624 research outputs found
Excitation of the odd-parity quasi-normal modes of compact objects
The gravitational radiation generated by a particle in a close unbounded
orbit around a neutron star is computed as a means to study the importance of
the modes of the neutron star. For simplicity, attention is restricted to
odd parity (``axial'') modes which do not couple to the neutron star's fluid
modes. We find that for realistic neutron star models, particles in unbounded
orbits only weakly excite the modes; we conjecture that this is also the
case for astrophysically interesting sources of neutron star perturbations. We
also find that for cases in which there is significant excitation of quadrupole
modes, there is comparable excitation of higher multipole modes.Comment: 18 pages, 21 figures, submitted to Phys. Rev.
Phase transition in the transverse Ising model using the extended coupled-cluster method
The phase transition present in the linear-chain and square-lattice cases of
the transverse Ising model is examined. The extended coupled cluster method
(ECCM) can describe both sides of the phase transition with a unified approach.
The correlation length and the excitation energy are determined. We demonstrate
the ability of the ECCM to use both the weak- and the strong-coupling starting
state in a unified approach for the study of critical behavior.Comment: 10 pages, 7 eps-figure
Salivary cortisone to estimate cortisol exposure and sampling frequency required based on serum cortisol measurements
Context: Population studies frequently measure cortisol as a marker of stress and excess cortisol is associated with increased mortality. Cortisol has a circadian rhythm and frequent blood sampling is impractical to assess exposure. We investigated measuring salivary cortisone and examined sampling frequency required to determine cortisol exposure. Methods: Serum and saliva with cortisol and cortisone measured by LC-MS/MS in independent cohorts. The relationship between serum cortisol and salivary cortisone was analysed in cohort 1 using a linear mixed effects model and resulting fixed effects component was applied to cohort 2. Saliva cannot easily be collected when sleeping so we determined minimum sampling required to estimate cortisol exposure (eAUC) using 24-hour cortisol profiles (AUC24) and calculated the relative error (RE - a measure similar to the coefficient of variation) for the eAUC. Results: >90% of variability in salivary cortisone could be accounted for by change in serum cortisol. A single serum cortisol measurement was a poor estimate of AUC24 especially in the morning or last thing at night (RE > 68%), however 3 equally spaced samples gave a median RE of 0% (Interquartile range (IQR) between -15.6% and 15.1%). In patients with adrenal incidentalomas the eAUC based on 3 serum cortisol samples showed a difference between those with autonomous cortisol secretion and those without (p=0.03). Interpretation: Accepting that most people sleep 7-8 hours, using approximately 8-hourly salivary cortisone measurements provides a non-invasive method of estimating 24-hour cortisol exposure for population studies
Resetting the Abnormal Circadian Cortisol Rhythm in Adrenal Incidentaloma Patients With Mild Autonomous Cortisol Secretion
Context
Adrenal incidentalomas (AIs) are found commonly on axial imaging. Around 30% exhibit autonomous cortisol secretion (ACS) associated with increased cardiovascular events and death.
Objective
We hypothesized that AI/ACS patients have an abnormal cortisol rhythm that could be reversed by use of carefully timed short-acting cortisol synthesis blockade, with improvement in cardiovascular disease markers.
Design, Setting, and Participants
In a phase 1/2a, prospective study (Eudract no. 2012-002586-35), we recruited six patients with AI/ACS and two control groups of six sex-, age-, and body mass index–matched individuals: (1) patients with AI and no ACS (AI/NoACS) and (2) healthy volunteers with no AI [healthy controls (HC)]. Twenty-four-hour circadian cortisol analysis was performed to determine any differences between groups and timing of intervention for cortisol lowering using the 11β-hydroxylase inhibitor metyrapone. Circadian profiles of serum interleukin-6 (IL-6) were assessed.
Results
Serum cortisol levels in group AI/ACS were significantly higher than both group AI/NoACS and group HC from 6 PM to 10 PM [area under the curve (AUC) difference: 0.81 nmol/L/h; P = 0.01] and from 10 PM to 2 AM (AUC difference: 0.86 nmol/L/h; P < 0.001). In light of these findings, patients with ACS received metyrapone 500 mg at 6 PM and 250 mg at 10 PM, and cortisol rhythms were reassessed. Postintervention evening serum cortisol was lowered, similar to controls [6 PM to 10 PM (AUC difference: –0.06 nmol/L/h; P = 0.85); 10 PM to 2 AM (AUC difference: 0.10 nmol/L/h; P = 0.76)]. Salivary cortisone showed analogous changes. IL-6 levels were elevated before treatment [10 PM to 2 PM (AUC difference: 0.42 pg/mL/h; P = 0.01)] and normalized post treatment.
Conclusions
In AI/ACS, the evening and nocturnal cortisol exposure is increased. Use of timed evening doses of metyrapone resets the cortisol rhythm to normal. This unique treatment paradigm is associated with a reduction in the cardiovascular risk marker IL-6
Energy relaxation of an excited electron gas in quantum wires: many-body electron LO-phonon coupling
We theoretically study energy relaxation via LO-phonon emission in an excited
one-dimensional electron gas confined in a GaAs quantum wire structure. We find
that the inclusion of phonon renormalization effects in the theory extends the
LO-phonon dominated loss regime down to substantially lower temperatures. We
show that a simple plasmon-pole approximation works well for this problem, and
discuss implications of our results for low temperature electron heating
experiments in quantum wires.Comment: 10 pages, RevTex, 4 figures included. Also available at
http://www-cmg.physics.umd.edu/~lzheng
Current-induced cooling phenomenon in a two-dimensional electron gas under a magnetic field
We investigate the spatial distribution of temperature induced by a dc
current in a two-dimensional electron gas (2DEG) subjected to a perpendicular
magnetic field. We numerically calculate the distributions of the electrostatic
potential phi and the temperature T in a 2DEG enclosed in a square area
surrounded by insulated-adiabatic (top and bottom) and isopotential-isothermal
(left and right) boundaries (with phi_{left} < phi_{right} and T_{left}
=T_{right}), using a pair of nonlinear Poisson equations (for phi and T) that
fully take into account thermoelectric and thermomagnetic phenomena, including
the Hall, Nernst, Ettingshausen, and Righi-Leduc effects. We find that, in the
vicinity of the left-bottom corner, the temperature becomes lower than the
fixed boundary temperature, contrary to the naive expectation that the
temperature is raised by the prevalent Joule heating effect. The cooling is
attributed to the Ettingshausen effect at the bottom adiabatic boundary, which
pumps up the heat away from the bottom boundary. In order to keep the adiabatic
condition, downward temperature gradient, hence the cooled area, is developed
near the boundary, with the resulting thermal diffusion compensating the upward
heat current due to the Ettingshausen effect.Comment: 25 pages, 7 figure
Computing gravitational waves from slightly nonspherical stellar collapse to black hole: Odd-parity perturbation
Nonspherical stellar collapse to a black hole is one of the most promising
gravitational wave sources for gravitational wave detectors. We numerically
study gravitational waves from a slightly nonspherical stellar collapse to a
black hole in linearized Einstein theory. We adopt a spherically collapsing
star as the zeroth-order solution and gravitational waves are computed using
perturbation theory on the spherical background. In this paper we focus on the
perturbation of odd-parity modes. Using the polytropic equations of state with
polytropic indices and 3, we qualitatively study gravitational waves
emitted during the collapse of neutron stars and supermassive stars to black
holes from a marginally stable equilibrium configuration. Since the matter
perturbation profiles can be chosen arbitrarily, we provide a few types for
them. For , the gravitational waveforms are mainly characterized by a
black hole quasinormal mode ringing, irrespective of perturbation profiles
given initially. However, for , the waveforms depend strongly on the
initial perturbation profiles. In other words, the gravitational waveforms
strongly depend on the stellar configuration and, in turn, on the ad hoc choice
of the functional form of the perturbation in the case of supermassive stars.Comment: 31 pages, accepted for publication in Phys. Rev. D, typos and minor
errors correcte
(A)cross-breed Genomic Prediction
Genomic prediction holds the promise to use information of other populations to improve prediction accuracy. Thus far, empirical evaluations showed limited benefit of multi-breed compared to single reed genomic prediction. We compared prediction accuracy of different models based on two losely related and one unrelated line of layer chickens. Multi-breed genomic prediction may be successful when lines are closely related, and when the number of training animals of the additional line is large compared to the line itself. Multi-breed genomic prediction requires models that are lexible enough to use beneficial and ignore detrimental sources of information in the training data. Combining linear and non-linear models may lead to small increases in accuracy of multibreed genomic prediction. Multitrait models, modelling a separate trait for each breed, appear especially beneficial when elationships between breeds are very low, or when the genetic correlation between breeds is negative
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Producing Policy-relevant Science by Enhancing Robustness and Model Integration for the Assessment of Global Environmental Change
We use the flexible model coupling technology known as the bespoke framework generator to link established existing modules representing dynamics in the global economy (GEMINI_E3), the energy system (TIAM-WORLD), the global and regional climate system (MAGICC6, PLASIM-ENTS and ClimGEN), the agricultural system, the hydrological system and ecosystems (LPJmL), together in a single integrated assessment modelling (IAM) framework, building on the pre-existing framework of the Community Integrated Assessment System. Next, we demonstrate the application of the framework to produce policy-relevant scientific information. We use it to show that when using carbon price mechanisms to induce a transition from a high-carbon to a low-carbon economy, prices can be minimised if policy action is taken early, if burden sharing regimes are used, and if agriculture is intensified. Some of the coupled models have been made available for use at a secure and user-friendly web portal. © 2018 The Author
Study of the production of and hadrons in collisions and first measurement of the branching fraction
The product of the () differential production
cross-section and the branching fraction of the decay () is
measured as a function of the beauty hadron transverse momentum, ,
and rapidity, . The kinematic region of the measurements is and . The measurements use a data sample
corresponding to an integrated luminosity of collected by the
LHCb detector in collisions at centre-of-mass energies in 2011 and in 2012. Based on previous LHCb
results of the fragmentation fraction ratio, , the
branching fraction of the decay is
measured to be \begin{equation*} \mathcal{B}(\Lambda_b^0\rightarrow J/\psi
pK^-)= (3.17\pm0.04\pm0.07\pm0.34^{+0.45}_{-0.28})\times10^{-4},
\end{equation*} where the first uncertainty is statistical, the second is
systematic, the third is due to the uncertainty on the branching fraction of
the decay , and the
fourth is due to the knowledge of . The sum of the
asymmetries in the production and decay between and
is also measured as a function of and .
The previously published branching fraction of , relative to that of , is updated.
The branching fractions of are determined.Comment: 29 pages, 19figures. All figures and tables, along with any
supplementary material and additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-032.htm
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