Giant enchondroma recurrence of the proximal phalanx of the fifth finger: A case report

Enchondroma (EC) is a benign and cartilage-forming tumor that causes intramedullary lesions. Moreover, EC is the most common bone tumor in the phalanges and metacarpal bones of the hand, deforming the structure and causing pain and functional limitation. The management of this neoplasia is the surgical treatment and the approach that is well-accepted consists in the curettage followed by the void augmentation with biological or synthetic fillers. The results from surgery are usually good and the recurrence rate is low (2-15%). In this article we report a case of EC recurrence of the proximal phalanx of the fifth finger of the hand after curettage and grafting. The patient was treated with the amputation of the fifth ray according to the Tsuge technique, obtaining a satisfying clinical result

Growth, carcass and meat quality of Casertana, Italian Large White and Duroc x (Landrace x Italian Large White) pigs reared outdoors

To compare growth, skeletal development, carcass traits and meat quality of different genotypes, 10 Casertana (CT), 10 Italian Large White (LW) and 10 Duroc x (Landrace x Italian Large White) (DU) crosses, barrows of 90 days of age, were allotted to the same outdoor rearing and feeding conditions. Live weight was recorded and average daily gain (ADG) was calculated. At slaughter (330-day-old) dressing and lean percentages were determined; backfat thickness and loin eye depth were measured. Carcasses were dissected into commercial cuts. Water holding capacity, pH and colour (45 min and 24 h post-mortem) were measured. Longissimus lumborum muscle samples were collected for cholesterol, \u3b1-tochopherol and intramuscular collagen (IMC) analyses. CT compared to DU and LW had the lowest growth rate and skeletal development. Casertana showed higher backfat thickness, lower lean cut/fatty cut ratio and less lean meat (P<0.05). Loin eye depth differed among genotypes with LW>DU>CT (P<0.05). CT showed higher red colour of the meat than DU and LW (P<0.05). CT compared to LW had the highest hydroxylysylpiridinoline (HLP) crosslink concentration and HLP/IMC ratio, and a lower IMC amount (P<0.05). Casertana pigs produced meat that could be tougher than that from the improved breed, but more acceptable from the technological point of view. At eleven months of age bone weight, length and diameter were clearly genetic type-related; differently, the bone maturit

A New Technique for Finding Needles in Haystacks: A Geometric Approach to Distinguishing Between a New Source and Random Fluctuations

We propose a new test statistic based on a score process for determining the statistical significance of a putative signal that may be a small perturbation to a noisy experimental background. We derive the reference distribution for this score test statistic; it has an elegant geometrical interpretation as well as broad applicability. We illustrate the technique in the context of a model problem from high-energy particle physics. Monte Carlo experimental results confirm that the score test results in a significantly improved rate of signal detection.Comment: 5 pages, 4 figure

Scalable Scheduling Policy Design for Open Soft Real-Time Systems

Open soft real-time systems, such as mobile robots, must respond adaptively to varying operating conditions, while balancing the need to perform multiple mission specific tasks against the requirement that those tasks complete in a timely manner. Setting and enforcing a utilization target for shared resources is a key mechanism for achieving this behavior. However, because of the uncertainty and non-preemptability of some tasks, key assumptions of classical scheduling approaches do not hold. In previous work we presented foundational methods for generating task scheduling policies to enforce proportional resource utilization for open soft real-time systems with these properties. However, these methods scale exponentially in the number of tasks, limiting their practical applicability. In this paper, we present a novel parameterized scheduling policy that scales our technique to a much wider range of systems. These policies can represent geometric features of the scheduling policies produced by our earlier methods, but only require a number of parameters that is quadratic in the number of tasks. We provide empirical evidence that the best of these policies are competitive with exact solution methods in small problems, and significantly outperform heuristic methods in larger ones

Acromion Clavicular Joint Reconstruction with LARS Ligament in Acute Dislocation

Background: The acromion clavicular joint dislocations are common injuries of the shoulder. The severity is dependent upon the degree of ligamentous injury. Surgical treatment is typically performed in higher grade acromioclavicular separation with several static and dynamic operative procedures with or without primary ligament replacement. Methods: 47 patients with acute Rockwood type III, IV, and V injuries were treated surgically with LARS reconstruction. The success of technique was evaluated by radiographic outcomes for each patient at every follow-up visit (one,three, 12 months), while to assess pain reduction and clinical evaluation Visual Analogue scale score (VAS) and Constant-Murley score (CMA) was performed, respectively. An One Way Analysis of Variance (Kruskal-Wallis test), a multiple comparison Turket test, or a t-test (Mann-Whitney Rank Sum Test) were used when required. Results: Follow-up radiographs revealed maintenance of anatomical reduction in 41 patients, and no bone erosions has been identified. In short-term joint functional recovery has been observed. Indeed, after 12 months pain on the VAS-scale in all groups decreased significantly (P < 0.05), and the CMS revealed a significant overall improvement (P < 0.05). Conclusion: These data demonstrate that the use of the LARS allows to provide stability to the joint and especially to ensure its natural elasticity, relieving pain and improving joint function already one month post-surgery. Level of evidence: II

Evaluation of gene expression profiles of pig skeletal muscle in response to energy content of the diets using human microarrays

The aim of the research was to compare gene transcription profiles of Musculus longissimus dorsi (MLD) between pigs fed diets with high (HED) or low (LED) energy contents. Two groups of 4 Casertana pigs were reared from 3 to 12 months of age in the same environmental conditions and fed HED or LED. In the HED, the ave rage daily gain and back fat thickness were significantly (P<0.05) higher than in LED pigs. Differential expression of genes in MLD of pigs fed diets with different energy density was assessed by a human high-density complementary DNA (cDNA) muscle microarray consisting of 4670 probes and further confirmed by quantitative real time RT-PCR analysis. Seven of the genes up-regulated in MLD of HED pigs were invo l ved in the glycolytic and ox i d a t i ve metabolism (phosphoglycerate mutase 2, glyc e ra l d e hyde-3-phosphate dehydrogenase, NADH dehydrogenase ubiquinone1 beta 9, muscle pyruvate kinase, enolase 3, muscle creatine kinase, isocitrate dehydrogenase 3 (NAD+) gamma) and four in the contractile apparatus (tropomyosin 1 alpha, troponin C2, fast, fast skeletal myosin light chain 2, troponin T3, skeletal, fast). Instead, HED diet reduced the level of expression of muscle proteins associated with slow fibre type (troponin T1, skeletal, slow, supervillin, myosin binding protein C, slow type, titin, myosin, heavy polypeptide 7, beta, calponin homology-associated smooth muscle) and signal transduction (SH3-binding domain protein 5-like, hypothetical protein FLJ21438, protein kinase cAMP-dependent, catalytic, rho guanine nucleotide exchange factor 15). The down-regulation of CTSB was also observed for HED group. From the results it can be assumed that high energy content of the diet influence physiological processes in the muscle tissue by switching slow fibres into fast reacting fibres and thus enhancing meat quality

UV/Optical Emission Accompanying Gamma-ray Burst

We discuss the possible simultaneously UV/optical emission accompanying Gamma-ray bursts (GRBs). We show that as long as the intrinsic spectrum of GRB can extend to $\sim$10 GeV or higher, there is a large amount of relativistic $e^\pm$ pairs generated due to the annihilation of the soft $\gamma-$rays with the very energetic photons, which dominates over the electrons/positrons associated with the fireball, no matter the fireball is highly magnetized or not (For the highly magnetized fireball, the magnetic field is ordered, the high linear polarization of the multi-wavelength emission is expected). We find that these $e^\pm$ pairs can power an UV flash with $m\simeq 12-13{\rm th}$ magnitude, and the corresponding optical emission can be up to $m_{\rm R}\simeq15-16{\rm th}$ magnitude. Such bright UV emission can be detected by the upcoming satellite Swift, planned for launch in early 2004. The behavior of the optical-UV spectrum ($F_{\nu}\propto \nu^{5/2}$) differs significantly from that of the reverse shock emission ($F_{\nu}\propto \nu^{-\beta/2}$, $\beta \simeq 2.2$), which is a signature of the emission accompanying with GRB. The mild optical emission can be detected with the ROTSE-IIIa telescope system, if the response to the GRB alert is fast enough.Comment: 5 pages, no figures. MNRAS in pres

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position. Although linked to several pathways including cell survival and metabolism, the molecular mechanisms underlying these outcomes are poorly understood. We identified a novel interaction of DPP9 with Filamin A, which recruits DPP9 to Syk, a central kinase in B-cell signalling. Syk signalling can be terminated by degradation, requiring the ubiquitin E3 ligase Cbl. We show that DPP9 cleaves Syk to produce a neo N-terminus with serine in position 1. Pulse-chases combined with mutagenesis studies reveal that Ser1 strongly influences Syk stability. Furthermore, DPP9 silencing reduces Cbl interaction with Syk, suggesting that DPP9 processing is a prerequisite for Syk ubiquitination. Consistently, DPP9 inhibition stabilizes Syk, thereby modulating Syk signalling. Taken together, we demonstrate DPP9 as a negative regulator of Syk and conclude that DPP9 is a novel integral aminopeptidase of the N-end rule pathway

The very early afterglow powered by the ultra-relativistic mildly magnetized outflows

In the Poynting Flux dominated outflow (the initial ratio of the electromagnetic energy flux to the particle energy flux $\sigma_0\gg1$) model for Gamma-ray bursts, nearly half of the internally dissipated magnetic energy is converted into the prompt $\gamma-$ray energy emission and the rest is converted into the kinetic energy of the outflow. Consequently, at the end of the $\gamma-$ray burst, $\sigma$ decreases significantly ($\sigma\sim 1$ or even smaller). We numerically investigate the very early reverse shock emission powered by such mildly magnetized outflows interacting with medium--uniform interstellar medium (ISM) or stellar wind (WIND). We show that for $\sigma\sim0.05-1$ and typical parameters of Gamma-ray bursts, both the ISM-ejecta interaction and the WIND-ejecta interaction can power very strong optical emission ($m_{\rm R}\sim 10-12{\rm th}$ magnitude or even brighter). Similar to the very early afterglow powered by the non-magnetized ejecta interacting with the external medium, the main difference between the ISM-ejecta interaction case and the WIND-ejecta interaction case is that, before the reverse shock crosses the ejecta, the R-band emission flux increases rapidly for the former, but for the latter it increases only slightly. (The abstract has been shortened). We suggest that the linear polarization detection of the early multi-wavelength afterglow is highly needed to see whether the outflows powering GRBs are magnetized or not.Comment: 8 pages, 3 figures, A&A in pres