A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score

[Abstract] Aim: To derive a new clinical score to improve the prediction of those at risk of poor International Normalized Ratio control among patients with atrial fibrillation taking vitamin K antagonists. Materials & methods: The score was calculated using PAULA database and validated in the FANTASIIA population. Results: The DAFNE score (cardiovascular Disease, concomitant treatment with Amiodarone, Food/dietary transgression and taking ≥7 pills daily, fEemale sex) score was related to a higher probability of poor International Normalized Ratio control. C-indexes were 0.611 and 0.576 (De Long test, p = 0.007) for the DAFNE and SAMe-TT2R2 scores, respectively. Conclusion: The DAFNE score is a new clinical score which may potentially help determine those patients with atrial fibrillation who are at high risk of poor anticoagulation control with vitamin K antagonists

Estudio experimental y numérico del comportamiento de un modelo de difusor de aire por desplazamiento acoplado a un suelo frío

En la última década se han realizado muchos trabajos sobre sistemas de refrigeración para grandes superficies usando ventilación por desplazamiento con suelos radiantes (por ejemplo en aeropuertos y estaciones). De especial interés tiene el conocimiento de los campos de velocidad y de temperatura. De forma simplificada, en este estudio se presentan los resultados de un difusor a escala que utiliza ventilación por desplazamiento con suelo radiante frío. Tres son los parámetros que se modifican: el caudal (Q), la diferencia entre la temperatura ambiente y el aire de impulsión (dT1) y la diferencia entre la temperatura del suelo y el aire de impulsión (dT2). Las visualizaciones y mediciones del campo de velocidad del flujo se han realizado para un régimen laminar en estado estacionario. Además, las simulaciones numéricas del campo de temperatura representado en la figura muestran buena concordancia con los datos experimentales. Las zonas de mayor interés en este estudio son: la salida del difusor, la zona cercana al suelo y la zona lejos del difusor sobre el suelo, donde las condiciones de contorno se discuten con detalle. La distancia radial (r) para la que cada difusor afecta a su alrededor en los términos de gradiente de temperatura y de velocidad es un parámetro importante para el diseño de la distribución espacial de estos difusores. Los principales resultados de este trabajo se basan en la relación r = f (Q, dT1, dT2).AIRZON

Project overview and update on WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope

We present an overview of and status report on the WEAVE next-generation spectroscopy facility for the William Herschel Telescope (WHT). WEAVE principally targets optical ground-based follow up of upcoming ground-based (LOFAR) and space-based (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing a new 2-degree prime focus field of view at the WHT, with a buffered pick-and-place positioner system hosting 1000 multi-object (MOS) fibres, 20 integral field units, or a single large IFU for each observation. The fibres are fed to a single spectrograph, with a pair of 8k(spectral) x 6k (spatial) pixel cameras, located within the WHT GHRIL enclosure on the telescope Nasmyth platform, supporting observations at R~5000 over the full 370-1000nm wavelength range in a single exposure, or a high resolution mode with limited coverage in each arm at R~20000. The project is now in the final design and early procurement phase, with commissioning at the telescope expected in 2017.Comment: 11 pages, 11 Figures, Summary of a presentation to Astronomical Telescopes and Instrumentation 201

Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis

Background: Antipsychotics modulate expression of inflammatory cytokines and inducible inflammatory enzymes. Elopiprazole (a phenylpiperazine antipsychotic drug in phase 1) has been characterized as a therapeutic drug to treat SARS-CoV-2 infection in a repurposing study. We aim to investigate the potential effects of aripiprazole (an FDA approved phenylpiperazine) on COVID-19-related immunological parameters. Methods: Differential gene expression profiles of non-COVID-19 vs. COVID-19 RNA-Seq samples (CRA002390 project in GSA database) and drug-naïve patients with non-affective psychosis at baseline and after three months of aripiprazole treatment were identified. An integrative transcriptomic analyses of aripiprazole effects on differentially expressed genes in COVID-19 patients was performed. Findings: 82 out the 377 genes (21.7%) with expression significantly altered by aripiprazole have also their expression altered in COVID-19 patients and in 93.9% of these genes their expression is reverted by aripiprazole. The number of common genes with expression altered in both analyses is significantly higher than expected (Fisher?s Exact Test, two tail; p value = 3.2e-11). 11 KEGG pathways were significantly enriched with genes with altered expression both in COVID-19 patients and aripiprazole medicated non-affective psychosis patients (p adj<0.05). The most significant pathways were associated to immune responses and mechanisms of hyperinflammation-driven pathology (i.e.,?inflammatory bowel disease (IBD)? (the most significant pathway with a p adj of 0.00021), ?Th1 and Th2 cell differentiation? and ?B cell receptor signaling pathway?) that have been also associated with COVID19 clinical outcome. Interpretation: This exploratory investigation may provide further support to the notion that a protective effect is exerted by aripiprazole (phenylpiperazine) by modulating the expression of genes that have shown to be altered in COVID-19 patients. Along with many ongoing studies and clinical trials, repurposing available medications could be of use in countering SARS-CoV-2 infection, but require further studies and trials.Funding: The present study was part of a larger prospective longitudinal study, the “First Episode Psychosis Clinical Program 10” (PAFIP10) study. ClinicalTrials.gov Identifiers: NCT02200588, NCT03481465, and NCT03476473. No pharmaceutical industry or institutional sponsors participated in the study conception and design, data collection, analysis and interpretation of the results, or drafting of the manuscript. This work was supported by: SAF2016- 76046-R and SAF2013-46292-R (MINECO and FEDER) to B.C.F.Acknowledgments: We are highly indebted to the participants and their families for their cooperation in this study. We also thank IDIVAL biobank (Ines Santiuste and Jana Arozamena) for clinical samples and ́ data as well as the PAFIP members (Marga Corredera) for the data collection. We kindly thank all clinical staff at the Hospital Universitario Virgen del Rocio for support to collect clinical records and provide clinical care to COVID-19 patients. We also kindly thank Dra. Marisa Barrigon for helpful discussions regarding clinical data analysis, and Idalino Rocha for manuscript editing and formatting. This manuscript has been released as a pre-print at medRxiv. Available at: https://doi.org/ 10.1101/2020.12.05.20244590 (Crespo-Facorro et al., 2020)

Diseño herramienta estratégica para intervención del riesgo químico en población indígena cultivadora de planta de cachaco del Municipio de Coyaima.

Diseñar una herramienta estratégica de intervención del riesgo químico en la comunidad indígena del municipio de Coyaima cultivadora de Cachaco.La comunidad indígena del Pueblo los Pijaos del sur del departamento de Tolima, ubicado en el municipio de Coyaima, en la población Totarco Dinde Independiente se dedican a la explotación de la hoja del Plátano Cachaco perteneciente al grupo Musa ABB, hoja en la que se envuelve uno de los productos más típicos de Colombia, el tamal

2023 IMEKO TC-4 International Conference on Metrology for Archaeology and Cultural Heritage

This work summarizes the results of a three-year project focused on the archaeometrical study of a collection of about one thousand pre-Roman glass beads found at the archaeological site of Pintia (Valladolid, Spain), located at the interior of Iberia. In addition to the morphological and contextual analysis of the entire collection, a representative set of 150 samples, including several unique and exquisite polychrome beads, have been studied in detail by diverse archaeometric techniques such as Raman spectroscopy, X-ray fluorescence, PIXE/PIGE, X-ray tomography, among others. The combined use of these techniques provided valuable data about the production processes of the polychrome beads. Remarkably, some previous conceptions about their fabrication have been modified, and evidence about their production in secondary workshops has been provided. Moreover, hints about the origin of the primary glasses employed in all the studied samples have been obtained, suggesting their origin was scattered between Egypt and Syria-Palestine

Diseño herramienta estratégica para intervención del riesgo químico en población indígena cultivadora de planta de cachaco del Municipio de Coyaima.

Diseñar una herramienta estratégica de intervención del riesgo químico en la comunidad indígena del municipio de Coyaima cultivadora de Cachaco.La comunidad indígena del Pueblo los Pijaos del sur del departamento de Tolima, ubicado en el municipio de Coyaima, en la población Totarco Dinde Independiente se dedican a la explotación de la hoja del Plátano Cachaco perteneciente al grupo Musa ABB, hoja en la que se envuelve uno de los productos más típicos de Colombia, el tamal

Análisis de los cuellos de botella en la logística internacional de las PYMES de confecciones en Colombia.

Análisis de los cuellos de botella en la logistica internacional de las pymes de confecciones en Colombia. Se realiza un analisis de la situacion actual de la logistica nacional enfocada a las pymes de confeccion en Colombia, realizando un comparativo con el mercado mundial, se evaluan opciones de mejoramiento y su implementacion en el mercado de la confeccion nacional.Analysis of bottlenecks in the international logistics of clothing SMEs in Colombia. An analysis of the current situation of the national logistics focused on clothing SMEs in Colombia is carried out, making a comparison with the world market, improvement options and their implementation in the national clothing market are evaluated

Desarrollo de una herramienta para la evaluación de los examen tipo test y sus aplicaciones en la mejora de la calidad y en los criterios de evaluación de estos exámenes

Depto. de Radiología, Rehabilitación y FisioterapiaFac. de MedicinaFALSEsubmitte