The new Checklist of British Columbia Lepidoptera and how it came to be

Volume: 110Start Page: 3End Page:

Defining the gap between research and practice in public relations programme evaluation - towards a new research agenda

The current situation in public relations programme evaluation is neatly summarized by McCoy who commented that 'probably the most common buzzwords in public relations in the last ten years have been evaluation and accountability' (McCoy 2005, 3). This paper examines the academic and practitioner-based literature and research on programme evaluation and it detects different priorities and approaches that may partly explain why the debate on acceptable and agreed evaluation methods continues. It analyses those differences and proposes a research agenda to bridge the gap and move the debate forward

Checklist of the Lepidoptera of British Columbia, Canada

This list documents 2832 Lepidoptera species reported for the province of British Columbia, Canada. It is based on examination of the major public insect collections in the province and the Canadian National Collection of Insects, Arachnids and Nematodes, Ottawa, Ontario. Records from relevant literature sources and online databases have also been examined and reliable ones have been included. The entry for each species includes the scientific name, the author and year of publication of the original description, and occurrence status. Taxonomic, distributional and biological notes are provided for selected species, and 134 species are flagged as introduced from outside North America. An additional 27 species which probably occur in British Columbia are included in the list. A list of 322 species erroneously reported from British Columbia in previous works is provided. Introductory sections provide an overview of the order Lepidoptera, review the province’s ecozones, and discuss the history of lepidopterology in British Columbia and its current state of knowledge. Each of the 70 families occurring in the province is briefly reviewed, along with information on its distinguishing features, general appearance and biology and diversity. An index of higher taxonomic names, genera, species, and common names is included

Radio spectral index images of the spiral galaxies NGC 0628, NGC 3627, and NGC 7331

In order to understand the cosmic ray propagation mechanism in galaxies, and its correlation with the sites of star formation, we compare the spatially resolved radio spectral index of three spiral galaxies with their IR distribution. We present new low-frequency radio continuum observations of the galaxies NGC 0628, NGC 3627, and NGC 7331, taken at 327 MHz with the Very Large Array. We complemented our data set with sensitive archival observations at 1.4 GHz and we studied the variations of the radio spectral index within the disks of these spiral galaxies. We also compared the spectral index distribution and the IR distribution, using 70 $\mu$m Spitzer observations. We found that in these galaxies the non-thermal spectral index is anticorrelated with the radio brightness. Bright regions, like the bar in NGC 3627 or the circumnuclear region in NGC 7331, are characterized by a flatter spectrum with respect to the underlying disk. Therefore, a systematic steepening of the spectral index with the increasing distance from the center of these galaxies is observed. Furthermore, by comparing the radio images with the 70 $\mu$m images of the Spitzer satellite we found that a similar anticorrelation exists between the radio spectral index and the infrared brightness, as expected on the basis of the local correlation between the radio continuum and the infrared emission. Our results support the idea that in regions of intense star formation the electron diffusion must be efficient. The observed anticorrelation between radio brightness and spectral index, may imply that the cosmic ray density and the magnetic field strength are significantly higher in these regions than in their surroundings.Comment: 12 pages, 11 figures, Accepted for pubblication in Astronomy & Astrophysics A high resolution version of the paper can be downloaded from: http://astro.uibk.ac.at/~rosita/paper/AA11870.pd

Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two mutations (N445K,T) in patients with multiple synostosis syndrome (SYM1) in the BMP–related ligand GDF5. Functional studies of both mutants in chicken micromass culture demonstrated a gain of function caused by a resistance to the BMP–inhibitor NOGGIN and an altered signaling effect. Residue N445, situated within overlapping receptor and antagonist interfaces, is highly conserved among the BMP family with the exception of BMP9 and BMP10, in which it is substituted with lysine. Like the mutant GDF5, both BMPs are insensitive to NOGGIN and show a high chondrogenic activity. Ectopic expression of BMP9 or the GDF5 mutants resulted in massive induction of cartilage in an in vivo chick model presumably by bypassing the feedback inhibition imposed by endogenous NOGGIN. Swapping residues at the mutation site alone was not sufficient to render Bmp9 NOG-sensitive; however, successive introduction of two additional substitutions imparted high to total sensitivity on customized variants of Bmp9. In conclusion, we show a new mechanism for abnormal joint development that interferes with a naturally occurring regulatory mechanism of BMP signaling

Multiwavelength Observations of LS I +61 303 with VERITAS, Swift and RXTE

We present results from a long-term monitoring campaign on the TeV binary LSI +61 303 with VERITAS at energies above 500 GeV, and in the 2-10 keV hard X-ray bands with RXTE and Swift, sampling nine 26.5 day orbital cycles between September 2006 and February 2008. The binary was observed by VERITAS to be variable, with all integrated observations resulting in a detection at the 8.8 sigma (2006/2007) and 7.3 sigma (2007/2008) significance level for emission above 500 GeV. The source was detected during active periods with flux values ranging from 5 to 20% of the Crab Nebula, varying over the course of a single orbital cycle. Additionally, the observations conducted in the 2007-2008 observing season show marginal evidence (at the 3.6 sigma significance level) for TeV emission outside of the apastron passage of the compact object around the Be star. Contemporaneous hard X-ray observations with RXTE and Swift show large variability with flux values typically varying between 0.5 and 3.0*10^-11 ergs cm^-2 s^-1 over a single orbital cycle. The contemporaneous X-ray and TeV data are examined and it is shown that the TeV sampling is not dense enough to detect a correlation between the two bands.Comment: 30 pages, 5 figures, 2 table, Accepted for publication in The Astrophysical Journa

Fur in Magnetospirillum gryphiswaldense Influences Magnetosomes Formation and Directly Regulates the Genes Involved in Iron and Oxygen Metabolism

Magnetospirillum gryphiswaldense strain MSR-1 has the unique capability of taking up large amounts of iron and synthesizing magnetosomes (intracellular magnetic particles composed of Fe3O4). The unusual high iron content of MSR-1 makes it a useful model for studying biological mechanisms of iron uptake and homeostasis. The ferric uptake regulator (Fur) protein plays a key role in maintaining iron homeostasis in many bacteria. We identified and characterized a fur-homologous gene (MGR_1314) in MSR-1. MGR_1314 was able to complement a fur mutant of E. coli in iron-responsive manner in vivo. We constructed a fur mutant strain of MSR-1. In comparison to wild-type MSR-1, the mutant strain had lower magnetosome formation, and was more sensitive to hydrogen peroxide and streptonigrin, indicating higher intracellular free iron content. Quantitative real-time RT-PCR and chromatin immunoprecipitation analyses indicated that Fur protein directly regulates expression of several key genes involved in iron transport and oxygen metabolism, in addition it also functions in magnetosome formation in M. gryphiswaldense

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor-binding domain (RBD). In one subject, just four IgG lineages accounted for 93.5% of the response, including an N-terminal domain (NTD)-directed antibody that was protective against lethal viral challenge. Genetic, structural, and functional characterization of a multi-donor class of “public” antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. These data show that “public” NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape