Recent Advances in Psychotherapeutic Treatment and Understanding of Alexithymia in Patients with Obesity and Diabetes Mellitus Type 2

Alexithymia is the inability to describe one’s own feelings and is being increasingly researched. According to contemporary psychodynamic theories, negative emotions cannot be adequately named and externalized, but remain trapped in the body. Recent research shows the connection of alexithymia with numerous somatic diseases. Diabetes mellitus type 2 and obesity represent great challenges in treatment, and the psychological profiles in these diseases are being studied more and more often. Therefore, alexithymia enters the focus of some research as a factor that could play a significant role in these diseases, namely as the one that makes a difference. The aim of this paper is a review of the literature with the purpose of understanding the current knowledge about the interconnection between alexithymia, obesity and type 2 diabetes mellitus

Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets

Macrophages protect the body from damage and disease by targeting antibody-opsonized cells for phagocytosis. Though antibodies can be raised against antigens with diverse structures, shapes, and sizes, it is unclear why some are more effective at triggering immune responses than others. Here, we define an antigen height threshold that regulates phagocytosis of both engineered and cancer-specific antigens by macrophages. Using a reconstituted model of antibody-opsonized target cells, we find that phagocytosis is dramatically impaired for antigens that position antibodies >10 nm from the target surface. Decreasing antigen height drives segregation of antibody-bound Fc receptors from the inhibitory phosphatase CD45 in an integrin-independent manner, triggering Fc receptor phosphorylation and promoting phagocytosis. Our work shows that close contact between macrophage and target is a requirement for efficient phagocytosis, suggesting that therapeutic antibodies should target short antigens in order to trigger Fc receptor activation through size-dependent physical segregation

Svečani koncert 4. odsjeka za pjevanje (studenti i profesori Muzičke akademije Sveučilišta u Zagrebu i gosti, 26. 1. 2022.)

Snimka svečanog koncerta 4. odsjeka za pjevanje. Koncert je održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 26. 1. 2022. Izvođači: Josipa Bilić (sopran), Josipa Gvozdanić (sopran), Eva Kirchmayer Bilić, umj. sav. (klavir), izv. prof. art. Martina Zadro (sopran), Darija Auguštan (sopran), Nikolina Hrkać (sopran), izv. prof. art. Martina Gojčeta Silić (mezzosopran), Domagoj Dorotić (tenor), doc. art. Alexei Tanovitski (bas), Darko Domitrović, umj. sav. (klavir), Sonja Runje (mezzosopran), doc. art. Simon Dešpalj (klavir), Matija Meić (bariton), Božo Letunić, v. umj. sur. (klavir), izv. prof. art. Miljenka Grđan (sopran), nasl. doc. art. Helena Lucić Šego (mezzosopran), Ivan Pernicki, umj. sur. (klavir), red. prof. art. Lidija Horvat Dunjko (sopran), Mario Čopor, umj. sav. (klavir), Valentina Fijačko Kobić (sopran), nasl. doc. art. Marija Kuhar Šoša (sopran), Lana Bradić, umj. sav. (klavir), Filip Filipović (tenor). Moderatorice: Josipa Bilić, Josipa Gvozdanić. Režija: doc. art. Dora Ruždjak Podolski. Oblikovanje svjetla: Anja Sekulić. Tehnička obrada video materijala: Vid Begić. Program: 1. Engelbert Humperdinck: Brate, dođi plesati, duet Ivice i Marice iz opere Ivica i Marica (izvođači: Josipa Bilić, Josipa Gvozdanić, Eva Kirchmayer Bilić); 2. Darko Domitrović: Dante songs (Inferno – Purgatorio – Paradiso) (izvođači: Martina Zadro, Darija Auguštan, Nikolina Hrkać, Martina Gojčeta Silić, Domagoj Dorotić, Alexei Tanovitski, Darko Domitrović); 3. Gioachino Rossini: Pensa alla patria, arija Isabelle iz opere Talijanka u Alžiru (izvođači: Sonja Runje, Simon Dešpalj); 4. Giuseppe Verdi: Cortigiani, vil razza dannata, arija Rigoletta iz opere Rigoletto (izvođači: Matija Meić, Božo Letunić); 5. Jacques Offenbach: Belle nuit, ô nuit d'amour, duet Giuliette i Nicklaussa iz opere Hoffmannove priče (izvođači: Miljenka Grđan, Helena Lucić Šego, Ivan Pernicki); 6. Emmerich Kálmán: Ciganske kad čujem pjesme, arija Marice iz operete Grofica Marica (izvođači: Lidija Horvat Dunjko, Mario Čopor); 7. Giacomo Puccini: O mio babbino caro, arija Laurette iz opere Gianni Schicchi (izvođači: Valentina Fijačko Kobić, Mario Čopor); 8. Charles Gounod: Je veux vivre, arija Julije iz opere Romeo i Julija (izvođači: Marija Kuhar Šoša, Lana Bradić); 9. Augustín Lara: Granada (izvođači: Filip Filipović, Lana Bradić); 10. Gaetano Donizetti: Cheti, cheti, immantinente, duet Don Pasqualea i Malateste iz opere Don Pasquale (izvođači: Filip Filipović, Lana Bradić)

Svečani koncert 4. odsjeka za pjevanje (studenti i profesori Muzičke akademije Sveučilišta u Zagrebu i gosti, 26. 1. 2022.)

Snimka svečanog koncerta 4. odsjeka za pjevanje. Koncert je održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 26. 1. 2022. Izvođači: Josipa Bilić (sopran), Josipa Gvozdanić (sopran), Eva Kirchmayer Bilić, umj. sav. (klavir), izv. prof. art. Martina Zadro (sopran), Darija Auguštan (sopran), Nikolina Hrkać (sopran), izv. prof. art. Martina Gojčeta Silić (mezzosopran), Domagoj Dorotić (tenor), doc. art. Alexei Tanovitski (bas), Darko Domitrović, umj. sav. (klavir), Sonja Runje (mezzosopran), doc. art. Simon Dešpalj (klavir), Matija Meić (bariton), Božo Letunić, v. umj. sur. (klavir), izv. prof. art. Miljenka Grđan (sopran), nasl. doc. art. Helena Lucić Šego (mezzosopran), Ivan Pernicki, umj. sur. (klavir), red. prof. art. Lidija Horvat Dunjko (sopran), Mario Čopor, umj. sav. (klavir), Valentina Fijačko Kobić (sopran), nasl. doc. art. Marija Kuhar Šoša (sopran), Lana Bradić, umj. sav. (klavir), Filip Filipović (tenor). Moderatorice: Josipa Bilić, Josipa Gvozdanić. Režija: doc. art. Dora Ruždjak Podolski. Oblikovanje svjetla: Anja Sekulić. Tehnička obrada video materijala: Vid Begić. Program: 1. Engelbert Humperdinck: Brate, dođi plesati, duet Ivice i Marice iz opere Ivica i Marica (izvođači: Josipa Bilić, Josipa Gvozdanić, Eva Kirchmayer Bilić); 2. Darko Domitrović: Dante songs (Inferno – Purgatorio – Paradiso) (izvođači: Martina Zadro, Darija Auguštan, Nikolina Hrkać, Martina Gojčeta Silić, Domagoj Dorotić, Alexei Tanovitski, Darko Domitrović); 3. Gioachino Rossini: Pensa alla patria, arija Isabelle iz opere Talijanka u Alžiru (izvođači: Sonja Runje, Simon Dešpalj); 4. Giuseppe Verdi: Cortigiani, vil razza dannata, arija Rigoletta iz opere Rigoletto (izvođači: Matija Meić, Božo Letunić); 5. Jacques Offenbach: Belle nuit, ô nuit d'amour, duet Giuliette i Nicklaussa iz opere Hoffmannove priče (izvođači: Miljenka Grđan, Helena Lucić Šego, Ivan Pernicki); 6. Emmerich Kálmán: Ciganske kad čujem pjesme, arija Marice iz operete Grofica Marica (izvođači: Lidija Horvat Dunjko, Mario Čopor); 7. Giacomo Puccini: O mio babbino caro, arija Laurette iz opere Gianni Schicchi (izvođači: Valentina Fijačko Kobić, Mario Čopor); 8. Charles Gounod: Je veux vivre, arija Julije iz opere Romeo i Julija (izvođači: Marija Kuhar Šoša, Lana Bradić); 9. Augustín Lara: Granada (izvođači: Filip Filipović, Lana Bradić); 10. Gaetano Donizetti: Cheti, cheti, immantinente, duet Don Pasqualea i Malateste iz opere Don Pasquale (izvođači: Filip Filipović, Lana Bradić)

Structural differences between yeast and mammalian microtubules revealed by cryo-EM

Microtubules are polymers of αβ-tubulin heterodimers essential for all eukaryotes. Despite sequence conservation, there are significant structural differences between microtubules assembled in vitro from mammalian or budding yeast tubulin. Yeast MTs were not observed to undergo compaction at the interdimer interface as seen for mammalian microtubules upon GTP hydrolysis. Lack of compaction might reflect slower GTP hydrolysis or a different degree of allosteric coupling in the lattice. The microtubule plus end-tracking protein Bim1 binds yeast microtubules both between αβ-tubulin heterodimers, as seen for other organisms, and within tubulin dimers, but binds mammalian tubulin only at interdimer contacts. At the concentrations used in cryo-electron microscopy, Bim1 causes the compaction of yeast microtubules and induces their rapid disassembly. Our studies demonstrate structural differences between yeast and mammalian microtubules that likely underlie their differing polymerization dynamics. These differences may reflect adaptations to the demands of different cell size or range of physiological growth temperatures