18 research outputs found
Hadron Energy Reconstruction for the ATLAS Calorimetry in the Framework of the Non-parametrical Method
This paper discusses hadron energy reconstruction for the ATLAS barrel
prototype combined calorimeter (consisting of a lead-liquid argon
electromagnetic part and an iron-scintillator hadronic part) in the framework
of the non-parametrical method. The non-parametrical method utilizes only the
known ratios and the electron calibration constants and does not require
the determination of any parameters by a minimization technique. Thus, this
technique lends itself to an easy use in a first level trigger. The
reconstructed mean values of the hadron energies are within of the
true values and the fractional energy resolution is . The value of the ratio
obtained for the electromagnetic compartment of the combined calorimeter is
and agrees with the prediction that for this
electromagnetic calorimeter. Results of a study of the longitudinal hadronic
shower development are also presented. The data have been taken in the H8 beam
line of the CERN SPS using pions of energies from 10 to 300 GeV.Comment: 33 pages, 13 figures, Will be published in NIM
The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators
The preferred solution conformation of the pseudodisaccharides 7â15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and Ă 1â6 or a and Ă 1â4 glucosaminyl-d-myo-inositol; a and Ă 1â6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties
Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)
International audienceObjectives: We aimed to describe features and outcomes of cryptococcosis among HIV-seronegative individuals in a large surveillance network for cryptococcosis in France.Methods: We included incident cases of cryptococcosis in HIV-seronegative individuals from 2005 to 2020. We compared patient characteristics, disease presentations, cryptococcal antigen (CrAg) results, and induction antifungal treatments according to underlying disease. We examined factors associated with 90-day mortality. Among patients with disseminated infections, we investigated whether receipt of flucytosine and polyene combination was associated with lower mortality.Results: Among 652 individuals, 209 (32.1%) had malignancy, 130 (19.9%) were solid-organ transplant (SOT) recipients, 204 (31.3%) had other immunocompromising conditions, and 109 (16.7%) had no reported underlying factor. The commonest presentations were disseminated infections (63.3%, 413/652) and isolated pulmonary infections (25.3%, 165/652). SOT patients were most likely to have disseminated infections and a positive serum CrAg result. Patients with malignancy were older and less likely to receive a flucytosine-containing regimen for disseminated infections than others (58.7%, 78/133 vs. 73.2%, 194/265, p=0.029). The crude 90-day case-fatality ratio was 27.2% (95%CI: 23.5%-31.1%). Age â„60 years (aOR: 2.75 [1.78-4.26], p<0.001), meningitis/fungaemia (aOR: 4.79 [1.80-12.7], p=0.002), and malignancy (aOR: 2.4 [1.14-5.07], p=0.02) were associated with higher 90-day mortality. Receipt of flucytosine and polyene combination was associated with lower 90-day mortality (aOR: 0.40 [0.23-0.71], p=0.002) in multivariable analysis and inverse probability of treatment weighted analysis (aOR: 0.45 [0.25-0.80], p=0.006).Conclusions: HIV-seronegative individuals with cryptococcosis comprise a wide range of underlying conditions with different presentations and outcomes, requiring a tailored approach to diagnosis and management