50 research outputs found
Biodistribution of the novel anticancer drug sodium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
No full text
LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma
No full textArsenic speciation in natural and contaminated waters using CZE with in situ derivatization by molybdate and direct UV-detection
No full textNew ways in qualitative and quantitative protein analysis: Nano chromatography coupled to element mass spectrometry
No full textThe first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes
No full textMEEKC is a powerful electrodriven separation technique with many applications in different disciplines, including medicinal chemistry; however the coupling to highly sensitive and selective mass spectrometric detectors was limited due to the ion suppressive effect of the surfactant SDS. Herein, the first example of the coupling of MEEKC to ICP-MS is presented and an MEEKC method for the separation of Pt(II) and Pt(IV) anticancer drugs and drug candidates was developed. Different compositions of microemulsions were evaluated and the data were compared to those collected with standard ultraviolet/visible spectroscopy (UV/vis) detection. The MEEKC–ICP-MS system was found to be more sensitive than MEEKC–UV/vis and the analysis of UV/vis silent compounds is now achievable. Furthermore, the migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their differences in structure
