The dynamical environment of asteroid 21 Lutetia according to different internal models

One of the most accurate models currently used to represent the gravity field of irregular bodies is the polyhedral approach. In this model, the mass of the body is assumed to be homogeneous, which may not be true for a real object. The main goal of the present paper is to study the dynamical effects induced by three different internal structures (uniform, three- and four-layers) of asteroid (21) Lutetia, an object that recent results from space probe suggest being at least partially differentiated. The Mascon gravity approach used in the present work, consists of dividing each tetrahedron into eight parts to calculate the gravitational field around the asteroid. The zero-velocity curves show that the greatest displacement of the equilibrium points occurs in the position of the E4 point for the four-layers structure and the smallest one occurs in the position of the E3 point for the three-layers structure. Moreover, stability against impact shows that the planar limit gets slightly closer to the body with the four-layered structure. We then investigated the stability of orbital motion in the equatorial plane of (21) Lutetia and propose numerical stability criteria to map the region of stable motions. Layered structures could stabilize orbits that were unstable in the homogeneous model.Comment: 10 pages, 7 figures, and 4 Tables. Accepted for publication in MNRA

Analysis of the orbital evolution of space debris using a solar sail and natural forces

In this work, the orbital evolution of these objects that are located in the geostationary orbit (GEO) is analyzed. Knowing this, the possibility of using a solar sail is considered to help to clean the space environment. The main natural environmental perturbations that act in the orbit of the debris are considered in the dynamics. Such forces acting in the solar sail can force the growth of the eccentricity of these objects in the GEO orbit. Several authors have presented models of the solar radiation pressure considering the single-averaged model. But, doing a literature research, we found that the authors consider the Earth around the Sun in a circular and inclined orbit. Our contribution to the SRP model is in developing a different approach from other authors, where we consider the Sun in an elliptical and inclined orbit, which is valid for other bodies in the solar system when the eccentricity cannot be neglected. The expression of the SRP is developed up to the second order. We found that the first-order term is much superior to the second-order term, so the quadrupole term can be neglected. Another contribution is the approach to identify the initial conditions of the perigee argument (g) and the longitude of the ascending node (h), where some values of the (g, h) plane contribute to amplify the eccentricity growth. In the numerical simulations we consider real data from space debris removed from the site Stuff in Space. The solar sail helps to clean up the space environment using a propulsion system that uses the Sun itself, a clean and abundant energy source, unlike chemical propellants, to contribute to the sustainability of space exploration

Analysis of the secular problem for triple star systems

The long-term dynamics of the three-body problem is studied. the goal is to study the motion of a planet (m(1)) around a star (m(0)) that is perturbed by a third-body (m(2)) (a planet or a brown dwarf star). the gravitational potential is developed in closed form up to the fourth order. Taking into account the triple system, it is shown here the evolution of some orbital parameters of the planet (m(1)). A comparison considering models with different orders for the disturbing potential is presented. We show that the behavior of the orbit of the inner planet can flip from prograde to retrograde trajectories. This is due to the third-order term, which strongly affects the eccentricity and inclination. We show that the effect of the fourth order term is to change the times when the phenomenon occurs.Universidade Federal de São Paulo, UNIFESP ICT, Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo, UNIFESP ICT, Sao Jose Dos Campos, SP, BrazilWeb of Scienc

The use of Copernicus Marine Service products to describe the state of the Tropical Western Pacific Ocean around the Islands: a case study

Fiji served as President of the UN General Assembly in 2017, linking climate (SDG13) and ocean (SDG14) as the foundation of blue economies for island and coastal states around the world. The resulting United Nations Oceans outcome statement stressed “the importance of enhancing understanding of the health and role of our ocean and the stressors on its ecosystems, including through assessments on the state of the ocean, based on science and on traditional knowledge systems. We also stress the need to further increase marine scientific research to inform and support decision-making, and to promote knowledge hubs and networks to enhance the sharing of scientific data, best practices and ‘know-how.’” (UN, 2017). The Copernicus Marine Service Atlas for the Pacific Ocean States goes beyond the unique compilation of CMIP3 climate model projections and data tools compiled by the Pacific Climate Change Science Program (PCCSP, 2011, 2014). A complete overview of tropical Pacific observing network is available in the WMO publication library (GCOS, 2014a, 2014b). Our study focuses on the application of the available CMEMS products to the Pacific domain defined by PCCSP. As president of COP23, Prime Minister Frank Bainimarama has emphasized the importance of the climate and ocean connection and the need to protect ocean health to protect the planet: ‘We are all in the same canoe’ (https://cop23.com.fj/fijian-prime-minister-cop23-president-remarks-assuming-presidency-cop23/). The Copernicus Marine Service Atlas for Pacific Ocean States compiled by the author team responds directly to Fiji’s requests at the 2017 United Nation Oceans for SDG 14, life below water and the 2017 COP23 for SDG13, climate action which goes beyond the Pacific

Beyond the Fragmentation Threshold Hypothesis: Regime Shifts in Biodiversity Across Fragmented Landscapes

Ecological systems are vulnerable to irreversible change when key system properties are pushed over thresholds, resulting in the loss of resilience and the precipitation of a regime shift. Perhaps the most important of such properties in human-modified landscapes is the total amount of remnant native vegetation. In a seminal study Andrén proposed the existence of a fragmentation threshold in the total amount of remnant vegetation, below which landscape-scale connectivity is eroded and local species richness and abundance become dependent on patch size. Despite the fact that species patch-area effects have been a mainstay of conservation science there has yet to be a robust empirical evaluation of this hypothesis. Here we present and test a new conceptual model describing the mechanisms and consequences of biodiversity change in fragmented landscapes, identifying the fragmentation threshold as a first step in a positive feedback mechanism that has the capacity to impair ecological resilience, and drive a regime shift in biodiversity. The model considers that local extinction risk is defined by patch size, and immigration rates by landscape vegetation cover, and that the recovery from local species losses depends upon the landscape species pool. Using a unique dataset on the distribution of non-volant small mammals across replicate landscapes in the Atlantic forest of Brazil, we found strong evidence for our model predictions - that patch-area effects are evident only at intermediate levels of total forest cover, where landscape diversity is still high and opportunities for enhancing biodiversity through local management are greatest. Furthermore, high levels of forest loss can push native biota through an extinction filter, and result in the abrupt, landscape-wide loss of forest-specialist taxa, ecological resilience and management effectiveness. The proposed model links hitherto distinct theoretical approaches within a single framework, providing a powerful tool for analysing the potential effectiveness of management interventions

Predictors and pathways of language and motor development in four prospective cohorts of young children in Ghana, Malawi, and Burkina Faso

BackgroundPrevious reviews have identified 44 risk factors for poor early child development (ECD) in low- and middle-income countries. Further understanding of their relative influence and pathways is needed to inform the design of interventions targeting ECD.MethodsWe conducted path analyses of factors associated with 18-month language and motor development in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements (iLiNS) Project in Ghana (n = 1,023), Malawi (n = 675 and 1,385), and Burkina Faso (n = 1,122). In two cohorts, women were enrolled during pregnancy. In two cohorts, infants were enrolled at 6 or 9 months. In multiple linear regression and structural equation models (SEM), we examined 22 out of 44 factors identified in previous reviews, plus 12 additional factors expected to be associated with ECD.ResultsOut of 42 indicators of the 34 factors examined, 6 were associated with 18-month language and/or motor development in 3 or 4 cohorts: child linear and ponderal growth, variety of play materials, activities with caregivers, dietary diversity, and child hemoglobin/iron status. Factors that were not associated with child development were indicators of maternal Hb/iron status, maternal illness and inflammation during pregnancy, maternal perceived stress and depression, exclusive breastfeeding during 6 months postpartum, and child diarrhea, fever, malaria, and acute respiratory infections. Associations between socioeconomic status and language development were consistently mediated to a greater extent by caregiving practices than by maternal or child biomedical conditions, while this pattern for motor development was not consistent across cohorts.ConclusionsKey elements of interventions to ensure quality ECD are likely to be promotion of caregiver activities with children, a variety of play materials, and a diverse diet, and prevention of faltering in linear and ponderal growth and improvement in child hemoglobin/iron status

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for nervous system-specific recombination. Selective maternal or paternal germline recombination is showcased with sample Cre lines. Collated data reveal germline recombination in over half of 64 commonly used Cre driver lines, in most cases with a parental sex bias related to Cre expression in sperm or oocytes. Slight differences among Cre driver lines utilizing common transcriptional control elements affect germline recombination rates. Specific target loci demonstrated differential recombination; thus, reporters are not reliable proxies for another locus of interest. Similar principles apply to other recombinase systems and other genetically targeted organisms. We hereby draw attention to the prevalence of germline recombination and provide guidelines to inform future research for the neuroscience and broader molecular genetics communities

Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma

BACKGROUND: Sorafenib induces frequent dose limiting toxicities (DLT) in patients with advanced hepatocellular carcinoma (HCC). Sarcopenia has been associated with poor performance status and shortened survival in cancer patients. PATIENTS AND METHODS: The characteristics of Child Pugh A cirrhotic patients with HCC receiving sorafenib in our institution were retrospectively analyzed. Sorafenib plasma concentrations were determined at each visit. Toxicities were recorded during the first month of treatment, and sarcopenia was determined from baseline CT-scans. RESULTS: Forty patients (30 males) were included. Eleven (27.5%) were sarcopenic. Eighteen patients (45%) experienced a DLT during the first month of treatment. Sarcopenic patients experienced significantly more DLTs than non-sarcopenic patients did (82% versus 31%, p = 0.005). Grade 3 diarrhea was significantly more frequent in sarcopenic patients than in non-sarcopenic patients (45.5% versus 6.9%, p = 0.01), but not grade 3 hand foot syndrome reaction (9% versus 17.2%, p = 1). On day 28, median sorafenib AUC (n = 17) was significantly higher in sarcopenic patients (102.4 mg/l.h versus 53.7 mg/l.h, p = 0.013). CONCLUSIONS: Among cirrhotic Child Pugh A patients with advanced HCC, sarcopenia predicts sorafenib exposure and the occurrence of DLT within the first month of treatment

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. Tumor-derived exosomes usually contain tumor antigens and have been used as a source of tumor antigens to stimulate anti-tumor immune responses. However, many reports also suggest that tumor-derived exosomes can facilitate tumor immune evasion through different mechanisms, most of which are antigen-independent. In the present study we used a mouse model of delayed-type hypersensitivity (DTH) and demonstrated that local administration of tumor-derived exosomes carrying the model antigen chicken ovalbumin (OVA) resulted in the suppression of DTH response in an antigen-specific manner. Analysis of exosome trafficking demonstrated that following local injection, tumor-derived exosomes were internalized by CD11c+ cells and transported to the draining LN. Exosome-mediated DTH suppression is associated with increased mRNA levels of TGF-β1 and IL-4 in the draining LN. The tumor-derived exosomes examined were also found to inhibit DC maturation. Taken together, our results suggest a role for tumor-derived exosomes in inducing tumor antigen-specific immunosuppression, possibly by modulating the function of APCs. © 2011 Yang et al