Different Approaches for Speaker Diarization

Audio diarization is the process of annotating an input audio channel with information that attributes (possibly overlapping) temporal regions of signal energy to their specific sources. These sources can include particular speakers, music, background noise sources and other signal source/channel characteristics. Speaker diarization is the task of determining “who spoke when?†in an audio or video recording that contains an unknown amount of speech and also an unknown number of speakers. Diarization can be used for helping speech recognition, facilitating the searching and indexing of audio archives and increasing the richness of automatic transcriptions, making them more readable. Over recent years, however, speaker diarization has become an important key technology for many tasks, such as navigation, retrieval or higher-level inference on audio data. Accordingly, many important improvements in accuracy and robustness have been reported in the area of conferences. The application domains, from broadcast news, to lectures and meetings, vary greatly and pose different problems, such as access to multiple microphones and multimodal information or overlapping speech

Demystifying Artificial Intelligence based Digital Twins in Manufacturing- A Bibliometric Analysis of Trends and Techniques

Nowadays, data is considered as a new life force for operations of physical systems in various domains such as manufacturing, healthcare, transportations, etc. However, the hugely generated data, which mirrors the working essence of the product life cycle, is still underutilised. Digital Twin (DT), a collective representation of active and passive captured data, is a virtual counterpart of the physical resources that could help prevent effective preventive maintenance in any applied domain. Currently, lots of research is going on about the applicability of digital twin in smart IOT based manufacturing industry 4.0 environment. Still, it lacks a formal study, which can provide a bird\u27s eye view about the research efforts and directions. In this paper, the authors represent a bibliometric survey of the digital twin concept based on the Scopus database to present a global view about scholars\u27 contributions in the manufacturing area. The study was conducted by retrieving 844 Scopus research papers published from 2015-2020 and analysed to find out critical insights such as publication volume, co-authorship networks, citation analysis, and demographic research distribution. The study revealed that significant contribution is made via concept propositions in conferences and some papers published in the journal. However, there is a scope of lots of research work in the direction of actual and secure digital twin implementation

ICU MONITORING SYSTEM USING RASPBERRY PI

The aim of this project is to have a quantitative assessment of the important physiological variables of patient using “Raspberry Piâ€. This system is used for measuring continuously automatically the values of patient’s physiological parameters such as body temperature, blood pressure, heart activity and humidity content present in the ICU room. This unit may be inserted in a bedside display unit to display the physiological conditions of the patients. The device detects vital parameters of the patient by the use of sensors and displays result on an monitor screen mounted on the gadget. If this values are not within the safe limit, then corresponding LED indicator will glow and alarm will start ringing

Enteroviruses in Patients with Acute Encephalitis, Uttar Pradesh, India

An outbreak of viral encephalitis occurred in northern India in 2006. Attempts to identify an etiologic agent in cerebrospinal fluid by using reverse transcription–PCR showed positivity to enterovirus (EV) in 66 (21.6%) of 306 patients. Sequencing and phylogenetic analyses of PCR products from 59 (89.3%) of 66 specimens showed similarity with EV-89 and EV-76 sequences

Enteroviruses in Patients with Acute Encephalitis, Uttar Pradesh, India

An outbreak of viral encephalitis occurred in northern India in 2006. Attempts to identify an etiologic agent in cerebrospinal fluid by using reverse transcription–PCR showed positivity to enterovirus (EV) in 66 (21.6%) of 306 patients. Sequencing and phylogenetic analyses of PCR products from 59 (89.3%) of 66 specimens showed similarity with EV-89 and EV-76 sequences

Farmer Assistant Android App

In India most of the population is depending on agriculture and Farmer is the backbone of the Indian economy. The system consists of smartphone applications. The System can be used by farmers on the android application on mobile devices. The paper proposes the utilization of information mining to give suggestions to ranchers to crops, crop data, and distinguishing proof of suitable manure. The smart-phone is used very commonly by everyone who is educated or non-educated. This application can provide different languages, which is Hindi and English this language commonly used and easy to use on the system.

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions. </jats:sec

An Empirical Study of Awareness and Use of ICT by School Teachers Before and During Lockdown Due to COVID-19 Pandemic

The COVID-19 pandemic has taken almost all the countries across the globe by surprise. It was this time a year ago when the sudden outbreak of the coronavirus forced the closure of educational institutions resulting billions of children out of the classroom. Like many countries worldwide, India also faced the challenges of unexpectedly switching to online classes. Given to this background the study aims at understanding the practical experiences of teachers who were part of the teaching which undertook remotely and on digital platforms. This is a quantitative research using survey technique through a questionnaire that comprised demographic variables, ICT awareness and use before and during lockdown and most importantly their opinion on integration of ICT in teaching and learning. A total of 209 returned questionnaires formed the datasets which have been analyzed based on the objectives of the study. The findings showed that ICT competency was instrumental in adapting to online teaching during COVID-19 school closures