Elaboración y caracterización de material de construcción a partir del reciclaje del bagazo de la caña de azúcar y plástico pet-2019.

El objetivo de la presente investigación fue elaborar y caracterizar un material de construcción a partir del reciclaje del bagazo de la caña de azúcar y plástico PET. La investigación es experimental puro, siendo de tipo, según su nivel o alcance, explicativa. La población estuvo conformada por 10.26 kg de plástico PET y 7.02 kg de bagazo de la caña de azúcar, para la elaboración de 36 probetas, distribuyéndose en unidades de probetas conformadas en concentraciones de plástico PET de 210 gr para P1, 360 gr para P2, y bagazo de la caña de azúcar con concentraciones de 250 gr para B1, 140 gr para B2. Para la técnica de observación experimental se empleó como instrumentos una ficha de registro de cantidades de plástico PET y bagazo de caña de azúcar-Tiempos empleados en proceso, así mismo para el análisis documental los documentos de laboratorio de ensayos físico-mecánicos. Logrando determinar que el material de construcción elaborado con las cantidades de 360gr de plástico PET y 250 gr de bagazo de la caña de azúcar, presenta mejores resultados en los ensayos físico-mecánicas, ya que logró soportar en los ensayos de tracción paralela una carga máxima de 689 kg con una resistencia de 9.19 kg/cm , así mismo en los ensayos de compresión paralela se obtuvo una carga máxima de 914 kg con una resistencia de 9 kg/cm 2 y finalmente en los ensayos de flexión estática una carga máxima de 678 kg con una resistencia de 6.61 kg/cm 2 ; resistencia que no llegan a cumplir con los parámetros de esfuerzos admisibles establecidos por la Norma E.010 Madera para uso estructural. Asimismo, se pudo determinar el costo de la elaboración del material de construcción con dicha composición que mejores resultados obtuvo, logrando estimar finalmente que el costo unitario es de S/ 1.90.

Mosaicos raster de cartografía vectorial: procedimiento automatizado de creación

En este documento se presenta una metodología, formada por un conjunto de tareas susceptibles de ser automatizadas, para producir un mosaico raster a partir de cartografía vectorial teselada. Como banco de prueba de la metodología se ha utilizado el Mapa Topográfico Nacional a escala 1:25.000 (MTN-25). La metodología propuesta implica: la eliminación de los elementos ajenos a la cartografía (cartela, etc.), la conversión de coordenadas proyectadas a geográficas, la creación de un mapa índice con la tesela para gestionar el mapa en modo continuo, la representación gráfica de la cartografía en forma de imagen en el sistema de referencia espacial deseado y, finalmente, la fusión de dichas imágenes. La característica que diferencia ésta metodología de otras, es el uso de un servicio de mapas en Web (WMS), implementado con MapServer, como herramienta que gestiona la tesela de archivos, realiza la representación gráfica y aplica las transformaciones necesarias entre sistemas de referencia espaciales. El producto generado con ésta metodología es un mosaico raster multi-resolución, de cartografía vectorial teselada, en formato de alta compresión (ECW). Este producto puede ser usados para, publicar de un modo más eficiente cartografía vectorial mediante servicios WMS, o como una capa raster en un sistema de información geográfica de escritorio

SERA: Sistema para la Evaluación y Retroalimentación Automática de Prácticas

En este artículo presentamos una sistema modular y altamente configurable que permite no sólo la generación y evaluación automática de prácticas de laboratorio sino también proporcionar una retroalimentación instantánea al estudiante para orientar el proceso de aprendizaje y fomentar su autonomía. Este sistema ha sido integrado dentro de la plataforma Moodle en varias asignaturas del Área de Ingeniería Telemática en la Universidad de Málaga.Este trabajo ha estado parcialmente financiado por el proyecto de innovación educativa PIE17-137 de la Universidad de Málaga

Intrahepatic Expression of Fatty Acid Translocase CD36 Is Increased in Obstructive Sleep Apnea

Nocturnal intermittent hypoxia (IH) featuring obstructive sleep apnea (OSA) dysregulates hepatic lipid metabolism and might contribute to the development of non-alcoholic fatty liver disease (NAFLD) observed in OSA patients. However, further research is required to better understanding the molecular mechanisms underlying IH-induced hepatic lipid accumulation. Therefore, the aim of the present study was to determine the effects of OSA on hepatic CD36 expression and the impact of IH by using a mouse model of OSA. Histological analysis, lipid content and CD36 expression were assessed in livers from subjects who underwent liver biopsy and polygraphic study during sleep, and in livers from mice submitted to chronic IH mimicking OSA. Among those who presented OSA features, NAFLD were significantly more frequent than in control subjects with normal respiratory function (77.8 vs. 36.4%, respectively), and showed more severe liver disease. Interestingly, CD36 expression was significantly overexpressed within the liver of OSA patients with respect to controls, and a significant positive correlation was observed between hepatic levels of CD36 and the values of two well-known respiratory parameters that characterized OSA: apnea/hypopnea index (AHI) and oxygen desaturation index (ODI). Moreover, hepatic lipid accumulation as well as induction of hepatic lipogenic genes, and CD36 mRNA and protein expression were significantly higher in livers from mice exposed to IH conditions for 8 weeks than in their corresponding littermates. This study provides novel evidence that IH featuring OSA could contribute to NAFLD setup partly by upregulating hepatic CD36 expression

A new design for the review and appraisal of semi-solid dosage forms: Semi-solid Control Diagram (SSCD)

The Semi-solid Control Diagram (SSCD) is a new tool designed for the study of different excipients and different semi-solid dosage forms. It can be used to review and evaluate different formulations and/or batches and facilitate the selection of one of them that will present the most suitable galenic characteristics for topical application. It is also useful to track stability studies by comparing the diagrams, which allows to measure the impact of subjecting the formulation to different conditions and times to be examined. In this study, the Semisolid Control Diagram (SSCD) is used as an instrument for studying and evaluating semisolid pharmaceutical dosage forms, by comparing several different semisolid preparations (lipogels). With these results, the tool is validated and the best formulation has been discriminated from the others

Proline-specific aminopeptidase P prevents replication-associated genome instability

Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular metabolism is less understood. We show that aminopeptidase P (APP1), a metalloprotease involved in the catabolism of peptides containing proline residues near their N-terminus, prevents replication-associated genome instability. Functional analysis of C. elegans mutants lacking APP-1 demonstrates that germ cells display replication defects including reduced proliferation, cell cycle arrest, and accumulation of mitotic DSBs. Despite these defects, app-1 mutants are competent in repairing DSBs induced by gamma irradiation, as well as SPO-11-dependent DSBs that initiate meiotic recombination. Moreover, in the absence of SPO-11, spontaneous DSBs arising in app-1 mutants are repaired as inter-homologue crossover events during meiosis, confirming that APP-1 is not required for homologous recombination. Thus, APP-1 prevents replication stress without having an apparent role in DSB repair. Depletion of APP1 (XPNPEP1) also causes DSB accumulation in mitotically-proliferating human cells, suggesting that APP1’s role in genome stability is evolutionarily conserved. Our findings uncover an unexpected role for APP1 in genome stability, suggesting functional connections between aminopeptidase-mediated protein catabolism and DNA replication

A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP

In neurons, power-law behavior with different scaling exponents has been reported at many different levels, including fluctuations in membrane potentials, synaptic transmission up to neuronal network dynamics. Unfortunately in most cases the source of this nonlinear feature remains controversial. Here we have analyzed the dynamics of spontaneous quantal release at hippocampal synapses and characterized their power-law behavior. While in control conditions a fractal exponent greater than zero was rarely observed, its value was greatly increased by α-latrotoxin (α-LTX), a potent stimulator of spontaneous release, known to act at the very last step of vesicle fusion. Based on computer modeling, we confirmed that at an increase in fusion probability would unmask a pre-docking phenomenon with 1/f structure, where α estimated from the release series appears to sense the increase in release probability independently from the number of active sites. In the simplest scenario the pre-docking 1/f process could coincide with the Brownian diffusion of synaptic vesicles. Interestingly, when the effect of long-term potentiation (LTP) was tested, a ∼200% long-lasting increase in quantal frequency was accompanied by a significant increase in the scaling exponent. The similarity between the action of LTP and of α-LTX suggests an increased contribution of high release probability sites following the induction of LTP. In conclusion, our results indicate that the source of the synaptic powerlaw behavior arises before synaptic vesicles dock to the active zone and that the fractal exponent α is capable of sensing a change in release probability independently from the number of active sites or synapses. © 2015 Lamanna, Signorini, Cerutti and Malgaroli

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