Orientaciones disciplinarias y enfoques metodológicos en la Investigación Educativa de la UAEM

Publicación derivada del primer congreso internacional de investigación educativa organizado por la red de cuerpos académicos en investigación educativa adscrito en la facultad de geografía de la UAEM.A tres años de su creación la REDCAIE de la UAEM, celebra organizando el Primer Congreso Internacional de Investigación Educativa (CIIE), haciendo participe a sus más de 100 integrantes para colaborar con las experiencias en la indagación del proceso educativo desde las diferentes orientaciones disciplinares y los enfoques metodológicos. Derivado del CIIE, se integra el presente libro electrónico con 27 capítulos integrados en seis apartados que nos presentan de forma particular la investigación educativa en; las ciencias naturales y exactas, las ciencias de la salud, en las tecnologías en la información y comunicación, en el Nivel Medio Superior, Formación y Práctica Docente, así como un anexo sobre las experiencias en la asesoría de tesis sobre investigación educativa. De esta forma, el presente documento, da cuenta de un primer acercamiento al objeto de estudio de los procesos académicos y las prácticas institucionales de la REDACIE de la UAEM, atendiendo su misión de generar trabajo colaborativo interdisciplinario, interinstitucional e intercultural como una vía para aportar conocimiento significativo y relevante para profesionalizar la docencia universitaria y orientar la repercusión favorable de sus resultados en el aprendizaje y enseñanza de las ciencias.Facultad de Geografía, RedCA, DECYD, IESU

Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

Abstract Objective To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)), and radiographic data (Bath Ankylosing Spondylitis Radiology Index (BASRI) score) were compared regarding HLA-B27 status. A univariate and multivariate analysis was performed to identify variables independently related to the presence of HLA-B27. Results Data from 1235 patients (74.8% male) were analyzed; 1029 were HLA-B27 positive (83%). HLA-B27-positive patients showed higher family aggregation and an earlier onset of disease compared with those who were HLA-B27 negative. HLA-B27-negative patients presented statistically higher BASDAI and BASFI scores and higher prevalence of arthritis, dactylitis, and extra-articular manifestations (psoriasis and inflammatory bowel disease (IBD)) but not anytime uveitis compared with those who were HLA-B27 positive. In the multivariate analysis, family history (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.27–3.49), younger age at diagnosis (OR 0.97, 95% CI 0.96–0.98), presence of peripheral arthritis (OR 0.53, 95% CI 0.32–0.89), dactylitis (OR 0.16, 95% CI 0.05–0.56), psoriasis (OR 0.45, 95% CI 0.26–0.78), and IBD (OR 0.22, 95% CI 0.12–0.40) were the main variables independently related to the presence or not of HLA-B27. Conclusion In Caucasian AS patients, the presence of HLA-B27 is related to an earlier disease onset and higher family aggregation. Absence of HLA-B27 is related to a higher frequency of peripheral arthritis, dactylitis, and extra-articular manifestations. Being HLAB27 positive is not related to a higher burden of disease or anytime uveitis

Correction to: Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database.

An amendment to this paper has been published and can be accessed via the original article

Contingent prenatal screening for frequent aneuploidies with cell-free fetal DNA analysis.

To analyze the results of contingent screening for common aneuploidies at our center from June 2017 to June 2019. Traditional screening tests were performed using a combination of biochemical markers and ultrasound measurements in the first and second trimesters to assess the risk of trisomies 21 (T21), 18 (T18) and 13 (T13). Cell-free DNA (cf-DNA) testing was offered (Harmony test) to pregnant women at high risk (>1/280 for T21 and > 1/150 for T13 and T18) and a normal early morphology scan. In positive cases, prenatal sampling was strongly recommended to confirm the results by gold standard methods (QF-PCR and karyotyping). Newborns' phenotypes were corroborated after birth in all cases. In this prospective study, 8153 pregnant women were enrolled, resulting in 390 at high risk according to traditional screening tests. cfDNA testing was offered to 383 women. Traditional screening tests showed a false negative rate of 9.68% for T21. Traditional test sensitivity for T21 was 90.3%, for a false positive rate of 4.17% and a positive predictive value of 7.6%. The positive and negative predictive value for cfDNA testing was 100%. The approach used avoided invasive procedures in 91.3% of women at high risk. The prevalence of chromosomal abnormalities in the population analyzed was 1 in 164, and 1 in 210 for T21. Our results show that offering cf-DNA testing to women at high risk in traditional tests (including those with risks >1 in 50) significantly reduces false positives and, therefore, the number of invasive tests. Extending the use of cf-DNA testing to intermediate risk categories may be cost effective

Bio-Inspired Molecules Extracted from Marine Macroalgae: A New Generation of Active Ingredients for Cosmetics and Human Health

International audienceMarine seaweeds produce protective and defensive compounds, for example, carbohydrates and phenolic compounds that are a source of bioinspiration for molecules with cosmetic and human health applications. This chapter provides a general description of seaweeds, together with a brief overview of the adaptive and chemical defenses developed by these organisms. Among the great diversity of metabolites produced by seaweeds, we focus on specific carbohydrates (floridoside and mannitol) and phenolic compounds (mycosporine-like amino acids and phlorotannins) produced by macroalgae. Particular attention is paid to their highly variable chemical structure and methods for their extraction and purification. Their mechanisms of action are discussed, focusing on osmoregulation, desiccation, and photoprotection, which affect seaweed ecophysiology. Finally, we review their utility for cosmetology as moisturizers, sunscreens, and antiaging agents, for human health as wound dressings, and for skin regeneration. We point out the challenges faced when using these natural compounds in the cosmetic and human health sectors and the problems linked to the exploitation of this natural resource