for an open, experimental, and interdisciplinary model of social science research
Cultural Ecosystem Services: A Critical Assessment
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Validity of questionnaire-based assessment of sedentary behaviour and physical activity in a population-based cohort of older men; comparisons with objectively measured physical activity data
- Author
- AA Atienza
- AG Shaper
- Barbara J. Jefferis
- BE Ainsworth
- BJ Jefferis
- BK Clark
- CA Celis-Morales
- Chief Medical Officers of England Scotland Wales and Northern Ireland
- Claudio Sartini
- E Stamatakis
- EB Hekler
- EG Wilmot
- EJ Shiroma
- ES Ford
- ES Ford
- GN Healy
- J Cauwenberg Van
- JGZ Uffelen van
- JL Copeland
- KP Gennuso
- L DiPietro
- Lucy T. Lennon
- M Chaudhury
- M Visser
- M Walker
- MG Davis
- PA Gardiner
- Peter H. Whincup
- R core team. R
- R Craig
- RC Klesges
- RG Cumming
- S. Goya Wannamethee
- SA Prince
- Sarah Ash
- Sedentary Behaviour Research Network
- SG Wannamethee
- SG Wannamethee
- SG Wannamethee
- SG Wannamethee
- Standardization of Spirometry 1994 Update
- StataCorp
- T Sugiyama
- TJ Harris
- TL Hart
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Vertical capitalism: Skyscrapers and organization
- Author
- Bingham N.
- Burke E
- Cooper R.
- Dale K.
- Darley G
- Darnton E
- De Certeau M
- DeLillo D
- Dewey J
- Domosh M
- Dorrian M
- Dupré J
- Fainstein S
- Fenske G
- Fine L
- Frank W.
- Frongia A
- Goss J
- Guillen M
- Harvey D
- Hitchcock H.
- Jungk R
- Kant I
- King A
- Landau S.
- Leach N.
- Lindner C
- Marqusee M.
- Martin Parker
- Moudry R.
- Nye D
- Nye D
- Page M
- Prince of Wales
- Pye M
- Rand A
- Ruskin J
- Sabbagh K
- Schleier M
- Shaw P
- Sorkin M.
- Sudjic D
- Watts S
- Wells M
- Willis C
- Wolf R
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes GarcĂa F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (HellĂn Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
- Akhter Rahman M. M.
- Akin E.
- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
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- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
- Alcaide Matas F.
- Aldokali N.
- Alemanno G.
- Alfieri S.
- Alghamdi M.
- Alhamed A.
- Alharthi M.
- Alhassan N.
- Ali M.
- Ali S.
- Aliyeva Z.
- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
- Alonso Poza A.
- Alonso- Lamberti L.
- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
- Alshammari S.
- Alsharif F.
- Altintoprak F.
- Alvarez E.
- Alyami M.
- Alzamanan M.
- Amaral M. J.
- Amin Sahid N.
- Amira G.
- Amorim E.
- Anania G.
- Anastasi A.
- Andrade R.
- Angelou D.
- Annamalai S.
- Annessi V.
- Antic A.
- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
- Aprile A.
- Argentina: Alurralde C.
- Arican C.
- Arikan A. E.
- Arkadopoulos N.
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- Armatura G.
- Arminio A.
- Arrowsmith L. Campbell W. (Causeway Hospital)
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- Ashcroft J.
- Ashmore C.
- Ashoush F.
- Askari A.
- Asqalan A.
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- Athanasiou A.
- Atherton R.
- Attia D.
- Avci E. K.
- Aversano A.
- Ayasra F.
- Ayasra Y.
- Aydin C.
- Ayorinde J.
- Aytac E.
- Ayub B.
- Ayubi A.
- Ayyaz M. (Services Hospital Lahore)
- Azam M.
- Azamat Ä°. F.
- Azevedo P.
- Babar M. S.
- Baca B.
- Badra R.
- Baena Sanfeliu E.
- Bagraith K.
- Baiao J. M.
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- Baker A.
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- Bandara G. B. K. D.
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- Bartolini I.
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- Becker R. Jonescheit J. (Heilig-Geist Hospital Bensheim)
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- Bekheit M.
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- Bellora P.
- Belluco C.
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- Bergeat D. Merdrignac A. (CHU Rennes â General Surgery)
- Bernante P.
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- Bertolani E.
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- Bhangu A.
- Bhangu Aneel
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- Bianchini M.
- Bianco F.
- Bianco F. (ASST Papa Giovanni XXIII â Bergamo)
- Bigelow B. (Johns Hopkins Hospital)
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- Biondi A.
- Bisagni P.
- Bisset C. Moug S. J. (Royal Alexandra Hospital)
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- Bouche P. A. Tzedakis S. (HĂŽpital Cochin â APHP)
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- Caiado A.
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- Cakmak G.
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- Calvo Espino P. Guillamot Ruano P. (Hospital Universitario de MĂłstoles)
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- Caminsky N. G.
- Campagnaro T.
- Campus Benjamin Franklin)
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- Capitan- Morales L.
- Capolupo G. T. Mazzotta E. (Policlinico Universitario Campus Bio Medico of Rome)
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- Cardoso P.
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- Carvello M. M.
- Casati M.
- Casiraghi T.
- Cassinotti E. (Fondazione IRCCS Caâ Granda â Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
- Castro Ruiz C.
- Cato L. D.
- Cayetano Paniagua L. GĂłmez FernĂĄndez L. (Consorci Sanitari de Terrassa)
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- Cervellera M.
- Cervera I.
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- Chan E.
- Chand M.
- Charalabopoulos A.
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- Chatzikomnitsa P.
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- Cicerchia P. M.
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- Cirillo B.
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- Claro M.
- Clifford R.
- Clinical Centre of Serbia)
- Coccolini F.
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- Coffey J. C.
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- Collera P.
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- Costanzi A.
- Costeira B.
- Costigan F.
- Cotoia A.
- Cotte E.
- Coughlin P.
- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
- Cozza V.
- Creavin B.
- Crichton A.
- Cristian D.
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- Crugnale A. S.
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- Cullivan O.
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- Cuneo)
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- Cunningham R. M.
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- Dainius E.
- Daliya P.
- Daly A.
- Danias N.
- Daniels I. R.
- Davies E.
- Davies R. J.
- Day A. (East Surrey Hospital)
- De Andres Olabarria U.
- De Andrés Asenjo B.
- De Lacy F. B.
- De Manzoni Garberini A. (Ospedale Civile Spirito Santo)
- De Miguel Ardevines M. D. C.
- De Nardi P.
- De Palma G. D.
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- De Sousa X. (Centro Hospitalar de SetĂșbal)
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- Delrio P.
- Demir H.
- Demirli Atıcı S.
- Demyttenaere S.
- Denet C.
- Depalma N.
- Department of Biomedical Sciences
- Derksen T.
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- Di Marzo F. (Valtiberina)
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- Diez Alonso M.
- Dijan E.
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- Dincer H. A. Erol T. (Hacettepe University Hospital)
- Divya G S.
- Dixon J.
- Diéguez B.
- Domingos J. C.
- DomĂnguez I.
- Donati D.
- Doyle A.
- Duchalais E. (Nantes University Hospital). Germany: Bork U.
- Dudi-Venkata N. N.
- Duff S.
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- Duque-Mallén V.
- DurĂĄn Ballesteros M.
- Dwidar O.
- Dziakova J.
- DĂaz Peña P.
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- Eastmond A.
- Economopoulou P.
- Efthimiou M.
- Egan R.
- Egoroff N.
- El Ahmadi B.
- El Amrani M.
- El Bouazizi Y.
- Elawad A. (King Khalid Hospital)
- Elazzazy E.
- Eldaly A. S. (El-Menshawy Hospital)
- Elkadi H.
- Elliott J. A.
- Ellojli I.
- Elsey E.
- Emerson H.
- Emiroglu M.
- Emmanuel K.
- Emslie K.
- EPE)
- ErgĂŒn S.
- Escartin J.
- Escolà D. Jiménez A. (Comarcal Alt Penedés)
- Eskander M. (Aseer Central Hospital)
- Eskander P.
- Eskinazi D (Sanatorio 9 De Julio Sa)
- Espin-Basany E.
- Esposito G.
- Essam E.
- Estaire GĂłmez M.
- Esteban AgustĂ E.
- Etchill E.
- Evans C.
- Evans J.
- Eweda M.
- Ezanno A.
- Fabbri N.
- Fabre I.
- Fahey B. A.
- Fahmawee T.
- Fares Bucci A.
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- Sagnotta A. (Ospedale San Filippo Neri)
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- Sahnan K. (Northwick Park Hospital)
- Salazar A.
- Saleem A.
- Salem H.
- Salgado-Nesme N.
- SalimoÄlu S.
- Salindera S.
- Sallam I.
- Samih A.
- Samir Abdelaal A.
- Samison L. H. (Joseph Ravoahangy Andrianavalona Hospital). Malaysia: Hamdan K. H.
- Samkari A.
- Sammarco G.
- Sammour T. (Royal Adelaide Hospital)
- Sampaio da NĂłvoa Gomes Miguel I. I. (Centro Hospitalar UniversitĂĄrio do Algarve â Unidade de PortimĂŁo)
- Sampietro G. M. (Ospedale di Rho â ASST Rhodense)
- San Francisco (UCSF))
- Sanchez Cabezudo Noguera F.
- Sanchez Gonzalez J.
- Sanchez Jimenez R.
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- Santanach C.
- Santarrufina Martinez S.
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- Sarantitis I.
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- Sarjanoja E. (LĂ€nsi-Pohja Central Hospital)
- Sarma D. R.
- Sarre C. (Instituto Nacional de Ciencias MĂ©dicas y NutriciĂłn âSalvador ZubirĂĄnâ). Morocco: Amrani L.
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- Sarveswaran J.
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- Sasia D.
- SaudĂ S. (Hospital Universitario Miguel Servet)
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- Sauvat F. (CHU RĂ©union). Romania: Bezede C.
- SavkoviÄ N.
- Sayyed R. (Patel Hospital)
- Scabini S.
- Scalabre A. (Chu Saint Etienne)
- Scanu A. M. (Cliniche San Pietro
- Schiavo M. (Ospedale Vittorio Emanuele III â Carate Brianza)
- Schiergens T.
- Schineis C. (Charité University Medicine
- Schizas D.
- Schlesinger N.
- Schwartz P.
- Scott L. (Pinderfields Hospital)
- Scotton G. (St Moritz Hospital)
- Scrima O.
- Sechenov Medical State University)
- Seebah K.
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- Seguin-Givelet A.
- Sehgal T.
- Selmani J.
- Semina E. (Moscow Research and Educational Center
- Senossi O.
- Serevina O. L.
- Serralta de Colsa D. (Infanta SofĂa University Hospital)
- Serrano GonzĂĄlez J. (Hospital Universitario de TorrejĂłn de Ardoz)
- Serrano-Navidad M.
- Sert Ä°.
- Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
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- Shah Z. A.
- Shaikh I.
- Shaikh S.
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- Sibilla M. G.
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- Solari F.
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- Souadka A. (Institut National dâOncologie
- Soulikia K.
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- Spencer N.
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- Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
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- Syed W. A. S.
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- SĂĄnchez del Pueblo C.
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- SĂĄnchez- Pernaute A.
- SĂĄnchez- Rubio M.
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- Tanzanu M.
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- TU Dresden)
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- Universiti Sains Malaysia)
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- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
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- Zervas K.
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- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
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- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Islam and the West
- Publication venue
- ŰŹŰ§Ù ŰčŰ© Ű„Ù۱ÙÙÙۧ ۧÙŰčۧÙÙ ÙŰ© - Ù Ű±ÙŰČ Ű§ÙŰšŰÙŰ« ÙۧÙۯ۱ۧ۳ۧŰȘ ۧÙŰ„Ù۱ÙÙÙŰ©
- Publication date
- 01/12/1993
- Field of study
- âŠ