The Pseudotransannular Ring Opening of 1-Aminocyclohept-4-ene-derived Epoxides in the Synthesis of Tropane Alkaloids: Total Synthesis of (±)-Ferrugine

We have optimized a synthetic approach to (±)-Ferrugine in 8 steps starting from 5-aminocyclohept-1-ene and using the Brønsted acid-catalyzed pseudotransannular ring-opening of the epoxide derived from this cycloheptene as the key step for the construction of the 8-azabicyclo[3.2.1]octane central core. While attempting the enantioselective synthesis of this natural product from enantiopure 2-hydroxy-8-azabicyclo[3.2.1]octane we have found that this compound shows a pronounced tendency to racemize via an achiral symmetric aziridinium intermediate. This racemization side process has been studied in detail using both experimental and computational methods

Spectroscopic Observations of Convective Patterns in the Atmospheres of Metal-Poor Stars

Convective line asymmetries in the optical spectrum of two metal-poor stars, Gmb1830 and HD140283, are compared to those observed for solar metallicity stars. The line bisectors of the most metal-poor star, the subgiant HD140283, show a significantly larger velocity span that the expectations for a solar-metallicity star of the same spectral type and luminosity class. The enhanced line asymmetries are interpreted as the signature of the lower metal content, and therefore opacity, in the convective photospheric patterns. These findings point out the importance of three-dimensional convective velocity fields in the interpretation of the observed line asymmetries in metal-poor stars, and in particular, urge for caution when deriving isotopic ratios from observed line shapes and shifts using one-dimensional model atmospheres. The mean line bisector of the photospheric atomic lines is compared with those measured for the strong Mg I b1 and b2 features. The upper part of the bisectors are similar, and assuming they overlap, the bottom end of the stronger lines, which are formed higher in the atmosphere, goes much further to the red. This is in agreement with the expected decreasing of the convective blue-shifts in upper atmospheric layers, and compatible with the high velocity redshifts observed in the chromosphere, transition region, and corona of late-type stars.Comment: 27 pages, LaTeX; 10 Figures (14 PostScript files); to be published in The Astrophysical Journa

Mortalidad de los pacientes con manejo médico/quirúrgico en base al score Apache II

El score Acute Physiology and Chronic Health Evaluation II (APACHE II), es un sistema de valoración pronostica de mortalidad, que se fundamenta en la determinación de variables fisiológicas y de parámetros de laboratorio cuya puntuación es un factor predictivo de mortalidad. Los objetivos de este estudio fueron determinar la relación entre la mortalidad y el valor del APACHE II al ingreso en pacientes con manejo médico/quirúrgico; y determinar el punto de corte del score APACHE II.Estudio retrospectivo observacional, realizado en un Servicio de Terapia Intensiva polivalente médico quirúrgico de la ciudad de Corrientes durante el periodo comprendidodesde agosto de 2003 hasta julio de 2006. Se incluyeron a todos los pacientes mayores de 18 años que recibieron manejo médico/quirúrgico; elemento que se utilizó para dividirlosen dos grupos y comparar las mortalidades de cada uno y de cada subgrupo APACHE II.Se analizaron 1143 pacientes. La mortalidad general fue de 49%; 55% en el grupo de pacientes con manejo médico, y 39% en el grupo con manejo quirúrgico.El punto de corte del score APACHE II que predice mortalidad según la curva de ROC fue 14, y los pacientes con scores APACHE II bajos, que han recibido manejo médico, tienen una mayor probabilidad de muerte que aquellos que han tenido manejo quirúrgico; en cambio en los pacientes con APACHE II elevados, aquellos con manejo quirúrgico presentaron mayor mortalidad.

Sermon panegyrico, de los gloriosos santos San Cosme, y San Damian, que en el dia veinte y siete de Septiembre deste presente año de mil setecientos y diez y nueve, se predicò en el Convento de Nuestra Señora de Belèn ... desta Ciudad de Granada...

Fecha de imp. tomada del tít. y de las licenciasPort. orladaInic. grab.Apostillas marginales134253-7-14-H-99A-031-184 (10)A-D

Socio-economic status and the risk of developing hand, hip or knee osteoarthritis: a region-wide ecological study

SummaryObjectiveTo determine the association between socio-economic status (SES) and risk of hand, hip or knee osteoarthritis (OA) at a population level.DesignRetrospective ecological study using the System for the Development of Research in Primary Care (SIDIAP) database (primary care anonymized records for >5 million people in Catalonia (Spain)). Urban residents >15 years old (2009–2012) were eligible. Outcomes: Validated area-based SES deprivation index MEDEA (proportion of unemployed, temporary workers, manual workers, low educational attainment and low educational attainment among youngsters) was estimated for each area based on census data as well as incident diagnoses (ICD-10 codes) of hand, hip or knee OA (2009–2012). Zero-inflated Poisson models were fitted to study the association between MEDEA quintiles and the outcomes.ResultsCompared to the least deprived, the most deprived areas were younger (43.29 (17.59) vs 46.83 (18.49), years (Mean SD), had fewer women (49.1% vs 54.8%), a higher percentage of obese (16.2% vs 8.4%), smokers (16.9% vs 11.9%) and high-risk alcohol consumption subjects (1.5% vs 1.3%). Compared to the least deprived, the most deprived areas had an excess risk of OA: age-sex-adjusted Incidence Rate Ratio (IRR) 1.26 (1.11–1.42) for hand, 1.23 (1.17–1.29) hip, and 1.51 (1.45–1.57) knee. Adjustment for obesity attenuated this association: 1.06 (0.93–1.20), 1.04 (0.99–1.09), and 1.23 (1.19–1.28) respectively.ConclusionsDeprived areas have higher rates OA (hand, hip, knee). Their increased prevalence of obesity accounts for a 50% of the excess risk of knee OA observed. Public health interventions to reduce the prevalence of obesity in this population could reduce health inequalities

Suborbital Flight: An Affordable and Feasible Option for Mexican Aerospace Development

Suborbital flights are a low-cost option for universities. To perform suborbital missions, it is necessary to design, plan, test, verify, and validate each and every one of the subsystems that integrate the payload without leaving the Earth. In Mexico, some experiments have been carried out since the 1990s to test communication systems in case of disaster and emergency. The Mexican Service Gondola (CSM) from 2015 to date has made suborbital flights in conjunction with the National Polytechnic Institute and the group of Protective Coatings Resistant to Thermal Changes and Cosmic Radiation (CRTCR) to test communication systems and glass-ceramic coatings. Suborbital flights are a great opportunity to explore the national territory and test new communication systems, structures, and materials

Solar-like oscillations with low amplitude in the CoRoT target HD 181906

Context: The F8 star HD 181906 (effective temperature ~6300K) was observed for 156 days by the CoRoT satellite during the first long run in the centre direction. Analysis of the data reveals a spectrum of solar-like acoustic oscillations. However, the faintness of the target (m_v=7.65) means the signal-to-noise (S/N) in the acoustic modes is quite low, and this low S/N leads to complications in the analysis. Aims: To extract global variables of the star as well as key parameters of the p modes observed in the power spectrum of the lightcurve. Methods: The power spectrum of the lightcurve, a wavelet transform and spot fitting have been used to obtain the average rotation rate of the star and its inclination angle. Then, the autocorrelation of the power spectrum and the power spectrum of the power spectrum were used to properly determine the large separation. Finally, estimations of the mode parameters have been done by maximizing the likelihood of a global fit, where several modes were fit simultaneously. Results: We have been able to infer the mean surface rotation rate of the star (~4 microHz) with indications of the presence of surface differential rotation, the large separation of the p modes (~87 microHz), and therefore also the ridges corresponding to overtones of the acoustic modes.Comment: Paper Accepted to be published in A&A. 10 Pages, 12 figure