110 research outputs found
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abera Semaw Ferede
- Abraha Haftom Niguse
- Abu-Raddad Laith J.
- Abu-Rmeileh Niveen M.E.
- Adedeji Isaac Akinkunmi
- Adedoyin Rufus Adesoji
- Adetifa Ifedayo Morayo O.
- Adetokunboh Olatunji
- Afshin Ashkan
- Aggarwal Rakesh
- Agrawal Anurag
- Agrawal Sutapa
- Ahmad Kiadaliri Aliasghar
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibthiel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akanda Ali Shafqat
- Akinyemiju Tomi F.
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Raddadi Rajaa
- Alabed Samer
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alasfoor Deena
- Aldridge Robert William
- Alene Kefyalew Addis
- Alhabib Samia
- Ali Raghib
- Alizadeh-Navaei Reza
- Aljunid Syed M.
- Alkaabi Juma M.
- Alkerwi Ala'a
- Alla François
- Allam Shalini D.
- Allebeck Peter
- Alsharif Ubai
- Altirkawi Khalid A.
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Ameh Emmanuel A.
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Anber Nahla
- Andrei Catalina Liliana
- Androudi Sofia
- Ansari Hossein
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arora Megha
- Artaman Al
- Aryal Krishna Kumar
- Asayesh Hamid
- Asgedom Solomon Weldegebreal
- Asghar Rana Jawad
- Assadi Reza
- Atey Tesfay Mehari
- Atre Sachin R.
- Avila-Burgos Leticia
- Avokpaho Euripide Frinel G. Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Babalola Tesleem Kayode
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Balalla Shivanthi
- Barac Aleksandra
- Barber Ryan M.
- Barboza Miguel A.
- Barker-Collo Suzanne L.
- Barquera Simon
- Barregard Lars
- Barrero Lope H.
- Baune Bernhard T.
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Bekele Bayu Begashaw
- Bell Michelle L.
- Bello Aminu K.
- Bennett Derrick A.
- Bennett James R.
- Bensenor Isabela M.
- Benson Jennifer
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Beuran Mircea
- Beyene Addisu Shunu
- Bhala Neeraj
- Bhansali Anil
- Bhaumik Soumyadeep
- Bhutta Zulfiqar A.
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
- Bisanzio Donal
- Bizuayehu Habtamu Mellie
- Bjerregaard Peter
- Blosser Christopher D.
- Boneya Dube Jara
- Boufous Soufiane
- Bourne Rupert R.A.
- Brazinova Alexandra
- Breitborde Nicholas J.K.
- Brenner Hermann
- Brugha Traolach S.
- Bukhman Gene
- Bulto Lemma Negesa Bulto
- Bumgarner Blair Randal
- Burch Michael
- Butt Zahid A.
- Bärnighausen Till
- Béjot Yannick
- Cahill Leah E.
- Cahuana-Hurtado Lucero
- Campos-Nonato Ismael Ricardo
- Car Josip
- Car Mate
- Carpenter David O.
- Carrero Juan Jesus
- Carter Austin
- Castañeda-Orjuela Carlos A.
- Castillo Rivas Jacqueline
- Castro Franz F.
- Castro Ruben Estanislao
- Catalá-López Ferrán
- Chen Honglei
- Chiang Peggy Pei-Chia
- Chibalabala Mirriam
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Choi Jee-Young Jasmine
- Christensen Hanne
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Cirillo Massimo
- Cohen Aaron J.
- Colquhoun Samantha M.
- Coresh Josef
- Criqui Michael H.
- Cromwell Elizabeth A.
- Crump John A.
- Cárdenas Rosario
- Dandona Lalit
- Dandona Rakhi
- Dargan Paul I.
- Das Neves José
- Davey Gail
- Davitoiu Dragos V.
- Davletov Kairat
- De Courten Barbora
- De Leo Diego
- Degenhardt Louisa
- Deiparine Selina
- Dellavalle Robert P.
- Deribe Kebede
- Deribew Amare
- Des Jarlais Don C.
- Dey Subhojit
- Dharmaratne Samath D.
- Dherani Mukesh K.
- Diaz-Torné Cesar
- Ding Eric L.
- Dixit Priyanka
- Djalalinia Shirin
- Do Huyen Phuc
- Doku David Teye
- Donnelly Christl Ann
- Dos Santos Kadine Priscila Bender
- Douwes-Schultz Dirk
- Driscoll Tim R.
- Duan Leilei
- Dubey Manisha
- Duncan Bruce Bartholow
- Dwivedi Laxmi Kant
- Ebrahimi Hedyeh
- El Bcheraoui Charbel
- El Sayed Zaki Maysaa
- Ellingsen Christian Lycke
- Enayati Ahmadali
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Eshetie Setegn
- Eshrati Babak
- Eskandarieh Sharareh
- Esteghamati Alireza
- Estep Kara
- Fanuel Fanuel Belayneh Bekele
- Faro André
- Farvid Maryam S.
- Farzadfar Farshad
- Feigin Valery L.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Jefferson G.
- Fernandes João C.
- Feyissa Tesfaye Regassa
- Filip Irina
- Fischer Florian
- Foigt Nataliya
- Foreman Kyle J.
- Frank Tahvi
- Franklin Richard C.
- Fraser Maya
- Friedman Joseph
- Frostad Joseph J.
- Fullman Nancy
- Furtado Joao M.
- Futran Neal D.
- Fürst Thomas
- Gakidou Emmanuela
- Gambashidze Ketevan
- Gamkrelidze Amiran
- Gankpé Fortuné Gbètoho
- Garcia-Basteiro Alberto L.
- Gebregergs Gebremedhin Berhe
- Gebrehiwot Tsegaye Tewelde
- Gebrekidan Kahsu Gebrekirstos
- Gebremichael Mengistu Welday
- Gelaye Amha Admasie
- Geleijnse Johanna M.
- Gemechu Bikila Lencha
- Gemechu Kasiye Shiferaw
- Genova-Maleras Ricard
- Gesesew Hailay Abrha
- Gething Peter W.
- Gibney Katherine B.
- Gill Paramjit Singh
- Gillum Richard F.
- Giref Ababi Zergaw
- Girma Bedilu Weji
- Giussani Giorgia
- Goenka Shifalika
- Gomez Beatriz
- Gona Philimon N.
- Gopalani Sameer Vali
- Goulart Alessandra Carvalho
- Graetz Nicholas
- Gugnani Harish Chander
- Gupta Prakash C.
- Gupta Rahul
- Gupta Rajeev
- Gupta Tanush
- Gupta Vipin
- Haagsma Juanita A.
- Hafezi-Nejad Nima
- Haghparast Bidgoli Hassan
- Hakuzimana Alex
- Halasa Yara A.
- Hamadeh Randah Ribhi
- Hambisa Mitiku Teshome
- Hamidi Samer
- Hammami Mouhanad
- Hancock Jamie
- Handal Alexis J.
- Hankey Graeme J.
- Hao Yuantao
- Harb Hilda L.
- Hareri Habtamu Abera
- Harikrishnan Sivadasanpillai
- Haro Josep Maria
- Hassanvand Mohammad Sadegh
- Havmoeller Rasmus
- Hay Roderick J.
- Hay Simon I.
- He Fei
- Heredia-Pi Ileana Beatriz
- Herteliu Claudiu
- Hilawe Esayas Haregot
- Hoek Hans W.
- Horita Nobuyuki
- Hosgood H. Dean
- Hostiuc Sorin
- Hotez Peter J.
- Hoy Damian G.
- Hsairi Mohamed
- Htet Aung Soe
- Hu Guoqing
- Huang Hsiang
- Huang John J.
- Iburg Kim Moesgaard
- Igumbor Ehimario Uche
- Ileanu Bogdan Vasile
- Inoue Manami
- Irenso Asnake Ararsa
- Irvine Caleb M.S.
- Islam Nazrul
- Islam Sheikh Mohammed Shariful
- Jacobsen Kathryn H.
- Jaenisch Thomas
- Jahanmehr Nader
- Jakovljevic Mihajlo B.
- Javanbakht Mehdi
- Jayatilleke Achala Upendra
- Jeemon Panniyammakal
- Jensen Paul N.
- Jha Vivekanand
- Jin Ye
- John Denny
- John Oommen
- Johnson Sarah Charlotte
- Jonas Jost B.
- Jürisson Mikk
- Kabir Zubair
- Kadel Rajendra
- Kahsay Amaha
- Kalkonde Yogeshwar
- Kamal Ritul
- Kan Haidong
- Karch André
- Karema Corine Kakizi
- Karimi Seyed M.
- Karthikeyan Ganesan
- Kasaeian Amir
- Kassaw Nigussie Assefa
- Kassebaum Nicholas J.
- Kastor Anshul
- Katikireddi Srinivasa Vittal
- Kaul Anil
- Kawakami Norito
- Kazanjan Konstantin
- Keiyoro Peter Njenga
- Kelbore Sefonias Getachew
- Kemp Andrew Haddon
- Kengne Andre Pascal
- Keren Andre
- Kereselidze Maia
- Kesavachandran Chandrasekharan Nair
- Ketema Ezra Belay
- Khader Yousef Saleh
- Khalil Ibrahim A.
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khang Young-Ho
- Khera Sahil
- Khoja Abdullah Tawfih Abdullah
- Khosravi Mohammad Hossein
- Kibret Getiye Dejenu
- Kieling Christian
- Kim Cho-Il
- Kim Daniel
- Kim Pauline
- Kim Sungroul
- Kim Yun Jin
- Kimokoti Ruth W.
- Kinfu Yohannes
- Kishawi Sami
- Kissimova-Skarbek Katarzyna A.
- Kissoon Niranjan
- Kivimaki Mika
- Knudsen Ann Kristin
- Kokubo Yoshihiro
- Kopec Jacek A.
- Kosen Soewarta
- Koul Parvaiz A.
- Koyanagi Ai
- Kravchenko Michael
- Krohn Kristopher J.
- Kuate Defo Barthelemy
- Kucuk Bicer Burcu
- Kuipers Ernst J.
- Kulikoff Xie Rachel
- Kulkarni Veena S.
- Kumar G. Anil
- Kumar Pushpendra
- Kumsa Fekede Asefa
- Kutz Michael
- Lachat Carl
- Lagat Abraham K.
- Lager Anton Carl Jonas
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lambert Nkurunziza
- Lan Qing
- Lansingh Van C.
- Larson Heidi J.
- Larsson Anders
- Laryea Dennis Odai
- Lavados Pablo M.
- Laxmaiah Avula
- Lee Paul H.
- Leigh James
- Leung Janni
- Leung Ricky
- Levi Miriam
- Li Yongmei
- Liao Yu
- Liben Misgan Legesse
- Lim Stephen S.
- Linn Shai
- Lipshultz Steven E.
- Liu Shiwei
- Lodha Rakesh
- Logroscino Giancarlo
- Lopez Alan D.
- Lorch Scott A.
- Lorkowski Stefan
- Lotufo Paulo A.
- Lozano Rafael
- Lunevicius Raimundas
- Lyons Ronan A.
- Ma Stefan
- Macarayan Erlyn Rachelle King
- Machado Isis Eloah
- Mackay Mark T.
- Magdy Abd El Razek Mohammed
- Magis-Rodriguez Carlos
- Mahdavi Mahdi
- Mahesh
- Majdan Marek
- Majdzadeh Reza
- Majeed Azeem
- Malekzadeh Reza
- Malhotra Rajesh
- Malta Deborah Carvalho
- Mantovani Lorenzo G.
- Manyazewal Tsegahun
- Mapoma Chabila C.
- Marczak Laurie B.
- Marks Guy B.
- Martin Elena Alvarez
- Martinez-Raga Jose
- Martins-Melo Francisco Rogerlândio
- Massano João
- Maulik Pallab K.
- Mayosi Bongani M.
- Mazidi Mohsen
- McAlinden Colm
- McGarvey Stephen Theodore
- McGrath John J.
- McKee Martin
- Mehata Suresh
- Mehndiratta Man Mohan
- Mehta Kala M.
- Meier Toni
- Mekonnen Tefera Chane
- Meles Kidanu Gebremariam
- Memiah Peter
- Memish Ziad A.
- Mendoza Walter
- Mengesha Melkamu Merid
- Mengistie Mubarek Abera
- Mengistu Desalegn Tadese
- Menon Geetha R.
- Menota Bereket Gebremichael
- Mensah George A.
- Meretoja Atte
- Meretoja Tuomo J.
- Mezgebe Haftay Berhane
- Micha Renata
- Mikesell Joseph
- Miller Ted R.
- Mills Edward J.
- Minnig Shawn
- Mirarefin Mojde
- Mirrakhimov Erkin M.
- Misganaw Awoke
- Mishra Shiva Raj
- Mohammad Karzan Abdulmuhsin
- Mohammadi Alireza
- Mohammed Kedir Endris
- Mohammed Shafiu
- Mohan Murali B.V.
- Mohanty Sanjay K.
- Mokdad Ali H.
- Molla Assaye Ashagre
- Mollenkopf Sarah K.
- Molokhia Mariam
- Monasta Lorenzo
- Montañez Hernandez Julio Cesar
- Montico Marcella
- Mooney Meghan D.
- Moore Ami R.
- Moradi-Lakeh Maziar
- Moraga Paula
- Morawska Lidia
- Moreno Velasquez Ilais
- Mori Rintaro
- Morrison Shane D.
- Mruts Kalayu Birhane
- Mueller Ulrich O.
- Mullany Erin
- Muller Kate
- Murray Christopher J.L.
- Murthy Gudlavalleti Venkata Satyanarayana
- Murthy Srinivas
- Musa Kamarul Imran
- Nachega Jean B.
- Nagata Chie
- Nagel Gabriele
- Naghavi Mohsen
- Naidoo Kovin S.
- Nanda Lipika
- Nangia Vinay
- Nascimento Bruno Ramos
- Natarajan Gopalakrishnan
- Negoi Ionut
- Nguyen Cuong Tat
- Nguyen Grant
- Nguyen Quyen Le
- Nguyen Trang Huyen
- Ningrum Dina Nur Anggraini
- Nisar Muhammad Imran
- Nomura Marika
- Nong Vuong Minh
- Norheim Ole F.
- Norrving Bo
- Noubiap Jean Jacques N.
- Nyakarahuka Luke
- O'Donnell Martin J.
- Obermeyer Carla Makhlouf
- Ogbo Felix Akpojene
- Oh In-Hwan
- Okoro Anselm
- Oladimeji Olanrewaju
- Olagunju Andrew Toyin
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Oren Eyal
- Ortiz Alberto
- Osgood-Zimmerman Aaron
- Ota Erika
- Owolabi Mayowa O.
- Oyekale Abayomi Samuel
- Pacella Rosana E.
- Pakhale Smita
- Pana Adrian
- Panda Basant Kumar
- Panda-Jonas Songhomitra
- Park Eun-Kee
- Parsaeian Mahboubeh
- Patel Tejas
- Patten Scott B.
- Patton George C.
- Paudel Deepak
- Pereira David M.
- Perez-Padilla Rogelio
- Perez-Ruiz Fernando
- Perico Norberto
- Pervaiz Aslam
- Pesudovs Konrad
- Peterson Carrie Beth
- Petri William Arthur
- Petzold Max
- Phillips Michael Robert
- Piel Frédéric B.
- Pigott David M.
- Pishgar Farhad
- Plass Dietrich
- Polinder Suzanne
- Popova Svetlana
- Postma Maarten J.
- Poulton Richie G.
- Pourmalek Farshad
- Prasad Narayan
- Purwar Manorama
- Qorbani Mostafa
- Rabiee Rynaz H.S.
- Radfar Amir
- Rafay Anwar
- Rahimi-Movaghar Afarin
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
- Rahman Sajjad Ur
- Rai Rajesh Kumar
- Rajsic Sasa
- Ram Usha
- Rana Saleem M.
- Ranabhat Chhabi Lal
- Rao Paturi Vishnupriya
- Rawaf Salman
- Ray Sarah E.
- Rego Maria Albertina Santiago
- Rehm Jürgen
- Reiner Robert C.
- Remuzzi Giuseppe
- Renzaho Andre M.N.N.
- Resnikoff Serge
- Rezaei Satar
- Rezai Mohammad Sadegh
- Ribeiro Antonio L.
- Rokni Mohammad Bagher
- Ronfani Luca
- Roshandel Gholamreza
- Roth Gregory A.
- Rothenbacher Dietrich
- Roy Ambuj
- Rubagotti Enrico
- Ruhago George Mugambage
- Saadat Soheil
- Sabde Yogesh Damodar
- Sachdev Perminder S.
- Sadat Nafis
- Safdarian Mahdi
- Safi Sare
- Safiri Saeid
- Sagar Rajesh
- Sahathevan Ramesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Salama Joseph
- Salamati Payman
- Salomon Joshua A.
- Salvi Sundeep Santosh
- Samy Abdallah M.
- Sanabria Juan Ramon
- Sanchez-Niño Maria Dolores
- Santos Itamar S.
- Santric Milicevic Milena M.
- Sarmiento-Suarez Rodrigo
- Sartorius Benn
- Satpathy Maheswar
- Sawhney Monika
- Saxena Sonia
- Saylan Mete I.
- Schmidt Maria Inês
- Schneider Ione J.C.
- Schutte Aletta E.
- Schwebel David C.
- Schwendicke Falk
- Seedat Soraya
- Seid Abdulbasit Musa
- Sepanlou Sadaf G.
- Servan-Mori Edson E.
- Shackelford Katya Anne
- Shaheen Amira
- Shahraz Saeid
- Shaikh Masood Ali
- Shamsipour Mansour
- Shamsizadeh Morteza
- Sharma Jayendra
- Sharma Rajesh
- She Jun
- Shen Jiabin
- Shetty Balakrishna P.
- Shi Peilin
- Shibuya Kenji
- Shigematsu Mika
- Shiri Rahman
- Shiue Ivy
- Shrime Mark G.
- Sigfusdottir Inga Dora
- Silberberg Donald H.
- Silpakit Naris
- Silva Diego Augusto Santos
- Silva João Pedro
- Silveira Dayane Gabriele Alves
- Sindi Shireen
- Singh Abhishek
- Singh Jasvinder A.
- Singh Prashant Kumar
- Singh Virendra
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Sligar Amber
- Smith David L.
- Sobaih Badr H.A.
- Sobngwi Eugene
- Soneji Samir
- Soriano Joan B.
- Sreeramareddy Chandrashekhar T.
- Srinivasan Vinay
- Stathopoulou Vasiliki
- Steel Nicholas
- Stein Dan J.
- Steiner Caitlyn
- Stokes Mark Andrew
- Strong Mark
- Stöckl Heidi
- Sufiyan Muawiyyah Babale
- Suliankatchi Rizwan Abdulkader
- Sunguya Bruno F.
- Sur Patrick J.
- Swaminathan Soumya
- Sykes Bryan L.
- Szoeke Cassandra E.I.
- Tabarés-Seisdedos Rafael
- Tadakamadla Santosh Kumar
- Tadese Fentaw
- Tandon Nikhil
- Tanne David
- Tarajia Musharaf
- Tavakkoli Mohammad
- Taveira Nuno
- Tehrani-Banihashemi Arash
- Tekelab Tesfalidet
- Tekle Dejen Yemane
- Temam Shifa Girma
- Temsah Mohamad-Hani
- Terkawi Abdullah Sulieman
- Tesema Cheru Leshargie
- Tesssema Belay
- Theis Andrew
- Thomas Nihal
- Thompson Alex H.
- Thomson Alan J.
- Thrift Amanda G.
- Tiruye Tenaw Yimer
- Tobe-Gai Ruoyan
- Tonelli Marcello
- Topor-Madry Roman
- Topouzis Fotis
- Tortajada Miguel
- Tran Bach Xuan
- Truelsen Thomas
- Trujillo Ulises
- Tsilimparis Nikolaos
- Tuem Kald Beshir
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley Nnanna
- Undurraga Eduardo A.
- Uthman Olalekan A.
- Uzochukwu Benjamin S. Chudi
- Van Boven Job F.M.
- Varakin Yuri Y.
- Varughese Santosh
- Vasankari Tommi
- Vasconcelos Ana Maria Nogales
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Violante Francesco S.
- Vishnu Abhishek
- Vladimirov Sergey K.
- Vlassov Vasiliy Victorovich
- Vollset Stein Emil
- Vos Theo
- Waid Jillian L.
- Wakayo Tolassa
- Wang Haidong
- Wang Yuan-Pang
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G.
- Werdecker Andrea
- Wesana Joshua
- Wijeratne Tissa
- Wilkinson James D.
- Wiysonge Charles Shey
- Woldeyes Belete Getahun
- Wolfe Charles D.A.
- Workicho Abdulhalik
- Workie Shimelash Bitew
- Xavier Denis
- Xu Gelin
- Yaghoubi Mohsen
- Yakob Bereket
- Yalew Ayalnesh Zemene
- Yan Lijing L.
- Yano Yuichiro
- Yaseri Mehdi
- Ye Pengpeng
- Yimam Hassen Hamid
- Yip Paul
- Yirsaw Biruck Desalegn
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Zaidi Zoubida
- Zeeb Hajo
- Zenebe Zerihun Menlkalew
- Zerfu Taddese Alemu
- Zhang Anthony Lin
- Zhang Xueying
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016.
METHODS: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0·5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone.
FINDINGS: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86·9 years (95% UI 86·7-87·2), and for men in Singapore, at 81·3 years (78·8-83·7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, an
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
- Author
- Abbott R.
- Abbott T.D.
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- Publication venue
- London : Institute of Physics Publ.
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
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- London : Institute of Physics Publ.
- Publication date
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- Field of study
Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets. © 2022. The Author(s). Published by the American Astronomical Society
An Exploration of Counter-Intuitive Conceptual Structures in Organizational Stories
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- Yanow D.
- Publication venue
- 'Human Kinetics'
- Publication date
- Field of study
Modulating mitophagy in mitochondrial disease
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- Anderson S.
- Beal M.F.
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- 'Bentham Science Publishers Ltd.'
- Publication date
- 01/01/2017
- Field of study
Mitochondrial diseases may result from mutations in the maternally-inherited mitochondrial DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi-genomic nature makes mitochondrial diseases a very heterogeneous group of disorders that can present at any age and can affect any type of tissue. The autophagic-lysosomal degradation pathway plays an important role in clearing dysfunctional and redundant mitochondria through a specific quality control mechanism termed mitophagy. Mitochondria could be targeted for autophagic degradation for a variety of reasons including basal turnover for recycling, starvation induced degradation, and degradation due to damage. While the core autophagic machinery is highly conserved and common to most pathways, the signaling pathways leading to the selective degradation of damaged mitochondria are still not completely understood. Type 1 mitophagy due to nutrient starvation is dependent on PI3K (phosphoinositide 3-kinase) for autophagosome formation but independent of mitophagy proteins, PINK1 (PTEN-induced putative kinase 1) and Parkin. Whereas type 2 mitophagy that occurs due to damage is dependent on PINK1 and Parkin but does not require PI3K. Autophagy and mitophagy play an important role in human disease and hence could serve as therapeutic targets for the treatment of mitochondrial as well as neurodegenerative disorders. Therefore, we reviewed drugs that are known modulators of autophagy (AICAR and metformin) and may effect this by activating the AMP-activated protein kinase signaling pathways. Furthermore, we reviewed data available on supplements, such as Coenzyme Q and the quinone idebenone, that we assert rescue increased mitophagy in mitochondrial disease by benefiting mitochondrial function
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980�2015: a systematic analysis for the Global Burden of Disease Study 2015
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- Publication date
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- Field of study
Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14�294 geography�year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, life expectancy from birth increased from 61·7 years (95 uncertainty interval 61·4�61·9) in 1980 to 71·8 years (71·5�72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7�17·4), to 62·6 years (56·5�70·2). Total deaths increased by 4·1 (2·6�5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0 (15·8�18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1 (12·6�16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1 (11·9�14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1, 39·1�44·6), malaria (43·1, 34·7�51·8), neonatal preterm birth complications (29·8, 24·8�34·9), and maternal disorders (29·1, 19·3�37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146�000 deaths, 118�000�183�000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393�000 deaths, 228�000�532�000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost YLLs) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. Interpretation At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems. Funding Bill & Melinda Gates Foundation. © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licens
A joint Fermi-GBM and Swift-BAT analysis of gravitational-wave candidates from the third gravitational-wave observing run
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- Xiao L.
- Yamada T.
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- Yamamoto K.
- Yamamoto T.
- Yamashita K.
- Yamazaki R.
- Yang F.W.
- Yang K.Z.
- Yang L.
- Yang Y.
- Yang Y.
- Yang Y.-C.
- Yap M.J.
- Yeeles D.W.
- Yeh S.-W.
- Yelikar A.B.
- Ying M.
- Yokoyama J.
- Yokozawa T.
- Yoo J.
- Yoshioka T.
- Yu H.
- Yu H.
- Yuzurihara H.
- Zadrożny A.
- Zanolin M.
- Zeidler S.
- Zelenova T.
- Zendri J.-P.
- Zevin M.
- Zhan M.
- Zhang H.
- Zhang J.
- Zhang L.
- Zhang R.
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Y.
- Zhao Y.
- Zhou R.
- Zhou Z.
- Zhu X.J.
- Zhu Z.-H.
- Zimmerman A.B.
- Zucker M.E.
- Zweizig J.
- Publication venue
- American Astronomical Society
- Publication date
- 01/04/2024
- Field of study
We present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational-wave (GW) candidate events identified during the third observing run of the Advanced LIGO and Advanced Virgo detectors. Using Fermi-GBM onboard triggers and subthreshold gamma-ray burst (GRB) candidates found in the Fermi-GBM ground analyses, the Targeted Search and the Untargeted Search, we investigate whether there are any coincident GRBs associated with the GWs. We also search the Swift-BAT rate data around the GW times to determine whether a GRB counterpart is present. No counterparts are found. Using both the Fermi-GBM Targeted Search and the Swift-BAT search, we calculate flux upper limits and present joint upper limits on the gamma-ray luminosity of each GW. Given these limits, we constrain theoretical models for the emission of gamma rays from binary black hole mergers
Search for gravitational-wave transients associated with magnetar bursts in advanced LIGO and advanced Virgo data from the third observing run
- Author
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- Abe H
- Acernese F
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- Ying M
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- Zweizig J
- Publication venue
- American Astronomical Society
- Publication date
- 01/01/2024
- Field of study
Gravitational waves are expected to be produced from neutron star oscillations associated with magnetar giant f lares and short bursts. We present the results of a search for short-duration (milliseconds to seconds) and longduration (∼100 s) transient gravitational waves from 13 magnetar short bursts observed during Advanced LIGO, Advanced Virgo, and KAGRA’s third observation run. These 13 bursts come from two magnetars, SGR1935 +2154 and SwiftJ1818.0−1607. We also include three other electromagnetic burst events detected by FermiGBM which were identified as likely coming from one or more magnetars, but they have no association with a known magnetar. No magnetar giant flares were detected during the analysis period. We find no evidence of gravitational waves associated with any of these 16 bursts. We place upper limits on the rms of the integrated incident gravitational-wave strain that reach 3.6 × 10−²³ Hz at 100 Hz for the short-duration search and 1.1 ×10−²² Hz at 450 Hz for the long-duration search. For a ringdown signal at 1590 Hz targeted by the short-duration search the limit is set to 2.3 × 10−²² Hz. Using the estimated distance to each magnetar, we derive upper limits upper limits on the emitted gravitational-wave energy of 1.5 × 1044 erg (1.0 × 1044 erg) for SGR 1935+2154 and 9.4 × 10^43 erg (1.3 × 1044 erg) for Swift J1818.0−1607, for the short-duration (long-duration) search. Assuming isotropic emission of electromagnetic radiation of the burst fluences, we constrain the ratio of gravitational-wave energy to electromagnetic energy for bursts from SGR 1935+2154 with the available fluence information. The lowest of these ratios is 4.5 × 103
Open data from the third observing run of LIGO, Virgo, KAGRA, and GEO
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- Publication venue
- American Astronomical Society
- Publication date
- 01/01/2023
- Field of study
The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages
Constraints on the cosmic expansion history from GWTC–3
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- Wang J.Z.
- Wang W.H.
- Ward R.L.
- Warner J.
- Was M.
- Washimi T.
- Washington N.Y.
- Watchi J.
- Weaver B.
- Weaving C.R.
- Webster S.A.
- Weinert M.
- Weinstein A.J.
- Weiss R.
- Weller C.M.
- Weller R.A.
- Wellmann F.
- Wen L.
- Wette K.
- Weßels P.
- Whelan J.T.
- White D.D.
- Whiting B.F.
- Whittle C.
- Wilken D.
- Williams D.
- Williams M.J.
- Williamson A.R.
- Willis J.L.
- Willke B.
- Wilson D.J.
- Wipf C.C.
- Wlodarczyk T.
- Woan G.
- Woehler J.
- Wofford J.K.
- Wong D.
- Wong I.C.F.
- Wrangel J.S.A.V.
- Wright M.
- Wu C.
- Wu D.S.
- Wu H.
- Wysocki D.M.
- Xiao L.
- Yamada T.
- Yamamoto H.
- Yamamoto K.
- Yamamoto T.
- Yamashita K.
- Yamazaki R.
- Yang F.W.
- Yang K.Z.
- Yang L.
- Yang Y.
- Yang Y.
- Yang Y.-C.
- Yap M.J.
- Yeeles D.W.
- Yeh S.-W.
- Yelikar A.B.
- Ying M.
- Yokoyama J.
- Yokozawa T.
- Yoo J.
- Yoshioka T.
- Yu H.
- Yu H.
- Yuzurihara H.
- Zadrożny A.
- Zanolin M.
- Zeidler S.
- Zelenova T.
- Zendri J.-P.
- Zevin M.
- Zhan M.
- Zhang H.
- Zhang J.
- Zhang L.
- Zhang R.
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Y.
- Zhao Y.
- Zhou R.
- Zhou Z.
- Zhu X.J.
- Zhu Z.-H.
- Zimmerman A.B.
- Zucker M.E.
- Zweizig J.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/06/2023
- Field of study
We use 47 gravitational wave sources from the Third LIGO–Virgo–Kamioka Gravitational Wave Detector Gravitational Wave Transient Catalog (GWTC–3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0. Each gravitational wave (GW) signal provides the luminosity distance to the source, and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34 M⊙, followed by a drop-off. Assuming this mass scale does not evolve with the redshift results in a H(z) measurement, yielding H0=68−8+12km s−1Mpc−1 (68% credible interval) when combined with the H0 measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0 estimate from GWTC–1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of H0=68−6+8km s−1Mpc−1 with the galaxy catalog method, an improvement of 42% with respect to our GWTC–1 result and 20% with respect to recent H0 studies using GWTC–2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0) is the well-localized event GW190814
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