498 research outputs found
I. Flux and color variations of the quadruply imaged quasar HE 0435-1223
aims: We present VRi photometric observations of the quadruply imaged quasar
HE 0435-1223, carried out with the Danish 1.54m telescope at the La Silla
Observatory. Our aim was to monitor and study the magnitudes and colors of each
lensed component as a function of time. methods: We monitored the object during
two seasons (2008 and 2009) in the VRi spectral bands, and reduced the data
with two independent techniques: difference imaging and PSF (Point Spread
Function) fitting.results: Between these two seasons, our results show an
evident decrease in flux by ~0.2-0.4 magnitudes of the four lensed components
in the three filters. We also found a significant increase (~0.05-0.015) in
their V-R and R-i color indices. conclusions: These flux and color variations
are very likely caused by intrinsic variations of the quasar between the
observed epochs. Microlensing effects probably also affect the brightest "A"
lensed component.Comment: 10 pages, 8 figure
Selenoprotein P Influences Colitis-Induced Tumorigenesis by Mediating Stemness and Oxidative Damage.
Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transported from the liver to target tissues via selenoprotein P (SEPP1). Target tissues also produce SEPP1, which is thought to possess an endogenous antioxidant function. Here, we have shown that mice with Sepp1 haploinsufficiency or mutations that disrupt either the selenium transport or the enzymatic domain of SEPP1 exhibit increased colitis-associated carcinogenesis as the result of increased genomic instability and promotion of a protumorigenic microenvironment. Reduced SEPP1 function markedly increased M2-polarized macrophages, indicating a role for SEPP1 in macrophage polarization and immune function. Furthermore, compared with partial loss, complete loss of SEPP1 substantially reduced tumor burden, in part due to increased apoptosis. Using intestinal organoid cultures, we found that, compared with those from WT animals, Sepp1-null cultures display increased stem cell characteristics that are coupled with increased ROS production, DNA damage, proliferation, decreased cell survival, and modulation of WNT signaling in response to H2O2-mediated oxidative stress. Together, these data demonstrate that SEPP1 influences inflammatory tumorigenesis by affecting genomic stability, the inflammatory microenvironment, and epithelial stem cell functions
Electrical detection of 31P spin quantum states
In recent years, a variety of solid-state qubits has been realized, including
quantum dots, superconducting tunnel junctions and point defects. Due to its
potential compatibility with existing microelectronics, the proposal by Kane
based on phosphorus donors in Si has also been pursued intensively. A key issue
of this concept is the readout of the P quantum state. While electrical
measurements of magnetic resonance have been performed on single spins, the
statistical nature of these experiments based on random telegraph noise
measurements has impeded the readout of single spin states. In this letter, we
demonstrate the measurement of the spin state of P donor electrons in silicon
and the observation of Rabi flops by purely electric means, accomplished by
coherent manipulation of spin-dependent charge carrier recombination between
the P donor and paramagnetic localized states at the Si/SiO2 interface via
pulsed electrically detected magnetic resonance. The electron spin information
is shown to be coupled through the hyperfine interaction with the P nucleus,
which demonstrates the feasibility of a recombination-based readout of nuclear
spins
Reverberation Mapping Measurements of Black Hole Masses in Six Local Seyfert Galaxies
We present the final results from a high sampling rate, multi-month,
spectrophotometric reverberation mapping campaign undertaken to obtain either
new or improved Hbeta reverberation lag measurements for several relatively
low-luminosity AGNs. We have reliably measured thetime delay between variations
in the continuum and Hbeta emission line in six local Seyfert 1 galaxies. These
measurements are used to calculate the mass of the supermassive black hole at
the center of each of these AGNs. We place our results in context to the most
current calibration of the broad-line region (BLR) R-L relationship, where our
results remove outliers and reduce the scatter at the low-luminosity end of
this relationship. We also present velocity-resolved Hbeta time delay
measurements for our complete sample, though the clearest velocity-resolved
kinematic signatures have already been published.Comment: 52 pages (AASTeX: 29 pages of text, 8 tables, 7 figures), accepted
for publication in the Astrophysical Journa
Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.
BACKGROUND:Many premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain. METHODS:Tracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant. RESULTS:At 24âh, surfactant treatment transiently increased surfactant protein B content (70%, pâ<â0.01), but did not affect recovered airway surfactant or total protein/phospholipid. The level of recovered surfactant during dosing was directly associated with content of surfactant protein B (râ=â0.50, pâ<â0.00001) and inversely related to total protein (râ=â0.39, pâ<â0.0001). For all infants, occurrence of BPD was associated with lower levels of recovered large aggregate surfactant, higher protein content, and lower SP-B levels. Tracheal aspirates with lower amounts of recovered surfactant had an increased proportion of small vesicle (inactive) surfactant. CONCLUSIONS:We conclude that many intubated premature infants are deficient in active surfactant, in part due to increased intra-alveolar metabolism, low SP-B content, and protein inhibition, and that the severity of this deficit is predictive of BPD. Late surfactant treatment at the frequency used did not provide a sustained increase in airway surfactant
A Photometric Survey for Variables and Transits in the Field of Praesepe with KELT
The Kilodegree Extremely Little Telescope (KELT) project is a small aperture,
wide-angle search for planetary transits of solar-type stars. In this paper, we
present the results of a commissioning campaign with the KELT telescope to
observe the open cluster Praesepe for 34 nights in early 2005. Lightcurves were
obtained for 69,337 stars, out of which we identify 58 long period variables
and 152 periodic variables. Sixteen of these are previously known as variable,
yielding 194 newly discovered variable stars for which we provide properties
and lightcurves. We also searched for planetary-like transits, finding four
transit candidates. Follow-up observations indicate that two of the candidates
are astrophysical false positives, with two candidates remaining as potential
planetary transits.Comment: 45 pages, 16 figures. Submitted to AJ. PDF version with full
resolution figures located at
http://www.astronomy.ohio-state.edu/~pepper/kelt.pd
The Race Between Stars and Quasars in Reionizing Cosmic Hydrogen
The cosmological background of ionizing radiation has been dominated by
quasars once the Universe aged by ~2 billion years. At earlier times (redshifts
z>3), the observed abundance of bright quasars declined sharply, implying that
cosmic hydrogen was reionized by stars instead. Here, we explain the physical
origin of the transition between the dominance of stars and quasars as a
generic feature of structure formation in the concordance LCDM cosmology. At
early times, the fraction of baryons in galaxies grows faster than the maximum
(Eddington-limited) growth rate possible for quasars. As a result, quasars were
not able to catch up with the rapid early growth of stellar mass in their host
galaxies.Comment: 5 pages, 1 figure, Accepted for publication in JCA
A Revised Broad-Line Region Radius and Black Hole Mass for the Narrow-Line Seyfert 1 NGC 4051
We present the first results from a high sampling rate, multi-month
reverberation mapping campaign undertaken primarily at MDM Observatory with
supporting observations from telescopes around the world. The primary goal of
this campaign was to obtain either new or improved Hbeta reverberation lag
measurements for several relatively low luminosity AGNs. We feature results for
NGC 4051 here because, until now, this object has been a significant outlier
from AGN scaling relationships, e.g., it was previously a ~2-3sigma outlier on
the relationship between the broad-line region (BLR) radius and the optical
continuum luminosity - the R_BLR-L relationship. Our new measurements of the
lag time between variations in the continuum and Hbeta emission line made from
spectroscopic monitoring of NGC 4051 lead to a measured BLR radius of R_BLR =
1.87 (+0.54 -0.50) light days and black hole mass of M_BH = 1.73 (+0.55 -0.52)
x 10^6 M_sun. This radius is consistent with that expected from the R_BLR-L
relationship, based on the present luminosity of NGC 4051 and the most current
calibration of the relation by Bentz et al. (2009a). We also present a
preliminary look at velocity-resolved Hbeta light curves and time delay
measurements, although we are unable to reconstruct an unambiguous
velocity-resolved reverberation signal.Comment: 38 pages, 7 figures, accepted for publication in ApJ, changes from v1
reflect suggestions from anonymous refere
Detection of Extrasolar Planets by Gravitational Microlensing
Gravitational microlensing provides a unique window on the properties and
prevalence of extrasolar planetary systems because of its ability to find
low-mass planets at separations of a few AU. The early evidence from
microlensing indicates that the most common type of exoplanet yet detected are
the so-called "super-Earth" planets of ~10 Earth-masses at a separation of a
few AU from their host stars. The detection of two such planets indicates that
roughly one third of stars have such planets in the separation range 1.5-4 AU,
which is about an order of magnitude larger than the prevalence of gas-giant
planets at these separations. We review the basic physics of the microlensing
method, and show why this method allows the detection of Earth-mass planets at
separations of 2-3 AU with ground-based observations. We explore the conditions
that allow the detection of the planetary host stars and allow measurement of
planetary orbital parameters. Finally, we show that a low-cost, space-based
microlensing survey can provide a comprehensive statistical census of
extrasolar planetary systems with sensitivity down to 0.1 Earth-masses at
separations ranging from 0.5 AU to infinity.Comment: 43 pages. Very similar to chapter 3 of Exoplanets: Detection,
Formation, Properties, Habitability, John Mason, ed. Springer (April 3, 2008
The Extreme Microlensing Event OGLE-2007-BLG-224: Terrestrial Parallax Observation of a Thick-Disk Brown Dwarf
Parallax is the most fundamental technique to measure distances to
astronomical objects. Although terrestrial parallax was pioneered over 2000
years ago by Hipparchus (ca. 140 BCE) to measure the distance to the Moon, the
baseline of the Earth is so small that terrestrial parallax can generally only
be applied to objects in the Solar System. However, there exists a class of
extreme gravitational microlensing events in which the effects of terrestrial
parallax can be readily detected and so permit the measurement of the distance,
mass, and transverse velocity of the lens. Here we report observations of the
first such extreme microlensing event OGLE-2007-BLG-224, from which we infer
that the lens is a brown dwarf of mass M=0.056 +- 0.004 Msun, with a distance
of 525 +- 40 pc and a transverse velocity of 113 +- 21 km/s. The velocity
places the lens in the thick disk, making this the lowest-mass thick-disk brown
dwarf detected so far. Follow-up observations may allow one to observe the
light from the brown dwarf itself, thus serving as an important constraint for
evolutionary models of these objects and potentially opening a new window on
sub-stellar objects. The low a priori probability of detecting a thick-disk
brown dwarf in this event, when combined with additional evidence from other
observations, suggests that old substellar objects may be more common than
previously assumed.Comment: ApJ Letters, in press, 15 pages including 2 figure
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