Collaborative innovation and scientific data repositories: proposed of an ambience to promote technologies for family farms

Diante das questões sobre a transferência de informação tecnológica para agricultores familiares é cada vez mais frequente o registro de experiências que propõem mudança de enfoque na geração de tecnologias e que abrangem a discussão sobre novos métodos, sendo que seus resultados enriquecem o debate sobre a construção de modelos inovadores. O processo de inovação tecnológica é fundamental para o desenvolvimento da agricultura nacional e, atualmente, tem sido visto de uma maneira ampla, integrando ao processo agentes internos e externos de uma organização (BUENO; BALESTRINI, 2012). Numa sociedade em que o imperativo é conhecer e ter maior capital intelectual (TOMAEL et al., 2005), abrir-se ao conhecimento externo é essencial às instituições, principalmente quando o amadurecimento das TICs, especialmente voltadas para a colaboração em massa, permitem a interação e criação com mais indivíduos em mais regiões do mundo, usando, por isto, um conjunto de capacidades mais versátil. A construção compartilhada, pensada para o processo de inovação tecnológica na agricultura, deve ser vista como um modelo capaz de romper as fronteiras organizacionais, criando conexões entre todos os atores envolvidos no processo: consumidores, parceiros, fornecedores e demais agentes, para agregar valor ao produto final.Um projeto da Embrapa tem como objetivo estruturar uma ambiência, que propõe a produção coletiva do conhecimento (crowdsourcing) a partir de serviços de informação tecnológica como repositórios de dados científicos de acesso aberto, como um processo alternativo e auxiliar de geração de novas tecnologias para a agricultura familiar.Para subsidiar o projeto, realizou-se um levantamento na base de dados “Agricola”, sobre o tema da colaboratividade e inovação e discutiu-se dois trabalhos, sobre estruturas de Serviços de Informação Tecnológica, onde ocorre a coleta e registro de informações oriundas dos consumidores e usuários, em que a colaboratividade tem sido vista de maneira estratégica para a resolução de questões comuns, bem como proposições de novas abordagens para a P&D.Faced with questions about the transfer of technological information to farmers is increasingly common logging experiments that propose change of focus on generating technologies and spanning the discussion on new methods, but results enrich the debate about building innovative models. The process of technological innovation is key to the development of national agriculture and currently has been seen in an extensive way, integrating the process internal and external stakeholders of an organization, (BUENO ; BALESTRINI 2012).In a society where the imperative is to know and have greater intellectual capital ( TOMAEL et al., 2005) , opening up to external knowledge is essential to the institutions, especially when the maturity of ICTs, especially geared for mass collaboration , allow interaction and creating more individuals in more parts of the world, using, for this, a set of versatile capabilities. The shared construction, designed for the process of technological innovation in agriculture, should be seen as a model capable of breaking organizational boundaries, creating connections between all actors involved in the process: customers, partners, suppliers and other agents, to add value to final product.A project of Embrapa aims to structure an ambience, which proposes the collective production of knowledge (crowdsourcing) from information technology services, as repositories of scientific data open access, as an alternative process and help to generate new technologies for family farming.To support the project, carried out a survey in the database " Agricola ", on the subject of colaboratividade and innovation was discussed two studies on structures of Information Technology Services, where the gathering and recording information from the occurs consumers and users, where co-creation has been seen in a strategic way to resolve common issues and proposals for new approaches to R&D.Ibero-American Science and Technology Education Consortiu

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol reactions. The activity of these compounds as inhibitors of p53–MDM2 interaction was investigated using a yeast-based screening assay. Using this approach two chalcones (3 and 4) were identified as putative small molecule inhibitors of p53–MDM2 interaction. The activity of both chalcones was further investigated in a panel of human tumor cells. Chalcones 3 and 4 revealed a pronounced tumor cell growth inhibitory effect on tumor cell lines. Additionally, chalcone 4 caused alterations in the cell cycle profile, induced apoptosis and increased the levels of p53, p21 and PUMA proteins in NCI-H460 cells. Computational docking studies allowed to predict that, like nutlin-3A (a well-known small-molecule inhibitor of p53–MDM2 interaction), chalcones 3 and 4 bind to the p53-binding site of MDM2. The results here presented will be valuable for the structure-based design of novel and potent p53–MDM2 inhibitors.This research was partially supported by the Strategic Funding UID/Multi/04423/2013 , ERDF , COMPETE , and FCT under the projects PTDC/MAR-BIO/4694/2014, and INNOVMAR – Innovation and Sustainability in the Management and Exploitation of Marine Resources, reference NORTE-01-0145-FEDER-000035 , Research Line NOVELMAR . This work also received financial support from the European Union (FEDER funds POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) under the Partnership Agreement PT2020 UID/QUI/50006/2013 and the FCT project PTDC/DTP-FTO/1981/2014, “PEst-C/SAU/LA0003/2013”, “NORTE-07-0162-FEDER-00018 – Contributos para o reforço da capacidade do IPATIMUP enquanto actor do sistema regional de inovação” and NORTE-07-0162-FEDER-000067 – Reforço e consolidação da capacidade infraestrutural do IPATIMUP para o sistema regional de inovação”, both supported by ON.2 – O Novo Norte, through FEDER funds under the QREN. IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT. The authors also thank FCT for the grants of R.T. Lima ( SFRH/BPD/68787/2010 ), J. Soares ( SFRH/BD/78971/2011 ), and S. Gomes ( SFRH/BD/96189/2013 ; Doctoral Programme BiotechHealth), L. Raimundo ( PD/BI/113926/2015 , Doctoral Programme BiotechHealth)

ANÁLISE DO IMPACTO DA PRODUÇÃO TÉCNICO-CIENTÍFICA DE UMA UNIDADE DA EMBRAPA ESPECIALIZADA EM GEOINFORMAÇÃO

O grande desafio imposto às organizações é o de saber transformar, compreender, interpretar e utilizar a enorme massa documental e informacional disponível. No contexto da Embrapa Territorial, as técnicas oriundas da Bibliometria e Cientometria vem sendo empregadas pela área de Transferência de tecnologias (TT) auxiliando no processo de gestão da informação, com vistas a apoiar a identificação de oportunidades a partir do acompanhamento do impacto dos trabalhos produzidos por este centro. Este trabalho tem o objetivo de obter inferências sobre o direcionamento da produção científica da Embrapa Monitoramento por Satélite a partir da análise do comportamento dos artigos de periódicos publicados pela instituição, no período de 2010 a 2015. As questões a serem respondidas para o alcance desse objetivo são: 1 - Qual o quantitativo informacional produzido pela Embrapa Territorial? 1.1. Qual a qualificação dos periódicos em que foram registrados os trabalhos no formato de artigos em periódicos; 2 - Qual o impacto dos trabalhos produzidos pela Unidade, nas bases de dados Web of Science e Google Scholar. 3. Qual a relação do impacto dos trabalhos com a rede de parcerias da Unidade

ANÁLISE DO IMPACTO DA PRODUÇÃO TÉCNICO-CIENTÍFICA DE UMA UNIDADE DA EMBRAPA ESPECIALIZADA EM GEOINFORMAÇÃO

O grande desafio imposto às organizações é o de saber transformar, compreender, interpretar e utilizar a enorme massa documental e informacional disponível. No contexto da Embrapa Territorial, as técnicas oriundas da Bibliometria e Cientometria vem sendo empregadas pela área de Transferência de tecnologias (TT) auxiliando no processo de gestão da informação, com vistas a apoiar a identificação de oportunidades a partir do acompanhamento do impacto dos trabalhos produzidos por este centro. Este trabalho tem o objetivo de obter inferências sobre o direcionamento da produção científica da Embrapa Monitoramento por Satélite a partir da análise do comportamento dos artigos de periódicos publicados pela instituição, no período de 2010 a 2015. As questões a serem respondidas para o alcance desse objetivo são: 1 - Qual o quantitativo informacional produzido pela Embrapa Territorial? 1.1. Qual a qualificação dos periódicos em que foram registrados os trabalhos no formato de artigos em periódicos; 2 - Qual o impacto dos trabalhos produzidos pela Unidade, nas bases de dados Web of Science e Google Scholar. 3. Qual a relação do impacto dos trabalhos com a rede de parcerias da Unidade

Learning the biochemical basis of axonal guidance: using Caenorhabditis elegans as a model

Aim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm Caenorhabditis elegans (C. elegans) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance and define nervous system structure and behavior at the organism level. Summary of work: A loosely oriented observational activity preceded detailed discussions on molecules implied in axonal migration. C. elegans mutants were used to introduce second-year medical students to the deleterious effects of gene malfunctioning in neuron response to extracellular biochemical cues and to establish links between molecular function, nervous system structure, and animal behavior. Students observed C. elegans cultures and associated animal behavior alterations with the lack of function of specific axon guidance molecules (the soluble cue netrin/UNC-6 or two receptors, DCC/UNC-40 and UNC-5H). Microscopical observations of these strains, in combination with pan-neuronal GFP expression, allowed optimal visualization of severely affected neurons. Once the list of mutated genes in each strain was displayed, students could also relate abnormal patterns in axon migration/ventral and dorsal nerve cord neuron formation in C. elegans with mutated molecular components homologous to those in humans. Summary of results: Students rated the importance and effectiveness of the activity very highly. Ninety-three percent found it helpful to grasp human axonal migration, and all students were surprised with the power of the model in helping to visualize the phenomenon.This work has been funded by National funds, through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020 and by the projects, NORTE01-0145-FEDER-000039 and NORTE-01-0145-FEDER-085468, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work has been also funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI—Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122). Additionally, C.V. and D.V.C. were supported by the FCT individual fellowships 2022.11176.BD and SFRH/BD/147826/2019, respectively

Building up an Open Data Plan for a public Research and Development organization and the challenge of an Open Agricultural Science

In keeping with the Open Data Policy of the Federal Executive Branch and the Law on Access to Information, the Brazilian Agricultural Research Corporation (Embrapa) has initiated discussions on the construction of its Open Data Plan – a planning tool for implementation and rationalization of open data publishing processes in public organizations. This paper aims to report the general strategy that was established for this purpose and the challenges that have been encountered in the preliminary stages of its implementation. As the opening of data by research institutions in Brazil is still in its infancy, Embrapa’s experience is expected to contribute to similar initiatives from other organizations

Estabelecimento de uma nova metodologia para o cálculo do índice de patogenicidade de amostras de Escherichia coli, em pintos de 1 dia

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Impact Assessment of Information and Communication Technologies in Agriculture: : Application of The Ambitec-TICs Method

An extraordinary moment of agricultural modernization is currently underway due to innovations in Information and Communication Technologies (ICTs). In this process, management precepts are renewed, fostering significant gains in efficiency, productivity, and sustainable use of natural resources and the environment. The growing supply of ICTs and the extension of connectivity in rural areas, with their transforming roles in productive practices and economic relations, bring about questions regarding their impacts. These technologies include precision positioning systems and large volume databases, electronic sensors of site-specific production and environmental conditions, repositories of relational data, statistical and crop forecasting software, methodologies and processes; web-based information services, among others. The assessment of impacts focused on ICTs for agriculture needs innovative approaches, due to the peculiarities of their applications, the different scales of their socioenvironmental scopes and, at the same time, the verification of effectiveness of institutional investments on research, development, and innovation (RD&I). Based on these premises, the objectives of this work are to present a ‘module of impact indicators for Information and Communication Technologies (Ambitec-TICs)’, and assess its application to six typical technology adoption cases resulting from agricultural RD&I projects. The results detail critical analyses of the contributions of the proposed module for the registration, interpretation, and communication of impacts, with recommendations for technology transfer and accountability in institutional Social Balance documentation

Increasing the chances of natural conception: opinion statement from the the brazilian federation of gynecology and obstetrics associations - FEBRASGO - committee of gynecological endocrinology

Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portuguese acronym) Committee on Endocrine Gynecology provides suggestions to optimize counseling for non-infertile people attempting spontaneous conception41318319