10 research outputs found
A posteriori correction of camera characteristics from large image data sets
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/03/2015
- Field of study
Large datasets are emerging in many fields of image processing including: electron microscopy, light microscopy, medical X-ray imaging, astronomy, etc. Novel computer-controlled instrumentation facilitates the collection of very large datasets containing thousands of individual digital images. In single-particle cryogenic electron microscopy (âcryo-EMâ), for example, large datasets are required for achieving quasi-atomic resolution structures of biological complexes. Based on the collected data alone, large datasets allow us to precisely determine the statistical properties of the imaging sensor on a pixel-by-pixel basis, independent of any âa prioriâ normalization routinely applied to the raw image data during collection (âflat field correctionâ). Our straightforward âa posterioriâ correction yields clean linear images as can be verified by Fourier Ring Correlation (FRC), illustrating the statistical independence of the corrected images over all spatial frequencies. The image sensor characteristics can also be measured continuously and used for correcting upcoming images
Does hyperthermia constrain flight duration in a short-distance migrant?
- Author
- Anthony J. Woakes
- Beaudinette RV
- Bernstein MH
- Berthold P
- Bevan RM
- Butler PJ
- David Pelletier
- Dawson WR
- Day RH
- Elias T. Polymeropoulos
- Hart JS
- Hudson DM
- Jacques Larochelle
- Jean-Marc Granbois
- Klaassen M
- Lunneborg CE
- Magella Guillemette
- McNab BK
- Michaeli G
- Newton I
- Patrick J. Butler
- Peter B. Frappell
- Rayner JMV
- Steven J. Portugal
- Taylor CR
- Thompson MW
- Torre-Bueno JR
- Torre-Bueno JR
- Ward S
- Publication venue
- 'The Royal Society'
- Publication date
- 15/08/2016
- Field of study
While some migratory birds perform non-stop flights of over 11 000 km, many species only spend around 15% of the day in flight during migration, posing a question as to why flight times for many species are so short. Here, we test the idea that hyperthermia might constrain flight duration (FD) in a short-distance migrant using remote biologging technology to measure heart rate, hydrostatic pressure and body temperature in 19 migrating eider ducks (Somateria mollissima), a short-distance migrant. Our results reveal a stop-and-go migration strategy where migratory flights were frequent (14 flights day(â1)) and short (15.7 min), together with the fact that body temperature increases by 1°C, on average, during such flights, which equates to a rate of heat storage index (HSI) of 4°C h(â1). Furthermore, we could not find any evidence that short flights were limited by heart rate, together with the fact that the numerous stops could not be explained by the need to feed, as the frequency of dives and the time spent feeding were comparatively small during the migratory period. We thus conclude that hyperthermia appears to be the predominant determinant of the observed migration strategy, and suggest that such a physiological limitation to FD may also occur in other species. This article is part of the themed issue âMoving in a moving medium: new perspectives on flightâ
Collective behavior as a driver of critical transitions in migratory populations
- Author
- A Berdahl
- A Berdahl
- A Berdahl
- A Corten
- A Dhooge
- A Flack
- A van Leeuwen
- A Wolf
- AM Simons
- ARE Sinclair
- BE Beisner
- C Brown
- CE Doughty
- CJ Torney
- D Biro
- D GrĂŒnbaum
- DA Peterson
- DE Schindler
- DJ Fraser
- DS Boukal
- E Codling
- E Hensor
- E Milner-Gulland
- EA Codling
- F Brauer
- F Courchamp
- F Figge
- G Beauchamp
- G De Luca
- G DellâAriccia
- G Harris
- G Huse
- GS Helfman
- H Dingle
- HS Niwa
- I Couzin
- IH McQuinn
- IJ Stewart
- JF Wilmshurst
- JGC Hopcraft
- JL Gould
- JM Black
- JM Fryxell
- JM Fryxell
- JO Irisson
- KA Schmidt
- L Berec
- M Dumond
- M Liermann
- M Scheffer
- M Scheffer
- M Somveille
- ML Keefer
- N Chernetsov
- P Petitgas
- PA Larkin
- PA Westley
- PA Westley
- RB Boone
- RD Estes
- RE McNicol
- RM Holdo
- RM May
- RV Solé
- S Bauer
- S Bauer
- S Bauer
- S Oppel
- SJ Cooke
- SJ Portugal
- T Avgar
- T Ito
- T Mueller
- T Mueller
- TP Quinn
- V Guttal
- V Guttal
- W Lenwood
- WC Leggett
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Predictive biomarkers and patient outcome in platinum-resistant (PLD-treated) ovarian cancer
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2020
- Field of study
Identification of predictive biomarkers for ovarian cancer (OC) treatment, particularly in the platinum-resistant/refractory setting, is highly relevant for clinical management. E-cadherin, vimentin, and osteopontin (OPN) are proteins associated with tumor microenvironment (TME) remodelling that play key roles in cancer. This study aimed to evaluate the association between the staining patterns of these proteins with survival outcomes in a series of OC patients, namely in patients with platinum-resistant/refractory disease. Low E-cadherin expression and high vimentin expression in all patient groups (as well as for E-cadherin in the platinum-resistant arm) were significantly associated with longer overall survival (OS). Low cytoplasmic OPN expression (and cytoplasmic and membrane OPN in the platinum-resistant arm) were significantly associated with longer OS. In patients that responded to treatment (pegylated liposomal doxorubicin (PLD) or other), low cytoplasmic OPN expression was also associated with longer progression-free survival (PFS). In the other hand, high nuclear OPN-c expression in patients that respond to treatment was associated with longer OS and longer PFS. Longer PFS was also associated with high expression of both nuclear and cytoplasm OPN-c, in platinum-resistant patients and in those that responded to PLD. Our study indicates that the expression of E-cadherin, vimentin, and OPN may have prognostic implications. Nuclear OPN-c and cytoplasm OPN expression are putative predictive markers in platinum-resistant (PLD treated) ovarian cancer patients.FEEI (Fundos Europeus Estruturais e de Investimento), FEDER (Fundo Europeu de Desenvolvimento Regional) funds through the COMPETE 2020, Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT (Fundação para a CiĂȘncia e a Tecnologia), in the framework of the project: Predicting patientâs response to liposomal anticancer drugs: focusing on LRP1B endocytic activityâPTDC/MEC-ONC/31520/2017. Further funding by the European Regional Development Fund (ERDF) through the Operational Programme for Competitiveness and Internationalization (COMPETE) 2020, and Portuguese national funds via FCT, under the project âPOCI-01-0145-FEDER-016390: CANCEL STEMâ
The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats
- Author
- Publication venue
- 'American Society for Biochemistry & Molecular Biology (ASBMB)'
- Publication date
- 01/01/2017
- Field of study
On the basis of tissue-specific enzyme activity and inhibition by catalytic products, Hans Krebs first demonstrated the existence of multiple glutaminases in mammals. Currently, two human genes are known to encode at least four glutaminase isoforms. However, the phylogeny of these medically relevant enzymes remains unclear, prompting us to investigate their origin and evolution. Using prokaryotic and eukaryotic glutaminase sequences, we built a phylogenetic tree whose topology suggested that the multidomain architecture was inherited from bacterial ancestors, probably simultaneously with the hosting of the proto-mitochondrion endosymbiont. We propose an evolutionary model wherein the appearance of the most active enzyme isoform, glutaminase C (GAC), which is expressed in many cancers, was a late retrotransposition event that occurred in fishes from the Chondrichthyes class. The ankyrin (ANK) repeats in the glutaminases were acquired early in their evolution. To obtain information on ANK folding, we solved two high-resolution structures of the ANK repeat-containing C-termini of both kidney-type glutaminase (KGA) and GLS2 isoforms (glutaminase B and liver-type glutaminase). We found that the glutaminase ANK repeats form unique intramolecular contacts through two highly conserved motifs; curiously, this arrangement occludes a region usually involved in ANK-mediated protein-protein interactions. We also solved the crystal structure of full-length KGA and present a small-angle X-ray scattering model for full-length GLS2. These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC. Collectively, these results provide information about glutaminases that may aid in the design of isoform-specific glutaminase inhibitors
Functional Diversification of Cerato-Platanins in Moniliophthora perniciosa as Seen by Differential Expression and Protein Function Specialization
- Author
- Publication venue
- 'Scientific Societies'
- Publication date
- 26/11/2015
- Field of study
Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Cerato-platanins (CP) are small, cysteine-rich fungal-secreted proteins involved in the various stages of the host-fungus interaction process, acting as phytotoxins, elicitors, and allergens. We identified 12 CP genes (MpCP1 to MpCP12) in the genome of Moniliophthora perniciosa, the causal agent of witches' broom disease in cacao, and showed that they present distinct expression profiles throughout fungal development and infection. We determined the X-ray crystal structures of MpCP1, MpCP2, MpCP3, and MpCP5, representative of different branches of a phylogenetic tree and expressed at different stages of the disease. Structure-based biochemistry, in combination with nuclear magnetic resonance and mass spectrometry, allowed us to define specialized capabilities regarding self-assembling and the direct binding to chitin and N-acetyl-glucosamine (NAG) tetramers, a fungal cell wall building block, and to map a previously unknown binding region in MpCP5. Moreover, fibers of MpCP2 were shown to act as expansin and facilitate basidiospore germination whereas soluble MpCP5 blocked NAG6-induced defense response. The correlation between these roles, the fungus life cycle, and its tug-of-war interaction with cacao plants is discussed.261112811293Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)LNBio [D03B-MX1, W01B-MX2]Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)FAPESP [2010/51884-8, 2010/14504-2, 2010/51891-4]CNPq [400796/2012-0]LNBio [D03B-MX1, W01B-MX2
Thermal stress and tropical reefs: mass coral bleaching in a stable temperature environment?
- Author
- AB Andrade
- AB Portugal
- AC Baker
- Alison A. Monroe
- Anne Larisse Alves Rebouças Gurgel
- B Bourles
- B Knoppers
- BP Ferreira
- BW Hoeksema
- BW Hoeksema
- BĂĄrbara Pereira Paiva
- C Cacciapaglia
- Carlos Eduardo Peres Teixeira
- CEP Teixeira
- DB Enfield
- DJ Suggett
- FC Costa
- FJS Dias
- HC Barkley
- IC Rosa
- IJB Alemu
- J Carili
- JA Marengo
- JG Monteiro
- JR Guest
- JR Guest
- M Sutthacheep
- Marcelo de Oliveira Soares
- Marcus Davis
- Maria Ozilea Bezerra Menezes
- MD Correia
- ML NohaĂŻc
- MMLD Barros
- MO Soares
- MO Soares
- NS Pereira
- PLA Erftemeijer
- PR Frade
- PR Muir
- RA Magris
- RB Francini-Filho
- RJ Miranda
- RV Woesik
- S Rossi
- Sarah Maria Cavalcante Ferreira
- SS Oigman-Pszczol
- Tallita Cruz Lopes Tavares
- TLP Dias
- TP Hughes
- TP Hughes
- V Schoepf
- ZMAN LeĂŁo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Paracoccidioidomycosis
- Author
- A Arantes
- A Calvo
- A Cardoso da Cunha
- A Carini
- A Carini
- A Carini
- A Carvalho
- A Carvalho
- A Casiello
- A Celis-PĂ©rez
- A Celis-PĂ©rez
- A Cellis-Peréz
- A Chirife
- A Conti-Diaz
- A Cordero
- A Diez
- A Donati
- A Donati
- A Fialho
- A Fialho
- A Fialho
- A Fialho
- A Fialho
- A Fialho
- A Fialho
- A Freire
- A Gonzalez Ochoa
- A Gonzalez Ochoa
- A Louzada
- A Lutz
- A Marano
- A Martinez-Coll
- A Monteiro
- A Monteiro
- A Monteiro
- A Moses
- A Nicho
- A Peisojovich
- A Pena Chavarria
- A Pena Chavarria
- A Pena Chavarria
- A Restrepo
- A Restrepo
- A Restrepo
- A Restrepo
- A Restrepo
- A Splendore
- A Splendore
- A Splendore
- A Splendore
- A Splendore
- A Splendore
- A Splendore
- A Trejos
- AA Prado
- AA Prado
- AA Prado
- AAP Sampaio
- AC Batista
- AC Cunha
- AC Cunha
- AC Pereira
- AEA Leao
- AEA Leao
- AF Costa Jr
- AM Pedroso
- AP Azevedo
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- AP Gonçalves
- APP Azevedo
- AR Cunha
- AR Cunha
- AS Leite
- AS Leite
- AT Henrici
- AT Londero
- AV Chirife
- B Bruni-Celli
- B Coelho
- B Fonseca Jr
- B Montenegro
- B Retamoso
- BP Souza
- C Bardy
- C Dominguez
- C Farah
- C Fava Netto
- C Fava Netto
- C Fava Netto
- C Fava Netto
- C Fava Netto
- C Fava Netto
- C Fried
- C Magarinos Torres
- C Pena
- C Pereira
- C Pinto
- C Rodriguez
- C Rodriguez
- C Rodriguez
- C Vargas
- C Yepez
- CA Ortega
- Cezar Pinto
- CJ Alvarez
- CM Torres
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
- CS Lacaz
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- CS Lacaz
- CS Lacaz
- D Borelli
- D Borelli
- D Borelli
- D Borelli
- D Borelli
- D Borelli
- D Mosto
- D Mosto
- D Mosto
- D Paula De
- D Peryassu
- D Peryassu
- D Peryassu
- DF Luna
- DF Luna
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DO Ribeiro
- DR Iriarte
- DR Iriarte
- DR Iriarte
- DS Martin
- DT Clausell
- DW Dodge
- E Belfort
- E Biocca
- E Casteran
- E Drouhet
- E Escomel
- E Escomel
- E Grose
- E Macclure
- E Oliveira
- E Rabello
- E Rabello
- E Rabello
- E Urdaneta
- EA Joseph
- EB Ribeiro
- EB Ribeiro
- EC Campos
- EC Campos
- EC Campos
- EC Campos
- ED Costa
- EJ Feijo
- ES Campos
- ES Campos
- ES Dowding
- ET Torres
- EVL Monteiro
- F Belfort
- F Fialho
- F Fialho
- F GuimarÄes
- F GuimarÄes
- F Laport
- F Londoño
- F Moncada-Reyes
- F Picado
- F Silva
- F Silva
- F Silva
- F Silva
- F Silva
- F Silva
- F Silva
- F Simas
- F Simas
- F Wenger
- FAS Barbosa
- FC Sahione
- FE Rabello Jr
- FE Rabello Jr
- FE Rabello Jr
- FE Rabello Jr
- FE Rabello Jr.
- FF Gunche
- FF Gunche
- FH Ritter
- FL Niño
- FL Niño
- FL Niño
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- FL Niño
- FL Niño
- FL Niño
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- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FL Niño
- FM Bustus
- FN GuimarÄes
- FN GutmarÄes
- FP Almeida
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- FP Almeida
- FP Almeida
- FP Soares Filho
- FS Terra
- FS Terra
- FXP Lima
- FXP Lima
- G Bertaccini
- G Cruz
- G Gonçalves
- G Kletter
- G Negro Del
- G Negro Del
- G Negro Del
- G Negro Del
- G Negro Del
- G Negro Del
- G Negro Del
- G Rocha
- G Rosenfeld
- GA Maeckelt
- GA Texeira
- GI Lythott
- GJL Moral
- GO Viana
- GS Leon
- GV Curban
- H Aleixo
- H Aleixo
- H Annes Diaz
- H Benaim Pinto
- H Benaim Pinto
- H Benaim Pinto
- H Benaim Pinto
- H Bittencourt
- H Campins
- H Campins
- H Cerruti
- H Cerruti
- H Cerruti
- H Garcia Cardenas
- H Marcano-Coello
- H Medina
- H Medina
- H Medina
- H Medina
- H Vinelli
- HA Dias
- HA Dias
- HA Dias
- HA Suarez
- HH Lopez
- HM Canelas
- HM Sadek
- HO Perry
- HR Lima
- I Bocalandro
- I Marsiglla
- IA Conti-Diaz
- J Aleixo
- J Aleixo
- J Americo
- J Bioggino
- J Borrero
- J Cancela-Freijo
- J Leitao
- J Llambias
- J Lobo
- J Lobo
- J Lobo
- J Lobo
- J Lobo
- J Lobo
- J Machado Filho
- J Machado Filho
- J Machado Filho
- J Machado Filho
- J Machado Filho
- J Machado Filho
- J Manzoli
- J Michalany
- J Montenegro
- J Morales
- J Moyses
- J Pellegrino
- J Pellegrino
- J Pellegrino
- J Pellegrino
- J Ramos e Silva
- JA Campos
- JA Levy
- JA Madeira
- JA Neves
- JA OâDaly
- JA Porto
- JA Pupo
- JA Pupo
- JA Pupo
- JA Ramos
- JA Taiana
- JB Fonseca
- JC Freijo
- JC Radice
- JC Radice
- JCF Carvalho
- JD Rodriguez
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE Mackinnon
- JE MacKinnon
- JE MacKinnon
- JE Mackinnon
- JE Mackinnon
- JER Barbosa
- JER Barbosa
- JF Barbosa
- JF Carneiro
- JH Barros
- JH Barros
- JH Barros
- JI Baldo
- JL Miranda
- JM Camargo
- JM Gomes
- JM Prado
- JM Sampaio
- JN Taves
- JR Silva
- JR Silva
- JR Silva
- JR Zerpa-Morales
- JT Nuñez Montiel
- JV Marin
- JW Jordan
- JW Tobias
- JW Tobias
- K Salfelder
- KVA Balakanov
- L Batista
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Bogliolo
- L Charosky
- L Faria
- L Friedman
- L Pollak
- L Pollak
- L Pollak
- L Pollak
- L Pollak
- L Pollak
- L Potenza
- L Potenza
- L Salman
- L Stachowsky
- LA Mendez
- LA Mendez
- LA Sodre
- LA Yarzabal
- LAM Torres
- LC Andrade
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Motta
- LC Oliveira
- LE Pierini
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LM Carbonell
- LN Gurgel
- LV Decourt
- M Aberastury
- M Aberastury
- M Adrianza
- M Barreto
- M Castro
- M Moore
- M Moore
- M Moore
- M Moore
- M Moore
- M Moore
- M Peruzzi
- M Quiroga
- M Robledo
- M Rocha
- MA Figuereido
- MB Castro
- MG Malfatti
- MJ Pereira Filho
- MJ Pereira Filho
- MJ Pereira Filho
- MJ Pereira Filho
- MJ Pereira Filho
- MJ Pereira Filho
- MJD Rodriguez
- MJD Rodriguez
- MJD Rodriguez
- MM Rosa
- MP Silva
- MP Silva
- MP Silva
- MP Silva
- MP Silva
- MP Silva
- MP Silva
- MP Silva
- MS Silva
- N GuimarÄes
- NF Conant
- NF Conant
- NF Conant
- NL Dillon
- NN Silva
- NN Silva
- NN Silva
- NV Greco
- O Castro
- O Castro
- O Fonseca
- O Fonseca Filho
- O Gomes
- O Jervis
- O Machado
- O Portugal
- O Seijas
- O Serra
- O Versiani
- O Versiani
- O Versiani
- OA Angulo
- OA Angulo
- OA Angulo
- OA Angulo
- OA Angulo
- OA Angulo
- OA Angulo
- OA Seva
- OA Seva
- OF Lima
- OM Barros
- OM Barros
- OOR Fonseca Filho
- OP Forattini
- OP Forattini
- OP Portugal
- OSS Lopes
- P Guerra
- P Madureira
- P Negroni
- P Negroni
- P Negroni
- P Negroni
- P Negroni
- P Negroni
- P Negroni
- P Redaelli
- P Redaelli
- P Redaelli
- P Redaelli
- P Rubinstein
- P Weiss
- P Weiss
- P Weiss
- PC Azevedo
- PD Silva
- PD Silva
- PD Silva
- PD Silva
- PD Silva
- PD Silva
- PD Silva
- PD Silva
- PJ Alvarez
- PM Barreto
- PN Silva
- R Ciferri
- R Ciferri
- R Ferguson
- R FernAndes
- R FernAndes
- R Garzon
- R Lima Filho
- R Londoño
- R Marengo
- R Nova
- R Nova
- R Nova
- R Sammartino
- R Teixeira
- R Tella
- R Veronesi
- RC Artagaveytia-Allende
- RC Artagaveytia-Allende
- RC Artagaveytia-Allende
- RC Artagaveytia-Allende
- RD Azulay
- RD Azulay
- RD Azulay
- RD Azulay
- RD Azulay
- RD Baker
- RD Sanson
- RD Sanson
- RD Sanson
- RF Kehl
- RN Miranda
- RV Talice
- S Mazza
- S Mazza
- S Mazza
- S Parodi
- S Queiroz
- SAP Sampaio
- SAP Sampaio
- SAP Sampaio
- SL Aranz
- SL Arauz
- T Elmore
- T Wegman
- TA Ftjrtado
- TA Ftjrtado
- TA Ftjrtado
- TA Ftjrtado
- TA Furtado
- TA Furtado
- TA Furtado
- U Paixao
- UA Silva
- V Dueñas
- V Griego
- V Pardo-Castello
- VF Rizzo
- VH Duenas
- W Basgal
- W Bungeler
- W Bungeler
- W Haberfeld
- W Haberfeld
- W Haberfeld
- W Haberfeld
- W Haberfeld
- W Juca
- WE Maffei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1971
- Field of study
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott TEF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdelaal SA
- Abdeldayem H
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- Abellan M
- Abosamak NE
- Abou Chaar MK
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Za'nouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf S
- Acebes Garcia F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina M
- Adamoli L
- Addae-Boateng E
- Ademuyiwa AO
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal A
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmed NR
- Ahmeidat A
- Ahn JH
- Aiken T
- Aime A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akilli H
- Akin E
- Akkour K
- Akkulak M
- Akmenkalne L
- Al Abdallah M
- Al Abdel S
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko F
- Alam F
- Alam N
- Alam R
- Alameer E
- Alamri A
- Alamri A
- Alanbuki A
- Alatar A
- Alawneh F
- Alazawi D
- Albertsmeier M
- Albertsmeiers M
- Albi Martin B
- Alburakan A
- Alcaide Matas F
- Alconchel F
- Aldayri Z
- Aldecoa Ansorregui I
- Alderson D
- Aldokali N
- Aleksic L
- Alemanno G
- Alexoudi V
- Alfaro-Goldaracena A
- Alfieri S
- Alga A
- Alghamdi M
- Alhalal H
- Alhamed A
- Alharthi M
- Alharthi R
- Alhassan B
- Alhassan N
- Alhefdhi A
- Ali AK
- Ali M
- Ali MF
- Ali S
- Aliyeva Z
- Aljanadi F
- Aljiffry M
- Alkadeeki GZ
- Alkarak S
- Allemand C
- Allison J
- Almalik O
- Almasri M
- Almeciga A
- Almeida A
- Almeida AC
- Almeida JI
- Almgla N
- Almond M
- Almond M
- Alnumani T
- Alobeed O
- Alomair A
- Alonso de la Fuente N
- Alonso Poza A
- Alonso-Lamberti L
- Alotaibi N
- Alqannas M
- Alresaini F
- Alriyees L
- Alsaif A
- Alsaif F
- Alsalamah R
- Alsaraireh O
- Alselaim N
- Alser O
- Alshaar M
- Alshahrani M
- Alshammari S
- Alshareea E
- Alsharif F
- Alshaygy I
- Alshryda S
- Alsobhi S
- Althobaiti W
- Altintoprak F
- Alurralde C
- Alvarez E
- Alvarez MR
- Alyami M
- Alzamanan M
- Amaral MJ
- Ameerally P
- Amira G
- Amonkar S
- Amorim E
- Ampollini L
- Amrani L
- Anania G
- Anastasi A
- Anchuelo Latorre J
- Andaleeb U
- Andaya V
- Andrade AK
- Andrade R
- Andrijasevic S
- Aneke IA
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- Angelo M
- Angelou D
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- Annessi V
- Ansarin M
- Anthoulakis C
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- Antonopoulou MI
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- Aquila F
- Aragon Achig EJ
- Aremu I
- Aremu M
- Aresu G
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- Arigoni M
- Arikan AE
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- Arkha Y
- Armao T
- Armatura G
- Arminio A
- Arnaud AP
- Arrangoiz R
- Arrowsmith L
- Artigues E
- Arulanantham A
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- Athanasakis E
- Athanasiou A
- Athayde Nemesio R
- Atherton R
- Athwal R
- Atici DS
- Atta R
- Attia D
- Augestad KM
- Australasian T
- Avci EK
- Avlund T
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- Ayub B
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- Azamat IF
- Azevedo C
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- Azizeldine MG
- Azizi A
- Azzam AY
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- Baiao JM
- Baietti AM
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- Balasubramaniam D
- Balasubramanian I
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- Baldi C
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- Baloyiannis I
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- Bartolini I
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- Battista MJ
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- Baxter K
- Bayazeed SA
- Bayhan Z
- Beamish A
- Beard D
- Beasley N
- Beatson K
- Becerra Garcia FC
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- Bekheit M
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- Belkhadir ZH
- Bellacci A
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- Belli A
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- Bellora P
- Belluco C
- Beltramini GA
- Beltran de Heredia J
- Belvedere A
- Benavides Buleje JA
- Benkabbou A
- Bennetts J
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- Bernal-Sprekelsen JC
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- Bezede C
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- Bhasin S
- Bhatti MI
- Biala M
- Bianchi MF
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- Cahill J
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- Zafar SN
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zatecky J
- Zegarac M
- Zelic M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortuzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Publication venue
- Br J Surg
- Publication date
- 11/11/2020
- Field of study
BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; Pâ=â0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas
Elective Cancer Surgery in COVID-19âFree Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- AbellĂĄn M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Zaânouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
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- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akhter Rahman MM
- Akilli H
- Akin E
- Akkour K
- Akkulak Murat
- Akmenkalne L
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
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- Al-Ishaq Z
- Al-Khayal K
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- Al-Mohammad A
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- Al-omishy H
- Al-Sarireh B
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- on behalf of the COVIDSurg Collaborative
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- Vallance A
- Vallance Abigail
- Valle Rubio A
- Valtzoglou V
- Valverde S
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Duijvendijk P
- Van Heinsbergen M
- Van Houdt W
- van Ramshorst Gabrielle H
- Van Wyngaard T
- Vanounou T
- Varazzani A
- Vargas L
- Varley I
- Varma M
- VasljeviÄ J
- Vassiliu P
- Vatansever D
- Vatish J
- Vatish M
- Vaz Pereira R
- Vaz OP
- Vaz S
- Vazquez fernandez A
- Veiga D
- Velagapudi S
- Velchuru V
- Velickovic D
- Velidedeoglu M
- Venetis G
- Venn M
- Venn Mary L
- Venn Mary L.
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Vidakovic S
- Videira JF
- Videria Jose Flavio
- Vidya R
- Vidya Raghavan
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vieira P
- Vignali A
- Vigorita V
- Vijayan D
- Vilatoba M
- Vilendecic Z
- Villalabeitia Ateca I
- Vimalachandran D
- Vimalachandran Dale
- Vimalchandran Dale
- Vinayagam R
- Violante T
- Visgauss J
- Viswambaram P
- Viswanath Y
- Vitali A
- Vitone L
- Vives RV
- Vo UG
- Vogel J
- Vollkommer T
- Von Papen M
- Vovola F
- Vucic N
- Vujanac V
- Wade R
- Wadham B
- Waheed S
- Wai K
- Wali A
- Walker C
- Walker D
- Walkes K
- Wallwork K
- Walton G
- Walton T
- Waqar SH
- Warburton H
- Ward D
- Ward S
- Waris Farooka M
- Warren O
- Warren Oliver J
- Waseem S
- Wasim T
- Watson D
- Watson LJ
- Watson N
- Weaver H
- Webber L
- Wedderburn Duane
- Weitz J
- Welsch T
- Wensley F
- Werner J
- West C
- West D
- Westwood E
- Whelan M
- Whelan P
- Whisker L
- Whitehall E
- Whitmore H
- Wilkin R
- Wilkin Richard JW
- Wilkins A
- Wilkins Alex
- Williams G
- Williams J
- Williams K
- Williams MA
- Williams T
- Williamson K
- Wilson M
- Wimberger P
- Wimmer A
- Winnand P
- Winter D
- Winter S
- Winter Stuart C
- Wolfer S
- Wong MPK
- Wong S
- Wong WJ
- Woodham A
- Woodun H
- Worku D
- Wright G
- Wright Naomi
- Wullschleger M
- Wustrack R
- Xenaki S
- Xu MJ
- Xyda SE
- Xynos E
- Yahaya AS
- Yang W
- Yassin N
- Ye G
- Yesantharao P
- Yetkin G
- YeĆilyurt D
- Yiallourou A
- Yıldırım A
- Yildiz A
- Ying Y
- Yip V
- Yordanov S
- Young R
- Yousof EA
- Youssef A
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zacharoulis D
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zegarac M
- ZeliÄ M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla OrtĂșzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Ăngelo M
- ĂlgĂ„ A
- ĂapoÄlu R
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ć imko K
- Ć ÄepanoviÄ V
- ĆœateckĂœ J
- ĐĐ°ĐŒĐ°Đ»ĐŸĐČ Đ
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study