Digital Crime Histories and Developing a Public Pedagogy of Criminal Justice

Crime history was a pioneer in the digital arena, democratising access to the past by engaging large public and academic audiences with primary datasets online. This article traces the evolution of digital crime history from 2003 to 2021 in the United Kingdom and Australia. It charts a shift from catering to a passive audience towards projects that actively engage public audiences through crowdsourced transcriptions, interactive data visualisations and other aural, visual and multimedia forms. It has never been easier to access these nations’ criminal pasts online, but we must pause to reflect on what the aims of public engagement are. What kinds of digital public pedagogy do we want to build, and how can they be critical, reflective and widely representative? We conclude by considering the challenges to this endeavour, including what roles academics and commercial gatekeepers might play, the effects of the COVID-19 pandemic and the uneven geographies of digitisation within the Southern Hemisphere

Scaling Up Early Childhood Development and Education in a Devolved Setting: Policy Making, Resource Allocations, and Impacts of the Tayari School Readiness Program in Kenya

Early childhood development and education (ECDE) is devolved in Kenya, which means that each of Kenya’s 47 counties budgets for and implements ECDE independently. Kenya provides two years of preprimary education to children ages four and five. Given scarce resources, constructing facilities and hiring teachers are often principal considerations for county governments. The present study investigated whether and how counties go beyond the basic provision of facilities and teachers to invest in learning materials, expand teacher professional development, and hire coaches to improve the quality of teaching. These results are presented in the context of the Tayari ECDE program, which was designed to improve school readiness in a cost-effective way. We present qualitative findings from several counties to describe how government bodies invest in additional elements of preprimary quality improvement. We also compare results across counties that do and do not implement the Tayari model to understand whether implementation of an effective program to increase ECDE quality encourages adjustments in government resource allocations. In addition, we present quantitative results from a large-scale longitudinal treatment and control study of the Tayari model, which tested the effectiveness of curriculum-aligned instructional materials and teacher training and support in improving learners’ school readiness in public and low-cost private learning centers. Finally, we present policy implications for decentralized government structures responsible for providing ECDE, noting how these can be supported and incentivized to increase investments in ECDE quality

Scaling Up Early Childhood Development and Education in a Devolved Setting: Policy Making, Resource Allocations, and Impacts of the Tayari School Readiness Program in Kenya

Early childhood development and education (ECDE) is devolved in Kenya, which means that each of Kenya’s 47 counties budgets for and implements ECDE independently. Kenya provides two years of preprimary education to children ages four and five. Given scarce resources, constructing facilities and hiring teachers are often principal considerations for county governments. The present study investigated whether and how counties go beyond the basic provision of facilities and teachers to invest in learning materials, expand teacher professional development, and hire coaches to improve the quality of teaching. These results are presented in the context of the Tayari ECDE program, which was designed to improve school readiness in a cost-effective way. We present qualitative findings from several counties to describe how government bodies invest in additional elements of preprimary quality improvement. We also compare results across counties that do and do not implement the Tayari model to understand whether implementation of an effective program to increase ECDE quality encourages adjustments in government resource allocations. In addition, we present quantitative results from a large-scale longitudinal treatment and control study of the Tayari model, which tested the effectiveness of curriculum-aligned instructional materials and teacher training and support in improving learners’ school readiness in public and low-cost private learning centers. Finally, we present policy implications for decentralized government structures responsible for providing ECDE, noting how these can be supported and incentivized to increase investments in ECDE quality

Territory Holders Are More Aggressive towards Older, More Dangerous Floaters

Animals that show aggression often risk injury and incur steep energetic costs. Thus, aggression should occur at such times and towards such opponents as to maximize fitness. We tested hypotheses predicting adaptive territorial aggression in the common loon, a species in which ease of observation of territory owners and floaters (prebreeders) seeking to evict them provide a rare window onto owner-floater competition. As predicted, older, more competitive floaters (4-year-olds and upwards) tended to intrude into territories that had produced chicks the previous year (and, hence, were of high quality). Older floaters also showed predicted increases in aggression and territorial yodeling, and a lower rate of submissive behaviors than younger floaters. Floaters of all ages intruded more often than neighboring territory owners, as predicted, but tended to avoid territories with chicks. For their part, owners yodeled more often and behaved more aggressively during chick-rearing, although yodels peaked in frequency 2 weeks before aggression, suggesting that males with young chicks yodel to discourage intrusions, but employ aggression to protect older chicks. Territory owners showed the predicted higher rates of aggression and yodeling towards older, more dangerous floaters than towards young, submissive ones. However, territorial pairs did not treat floaters more aggressively than neighbors, overall. Moreover, owners showed no spike in aggression nor yodeling following a year with chicks, perhaps to avoid providing social information to floaters that use chicks as social information to target territories for eviction

Digital Crime Histories and Developing a Public Pedagogy of Criminal Justice

Crime history was a pioneer in the digital arena, democratising access to the past by engaging large public and academic audiences with primary datasets online. This article traces the evolution of digital crime history from 2003 to 2021 in the United Kingdom and Australia. It charts a shift from catering to a passive audience towards projects that actively engage public audiences through crowdsourced transcriptions, interactive data visualisations and other aural, visual and multimedia forms. It has never been easier to access these nations’ criminal pasts online, but we must pause to reflect on what the aims of public engagement are. What kinds of digital public pedagogy do we want to build, and how can they be critical, reflective and widely representative? We conclude by considering the challenges to this endeavour, including what roles academics and commercial gatekeepers might play, the effects of the COVID-19 pandemic and the uneven geographies of digitisation within the Southern Hemisphere.</jats:p

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

The Kaposi's sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC class I. K3 is an E3 ubiquitin ligase that promotes Lys(63)-linked polyubiquitination of MHC class I, providing the signal for clathrin-mediated endocytosis. Endocytosis is followed by sorting into the intralumenal vesicles (ILVs) of multivesicular bodies (MVBs) and eventual delivery to lysosomes. The sorting of MHC class I into MVBs requires many individual proteins of the four endosomal sorting complexes required for transport (ESCRTs). In HeLa cells expressing the KSHV K3 ubiquitin ligase, the effect of RNAi-mediated depletion of individual proteins of the ESCRT-0 and ESCRT-I complexes and three ESCRT-III proteins showed that these are required to down-regulate MHC class I. However, depletion of proteins of the ESCRT-II complex or of the ESCRT-III protein, VPS20 (vacuolar protein sorting 20)/CHMP6 (charged MVB protein 6), failed to prevent the loss of MHC class I from the cell surface. Depletion of histidine domain phosphotyrosine phosphatase (HD-PTP) resulted in an increase in the cell surface concentration of MHC class I in HeLa cells expressing the KSHV K3 ubiquitin ligase. Rescue experiments with wild-type (WT) and mutant HD-PTP supported the conclusion that HD-PTP acts as an alternative to ESCRT-II and VPS20/CHMP6 as a link between the ESCRT-I and those ESCRT-III protein(s) necessary for ILV formation. Thus, the down-regulation of cell surface MHC class I, polyubiquitinated by the KSHV K3 ubiquitin ligase, does not employ the canonical ESCRT pathway, but instead utilizes an alternative pathway in which HD-PTP replaces ESCRT-II and VPS20/CHMP6.This work was supported by an MRC research grant to J.P.L. (G0900113). M.D.J.P. and J.L.E. were MRC research students and S.P. a Wellcome Trust research student. K.B. was a British Heart Foundation Intermediate Fellow and P.J.L. is a Wellcome Trust Principal Fellow. The CIMR is supported by a Wellcome Trust Strategic Award 100140 and an electron microscope was purchased with Wellcome Trust grant 093026.This is the final version of the article. It first appeared from Portland Press via http://dx.doi.org/10.1042/BJ2015033

Bringing numerous methods for expression and promoter analysis to a public cloud computing service

Every year, a large number of novel algorithms are introduced to the scientific community for a myriad of applications, but using these across different research groups is often troublesome, due to suboptimal implementations and specific dependency requirements. This does not have to be the case, as public cloud computing services can easily house tractable implementations within self-contained dependency environments, making the methods easily accessible to a wider public. We have taken 14 popular methods, the majority related to expression data or promoter analysis, developed these up to a good implementation standard and housed the tools in isolated Docker containers which we integrated into the CyVerse Discovery Environment, making these easily usable for a wide community as part of the CyVerse UK project

SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis

Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptional regulation in vivo governing fibrotic matrix deposition by liver myofibroblasts. This gap in understanding has hampered molecular predictions of disease severity and clinical progression and restricted targets for antifibrotic drug development. In this study we show the prevalence of SOX9 in biopsies from patients with chronic liver disease correlated with fibrosis severity and accurately predicted disease progression towards cirrhosis. Inactivation of Sox9 in mice protected against both parenchymal and biliary fibrosis, improved liver function and ameliorated chronic inflammation. SOX9 was downstream of mechanosignaling factor, YAP1. These data demonstrate a role for SOX9 in liver fibrosis and open the way for the transcription factor and its dependent pathways as new diagnostic, prognostic and therapeutic targets in patients with liver fibrosis

Brief Measure for Screening Complicated Grief: Reliability and Discriminant Validity

BACKGROUND: Complicated grief, which is often under-recognized and under-treated, can lead to substantial impairment in functioning. The Brief Grief Questionnaire (BGQ) is a 5-item self-report or interview instrument for screening complicated grief. Although investigations with help-seeking samples suggest that the BGQ is valid and reliable, it has not been validated in a broader population. METHODOLOGY/PRINCIPAL FINDINGS: A questionnaire was mailed to a randomly selected sample (n = 5000) residing in one of 4 areas of Japan. The BCQ was examined for responders who were bereaved more than 6 months and less than 10 years (n = 915). Non-specific psychological distress was assessed with the K6 screening scale. Multiple group confirmatory factor analysis supported a uni-dimensional factor structure and the invariance of parameters across gender and age. Cronbach's alpha was sufficiently high (alpha = .75) to confirm internal consistency. Average Variance Extracted (0.39) was higher than the shared covariance (0.14) between BGQ and K6, suggesting discriminant validity. CONCLUSIONS: The results of this study support the reliability and validity of the BGQ in the Japanese population. Future studies should examine predictive validity by using structured interviews or more detailed scales for complicated grief